Lineas de Investigación

01. Angiogénesis y microentorno tumoral: Identificación y caracterización de moduladores de angiogénesis. Metabolismo en el microentorno tumoral.

02. Metabolismo de aminas biógenas y poliaminas en la salud y la enfermedad.

03. Bioinformática y redes: Modelos de interactomas, redes de enfermedad y de fármacos con métodos predictivos.

04. Flujos de trabajo bioinformáticos para la automatizacion de análisis genómicos. Análisis de expresión de transposones en cáncer.

05. Aplicaciones de las líneas 1-4 a las enfermedades raras.



Proyectos de Investigación

Medina Torres, Miguel Ángel

IP Acciones Complementarias

PLAN PROPIO_AREA 5_2020 Área 5. IBIMA Rare: Enfermedades raras

Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
. 2020

PID2019-108096RB-C21 Aproximaciones sistémicas basadas en asociaciones fenotipo-genotipo para mejorar el diagnóstico de pacientes con enfermedades raras

Ministerio de Asuntos Económicos y Transformación Digital
. 2020

PID2019-105010RB-I00. ANGIOGENESIS, INFLAMACION Y METABOLISMO COMO DIANAS TERAPEUTICAS DE LA ANGIOGENESIS PATOLOGICA EMPLEANDO ENFOQUES BIOTECNOLOGICOS

Ministerio de Asuntos Económicos y Transformación Digital
. 2020

PI-0075-2017 Utilización de Datos Clínicos E In Vitro para Desarrollar Un Modelo Predictivo de la Alergenicidad de Proteínas Vegetales de la Familia Ltp Mediante Métodos Bioinformáticos de Aprendizaje Autómatico.

CONSEJERÍA DE SALUD
PROYECTOS DE INVESTIGACIÓN EN SALUD 2017

Publicaciones científicas

  • Todo
  • D1
  • Q1
  • Q2
  • Otro

A comparative study of the antiangiogenic activity of hydroxytyrosyl alkyl ethers

Marrero AD, Castilla L, Espartero JL, Madrona A, R Quesada A, Medina MÁ, Martínez-Poveda B
Food Chem 2020 Dec 15;333:127476


Control of tumor angiogenesis and metastasis through modulation of cell redox state

Serrano JJ, Delgado B, Medina MÁ
Biochim Biophys Acta Rev Cancer 2020 Apr;1873(2):188352


An improved de novo assembling and polishing of Solea senegalensis transcriptome shed light on retinoic acid signalling in larvae

Córdoba-Caballero J, Seoane P, Jabato FM, Perkins JR, Manchado M, Claros MG
Sci Rep 2020 Nov 26;10(1):20654


Development of whole-genome multiplex assays and construction of an integrated genetic map using SSR markers in Senegalese sole

Guerrero-Cózar I, Perez-Garcia C, Benzekri H, Sánchez JJ, Seoane P, Cruz F, Gut M, Zamorano MJ, Claros MG, Manchado M
Sci Rep 2020 Dec 14;10(1):21905


Fasentin diminishes endothelial cell proliferation, differentiation and invasion in a glucose metabolism-independent manner

Ocaña MC, Martínez-Poveda B, Marí-Beffa M, Quesada AR, Medina MÁ
Sci Rep 2020 Apr 9;10(1):6132


Glucose Favors Lipid Anabolic Metabolism in the Invasive Breast Cancer Cell Line MDA-MB-231

Ocaña MC, Martínez-Poveda B, Quesada AR, Medina MÁ
Biology (Basel) 2020 Jan 10;9(1):16


In vitro evaluation of the antitumoral and antiangiogenic effects of extracts from Spondias mombin L

Rey-Blanes C, Pérez-Portero Y, Morris-Quevedo HJ, Casas V, Abdala R, Quesada AR, Martínez-Poveda B, Medina MÁ
leaves Biomed Pharmacother


Metabolic Reprogramming is a Hallmark of Metabolism Itself

Medina MÁ
Bioessays 2020 Oct;42(10):e2000058


Phenotype-genotype comorbidity analysis of patients with rare disorders provides insight into their pathological and molecular bases

Díaz-Santiago E, Jabato FM, Rojano E, Seoane P, Pazos F, Perkins JR, Ranea JAG
PLoS Genet 2020 Oct 1;16(10):e1009054


Gene Expression Profile of Mexican Lime (Citrus aurantifolia) Trees in Response to Huanglongbing Disease caused by Candidatus Liberibacter asiaticus

Arce-Leal ÁP, Bautista R, Rodríguez-Negrete EA, Manzanilla-Ramírez MÁ, Velázquez-Monreal JJ, Santos-Cervantes ME, Méndez-Lozano J, Beuzón CR, Bejarano ER, Castillo AG, Claros MG, Leyva-López NE
Microorganisms 2020 Apr 7;8(4):528


