Bases Moleculares de la Proliferación Celular y Enfermedades Raras

Lineas de Investigación

01. Angiogénesis y microentorno tumoral: Identificación y caracterización de moduladores de angiogénesis. Metabolismo en el microentorno tumoral.

02. Metabolismo de aminas biógenas y poliaminas en la salud y la enfermedad.

03. Bioinformática y redes: Modelos de interactomas, redes de enfermedad y de fármacos con métodos predictivos.

04. Flujos de trabajo bioinformáticos para la automatizacion de análisis genómicos. Análisis de expresión de transposones en cáncer.

05. Aplicaciones de las líneas 1-4 a las enfermedades raras.



Proyectos de Investigación

PI-0075-2017 Utilización de Datos Clínicos E In Vitro para Desarrollar Un Modelo Predictivo de la Alergenicidad de Proteínas Vegetales de la Familia Ltp Mediante Métodos Bioinformáticos de Aprendizaje Autómatico.

CONSEJERÍA DE SALUD
PROYECTOS DE INVESTIGACIÓN EN SALUD 2017

Publicaciones científicas

  • Todo
  • D1
  • Q1
  • Q2
  • Otro
  1. Ashford, P, Pang, CSM, Moya-García, AA, Adeyelu, T, Orengo, CA. A CATH domain functional family based approach to identify putative cancer driver genes and driver mutations. Sci Rep. 2019;9 (1):263. doi: 10.1038/s41598-018-36401-4. PubMed PMID:30670742 PubMed Central PMC6343001.
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  1. Arroyo, M, Bautista, R, Larrosa, R, Cobo, MÁ, Claros, MG. Biomarker potential of repetitive-element transcriptome in lung cancer. 2019;7 :e8277. doi: 10.7717/peerj.8277. PubMed PMID:31875158 PubMed Central PMC6925957.
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  1. Doña, I, Jurado-Escobar, R, Perkins, JR, Ayuso, P, Plaza-Serón, MC, Pérez-Sánchez, N et al.. Eicosanoid mediator profiles in different phenotypes of nonsteroidal anti-inflammatory drug-induced urticaria. Allergy. 2019;74 (6):1135-1144. doi: 10.1111/all.13725. PubMed PMID:30667070 .
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  1. Carrillo, P, Martínez-Poveda, B, Cheng-Sánchez, I, Guerra, J, Tobia, C, López-Romero, JM et al.. Exploring the Antiangiogenic Potential of Solomonamide A Bioactive Precursors: In Vitro and in Vivo Evidences of the Inhibitory Activity of Solo F-OH During Angiogenesis. Mar Drugs. 2019;17 (4):. doi: 10.3390/md17040228. PubMed PMID:30991727 PubMed Central PMC6520732.
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  1. Rodriguez, MJ, Ramos-Soriano, J, Perkins, JR, Mascaraque, A, Torres, MJ, Gomez, F et al.. Glycosylated nanostructures in sublingual immunotherapy induce long-lasting tolerance in LTP allergy mouse model. Sci Rep. 2019;9 (1):4043. doi: 10.1038/s41598-019-40114-7. PubMed PMID:30858392 PubMed Central PMC6411722.
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  1. Ocaña, MC, Martínez-Poveda, B, Quesada, AR, Medina, MÁ. Highly Glycolytic Immortalized Human Dermal Microvascular Endothelial Cells are Able to Grow in Glucose-Starved Conditions. Biomolecules. 2019;9 (8):. doi: 10.3390/biom9080332. PubMed PMID:31374952 PubMed Central PMC6723428.
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  1. Abdala Díaz, RT, Casas Arrojo, V, Arrojo Agudo, MA, Cárdenas, C, Dobretsov, S, Figueroa, FL et al.. Immunomodulatory and Antioxidant Activities of Sulfated Polysaccharides from Laminaria ochroleuca, Porphyra umbilicalis, and Gelidium corneum. Mar. Biotechnol. 2019;21 (4):577-587. doi: 10.1007/s10126-019-09905-x. PubMed PMID:31250232 .
