Aspectos Básicos y Aplicados de las Enfermedades Neuropsiquiatricas y Neurodegenerativas

Lineas de Investigación

Esta línea estudia desde aspectos biomédicos básicos de la neurotransmisión y regeneración en el Sistema Nervioso Central hasta aspectos aplicados a clínica y terapéutica. Está formado por diferentes equipos de trabajo que conforman un grupo multidisciplinar que permite el abordaje de enfermedades neuropsiquiatras y neurodegenerativas desde diferentes aproximaciones pero que convergen en el estudio de mecanismos básicos que permitirán el desarrollo de nuevas herramientas diagnósticas y terapéuticas en el tratamiento de estas enfermedades. Este grupo está avalado por años de investigación y docencia

01. Estudiar el papel de los neuropéptidos en el Sistema Nervioso Central (SNC), en áreas clave en la mediación de las funciones de comportamiento asociados con la ansiedad, depresión y el miedo

02. Analizar la interacción funcional de los sistemas opioide y dopaminérgico durante la dependencia a opiáceos en áreas relacionadas con el aprendizaje y consolidación de hábitos de conducta adictiva.

03. Profundizar en las bases moleculares y celulares implicados (como el estrés oxidativo) en la génesis de procesos neurodegenerativos como envejecimiento y Parkinson y estudiar los efectos neuroprotectores de IGF-II.

04. Diagnóstico precoz, monitorización e intervención en enfermedades neurodegenerativas y neuropsiquiátricas y mediante técnicas de evaluación autonómica y cognitiva. Aspectos básicos y aplicados.



Publicaciones científicas

  • Todo
  • D1
  • Q1
  • Q2
  • Otro

Effects of Long-Term Alcohol Drinking on the Dopamine D2 Receptor: Gene Expression and Heteroreceptor Complexes in the Striatum in Rats

Feltmann, K; Borroto-Escuela, DO; Ruegg, J; Pinton, L; Sergio TD; Narvaez, M; Jimenez-Beristain, A; Ekstrom, TJ; Fuxe, K; Steensland, P
Alcoholism-Clinical And Experimental Research 2018


Synthesis and dopaminergic activity of a series of new 1-aryl tetrahydroisoquinolines and 2-substituted 1-aryl-3-tetrahydrobenzazepines

Lucena-Serrano, C; Lucena-Serrano, A; Rivera, A; Lopez-Romero, JM; Valpuesta, M; Diaz, A
Bioorganic Chemistry 2018


Immunohistochemical mapping of neurotensin in the alpaca diencephalon

Sanchez, ML; Mangas, A; Medina, LE; Aguilar, LA; Diaz-Cabiale, Z; Narvaez, JA; Covenas, R
Folia Histochemica Et Cytobiologica 2018


A Novel Integrative Mechanism in Anxiolytic Behavior Induced by Galanin 2/Neuropeptide Y Y1 Receptor Interactions on Medial Paracapsular Intercalated Amygdala in Rats

Narvaez, M; Borroto-Escuela, DO; Santin, L; Millon, C; Gago, B; Flores-Burgess, A; Barbancho, MA; de la Mora, MP; Narvaez, JA; Diaz-Cabiale, Z; Fuxe, K
Frontiers In Cellular Neuroscience 2018


Oral Photoprotection: Effective Agents and Potential Candidates

Parrado, C; Philips, N; Gilaberte, Y; Juarranz, A; Gonzalez, S
Frontiers In Medicine 2018


Brain Dopamine Transmission in Health and Parkinson’s Disease: Modulation of Synaptic Transmission and Plasticity Through Volume Transmission and Dopamine Heteroreceptors

Borroto-Escuela, DO; De la Mora, MP; Manger, P; Narvaez, M; Beggiato, S; Crespo-Ramirez, M; Navarro, G; Wydra, K; Diaz-Cabiale, Z; Rivera, A; Ferraro, L; Tanganelli, S; Filip, G; Franco, R; Fuxe, K
Frontiers In Synaptic Neuroscience 2018


Excessive habit formation in schedule-induced polydipsia: Microstructural analysis of licking among rat strains and involvement of the orbitofrontal cortex.