Graphene Oxide and Reduced Derivatives, as Powder or Film Scaffolds, Differentially Promote Dopaminergic Neuron Differentiation and Survival

Rodriguez-Losada N, Wendelbob R, Ocaña MC, Casares AD, Guzman de Villoría R, Aguirre Gomez JA, Arraez MA, Gonzalez-Alegre P, Medina MA, Arenas E, Narvaez JA
Front Neurosci 2020 Dec 21;14:570409


Expression-based, consistent biomarkers for prognosis and diagnosis in lung cancer

Arroyo M, Larrosa R, Gómez-Maldonado J, Cobo MÁ, Claros MG, Bautista R
Clin Transl Oncol 2020 Oct;22(10):1867-1874

  1. Ashford, P, Pang, CSM, Moya-García, AA, Adeyelu, T, Orengo, CA. A CATH domain functional family based approach to identify putative cancer driver genes and driver mutations. Sci Rep. 2019;9 (1):263. doi: 10.1038/s41598-018-36401-4. PubMed PMID:30670742 PubMed Central PMC6343001.
Search PubMed
  1. Arroyo, M, Bautista, R, Larrosa, R, Cobo, MÁ, Claros, MG. Biomarker potential of repetitive-element transcriptome in lung cancer. PeerJ. 2019;7 :e8277. doi: 10.7717/peerj.8277. PubMed PMID:31875158 PubMed Central PMC6925957.
Search PubMed
  1. Doña, I, Jurado-Escobar, R, Perkins, JR, Ayuso, P, Plaza-Serón, MC, Pérez-Sánchez, N et al.. Eicosanoid mediator profiles in different phenotypes of nonsteroidal anti-inflammatory drug-induced urticaria. Allergy. 2019;74 (6):1135-1144. doi: 10.1111/all.13725. PubMed PMID:30667070 .
Search PubMed
  1. Carrillo, P, Martínez-Poveda, B, Cheng-Sánchez, I, Guerra, J, Tobia, C, López-Romero, JM et al.. Exploring the Antiangiogenic Potential of Solomonamide A Bioactive Precursors: In Vitro and in Vivo Evidences of the Inhibitory Activity of Solo F-OH During Angiogenesis. Mar Drugs. 2019;17 (4):. doi: 10.3390/md17040228. PubMed PMID:30991727 PubMed Central PMC6520732.
Search PubMed
  1. Rodriguez, MJ, Ramos-Soriano, J, Perkins, JR, Mascaraque, A, Torres, MJ, Gomez, F et al.. Glycosylated nanostructures in sublingual immunotherapy induce long-lasting tolerance in LTP allergy mouse model. Sci Rep. 2019;9 (1):4043. doi: 10.1038/s41598-019-40114-7. PubMed PMID:30858392 PubMed Central PMC6411722.
Search PubMed
  1. Ocaña, MC, Martínez-Poveda, B, Quesada, AR, Medina, MÁ. Highly Glycolytic Immortalized Human Dermal Microvascular Endothelial Cells are Able to Grow in Glucose-Starved Conditions. Biomolecules. 2019;9 (8):. doi: 10.3390/biom9080332. PubMed PMID:31374952 PubMed Central PMC6723428.
Search PubMed
  1. Abdala Díaz, RT, Casas Arrojo, V, Arrojo Agudo, MA, Cárdenas, C, Dobretsov, S, Figueroa, FL et al.. Immunomodulatory and Antioxidant Activities of Sulfated Polysaccharides from Laminaria ochroleuca, Porphyra umbilicalis, and Gelidium corneum. Mar Biotechnol (NY). 2019;21 (4):577-587. doi: 10.1007/s10126-019-09905-x. PubMed PMID:31250232 .
Search PubMed
  1. Ocaña, MC, Martínez-Poveda, B, Quesada, AR, Medina, MÁ. Metabolism within the tumor microenvironment and its implication on cancer progression: An ongoing therapeutic target. Med Res Rev. 2019;39 (1):70-113. doi: 10.1002/med.21511. PubMed PMID:29785785 .
Search PubMed
  1. González-Gordo, S, Bautista, R, Claros, MG, Cañas, A, Palma, JM, Corpas, FJ et al.. Nitric oxide-dependent regulation of sweet pepper fruit ripening. J Exp Bot. 2019;70 (17):4557-4570. doi: 10.1093/jxb/erz136. PubMed PMID:31046097 PubMed Central PMC6736391.
Search PubMed
  1. García-Ponce, ÁL, Martínez-Poveda, B, Blanco-López, Á, Medina, MÁ, Quesada, AR. Not all has been said about glucose oxidase/peroxidase: New pedagogical uses for a classical and robust undergraduate laboratory experiment. Biochem Mol Biol Educ. 2019;47 (3):341-347. doi: 10.1002/bmb.21224. PubMed PMID:30735292 .
Search PubMed