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  1. Ocaña, MC, Martínez-Poveda, B, Quesada, AR, Medina, MÁ. Metabolism within the tumor microenvironment and its implication on cancer progression: An ongoing therapeutic target. Med Res Rev. 2019;39 (1):70-113. doi: 10.1002/med.21511. PubMed PMID:29785785 .
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  1. González-Gordo, S, Bautista, R, Claros, MG, Cañas, A, Palma, JM, Corpas, FJ et al.. Nitric oxide-dependent regulation of sweet pepper fruit ripening. J. Exp. Bot. 2019;70 (17):4557-4570. doi: 10.1093/jxb/erz136. PubMed PMID:31046097 PubMed Central PMC6736391.
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  1. García-Ponce, ÁL, Martínez-Poveda, B, Blanco-López, Á, Medina, MÁ, Quesada, AR. Not all has been said about glucose oxidase/peroxidase: New pedagogical uses for a classical and robust undergraduate laboratory experiment. Biochem Mol Biol Educ. 2019;47 (3):341-347. doi: 10.1002/bmb.21224. PubMed PMID:30735292 .
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  1. Sánchez-Jiménez, F, Medina, MÁ, Villalobos-Rueda, L, Urdiales, JL. Polyamines in mammalian pathophysiology. Cell. Mol. Life Sci. 2019;76 (20):3987-4008. doi: 10.1007/s00018-019-03196-0. PubMed PMID:31227845 .
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  1. Perkins, JR, Acosta-Herrera, M, Plaza-Serón, MC, Jurado-Escobar, R, Doña, I, García-Martín, E et al.. Polymorphisms in CEP68 gene associated with risk of immediate selective reactions to non-steroidal anti-inflammatory drugs. Pharmacogenomics J. 2019;19 (2):191-199. doi: 10.1038/s41397-018-0038-0. PubMed PMID:30093714 .
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  1. Palomares, F, Ramos-Soriano, J, Gomez, F, Mascaraque, A, Bogas, G, Perkins, JR et al.. Pru p 3-Glycodendropeptides Based on Mannoses Promote Changes in the Immunological Properties of Dendritic and T-Cells from LTP-Allergic Patients. Mol Nutr Food Res. 2019;63 (20):e1900553. doi: 10.1002/mnfr.201900553. PubMed PMID:31368251 .
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  1. Polonio, Á, Pineda, M, Bautista, R, Martínez-Cruz, J, Pérez-Bueno, ML, Barón, M et al.. RNA-seq analysis and fluorescence imaging of melon powdery mildew disease reveal an orchestrated reprogramming of host physiology. Sci Rep. 2019;9 (1):7978. doi: 10.1038/s41598-019-44443-5. PubMed PMID:31138852 PubMed Central PMC6538759.
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  1. Cheng-Sánchez, I, Torres-Vargas, JA, Martínez-Poveda, B, Guerrero-Vásquez, GA, Medina, MÁ, Sarabia, F et al.. Synthesis and Antitumor Activity Evaluation of Compounds Based on Toluquinol. Mar Drugs. 2019;17 (9):. doi: 10.3390/md17090492. PubMed PMID:31450731 PubMed Central PMC6780176.
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  1. Seoane, P, Tapia-Paniagua, ST, Bautista, R, Alcaide, E, Esteve, C, Martínez-Manzanares, E et al.. TarSynFlow, a workflow for bacterial genome comparisons that revealed genes putatively involved in the probiotic character of Shewanella putrefaciens strain Pdp11. 2019;7 :e6526. doi: 10.7717/peerj.6526. PubMed PMID:30842906 PubMed Central PMC6397758.
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  1. Polonio, Á, Seoane, P, Claros, MG, Pérez-García, A. The haustorial transcriptome of the cucurbit pathogen Podosphaera xanthii reveals new insights into the biotrophy and pathogenesis of powdery mildew fungi. BMC Genomics. 2019;20 (1):543. doi: 10.1186/s12864-019-5938-0. PubMed PMID:31272366 PubMed Central PMC6611051.
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  1. Martínez-Poveda, B, Torres-Vargas, JA, Ocaña, MDC, García-Caballero, M, Medina, MÁ, Quesada, AR et al.. The Mediterranean Diet, a Rich Source of Angiopreventive Compounds in Cancer. Nutrients. 2019;11 (9):. doi: 10.3390/nu11092036. PubMed PMID:31480406 PubMed Central PMC6769787.
