Grupo universitario con experiencia en investigaciones sobre el sistema cardiovascular en Vertebrados, utilizando modelos animales de enfermedad de relevancia biomédica

Líneas de investigación

  • Etiología y fisiopatología de la enfermedad de la válvula aórtica bicúspide.
  • Etiología de las anomalías congénitas de las arterias coronarias.
  • Crecimiento vascular: angiogénesis y arteriogénesis.
  • Desarrollo embrionario del sistema cardiovascular.
  • Anatomía comparada y evolución del sistema cardiovascular.
  • Publicaciones principales
  • Personal adscrito

 

  • Soto-Navarrete MT, Arqué JM, Durán AC, Fernández MC, López-Unzu MA, Lorenzale M, Sans-Coma V, Fernández B 2018 The arrangement of the coronary artery trunks is subject to inheritance factors: A study in Syrian hamsters. Anat Histol Embryol 47(2):140-144. doi: 10.1111/ahe.12333
  • Lorenzale M, López-Unzu MA, Rodríguez C, Fernández B, Durán AC, Sans-Coma V 2018 The anatomical components of the cardiac outflow tract of chondrichthyans and actinopterygians. Biol Rev Camb Philos Soc 93(3):1604-1619. doi: 10.1111/brv.12411
  • Martínez-Vargas J, Ventura J, Machuca Á, Muñoz-Muñoz F, Fernández MC, Soto-Navarrete MT, Durán AC, Fernández B 2017 Cardiac, mandibular and thymic phenotypical association indicates that cranial neural crest underlies bicuspid aortic valve formation in hamsters. PLoS One 12(9):e0183556. doi: 10.1371/journal.pone.0183556
  • Rueda-Martínez C, Lamas O, Carrasco-Chinchilla F, Robledo-Carmona J, Porras C, Sánchez-Espín G, Navarro MJ, Fernández B 2017 Increased blood levels of transforming growth factor β in patients with aortic dilatation. Interact Cardiovasc Thorac Surg 25(4):571-574. doi: 10.1093/icvts/ivx153
  • Rueda-Martínez C, Lamas O, Mataró MJ, Robledo-Carmona J, Sánchez-Espín G, Moreno-Santos I, Carrasco-Chinchilla F, Gallego P, Such-Martínez M, de Teresa E, Jiménez-Navarro M, Fernández B 2017 Fibrillin 2 is upregulated in the ascending aorta of patients with bicuspid aortic valve. Eur J Cardiothorac Surg 51(1):104-111. doi: 10.1093/ejcts/ezw277
  • López-García A, Soto-Navarrete MT, Fernández MC, Moncayo-Arlandi J, Durán AC, López-Unzu MA, Alonso-Briales JH, Fernández B 2016 Unusual anatomical origins of the coronary arteries in C57BL/6 mice. Are they strain-specific? J Anat 229(5):703-709. doi: 10.1111/joa.12512
  • Rueda-Martínez C, Fernández MC, Soto-Navarrete MT, Jiménez-Navarro M, Durán AC, Fernández B 2016 Identification of Reference Genes for Quantitative Real Time PCR Assays in Aortic Tissue of Syrian Hamsters with Bicuspid Aortic Valve. PLoS One 11(10):e0164070. doi: 10.1371/journal.pone.0164070
  • Moncayo-Arlandi J, López-García A, Fernández MC, Durán AC, Fernández B 2014 Osteoglycin deficiency does not affect atherosclerosis in mice. Atherosclerosis 237(2):418-425. doi: 10.1016/j.atherosclerosis.2014.09.016
  • Rueda-Martínez C, Lamas O, Mataró MJ, Robledo-Carmona J, Sánchez-Espín G, Jiménez-Navarro M, Such-Martínez M, Fernández B 2014 Selection of reference genes for quantitative real time PCR (qPCR) assays in tissue from human ascending aorta. PLoS One 19;9(5):e97449. doi: 10.1371/journal.pone.0097449
  • Pagel JI, Ziegelhoeffer T, Heil M, Fischer S, Fernández B, Schaper W, Preissner KT, Deindl E 2012 Role of early growth response 1 in arteriogenesis: impact on vascular cell proliferation and leukocyte recruitment in vivo. Thromb Haemost 107(3):562-574. doi: 10.1160/TH11-07-0490
  • Sans-Coma V, Carmen Fernández M, Fernández B, Durán AC, Anderson RH, Arqué JM 2012 Genetically alike Syrian hamsters display both bifoliate and trifoliate aortic valves. J Anat 220(1):92-101. doi: 10.1111/j.1469-7580.2011.01440.x
  • Fernández B, Durán AC, Fernández-Gallego T, Fernández MC, Such M, Arqué JM, Sans-Coma V 2009 Bicuspid aortic valves with different spatial orientations of the leaflets are distinct etiological entities. J Am Coll Cardiol 8;54(24):2312-2318. doi: 10.1016/j.jacc.2009.07.044
  • Kampmann A, Fernández B, Deindl E, Kubin T, Pipp F, Eitenmüller I, Hoefer IE, Schaper W, Zimmermann R 2009 The proteoglycan osteoglycin/mimecan is correlated with arteriogenesis. Mol Cell Biochem 322(1-2):15-23. doi: 10.1007/s11010-008-9935-x2008
  • Agustina María Torres Prioris
  • Alejandro Lopez Garcia
  • Ana Carmen Durán Boyero
  • Francisco De Borja Fernández Corujo
    Investigador Responsable
  • Valentin Sans Coma
Modelos Animales en Investigaciones Cardiovasculares