  1. Sánchez-Jiménez, F, Medina, MÁ, Villalobos-Rueda, L, Urdiales, JL. Polyamines in mammalian pathophysiology. Cell Mol Life Sci. 2019;76 (20):3987-4008. doi: 10.1007/s00018-019-03196-0. PubMed PMID:31227845 .
Search PubMed
  1. Perkins, JR, Acosta-Herrera, M, Plaza-Serón, MC, Jurado-Escobar, R, Doña, I, García-Martín, E et al.. Polymorphisms in CEP68 gene associated with risk of immediate selective reactions to non-steroidal anti-inflammatory drugs. Pharmacogenomics J. 2019;19 (2):191-199. doi: 10.1038/s41397-018-0038-0. PubMed PMID:30093714 .
Search PubMed
  1. Palomares, F, Ramos-Soriano, J, Gomez, F, Mascaraque, A, Bogas, G, Perkins, JR et al.. Pru p 3-Glycodendropeptides Based on Mannoses Promote Changes in the Immunological Properties of Dendritic and T-Cells from LTP-Allergic Patients. Mol Nutr Food Res. 2019;63 (20):e1900553. doi: 10.1002/mnfr.201900553. PubMed PMID:31368251 .
Search PubMed
  1. Polonio, Á, Pineda, M, Bautista, R, Martínez-Cruz, J, Pérez-Bueno, ML, Barón, M et al.. RNA-seq analysis and fluorescence imaging of melon powdery mildew disease reveal an orchestrated reprogramming of host physiology. Sci Rep. 2019;9 (1):7978. doi: 10.1038/s41598-019-44443-5. PubMed PMID:31138852 PubMed Central PMC6538759.
Search PubMed
  1. Cheng-Sánchez, I, Torres-Vargas, JA, Martínez-Poveda, B, Guerrero-Vásquez, GA, Medina, MÁ, Sarabia, F et al.. Synthesis and Antitumor Activity Evaluation of Compounds Based on Toluquinol. Mar Drugs. 2019;17 (9):. doi: 10.3390/md17090492. PubMed PMID:31450731 PubMed Central PMC6780176.
Search PubMed
  1. Seoane, P, Tapia-Paniagua, ST, Bautista, R, Alcaide, E, Esteve, C, Martínez-Manzanares, E et al.. TarSynFlow, a workflow for bacterial genome comparisons that revealed genes putatively involved in the probiotic character of Shewanella putrefaciens strain Pdp11. PeerJ. 2019;7 :e6526. doi: 10.7717/peerj.6526. PubMed PMID:30842906 PubMed Central PMC6397758.
Search PubMed
  1. Polonio, Á, Seoane, P, Claros, MG, Pérez-García, A. The haustorial transcriptome of the cucurbit pathogen Podosphaera xanthii reveals new insights into the biotrophy and pathogenesis of powdery mildew fungi. BMC Genomics. 2019;20 (1):543. doi: 10.1186/s12864-019-5938-0. PubMed PMID:31272366 PubMed Central PMC6611051.
Search PubMed
  1. Martínez-Poveda, B, Torres-Vargas, JA, Ocaña, MDC, García-Caballero, M, Medina, MÁ, Quesada, AR et al.. The Mediterranean Diet, a Rich Source of Angiopreventive Compounds in Cancer. Nutrients. 2019;11 (9):. doi: 10.3390/nu11092036. PubMed PMID:31480406 PubMed Central PMC6769787.
Search PubMed
  1. Carrillo, P, Martínez-Poveda, B, Medina, MÁ, Quesada, AR. The strigolactone analog GR-24 inhibits angiogenesis in vivo and in vitro by a mechanism involving cytoskeletal reorganization and VEGFR2 signalling. Biochem Pharmacol. 2019;168 :366-383. doi: 10.1016/j.bcp.2019.07.019. PubMed PMID:31351052 .
Search PubMed
  1. Rodriguez, MJ, Palomares, F, Bogas, G, Torres, MJ, Diaz-Perales, A, Rojo, J et al.. Transcriptional Profiling of Dendritic Cells in a Mouse Model of Food-Antigen-Induced Anaphylaxis Reveals the Upregulation of Multiple Immune-Related Pathways. Mol Nutr Food Res. 2019;63 (3):e1800759. doi: 10.1002/mnfr.201800759. PubMed PMID:30458065 .
Search PubMed
  1. Carmona, R, Claros, M, de Alché, J. Bioinformatic Prediction of S-Nitrosylation Sites in Large Protein Datasets. Methods Mol Biol. 2018;1747 :241-250. doi: 10.1007/978-1-4939-7695-9_19. PubMed PMID:29600464 .
Search PubMed
  1. López-Jiménez, A, Gallardo, E, Espartero, JL, Madrona, A, Quesada, AR, Medina, MÁ et al.. Comparison of the anti-angiogenic potential of hydroxytyrosol and five derivatives. Food Funct. 2018;9 (8):4310-4316. doi: 10.1039/c8fo01140k. PubMed PMID:30040093 .
