Investigación clínica, molecular y tecnológica en Oncología Radioterápica

Lineas de Investigación

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Publicaciones científicas

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Role of radiotherapy in the treatment of metastatic head and neck cancer.

Ordoñez R, Otero A, Jerez I, Medina JA, Lupiañez-Pérez Y, Gomez-Millan J.
Onco Targets Ther. 2019 Jan 18;12:677-683.

In metastatic or locally advanced head and neck tumors that present in frail patients or after chemotherapy progression, radiotherapy is normally used as a palliative treatment, with a high rate of symptom palliation and improvement in quality of life. However, there is controversy about what the optimal regimen is. Moreover, despite the poor prognosis of metastatic head and neck cancer, different retrospective studies have shown that a minority […]

Causes of death in patients with locally advanced head and neck cancer treated with radiotherapy and systemic therapy.

Zapata I, Alvarez M, Hidalgo R, Pajares B, Garcia-Anaya MJ, Toledo MD, Trigo JM, Lupiañez-Perez Y, Medina JA, Jaime Gomez-Millan J.
BMC Cancer. 2019 Dec 21;19(1):1241.

To investigate the incidence of non-cancer mortalities and prognostic factors associated with competitive causes of death in a homogeneous cohort of patients with locally advanced head and neck cancer treated with radiotherapy and systemic treatment. […]

Causes of death in patients with locally advanced head and neck cancer treated with radiotherapy and systemic therapy.

Zapata I, Alvarez M, Hidalgo R, Pajares B, Garcia-Anaya MJ, Toledo MD, Trigo JM, Lupiañez-Perez Y, Medina JA, Jaime Gomez-Millan J.
BMC Cancer. 2019 Dec 21;19(1):1241.

To investigate the incidence of non-cancer mortalities and prognostic factors associated with competitive causes of death in a homogeneous cohort of patients with locally advanced head and neck cancer treated with radiotherapy and systemic treatment. […]

Efficacy and safety of a simplified SBRT regimen for central and peripheral lung tumours.

Román A, Perez-Rozos A, Otero A, Jodar C, García-Ríos I, Lupiañez-Perez Y, Antonio Medina J, Gomez-Millan J.
Clin Transl Oncol. 2020 Jan;22(1):144-150.

Evaluate the safety, toxicity and efficacy of an institutional-simplified SBRT protocol with two short SBRT regimens (three or five fractions) for the treatment of lung cancer and oligometastases, according to the volume and localization of tumours. […]

O6-methylguanine-DNA Methyltransferase Promoter Methylation in Patients with Rectal Adenocarcinoma After Chemoradiotherapy Treatment: Clinical Implications

Oliver JA, Gómez-Millán J, Medina JA, Cabeza L, Perazzoli G, Jimenez-Luna C, Doello K, Ortiz R.
Balkan Med J. 2019 Aug 22;36(5):283-286.

To analyze the clinical relevance of O6-methylguanine-DNA methyltransferase in rectal adenocarcinoma treated with chemoradiotherapy followed by surgery. […]

Soft tissue sarcoma of the extremities: pending questions on surgery and radiotherapy.

Hoefkens F, Dehandschutter C, Somville J, Meijnders P, Van Gestel D.
Radiat Oncol. 2016 Oct 12;11(1):136.

Soft tissue sarcomas are uncommon tumours of mesenchymal origin, most commonly arising in the extremities. Treatment includes surgical resection in combination with radiotherapy. Resection margins are of paramount importance in surgical treatment of soft tissue sarcomas but unambiguous guidelines for ideal margins of resection are still missing as is an uniform guideline on the use of radiotherapy.The present paper reviews the literature on soft […]

Improving efficacy and efficiency through the implementation of a new organisational model in a Radiation Oncology Department.

Lupiañez-Perez Y, Gomez-Millan J, Lobato M, Pedrosa P, Lupiañez-Perez I, Medina JA.
Clin Transl Oncol. 2017 Nov;19(11):1375-1381.

