Grupo de investigación en Medicina Maternofetal, epigenética, enfermedades de la mujer y salud reproductiva

Como grupo estamos interesados en obtener el reconocimiento del instituto e integrarnos en el funcionamiento del mismo.

Lineas de Investigación

01. Exposición perinatal y desarrollo psicoevolutiivo.

02. Prematuridad, marcadores pronósticos de neurodesarrollo fetal, trastornos del ánimo en el período perinatal, gestación múltiple, patología reproductiva.

Proyectos de Investigación


Primal Health Research Center
. 2012

Publicaciones científicas

  • Todo
  • D1
  • Q1
  • Q2
  • Otro
Anxiety and attitudes towards sex in women requesting emergency contraception.

González-Mesa ES, Bueno-Cobos L, Barroso-García N, Vilches-Jiménez JC.
J Psychosom Obstet Gynaecol. 2019 Mar;40(1):75-81.

We performed an observational descriptive study on 89 women who requested for emergency contraception (EC) at the emergency units of two hospitals, Virgen de la Victoria Hospital, and Regional University Hospital in Malaga between October 2016 and April 2017. Both hospitals are on the Andalusian Public Health System. We evaluated a group of socio-demographic variables and others related to the beliefs and the knowledge about EC and contraception […]

Correlates for state and trait anxiety in a multicultural sample of Turkish and Spanish women at first trimester of pregnancy.

González-Mesa E, Kabukcuoglu K, Körükcü O, Blasco M, Ibrahim N, Cazorla-Granados O, Kavas T.
J Affect Disord. 2019 Apr 15;249:1-7.

The main objective of this research was to assess the potential influence of cultural factors on the anxiety levels of a multicultural sample of Spanish and Turkish pregnant women at the beginning of the pregnancy. […]

Mood state at the beginning of the pregnancy and its influence on obstetric and perinatal outcomes.

González-Mesa ES, Arroyo-González ML, Ibrahim-Díez N, Cazorla-Granados O.
J Psychosom Obstet Gynaecol. 2019 Jun;40(2):106-113.

Aim: We designed this study to ascertain the prevalence of depressive disorders and anxiety at the beginning of the pregnancy, studying possible associated factors and assessing the influence of mood disorders on perinatal outcomes. Methods: A representative sample of 191 pregnant women at first trimester of their pregnancies completed a questionnaire that included the Whooley´s questions, the Spanish version of the Beck Depression Inventory (BD […]

Nutr Hosp. 2018 Jul 9;35(4):751-752.


Poor sleep quality is associated with perinatal depression. A systematic review of last decade scientific literature and meta-analysis.

González-Mesa E, Cuenca-Marín C, Suarez-Arana M, Tripiana-Serrano B, Ibrahim-Díez N, Gonzalez-Cazorla A, Blasco-Alonso M.
J Perinat Med. 2019 Sep 25;47(7):689-703.

Background Although pregnancy is frequently associated with mental states of happiness, hope and well-being, some physical and psychological changes can contribute to increased sleep disturbances and worsened sleep quality. Sleep quality has been linked to negative emotions, anxiety and depression. The main objective of this paper was to systematically review the impact of sleep during pregnancy on maternal mood, studying the association between […]

Type of delivery and reading, writing, and arithmetic learning in twin births.

González-Valenzuela MJ, López-Montiel D, Cazorla-Granados O, González-Mesa E.
Dev Psychobiol. 2019 Oct 31.

This study analyses, in children born in twin births, the relationship between reading, writing and arithmetic learning, on the one hand, and type of delivery, on the other, controlling for the effect of interaction and/or confusion of third variables (maternal age at delivery, gestational age, fetal position, birthweight, 1-min Apgar score). In the planned retrospective cohort design, the exposed cohort consisted of children born by caesarean se […]

Type of Delivery, Neuropsychological Development and Intelligence in Twin Births.