Search PubMed
  1. Romero-Sánchez, LB, Marí-Beffa, M, Carrillo, P, Medina, MÁ, Díaz-Cuenca, A. Copper-containing mesoporous bioactive glass promotes angiogenesis in an in vivo zebrafish model. Acta Biomater. 2018;68 :272-285. doi: 10.1016/j.actbio.2017.12.032. PubMed PMID:29288822 .
Search PubMed
  1. Cheng-Sánchez, I, Carrillo, P, Sánchez-Ruiz, A, Martínez-Poveda, B, Quesada, AR, Medina, MA et al.. Exploring the Ring-Closing Metathesis for the Construction of the Solomonamide Macrocyclic Core: Identification of Bioactive Precursors. J Org Chem. 2018;83 (10):5365-5383. doi: 10.1021/acs.joc.7b02988. PubMed PMID:29676156 .
Search PubMed
  1. García-Caballero, M, Quesada, AR, Medina, MA, Marí-Beffa, M. Fishing anti(lymph)angiogenic drugs with zebrafish. Drug Discov Today. 2018;23 (2):366-374. doi: 10.1016/j.drudis.2017.10.018. PubMed PMID:29081356 .
Search PubMed
  1. García-Vilas, JA, Morilla, I, Bueno, A, Martínez-Poveda, B, Medina, MÁ, Ranea, JAG et al.. In silico prediction of targets for anti-angiogenesis and their in vitro evaluation confirm the involvement of SOD3 in angiogenesis. Oncotarget. 2018;9 (25):17349-17367. doi: 10.18632/oncotarget.24693. PubMed PMID:29707113 PubMed Central PMC5915121.
Search PubMed
  1. Medina, MÁ. Mathematical modeling of cancer metabolism. Crit Rev Oncol Hematol. 2018;124 :37-40. doi: 10.1016/j.critrevonc.2018.02.004. PubMed PMID:29548484 .
Search PubMed
  1. Bueno, A, Rodríguez-López, R, Reyes-Palomares, A, Rojano, E, Corpas, M, Nevado, J et al.. Phenotype-loci associations in networks of patients with rare disorders: application to assist in the diagnosis of novel clinical cases. Eur J Hum Genet. 2018;26 (10):1451-1461. doi: 10.1038/s41431-018-0139-x. PubMed PMID:29946186 PubMed Central PMC6138686.
Search PubMed
  1. Herrera-Uribe, J, Zaldívar-López, S, Aguilar, C, Luque, C, Bautista, R, Carvajal, A et al.. Regulatory role of microRNA in mesenteric lymph nodes after Salmonella Typhimurium infection. Vet Res. 2018;49 (1):9. doi: 10.1186/s13567-018-0506-1. PubMed PMID:29391047 PubMed Central PMC5796392.
Search PubMed
  1. Li, D, Zhang, Q, Sun, D, Yang, C, Luo, G. Accumulation and risk assessment of heavy metals in rice: a case study for five areas of Guizhou Province, China. Environ Sci Pollut Res Int. 2022; :. doi: 10.1007/s11356-022-21739-0. PubMed PMID:35776312 .
  2. Maiti, A, Manna, SK, Halder, S, Mandal, M, Karak, A, Banik, D et al.. A benzothiazole-based dual reaction site fluorescent probe for the selective detection of hydrazine in water and live cells. Org Biomol Chem. 2022;20 (24):4949-4963. doi: 10.1039/d2ob00709f. PubMed PMID:35661852 .
  3. Walsh, S, Moseley, GL, Gray, RJ, Gillam, M, Gunn, KM, Barker, T et al.. Use of behavioural activation to manage pain: a systematic scoping review. BMJ Open. 2022;12 (6):e056404. doi: 10.1136/bmjopen-2021-056404. PubMed PMID:35649614 .
  4. Varodi, C, Pogăcean, F, Coroş, M, Ciorîță, A, Pruneanu, S. Electrochemical L-Tyrosine Sensor Based on a Glassy Carbon Electrode Modified with Exfoliated Graphene. Sensors (Basel). 2022;22 (10):. doi: 10.3390/s22103606. PubMed PMID:35632015 .
  5. Sayad, A, Uddin, SM, Yao, S, Wilson, H, Chan, J, Zhao, H et al.. A magnetoimpedance biosensor microfluidic platform for detection of glial fibrillary acidic protein in blood for acute stroke classification. Biosens Bioelectron. 2022;211 :114410. doi: 10.1016/j.bios.2022.114410. PubMed PMID:35617799 .