Merchan, A; Mora, S; Gago, B; Rodriguez-Ortega, E; Fernandez-Teruel, A; Puga, J L; Sanchez-Santed, F; Moreno, M; Flores, P
Genes, Brain, And Behavior 2018


Glutamate receptors of the A5 region modulate cardiovascular responses evoked from the dorsomedial hypothalamic nucleus and perifornical area

Lopez-Gonzalez, MV; Diaz-Casares, A; Gonzalez-Garcia, M; Peinado-Aragones, CA; Barbancho, MA; de Albornoz, MC; Dawid-Milner, MS
Journal Of Physiology And Biochemistry 2018


Doppler Resistivity and Cerebral Small Vessel Disease: Hemodynamic Structural Correlation and Usefulness for the Etiological Classification of Acute Ischemic Stroke

de la Cruz-Cosme, C; Dawid-Milner, MS; Ojeda-Burgos, G; Gallardo-Tur, A; Segura, T
Journal Of Stroke & Cerebrovascular Diseases 2018


Receptor-Receptor Interactions in Multiple 5-HT1A Heteroreceptor Complexes in Raphe-Hippocampal 5-HT Transmission and Their Relevance for Depression and Its Treatment

Borroto-Escuela, DO; Narvaez, M; Ambrogini, P; Ferraro, L; Brito, I; Romero-Fernandez, W; Andrade-Talavera, Y; Flores-Burgess, A; Millon, C; Gago, B; Narvaez, JA; Odagaki, Y; Palkovits, M; Diaz-Cabiale, Z; Fuxe, K
Molecules 2018


Ratios of proteins in cerebrospinal fluid in Parkinson’s disease cognitive decline: prospective study

Delgado-Alvarado, M; Dacosta-Aguayo, R; Navalpotro-Gomez, I; Gago, B; Gorostidi, A; Jimenez-Urbieta, H; Quiroga-Varela, A; Ruiz-Martinez, J; Bergareche, A; Rodriguez-Oroz, MC
Movement Disorders 2018


Selective ablation of striatal striosomes produces the deregulation of dopamine nigrostriatal pathway

Shumilov, K; Real, MA; Valderrama-Carvajal, A; Rivera, A
Plos One 2018


Predicted change in the number of permanent medical teachers from 2017 to 2026. The training of future physicians in critical condition.

Lara, J P; Compan, A; Vargas-Nunez, J A; Cardellach, F; Fernandez-Gonzalez, S; Lopez-Muniz, A; Alvarez-Sala, J L
Revista Clinica Espanola 2018


Transcriptomic integration of D4R and MOR signaling in the rat caudate putamen

Valderrama-Carvajal, A; Irizar, H; Gago, B; Jimenez-Urbieta, H; Fuxe, K; Rodriguez-Oroz, MC; Otaegui, D; Rivera, A
Scientific Reports 2018

Disturbances in the FGFR1-5-HT1A Heteroreceptor Complexes in the Raphe-Hippocampal 5-HT System Develop in a Genetic Rat Model of Depression

Borroto-Escuela, DO; DuPont, CM; Li, X; Savelli, D; Lattanzi, D; Srivastava, I; Narvaez, M; Di Palma, M; Barbieri, E; Andrade-Talavera, Y; Cuppini, R; Odagaki, Y; Palkovits, M; Ambrogini, P; Lindskog, M; Fuxe, KFrontiers In Cellular Neuroscience. 2017

Dopamine D-4 receptor stimulation prevents nigrostriatal dopamine pathway activation by morphine: relevance for drug addiction

Rivera, A; Gago, B; Suarez-Boomgaard, D; Yoshitake, T; Roales-Bujan, R; Valderrama-Carvajal, A; Bilbao, A; Medina-Luque, J; Diaz-Cabiale, Z; Van Craenenbroeck, K; Borroto-Escuela, DO; Kehr, J; de Fonseca, FR; Santin, L; de la Calle, A; Fuxe, KAddiction Biology. 2017

Galanin (1-15) enhancement of the behavioral effects of Fluoxetine in the forced swimming test gives a new therapeutic strategy against depression

Flores-Burgess, A; Millon, C; Gago, B; Narvaez, M; Borroto-Escuela, DO; Mengod, G; Narvaez, JA; Fuxe, K; Santin, L; Diaz-Cabiale, ZNeuropharmacology. 2017

IGF-II promotes neuroprotection and neuroplasticity recovery in a long-lasting model of oxidative damage induced by glucocorticoids