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  1. Carrillo, P, Martínez-Poveda, B, Medina, MÁ, Quesada, AR. The strigolactone analog GR-24 inhibits angiogenesis in vivo and in vitro by a mechanism involving cytoskeletal reorganization and VEGFR2 signalling. Biochem. Pharmacol. 2019;168 :366-383. doi: 10.1016/j.bcp.2019.07.019. PubMed PMID:31351052 .
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  1. Rodriguez, MJ, Palomares, F, Bogas, G, Torres, MJ, Diaz-Perales, A, Rojo, J et al.. Transcriptional Profiling of Dendritic Cells in a Mouse Model of Food-Antigen-Induced Anaphylaxis Reveals the Upregulation of Multiple Immune-Related Pathways. Mol Nutr Food Res. 2019;63 (3):e1800759. doi: 10.1002/mnfr.201800759. PubMed PMID:30458065 .
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  1. Carmona, R, Claros, M, de Alché, J. Bioinformatic Prediction of S-Nitrosylation Sites in Large Protein Datasets. Methods Mol. Biol. 2018;1747 :241-250. doi: 10.1007/978-1-4939-7695-9_19. PubMed PMID:29600464 .
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  1. López-Jiménez, A, Gallardo, E, Espartero, JL, Madrona, A, Quesada, AR, Medina, MÁ et al.. Comparison of the anti-angiogenic potential of hydroxytyrosol and five derivatives. Food Funct. 2018;9 (8):4310-4316. doi: 10.1039/c8fo01140k. PubMed PMID:30040093 .
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  1. Romero-Sánchez, LB, Marí-Beffa, M, Carrillo, P, Medina, MÁ, Díaz-Cuenca, A. Copper-containing mesoporous bioactive glass promotes angiogenesis in an in vivo zebrafish model. Acta Biomater. 2018;68 :272-285. doi: 10.1016/j.actbio.2017.12.032. PubMed PMID:29288822 .
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  1. Cheng-Sánchez, I, Carrillo, P, Sánchez-Ruiz, A, Martínez-Poveda, B, Quesada, AR, Medina, MA et al.. Exploring the Ring-Closing Metathesis for the Construction of the Solomonamide Macrocyclic Core: Identification of Bioactive Precursors. J. Org. Chem. 2018;83 (10):5365-5383. doi: 10.1021/acs.joc.7b02988. PubMed PMID:29676156 .
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  1. García-Caballero, M, Quesada, AR, Medina, MA, Marí-Beffa, M. Fishing anti(lymph)angiogenic drugs with zebrafish. Drug Discov. Today. 2018;23 (2):366-374. doi: 10.1016/j.drudis.2017.10.018. PubMed PMID:29081356 .
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  1. García-Vilas, JA, Morilla, I, Bueno, A, Martínez-Poveda, B, Medina, MÁ, Ranea, JAG et al.. In silico prediction of targets for anti-angiogenesis and their in vitro evaluation confirm the involvement of SOD3 in angiogenesis. Oncotarget. 2018;9 (25):17349-17367. doi: 10.18632/oncotarget.24693. PubMed PMID:29707113 PubMed Central PMC5915121.
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  1. Medina, MÁ. Mathematical modeling of cancer metabolism. Crit. Rev. Oncol. Hematol. 2018;124 :37-40. doi: 10.1016/j.critrevonc.2018.02.004. PubMed PMID:29548484 .
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  1. Bueno, A, Rodríguez-López, R, Reyes-Palomares, A, Rojano, E, Corpas, M, Nevado, J et al.. Phenotype-loci associations in networks of patients with rare disorders: application to assist in the diagnosis of novel clinical cases. Eur. J. Hum. Genet. 2018;26 (10):1451-1461. doi: 10.1038/s41431-018-0139-x. PubMed PMID:29946186 PubMed Central PMC6138686.