To evaluate a new organisational model, «process management» (PM), implemented in the Hospital Universitario Virgen de la Victoria (HUVV) compared with traditional models used in other Radiation Oncology Departments (RODs), in terms of efficacy and efficiency. […]

The role of stereotactic body radiotherapy in reirradiation of head and neck cancer recurrence.

Román A A, Jodar C, Perez-Rozos A, Lupiañez-Perez Y, Medina JA, Gomez-Millan J.
Crit Rev Oncol Hematol. 2018 Feb;122:194-201.

Head and neck cancer recurrence is a therapeutic challenge due to the anatomical and functional constraints of the head and neck area. Stereotactic body radiotherapy (SBRT) is a high-precision technique of radiotherapy that consists of delivering a high ablative biological dose in 1-5 high-dose fractions, requiring a very high precision of the radiotherapy process with potential application in this clinical setting METHODS: Different studies that […]

The impact of body mass index and nuclear β-catenin on survival in locally advanced rectal cancer treated with preoperative radiochemotherapy.

Gomez-Millan J, Queipo MI, Del Mar Delgado M, Perez-Villa L, Roman A, De la Portilla F, Torres E, De Luque V, Bayo E, Medina JA.
J Surg Oncol. 2017 Mar;115(3):301-306.

We examined the prognostic value of obesity and nuclear β-catenin in patients with locally advanced rectal cancer. […]

Subcellular localisation of pMEK has a different prognosis in locally advanced head and neck cancer treated with concomitant radiochemotherapy.

Gomez-Millan J, Pajares B, Perez-Villa L, Carnero A, Alvarez M, De Luque V, Rivas F, Trigo JM, Toledo MD, Alba E, Medina JA.
BMC Cancer. 2016 Oct 28;16(1):829.

MEK1 (MAP2K1) and MEK2 (MAP2K2) are closely related dual-specificity protein kinases which function by phosphorylating both serine/threonine and tyrosine residues of their substrates ERK1 and ERK2, controlling fundamental cellular processes that include cell growth and proliferation. To investigate the prognostic significance of pMEK expression in the nucleus and cytoplasm among patients with locally advanced head and neck cancer treated with con […]

Process management in a Radiation Oncology Department of Spain: Effectiveness and efficiency.

Lupiañez-Perez Y, Gomez-Millan J, Lobato M, Pedrosa P, Lupiañez-Perez I, Medina JA.
Radiother Oncol. 2016 Mar;118(3):581-2.

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Advances in Radiotherapy for Prostate Cancer Treatment.

Podder TK, Fredman ET, Ellis RJ.
Adv Exp Med Biol. 2018;1096:31-47.

Major categories of radiotherapy (RT) for prostate cancer (CaP) treatment are: (1) external beam RT (EBRT), and (2) brachytherapy (BT). EBRT are performed using different techniques like three-dimensional conformal RT (3D-CRT), intensity modulated RT (IMRT), volumetric modulated arc therapy (VMAT), and stereotactic body radiation therapy (SBRT), stereotactic radiosurgery (SRS) and intensity modulated proton therapy (IMPT), etc., using a variety o […]

Potential advantages of volumetric arc therapy in head and neck cancer.

Gomez-Millan Barrachina J, Jerez Sainz I, Perez Rozos A, Ramirez Ros JC, Toledo Serrano MD, Lupiañez Perez Y, Medina Carmona JA.
Head Neck. 2015 Jun;37(6):909-14.

Intensity-modulated radiation therapy (IMRT) uses solid compensators or multileaf collimators to modulate the intensity of radiation in each field, delivering highly conformal dose distributions. This technique allows treating volumes with concave shapes when the target is close to a critical structure. The movement of multileaf collimator under computer control can modulate the dose in 3 main ways: IMRT with static field with segments, IMRT with […]


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