  6. Cheng, H, Li, X, Li, T, Tang, T, Qin, D. Electrochemiluminescence sensor based on Electrospun Crosslinked Carbon Nanofibers for the Detection of Difenidol Hydrochloride. Comb Chem High Throughput Screen. 2022; :. doi: 10.2174/1386207325666220524093530. PubMed PMID:35611783 .
  7. Cao, Y, Chen, B, Zhong, H, Pei, L, Liu, G, Xu, Z et al.. Ti2C3Tx/Polyurethane Constructed by Gas-Liquid Interface Self-Assembly for Underwater Sensing. ACS Appl Mater Interfaces. 2022;14 (21):24659-24667. doi: 10.1021/acsami.2c03565. PubMed PMID:35584532 .
  8. Zhang, L, Yan, JL, Wang, Y, Zhao, XL, Wu, WN, Fan, YC et al.. A novel indene-chalcone-based fluorescence probe with lysosome-targeting for detection of endogenous carboxylesterases and bioimaging. Spectrochim Acta A Mol Biomol Spectrosc. 2022;278 :121329. doi: 10.1016/j.saa.2022.121329. PubMed PMID:35576837 .
  9. Lin, X, Chen, BB, Li, W, Meng, ZY, Shi, T. Exciton Proliferation and Fate of the Topological Mott Insulator in a Twisted Bilayer Graphene Lattice Model. Phys Rev Lett. 2022;128 (15):157201. doi: 10.1103/PhysRevLett.128.157201. PubMed PMID:35499872 .
  10. Makowska, K, Martín, J, Rychlik, A, Aparicio, I, Santos, JL, Alonso, E et al.. Hair Sample Analysis as a Method of Monitoring Exposure to Bisphenol A in Dogs. Int J Environ Res Public Health. 2022;19 (8):. doi: 10.3390/ijerph19084600. PubMed PMID:35457463 PubMed Central PMC9030106.
  11. Islam, MR, Gupta, SS, Jana, SK, Pradeep, T. Industrial Utilization of Capacitive Deionization Technology for the Removal of Fluoride and Toxic Metal Ions (As3+/5+ and Pb2+). Glob Chall. 2022;6 (4):2100129. doi: 10.1002/gch2.202100129. PubMed PMID:35433026 PubMed Central PMC8995710.
  12. Khan, YK, Toqeer, M, Shah, MH. Mobility, bioaccessibility, pollution assessment and risk characterization of potentially toxic metals in the urban soil of Lahore, Pakistan. Environ Geochem Health. 2022; :. doi: 10.1007/s10653-022-01270-4. PubMed PMID:35429312 .
  13. Vaschetti, VM, Viada, BN, Tamborelli, A, Eimer, GA, Rivas, GA, Dalmasso, PR et al.. Ultrasensitive multiwall carbon nanotube-mesoporous MCM-41 hybrid-based platform for the electrochemical detection of ascorbic acid. Analyst. 2022;147 (10):2130-2140. doi: 10.1039/d2an00473a. PubMed PMID:35421882 .
  14. Joseph, XB, Sherlin V, A, Wang, SF, George, M. Integration of iron-manganese layered double hydroxide/tungsten carbide composite: An electrochemical tool for diphenylamine H•+ analysis in environmental samples. Environ Res. 2022;212 (Pt B):113291. doi: 10.1016/j.envres.2022.113291. PubMed PMID:35421390 .
  15. Liu, C, Kreisel, A, Zhong, S, Li, Y, Andersen, BM, Hirschfeld, P et al.. Orbital-Selective High-Temperature Cooper Pairing Developed in the Two-Dimensional Limit. Nano Lett. 2022;22 (8):3245-3251. doi: 10.1021/acs.nanolett.1c04863. PubMed PMID:35416679 .
  16. Chowdhury, M, Ghosh, S, Padhy, PK. Effects of indoor air pollution on tribal community in rural India and health risk assessment due to domestic biomass burning: a realistic approach using the lung deposition model. Environ Sci Pollut Res Int. 2022; :. doi: 10.1007/s11356-022-19973-7. PubMed PMID:35391641 .
  17. Selvam, S, Jesuraja, K, Roy, PD, Venkatramanan, S, Khan, R, Shukla, S et al.. Human health risk assessment of heavy metal and pathogenic contamination in surface water of the Punnakayal estuary, South India. Chemosphere. 2022;298 :134027. doi: 10.1016/j.chemosphere.2022.134027. PubMed PMID:35301998 .
  18. Seal, K, Chaudhuri, H, Pal, S, Srivastava, RR, Soldatova, E. A study on water pollution scenario of the Damodar river basin, India: assessment of potential health risk using long term database (1980-2019) and statistical analysis. Environ Sci Pollut Res Int. 2022; :. doi: 10.1007/s11356-022-19402-9. PubMed PMID:35287189 .