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  1. Herrera-Uribe, J, Zaldívar-López, S, Aguilar, C, Luque, C, Bautista, R, Carvajal, A et al.. Regulatory role of microRNA in mesenteric lymph nodes after Salmonella Typhimurium infection. Vet. Res. 2018;49 (1):9. doi: 10.1186/s13567-018-0506-1. PubMed PMID:29391047 PubMed Central PMC5796392.
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  1. Cao, L, Xiao, H, Fang, C, Zhao, F, Chen, Z. Electrochemical immunosensor based on binary nanoparticles decorated rGO-TEPA as magnetic capture and Au@PtNPs as probe for CEA detection. Mikrochim Acta. 2020;187 (10):584. doi: 10.1007/s00604-020-04559-2. PubMed PMID:32990786 .
  2. Skröder, H, Pettersson, H, Norlén, F, Gustavsson, P, Rylander, L, Albin, M et al.. Occupational exposure to whole body vibrations and birth outcomes - A nationwide cohort study of Swedish women. Sci. Total Environ. 2020;751 :141476. doi: 10.1016/j.scitotenv.2020.141476. PubMed PMID:32871309 .
  3. Tudi, M, Ruan, HD, Yu, Y, Wang, L, Wei, B, Tong, S et al.. Bioaccumulation and translocation of trace elements in soil-irrigation water-wheat in arid agricultural areas of Xin Jiang, China. Ecotoxicology. 2020; :. doi: 10.1007/s10646-020-02267-4. PubMed PMID:32860622 .
  4. Kim, SJ, Oh, MJ. Potentiality to natural immunization inducement against VHS in olive flounder by live VHSV immersion vaccination at temperature controlled culture condition. Virus Res. 2020;288 :198140. doi: 10.1016/j.virusres.2020.198140. PubMed PMID:32846195 .
  5. Wallentine, S, Bandaranayake, S, Biswas, S, Baker, LR. Plasmon-Resonant Vibrational Sum Frequency Generation of Electrochemical Interfaces: Direct Observation of Carbon Dioxide Electroreduction on Gold. J Phys Chem A. 2020; :. doi: 10.1021/acs.jpca.0c04268. PubMed PMID:32846085 .
  6. Tirloni, E, Nauta, M, Vasconi, M, Di Pietro, V, Bernardi, C, Stella, S et al.. Growth of Listeria monocytogenes in ready-to-eat "shrimp cocktail": Risk assessment and possible preventive interventions. Int. J. Food Microbiol. 2020;334 :108800. doi: 10.1016/j.ijfoodmicro.2020.108800. PubMed PMID:32829187 .
  7. Dey Bhowmik, A, Podder, S, Mondal, P, Shaw, P, Bandyopadhyay, A, Das, A et al.. Chronic exposure to environmentally relevant concentration of fluoride alters Ogg1 and Rad51 expressions in mice: Involvement of epigenetic regulation. Ecotoxicol. Environ. Saf. 2020;202 :110962. doi: 10.1016/j.ecoenv.2020.110962. PubMed PMID:32800233 .
  8. Mahfooz, Y, Yasar, A, Guijian, L, Islam, QU, Akhtar, ABT, Rasheed, R et al.. Critical risk analysis of metals toxicity in wastewater irrigated soil and crops: a study of a semi-arid developing region. Sci Rep. 2020;10 (1):12845. doi: 10.1038/s41598-020-69815-0. PubMed PMID:32733057 PubMed Central PMC7393170.
  9. Han, L, Peng, R, Jiang, W, Xu, T, Zhang, C, Chen, K et al.. Coordination-driven reversible surfaces with site-specifically immobilized nanobody for dynamic cancer cell capture and release. J Mater Chem B. 2020;8 (33):7511-7520. doi: 10.1039/d0tb00574f. PubMed PMID:32677632 .
  10. Zhao, ML, Zeng, WJ, Chai, YQ, Yuan, R, Zhuo, Y. An Affinity-Enhanced DNA Intercalator with Intense ECL Embedded in DNA Hydrogel for Biosensing Applications. Anal. Chem. 2020;92 (16):11044-11052. doi: 10.1021/acs.analchem.0c00152. PubMed PMID:32677426 .