Martin-Montanez, E; Millon, C; Boraldi, F; Garcia-Guirado, F; Pedraza, C; Lara, E; Santin, LJ; Pavia, J; Garcia-Fernandez, MRedox Biology. 2017

Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis

de Guevara-Miranda, DL; Millon, C; Rosell-Valle, C; Perez-Fernandez, M; Missiroli, M; Serrano, A; Pavon, FJ; de Fonseca, FR; Martinez-Losa, M; Alvarez-Dolado, M; Santin, LJ; Castilla-Ortega, EDisease Models & Mechanisms. 2017

maLPA1-null mice as an endophenotype of anxious depression

Moreno-Fernandez, RD; Perez-Martin, M; Castilla-Ortega, E; del Valle, CR; Garcia-Fernandez, MI; Chun, J; Estivill-Torrus, G; de Fonseca, FR; Santin, LJ; Pedraza, CTranslational Psychiatry. 2017

Non-linear classifiers applied to EEG analysis for epilepsy seizure detection

Martinez-Del-Rincon, J; Santofimia, MJ; del Toro, X; Barba, J; Romero, F; Navas, P; Lopez, JCExpert Systems With Applications. 2017

Understanding the Role of GPCR Heteroreceptor Complexes in Modulating the Brain Networks in Health and Disease

Borroto-Escuela, DO; Carlsson, J; Ambrogini, P; Narvaez, M; Wydra, K; Tarakanov, AO; Li, X; Millon, C; Ferraro, L; Cuppini, R; Tanganelli, S; Liu, F; Filip, M; Diaz-Cabiale, Z; Fuxe, KFrontiers In Cellular Neuroscience. 2017

Cocaine self-administration specifically increases A2AR-D2R and D2R-sigma1 R heteroreceptor complexes in the rat nucleus accumbens shell. Relevance for cocaine use disorder

Borroto-Escuela, DO; Narvaez, M; Wydra, K; Pintsuk, J; Pinton, L; Jimenez-Beristain, A; Di Palma, M; Jastrzebska, J; Filip, M; Fuxe, KPharmacology Biochemistry And Behavior. 2017

Cryptomphalus aspersa Mollusc Egg Extract Promotes Regenerative Effects in Human Dermal Papilla Stem Cells

Alameda, MT; Morel, E; Parrado, C; Gonzalez, S; Juarranz, AInternational Journal Of Molecular Sciences. 2017

The neuropeptides Galanin and Galanin(1-15) in depression-like behaviours

Millon, C; Flores-Burgess, A; Narvaez, M; Borroto-Escuela, DO; Gago, B; Santin, L; Castilla-Ortega, E; Narvaez, JA; Fuxe, K; Diaz-Cabiale, ZNeuropeptides. 2017

Acute polyneuropathies in a hospital in the south of Spain: ten years» experience

Alonso-Montejo, MM; Pradillo, MC; Moreno-Medinilla, EE; Navas-Sanchez, P; Martinez-Anton, JLRevista De Neurologia. 2017

Mapping of enkephalins and adrenocorticotropic hormone in the squirrel monkey brainstem

Duque-Diaz, E; Diaz-Cabiale, Z; Narvaez, J; Covenas, RAnatomical Science International. 2017

The impact of graphene on neural regenerative medicine

Rodriguez-Losada, N; Aguirre, JANeural Regeneration Research. 2017

Existence of Brain 5-HT1A-5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor-Receptor Interactions Regulating 5-HT1A Receptor Recognition

Borroto-Escuela, DO; Li, X; Tarakanov, AO; Savelli, D; Narvaez, M; Shumilov, K; Andrade-Talavera, Y; Jimenez-Beristain, A; Pomierny, B; Diaz-Cabiale, Z; Cuppini, R; Ambrogini, P; Lindskog, M; Fuxe, KAcs Omega. 2017

Brainstem and Autonomic Nervous System Dysfunction: A Neurosurgical Point of View

Martin-Gallego, A; Gonzalez-Garcia, L; Carrasco-Brenes, A; Segura-Fernandez-Nogueras, M; Delgado-Babiano, A; Ros-Sanjuan, A; Romero-Moreno, L; Dominguez-Paez, M; Dawid-Milner, M S; Arraez-Sanchez, M AActa Neurochirurgica. Supplement. 2017


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