  19. Amara, U, Mahmood, K, Awais, M, Khalid, M, Nasir, M, Riaz, S et al.. Nickel -doped iron oxide nanoparticle-conjugated porphyrin interface (porphyrin/Fe2O3@Ni) for the non-enzymatic detection of dopamine from lacrimal fluid. Dalton Trans. 2022;51 (13):5098-5107. doi: 10.1039/d2dt00074a. PubMed PMID:35266502 .
  20. Rajmohan, N, Niyazi, BAM, Masoud, MHZ. Trace metals pollution, distribution and associated health risks in the arid coastal aquifer, Hada Al-Sham and its vicinities, Saudi Arabia. Chemosphere. 2022;297 :134246. doi: 10.1016/j.chemosphere.2022.134246. PubMed PMID:35259356 .
Search PubMed
  1. García-Vilas, JA, Medina, MÁ. Updates on the hepatocyte growth factor/c-Met axis in hepatocellular carcinoma and its therapeutic implications. World J Gastroenterol. 2018;24 (33):3695-3708. doi: 10.3748/wjg.v24.i33.3695. PubMed PMID:30197476 PubMed Central PMC6127652.
Search PubMed
  1. Carmona, R, Arroyo, M, Jiménez-Quesada, MJ, Seoane, P, Zafra, A, Larrosa, R et al.. Automated identification of reference genes based on RNA-seq data. Biomed Eng Online. 2017;16 (Suppl 1):65. doi: 10.1186/s12938-017-0356-5. PubMed PMID:28830520 PubMed Central PMC5568602.
Search PubMed
  1. Olsson, S, Seoane-Zonjic, P, Bautista, R, Claros, MG, González-Martínez, SC, Scotti, I et al.. Development of genomic tools in a widespread tropical tree, Symphonia globulifera L.f.: a new low-coverage draft genome, SNP and SSR markers. Mol Ecol Resour. 2017;17 (4):614-630. doi: 10.1111/1755-0998.12605. PubMed PMID:27718316 .
Search PubMed
  1. Jimenez-Quesada, MJ, Carmona, R, Lima-Cabello, E, Traverso, JÁ, Castro, AJ, Claros, MG et al.. Generation of nitric oxide by olive (Olea europaea L.) pollen during in vitro germination and assessment of the S-nitroso- and nitro-proteomes by computational predictive methods. Nitric Oxide. 2017;68 :23-37. doi: 10.1016/j.niox.2017.06.005. PubMed PMID:28645873 .
Search PubMed
  1. Balado, M, Benzekri, H, Labella, AM, Claros, MG, Manchado, M, Borrego, JJ et al.. Genomic analysis of the marine fish pathogen Photobacterium damselae subsp. piscicida: Insertion sequences proliferation is associated with chromosomal reorganisations and rampant gene decay. Infect Genet Evol. 2017;54 :221-229. doi: 10.1016/j.meegid.2017.07.007. PubMed PMID:28688976 .
Search PubMed
  1. Díaz-Santiago, E, Rodríguez-Caso, L, Cárdenas, C, Serrano, JJ, Quesada, AR, Medina, MÁ et al.. Homocysteine pre-treatment increases redox capacity in both endothelial and tumor cells. Redox Rep. 2017;22 (4):183-189. doi: 10.1080/13510002.2016.1183348. PubMed PMID:27198616 PubMed Central PMC6837415.
Search PubMed
  1. García-Vilas, JA, Quesada, AR, Medina, MÁ. Hydroxytyrosol targets extracellular matrix remodeling by endothelial cells and inhibits both ex vivo and in vivo angiogenesis. Food Chem. 2017;221 :1741-1746. doi: 10.1016/j.foodchem.2016.10.111. PubMed PMID:27979155 .
Search PubMed
  1. Zafra, A, Carmona, R, Traverso, JA, Hancock, JT, Goldman, MHS, Claros, MG et al.. Identification and Functional Annotation of Genes Differentially Expressed in the Reproductive Tissues of the Olive Tree (Olea europaea L.) through the Generation of Subtractive Libraries. Front Plant Sci. 2017;8 :1576. doi: 10.3389/fpls.2017.01576. PubMed PMID:28955364 PubMed Central PMC5601413.
Search PubMed
  1. Martínez-Poveda, B, Quesada, AR, Medina, MÁ. Pleiotropic Role of Puupehenones in Biomedical Research. Mar Drugs. 2017;15 (10):. doi: 10.3390/md15100325. PubMed PMID:29065486 PubMed Central PMC5666431.
Search PubMed