  11. Yu, H, McCuller, L, Tse, M, Kijbunchoo, N, Barsotti, L, Mavalvala, N et al.. Quantum correlations between light and the kilogram-mass mirrors of LIGO. Nature. 2020;583 (7814):43-47. doi: 10.1038/s41586-020-2420-8. PubMed PMID:32612226 .
  12. Souza Neto, HF, Pereira, WVDS, Dias, YN, Souza, ES, Teixeira, RA, Lima, MW et al.. Environmental and human health risks of arsenic in gold mining areas in the eastern Amazon. Environ. Pollut. 2020;265 (Pt B):114969. doi: 10.1016/j.envpol.2020.114969. PubMed PMID:32559696 .
  13. Ge, R, Zhao, H, Wei, JX, Duan, YQ, Bai, Z, Li, C et al.. Improved two-step optimization procedure used for designing an apodizer and Lyot stop in the Lyot coronagraph. Appl Opt. 2020;59 (16):4939-4952. doi: 10.1364/AO.391959. PubMed PMID:32543491 .
  14. Akshaya, KB, Anitha, V, Nidhin, M, Sudhakar, YN, Louis, G. Electrochemical sensing of vitamin B12 deficiency marker methylmalonic acid using PdAu-PPy tailored carbon fiber paper electrode. Talanta. 2020;217 :121028. doi: 10.1016/j.talanta.2020.121028. PubMed PMID:32498897 .
  15. Tamele, IJ, Vasconcelos, V. Microcystin Incidence in the Drinking Water of Mozambique: Challenges for Public Health Protection. Toxins (Basel). 2020;12 (6):. doi: 10.3390/toxins12060368. PubMed PMID:32498435 PubMed Central PMC7354522.
  16. Bandi, R, Alle, M, Park, CW, Han, SY, Kwon, GJ, Kim, JC et al.. Rapid synchronous synthesis of Ag nanoparticles and Ag nanoparticles/holocellulose nanofibrils: Hg(II) detection and dye discoloration. Carbohydr Polym. 2020;240 :116356. doi: 10.1016/j.carbpol.2020.116356. PubMed PMID:32475600 .
  17. Zhao, X, Yang, Y, Chiribella, G. Quantum Metrology with Indefinite Causal Order. Phys. Rev. Lett. 2020;124 (19):190503. doi: 10.1103/PhysRevLett.124.190503. PubMed PMID:32469602 .
  18. Ayres Cacciatore, F, Dalmás, M, Maders, C, Ataíde Isaía, H, Brandelli, A, da Silva Malheiros, P et al.. Carvacrol encapsulation into nanostructures: Characterization and antimicrobial activity against foodborne pathogens adhered to stainless steel. Food Res. Int. 2020;133 :109143. doi: 10.1016/j.foodres.2020.109143. PubMed PMID:32466924 .
  19. Wang, Y, Yu, J, Mao, YF, Chen, J, Wang, S, Chen, HZ et al.. Stable, high-performance sodium-based plasmonic devices in the near infrared. Nature. 2020;581 (7809):401-405. doi: 10.1038/s41586-020-2306-9. PubMed PMID:32461649 .
  20. Löfgren, L, Forsberg, GB, Davidsson, P, Eketjäll, S, Whatling, C. Development of a highly sensitive liquid chromatography-mass spectrometry method to quantify plasma leukotriene E4 and demonstrate pharmacological suppression of endogenous 5-LO pathway activity in man. Prostaglandins Other Lipid Mediat. 2020;150 :106463. doi: 10.1016/j.prostaglandins.2020.106463. PubMed PMID:32450304 .
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  1. Seoane, P, Espigares, M, Carmona, R, Polonio, Á, Quintana, J, Cretazzo, E et al.. TransFlow: a modular framework for assembling and assessing accurate de novo transcriptomes in non-model organisms. BMC Bioinformatics. 2018;19 (Suppl 14):416. doi: 10.1186/s12859-018-2384-y. PubMed PMID:30453874 PubMed Central PMC6245506.
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  1. García-Vilas, JA, Medina, MÁ. Updates on the hepatocyte growth factor/c-Met axis in hepatocellular carcinoma and its therapeutic implications. World J. Gastroenterol. 2018;24 (33):3695-3708. doi: 10.3748/wjg.v24.i33.3695. PubMed PMID:30197476 PubMed Central PMC6127652.