González-Valenzuela MJ, González-Mesa E, Cazorla-Granados O, López-Montiel D.
Front Psychol. 2019 May 3;10:972.

Based on a retrospective cohort design with 6-year-old children born in twin births, the relationship between verbal, non-verbal, global neuropsychological development, general intelligence and type of delivery has been studied. To this end, the possible effect of third gestational, obstetric and neonatal variables, such as maternal age at delivery, fetal presentation, gestational age, newborn weight and Apgar at minute one, was controlled. The e […]

2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy.

Regitz-Zagrosek V, Roos-Hesselink JW, Bauersachs J, Blomstrom-Lundqvist C, Cifkova R, De Bonis M, Iung B, Johnson MR, Kintscher U, Kranke P, Lang IM, Morais J, Pieper PG, Presbitero P, Price S, Rosano GMC, Seeland U, Simoncini T, Swan L, Warnes CA.
Kardiol Pol. 2019;77(3):245-326.


Cultural factors influencing antenatal depression: A cross-sectional study in a cohort of Turkish and Spanish women at the beginning of the pregnancy.

González-Mesa E, Kabukcuoglu K, Körükcü O, Blasco M, Ibrahim N, Kavas T.
J Affect Disord. 2018 Oct 1;238:256-260.

Depression is the most frequent mental disorder during pregnancy, and its prevalence is at least as high as that of postnatal depression. Differences between Western and Eastern countries may exist according to cultural and educational factors. […]

Neurological complications after therapy for fetal-fetal transfusion syndrome: a systematic review of the outcomes at 24 months.

Miralles-Gutiérrez A, Narbona-Arias I, González-Mesa E.
J Perinat Med. 2018 Nov 27;46(9):991-997.

The main objective of this study was to review the available scientific evidence about mid-term neurological outcomes in twins after laser therapy for twin-to-twin transfusion syndrome (TTTS). […]

Toxic elements in hair and in vitro fertilization outcomes: A prospective cohort study.

García-Fortea P, Cohen-Corcia I, Córdoba-Doña JA, Reche-Rosado A, González-Mesa E.
Reprod Toxicol. 2018 Apr;77:43-52.

We analysed the association between the concentration of four toxic elements (As, Cd, Hg and Pb) and diverse reproductive outcomes in a cohort of 194 women with fertility disorders undergoing IVF in a public hospital. Concentration in hair specimens was explored as biomarker of exposure during the three months prior to oocyte retrieval. The proportion of negative results, especially regarding pregnancy and birth outcomes, is remarkable. However, […]

Temporal trends for pregnancy length in a hospital setting of Southern Spain.

González-Mesa E, Villegas E.
J Obstet Gynaecol. 2017 Jan;37(1):38-43.

For centuries it has been considered that the due date for delivery in our species is 280 days after the onset of the last menstruation. However, in most cases this statement is not accurate. The main objective of this study was to determine the mean duration of pregnancy in our setting and whether it has experienced changes in recent years. A retrospective, population-based descriptive study was made of 102,169 deliveries assisted in Malaga Univ […]

Hair mercury concentrations and in vitro fertilization (IVF) outcomes among women from a fertility clinic.

Wright DL, Afeiche MC, Ehrlich S, Smith K, Williams PL, Chavarro JE, Batsis M, Toth TL, Hauser R.
Reprod Toxicol. 2015 Jan;51:125-132.

Total hair mercury (Hg) was measured among 205 women undergoing in vitro fertilization (IVF) treatment and the association with prospectively collected IVF outcomes (229 IVF cycles) was evaluated. Hair Hg levels (median=0.62ppm, range: 0.03-5.66ppm) correlated with fish intake (r=0.59), and exceeded the recommended EPA reference of 1ppm in 33% of women. Generalized linear mixed models with random intercepts accounting for within-woman correlation […]

The increasing number of multiple pregnancies in recent years has raised a particular concern about the problems associated to these pregnancies. It still remains unclear whether twin deliveries, as currently conceived, provide the same future health chances to both fetuses. In this regard, it is worth mentioning that the effects of obstetric and neonatal care beyond the perinatal period have not often been evaluated. The main objective of this r […]

The dynamic experience of pain in burn patients: A phenomenological study.