  1. Acosta-Andrade, C, Artetxe, I, Lete, MG, Monasterio, BG, Ruiz-Mirazo, K, Goñi, FM et al.. Polyamine-RNA-membrane interactions: From the past to the future in biology. Colloids Surf B Biointerfaces. 2017;155 :173-181. doi: 10.1016/j.colsurfb.2017.04.005. PubMed PMID:28456048 .
Search PubMed
  1. Moya-García, A, Adeyelu, T, Kruger, FA, Dawson, NL, Lees, JG, Overington, JP et al.. Structural and Functional View of Polypharmacology. Sci Rep. 2017;7 (1):10102. doi: 10.1038/s41598-017-10012-x. PubMed PMID:28860623 PubMed Central PMC5579063.
Search PubMed
  1. García-Caballero, M, Paupert, J, Blacher, S, Van de Velde, M, Quesada, AR, Medina, MA et al.. Targeting VEGFR-3/-2 signaling pathways with AD0157: a potential strategy against tumor-associated lymphangiogenesis and lymphatic metastases. J Hematol Oncol. 2017;10 (1):122. doi: 10.1186/s13045-017-0484-1. PubMed PMID:28629427 PubMed Central PMC5477162.
Search PubMed
  1. García-Caballero, M, Martínez-Poveda, B, Medina, MA, Quesada, AR. The Natural Antiangiogenic Compound AD0157 Induces Caspase-Dependent Apoptosis in Human Myeloid Leukemia Cells. Front Pharmacol. 2017;8 :802. doi: 10.3389/fphar.2017.00802. PubMed PMID:29163182 PubMed Central PMC5682012.
Search PubMed
  1. García-Vilas, JA, Pino-Ángeles, A, Martínez-Poveda, B, Quesada, AR, Medina, MÁ. The noni anthraquinone damnacanthal is a multi-kinase inhibitor with potent anti-angiogenic effects. Cancer Lett. 2017;385 :1-11. doi: 10.1016/j.canlet.2016.10.037. PubMed PMID:27816491 .
Search PubMed
  1. Acosta-Andrade, C, Lambertos, A, Urdiales, JL, Sánchez-Jiménez, F, Peñafiel, R, Fajardo, I et al.. A novel role for antizyme inhibitor 2 as a regulator of serotonin and histamine biosynthesis and content in mouse mast cells. Amino Acids. 2016;48 (10):2411-21. doi: 10.1007/s00726-016-2230-3. PubMed PMID:27084713 .
Search PubMed
  1. García-Vilas, JA, Martínez-Poveda, B, Quesada, AR, Medina, MÁ. Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug. Mar Drugs. 2015;14 (1):1. doi: 10.3390/md14010001. PubMed PMID:26703630 PubMed Central PMC4728498.
Search PubMed
  1. Rojano, E, Ranea, JA, Perkins, JR. Characterisation of non-coding genetic variation in histamine receptors using AnNCR-SNP. Amino Acids. 2016;48 (10):2433-42. doi: 10.1007/s00726-016-2265-5. PubMed PMID:27270572 .
Search PubMed
  1. Rodríguez, CE, Palacios, J, Fajardo, I, Urdiales, JL, Le Guével, X, Lozano, J et al.. Conventional Matrices Loaded Onto a Graphene Layer Enhances MALDI-TOF/TOF Signal: Its Application to Improve Detection of Phosphorylated Peptides. J Am Soc Mass Spectrom. 2016;27 (2):366-9. doi: 10.1007/s13361-015-1299-3. PubMed PMID:26620529 .
Search PubMed
  1. Seoane-Zonjic, P, Cañas, RA, Bautista, R, Gómez-Maldonado, J, Arrillaga, I, Fernández-Pozo, N et al.. Establishing gene models from the Pinus pinaster genome using gene capture and BAC sequencing. BMC Genomics. 2016;17 :148. doi: 10.1186/s12864-016-2490-z. PubMed PMID:26922242 PubMed Central PMC4769843.
Search PubMed
  1. Bueno, A, Morilla, I, Diez, D, Moya-Garcia, AA, Lozano, J, Ranea, JA et al.. Exploring the interactions of the RAS family in the human protein network and their potential implications in RAS-directed therapies. Oncotarget. 2016;7 (46):75810-75826. doi: 10.18632/oncotarget.12416. PubMed PMID:27713118 PubMed Central PMC5342780.
Search PubMed
  1. García-Caballero, M, Blacher, S, Paupert, J, Quesada, AR, Medina, MA, Noël, A et al.. Novel application assigned to toluquinol: inhibition of lymphangiogenesis by interfering with VEGF-C/VEGFR-3 signalling pathway. Br J Pharmacol. 2016;173 (12):1966-87. doi: 10.1111/bph.13488. PubMed PMID:27018653 PubMed Central PMC4882490.
Search PubMed