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  1. Fernández-Reina, A, Urdiales, JL, Sánchez-Jiménez, F. What We Know and What We Need to Know about Aromatic and Cationic Biogenic Amines in the Gastrointestinal Tract. 2018;7 (9):. doi: 10.3390/foods7090145. PubMed PMID:30181486 PubMed Central PMC6164962.
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  1. Carmona, R, Arroyo, M, Jiménez-Quesada, MJ, Seoane, P, Zafra, A, Larrosa, R et al.. Automated identification of reference genes based on RNA-seq data. Biomed Eng Online. 2017;16 (Suppl 1):65. doi: 10.1186/s12938-017-0356-5. PubMed PMID:28830520 PubMed Central PMC5568602.
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  1. Olsson, S, Seoane-Zonjic, P, Bautista, R, Claros, MG, González-Martínez, SC, Scotti, I et al.. Development of genomic tools in a widespread tropical tree, Symphonia globulifera L.f.: a new low-coverage draft genome, SNP and SSR markers. Mol Ecol Resour. 2017;17 (4):614-630. doi: 10.1111/1755-0998.12605. PubMed PMID:27718316 .
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  1. Jimenez-Quesada, MJ, Carmona, R, Lima-Cabello, E, Traverso, JÁ, Castro, AJ, Claros, MG et al.. Generation of nitric oxide by olive (Olea europaea L.) pollen during in vitro germination and assessment of the S-nitroso- and nitro-proteomes by computational predictive methods. Nitric Oxide. 2017;68 :23-37. doi: 10.1016/j.niox.2017.06.005. PubMed PMID:28645873 .
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  1. Balado, M, Benzekri, H, Labella, AM, Claros, MG, Manchado, M, Borrego, JJ et al.. Genomic analysis of the marine fish pathogen Photobacterium damselae subsp. piscicida: Insertion sequences proliferation is associated with chromosomal reorganisations and rampant gene decay. Infect. Genet. Evol. 2017;54 :221-229. doi: 10.1016/j.meegid.2017.07.007. PubMed PMID:28688976 .
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  1. Díaz-Santiago, E, Rodríguez-Caso, L, Cárdenas, C, Serrano, JJ, Quesada, AR, Medina, MÁ et al.. Homocysteine pre-treatment increases redox capacity in both endothelial and tumor cells. Redox Rep. 2017;22 (4):183-189. doi: 10.1080/13510002.2016.1183348. PubMed PMID:27198616 PubMed Central PMC6837415.
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  1. García-Vilas, JA, Quesada, AR, Medina, MÁ. Hydroxytyrosol targets extracellular matrix remodeling by endothelial cells and inhibits both ex vivo and in vivo angiogenesis. Food Chem. 2017;221 :1741-1746. doi: 10.1016/j.foodchem.2016.10.111. PubMed PMID:27979155 .
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  1. Zafra, A, Carmona, R, Traverso, JA, Hancock, JT, Goldman, MHS, Claros, MG et al.. Identification and Functional Annotation of Genes Differentially Expressed in the Reproductive Tissues of the Olive Tree (Olea europaea L.) through the Generation of Subtractive Libraries. 2017;8 :1576. doi: 10.3389/fpls.2017.01576. PubMed PMID:28955364 PubMed Central PMC5601413.
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  1. Martínez-Poveda, B, Quesada, AR, Medina, MÁ. Pleiotropic Role of Puupehenones in Biomedical Research. Mar Drugs. 2017;15 (10):. doi: 10.3390/md15100325. PubMed PMID:29065486 PubMed Central PMC5666431.
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  1. Acosta-Andrade, C, Artetxe, I, Lete, MG, Monasterio, BG, Ruiz-Mirazo, K, Goñi, FM et al.. Polyamine-RNA-membrane interactions: From the past to the future in biology. Colloids Surf B Biointerfaces. 2017;155 :173-181. doi: 10.1016/j.colsurfb.2017.04.005. PubMed PMID:28456048 .