Pérez Boluda MT, Morales Asencio JM, Carrera Vela A, García Mayor S, León Campos A, López Leiva I, Rengel Díaz C, Kaknani-Uttumchandani S.
Burns. 2016 Aug;42(5):1097-1104.

Although pain is one of the main sources of suffering during the acute phase and rehabilitation in burn patients, it remains as a major challenge for burn care, and clinical management not always correlates with the experience felt by patients. The aim of this study was to understand the experience of pain from people who has suffered severe burns, to identify personal strategies used to cope with this challenging event. A qualitative phenomenolo […]

Changes in Quality of Life after 3 months of Usual Care in a Large Sample of Patients with Noncancer Pain: The «QOOL: Quality of Life and Pain» Study.

Velázquez Rivera I, García Escobar M, Moya Riera JJ, Del Saz de la Torre JM, Fenollosa Vázquez P, González Mesa JM, Casado A, Martín Fuentes M, de Andrés Ares J.
Pain Pract. 2015 Sep;15(7):633-42.

Large-scale observational studies can provide useful information on changes in health outcomes over time. The aim of this study was to investigate the effect of 3 months of usual care on quality of life (QOL) and pain outcomes in noncancer chronic pain patients managed by pain specialists and to examine factors associated with changes in QOL. This was assessed using the EQ-5D and pain outcomes using the Brief Pain Inventory (BPI). Changes in QOL […]

Exposure to synthetic oxytocin during delivery and its effect on psychomotor development.

González-Valenzuela MJ, López-Montiel D, González-Mesa ES.
Dev Psychobiol. 2015 Dec;57(8):908-20.

The main objective is to examine the influence of oxytocin administration during delivery on psychomotor development at age five years. This was a retrospective cohort study involving two groups: children of mothers exposed vs. not exposed to oxytocin during labor. Of the 7,465 newborns registered in our maternity service during 2006 we randomly selected an initial sample of 400 children. Of these, 146 children were assessed using the motor scale […]

Exposure to tobacco, alcohol and drugs of abuse during pregnancy. A study of prevalence among pregnant women in Malaga (Spain).

Blasco-Alonso M, González-Mesa E, Gálvez Montes M, Lozano Bravo I, Merino Galdón F, Cuenca Campos F, Marín Schiaffino G, Pérez Torres S, Herrera Peral J, Bellido Estévez I.
Adicciones. 2015 Jun 17;27(2):99-108.


High levels of alcohol consumption in pregnant women from a touristic area of Southern Spain.

González-Mesa E, Blasco-Alonso M, Gálvez Montes M, Lozano Bravo I, Merino-Galdón F, Cuenca-Campos F, Marín-Schiaffino G, Bellido-Estévez I.
J Obstet Gynaecol. 2015;35(8):821-4.

The prevalence of alcohol intake in women who become pregnant is similar to that found in the general population, especially in cases of unplanned pregnancies. Consequently, foetal exposure is high during the period of maximum vulnerability. The present study was carried out to determine the prenatal level of exposure to alcohol in Málaga, a Mediterranean region whose economy is based on the touristic sector (Costa del Sol). A cross-sectional, o […]

Use of a temporary inferior vena cava filter during pregnancy in patients with thromboembolic events.

González-Mesa E, Azumendi P, Marsac A, Armenteros A, Molina N, Narbona I, Herrera J, Artero I, Rodríguez-Mesa JM.
J Obstet Gynaecol. 2015;35(8):771-6.