  1. Reyes-Palomares, A, Bueno, A, Rodríguez-López, R, Medina, MÁ, Sánchez-Jiménez, F, Corpas, M et al.. Systematic identification of phenotypically enriched loci using a patient network of genomic disorders. BMC Genomics. 2016;17 :232. doi: 10.1186/s12864-016-2569-6. PubMed PMID:26980139 PubMed Central PMC4792099.
Search PubMed
  1. Uribe, JH, Collado-Romero, M, Zaldívar-López, S, Arce, C, Bautista, R, Carvajal, A et al.. Transcriptional analysis of porcine intestinal mucosa infected with Salmonella Typhimurium revealed a massive inflammatory response and disruption of bile acid absorption in ileum. Vet Res. 2016;47 :11. doi: 10.1186/s13567-015-0286-9. PubMed PMID:26738723 PubMed Central PMC4704413.
Search PubMed
  1. Caso, E, Maestro, A, Sabiers, CC, Godino, M, Caracuel, Z, Pons, J et al.. Whole-exome sequencing analysis in twin sibling males with an anterior cruciate ligament rupture. Injury. 2016;47 Suppl 3 :S41-S50. doi: 10.1016/S0020-1383(16)30605-2. PubMed PMID:27692106 .
Search PubMed
  1. Garcia-Vilas, JA, Medina, MA, Melo, FR, Pejler, G, Garcia-Faroldi, G. Damnacanthal inhibits IgE receptor-mediated activation of mast cells. Mol Immunol. 2015;65 (1):86-93. doi: 10.1016/j.molimm.2015.01.008. PubMed PMID:25656801 .
Search PubMed
  1. García-Vilas, JA, Quesada, AR, Medina, MA. Damnacanthal, a noni anthraquinone, inhibits c-Met and is a potent antitumor compound against Hep G2 human hepatocellular carcinoma cells. Sci Rep. 2015;5 :8021. doi: 10.1038/srep08021. PubMed PMID:25620570 PubMed Central PMC4306130.
Search PubMed
  1. Lees, JG, Hériché, JK, Morilla, I, Fernández, JM, Adler, P, Krallinger, M et al.. FUN-L: gene prioritization for RNAi screens. Bioinformatics. 2015;31 (12):2052-3. doi: 10.1093/bioinformatics/btv073. PubMed PMID:25667547 .
Search PubMed
  1. Lees, JG, Ranea, JA, Orengo, CA. Identifying and characterising key alternative splicing events in Drosophila development. BMC Genomics. 2015;16 :608. doi: 10.1186/s12864-015-1674-2. PubMed PMID:26275604 PubMed Central PMC4537583.
Search PubMed
  1. Navas-Delgado, I, García-Godoy, MJ, López-Camacho, E, Rybinski, M, Reyes-Palomares, A, Medina, MÁ et al.. kpath: integration of metabolic pathway linked data. Database (Oxford). 2015;2015 :bav053. doi: 10.1093/database/bav053. PubMed PMID:26055101 PubMed Central PMC4460419.
Search PubMed
  1. Ocaña, S, Seoane, P, Bautista, R, Palomino, C, Claros, GM, Torres, AM et al.. Large-Scale Transcriptome Analysis in Faba Bean (Vicia faba L.) under Ascochyta fabae Infection. PLoS One. 2015;10 (8):e0135143. doi: 10.1371/journal.pone.0135143. PubMed PMID:26267359 PubMed Central PMC4534337.
Search PubMed
  1. Prigione, A, Ruiz-Pérez, MV, Bukowiecki, R, Adjaye, J. Metabolic restructuring and cell fate conversion. Cell Mol Life Sci. 2015;72 (9):1759-77. doi: 10.1007/s00018-015-1834-1. PubMed PMID:25586562 .
Search PubMed
  1. Ruiz-Pérez, MV, Medina, MÁ, Urdiales, JL, Keinänen, TA, Sánchez-Jiménez, F. Polyamine metabolism is sensitive to glycolysis inhibition in human neuroblastoma cells. J Biol Chem. 2015;290 (10):6106-19. doi: 10.1074/jbc.M114.619197. PubMed PMID:25593318 PubMed Central PMC4358251.
Search PubMed
  1. Carmona, R, Zafra, A, Seoane, P, Castro, AJ, Guerrero-Fernández, D, Castillo-Castillo, T et al.. ReprOlive: a database with linked data for the olive tree (Olea europaea L.) reproductive transcriptome. Front Plant Sci. 2015;6 :625. doi: 10.3389/fpls.2015.00625. PubMed PMID:26322066 PubMed Central PMC4531244.
Search PubMed

Consulta el histórico de Newsletter:

Calle Severo Ochoa, 35
Parque Tecnolgico de Andaluca (PTA) Campanillas, Mlaga 29590

(+34) 951 440 260
Fax: (+34) 951 440 263