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  1. Moya-García, A, Adeyelu, T, Kruger, FA, Dawson, NL, Lees, JG, Overington, JP et al.. Structural and Functional View of Polypharmacology. Sci Rep. 2017;7 (1):10102. doi: 10.1038/s41598-017-10012-x. PubMed PMID:28860623 PubMed Central PMC5579063.
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  1. García-Caballero, M, Paupert, J, Blacher, S, Van de Velde, M, Quesada, AR, Medina, MA et al.. Targeting VEGFR-3/-2 signaling pathways with AD0157: a potential strategy against tumor-associated lymphangiogenesis and lymphatic metastases. J Hematol Oncol. 2017;10 (1):122. doi: 10.1186/s13045-017-0484-1. PubMed PMID:28629427 PubMed Central PMC5477162.
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  1. García-Caballero, M, Martínez-Poveda, B, Medina, MA, Quesada, AR. The Natural Antiangiogenic Compound AD0157 Induces Caspase-Dependent Apoptosis in Human Myeloid Leukemia Cells. 2017;8 :802. doi: 10.3389/fphar.2017.00802. PubMed PMID:29163182 PubMed Central PMC5682012.
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  1. García-Vilas, JA, Pino-Ángeles, A, Martínez-Poveda, B, Quesada, AR, Medina, MÁ. The noni anthraquinone damnacanthal is a multi-kinase inhibitor with potent anti-angiogenic effects. Cancer Lett. 2017;385 :1-11. doi: 10.1016/j.canlet.2016.10.037. PubMed PMID:27816491 .
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  1. Acosta-Andrade, C, Lambertos, A, Urdiales, JL, Sánchez-Jiménez, F, Peñafiel, R, Fajardo, I et al.. A novel role for antizyme inhibitor 2 as a regulator of serotonin and histamine biosynthesis and content in mouse mast cells. Amino Acids. 2016;48 (10):2411-21. doi: 10.1007/s00726-016-2230-3. PubMed PMID:27084713 .
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  1. García-Vilas, JA, Martínez-Poveda, B, Quesada, AR, Medina, MÁ. Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug. Mar Drugs. 2015;14 (1):1. doi: 10.3390/md14010001. PubMed PMID:26703630 PubMed Central PMC4728498.
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  1. Rojano, E, Ranea, JA, Perkins, JR. Characterisation of non-coding genetic variation in histamine receptors using AnNCR-SNP. Amino Acids. 2016;48 (10):2433-42. doi: 10.1007/s00726-016-2265-5. PubMed PMID:27270572 .
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  1. Rodríguez, CE, Palacios, J, Fajardo, I, Urdiales, JL, Le Guével, X, Lozano, J et al.. Conventional Matrices Loaded Onto a Graphene Layer Enhances MALDI-TOF/TOF Signal: Its Application to Improve Detection of Phosphorylated Peptides. J. Am. Soc. Mass Spectrom. 2016;27 (2):366-9. doi: 10.1007/s13361-015-1299-3. PubMed PMID:26620529 .
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  1. Seoane-Zonjic, P, Cañas, RA, Bautista, R, Gómez-Maldonado, J, Arrillaga, I, Fernández-Pozo, N et al.. Establishing gene models from the Pinus pinaster genome using gene capture and BAC sequencing. BMC Genomics. 2016;17 :148. doi: 10.1186/s12864-016-2490-z. PubMed PMID:26922242 PubMed Central PMC4769843.
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  1. Bueno, A, Morilla, I, Diez, D, Moya-Garcia, AA, Lozano, J, Ranea, JA et al.. Exploring the interactions of the RAS family in the human protein network and their potential implications in RAS-directed therapies. Oncotarget. 2016;7 (46):75810-75826. doi: 10.18632/oncotarget.12416. PubMed PMID:27713118 PubMed Central PMC5342780.
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  1. García-Caballero, M, Blacher, S, Paupert, J, Quesada, AR, Medina, MA, Noël, A et al.. Novel application assigned to toluquinol: inhibition of lymphangiogenesis by interfering with VEGF-C/VEGFR-3 signalling pathway. Br. J. Pharmacol. 2016;173 (12):1966-87. doi: 10.1111/bph.13488. PubMed PMID:27018653 PubMed Central PMC4882490.
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