There are circumstances in the management of thromboembolic events during pregnancy when anticoagulant therapy is either contraindicated or not advisable, such as when pulmonary embolism (PE) or deep venous thrombosis is diagnosed close to term, given the risk of bleeding during delivery. In these cases, the thromboembolic risk can be controlled using temporary inferior vena cava filters (T-IVCFs). We present the case of a pregnant woman with thr […]

Approach to the management of pregnancy in patients with pseudoxanthoma elasticum: a review.

Camacho M, Rengel C, López-Herrero E, Carrillo JL, Eslava AJ, Valdivielso P.
J Obstet Gynaecol. 2016 Nov;36(8):1061-1066.

Management of pregnancy in patients with rare diseases is often guided by incomplete knowledge because of a lack of high-quality case control studies or single-centre experience. Pseudoxanthoma elasticum (PXE) is an autosomal recessive metabolic disorder that results in calcification of elastic fibres of the skin, retina, and arteries, leading to skin lesions, eventual central visual loss, and potential arterial insufficiency in most patients. It […]

Effects of oxytocin used during delivery on development: a retrospective cohort study.

González-Valenzuela MJ, García-Fortea P, Delgado-Ríos M, Cazorla-Granados O, Blasco-Alonso M, González-Mesa E.
J Clin Exp Neuropsychol. 2014;36(7):680-90.

The objective was to evaluate the potential influence of oxytocin administered during delivery on children’s development at the age of 5. […]

Oxytocin administered during labor and breast-feeding: a retrospective cohort study.

García-Fortea P, González-Mesa E, Blasco M, Cazorla O, Delgado-Ríos M, González-Valenzuela MJ.
J Matern Fetal Neonatal Med. 2014 Oct;27(15):1598-603.

The relationship between labor physiology and the onset of lactation leads to assess the potential correlation between oxytocin administration during labor and duration of breast-feeding. […]

Tubal ectopic pregnancy two years after laparoscopic supracervical hysterectomy.

Villegas E, González-Mesa E, Benítez MJ, Luna S, Gómez C, Marsac A, Jiménez J.
BMC Womens Health. 2014 May 24;14:69.

Ectopic pregnancy after hysterectomy is a very rare condition, but it must be kept in mind in women with history of hysterectomy who present with abdominal pain and ecographic adnexal heterogeneous images. Since first described by Wendeler in 1895, at least 67 ectopic pregnancies (tubal, ovarian and abdominal) have been described in patients subjected to prior hysterectomy. […]

Maternal-fetal thyroid function at the time of birth and its relation with iodine intake.

Velasco I, Martín J, Gallego M, Gutiérrez-Repiso C, Santiago P, López-Siguero JP, Mesa EG, Peral JH, Pérez V, García-Fuentes E, Soriguer F.
Thyroid. 2013 Dec;23(12):1619-26.

The effects of moderate variations in dietary iodine intake on maternal and fetal thyroid function are poorly understood. Recent studies question the usefulness of neonatal screening of congenital hypothyroidism as a tool for monitoring iodine deficiency. We proposed to test the hypothesis of an association between iodine intake during the last trimester of pregnancy and fetal thyroid function at the time of birth. […]

Temporal trends of latency period and perinatal survival after very early preterm premature rupture of fetal membranes.

González-Mesa E, Herrera JA, Urgal A, Lazarraga C, Benítez MJ, Gómez C.
Arch Gynecol Obstet. 2012 Aug;286(2):347-52.

This paper shows temporal trends of latency period and perinatal survival after preterm premature rupture of membranes at or before 28 weeks (very early PPROM). […]

Temporal trends of latency period and perinatal survival after very early preterm premature rupture of fetal membranes.

González-Mesa E, Herrera JA, Urgal A, Lazarraga C, Benítez MJ, Gómez C.
Arch Gynecol Obstet. 2012 Aug;286(2):347-52.

This paper shows temporal trends of latency period and perinatal survival after preterm premature rupture of membranes at or before 28 weeks (very early PPROM). […]


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