Basic and Applied Aspects of Neuropsychiatric and Neurodegenerative Diseases

Lineas de Investigación

This line of research studies everything from basic biomedical aspects of neurotransmission and regeneration of the central nervous system to applied clinical and therapeutic aspects. Different teams make up this multidisciplinary group, which allows for addressing neuropsychiatric and neurodegenerative diseases from different approaches that converge on the study of their basic mechanisms. This leads to the development of new diagnostic and therapeutic tools for the treatment of these diseases. This group is endorsed by its years of research and teaching.

01. Study of the role of neuropeptides in the central nervous system (CNS) in key areas for the mediation of behavioural functions associated with anxiety, depression, and fear.

02. Analysis of the functional interaction of the opioid and dopaminergic systems during opiate dependence in areas related to learning and consolidation of the habits of addictive behaviour.

03. Further research into the molecular and cellular bases (such as oxidative stress) involved in the genesis of neurodegenerative processes such as ageing and Parkinson’s disease as well as the study of the neuroprotective effects of IGF-II.

04. Early diagnosis, monitoring, and intervention in neurodegenerative and neuropsychiatric diseases and through techniques for autonomic and cognitive evaluation. Basic and applied aspects.

Proyectos de Investigación


Consejería de Salud y Familias
. 2019

Papel del heteromero GALR2/NPYY1R en la neurogenesis hipocampal: Una posible estrategia terapeutica para la enfermedad de Alzheimer

Programa Operativo FEDER Andalucía 2014-2020
Programa Operativo FEDER Andalucía 2014-2020 (convocatoria 2018) de generación de conocimiento "frontera" (consolidados y emergentes) 2018

Papel del heteromero GALR2/NPYY1R en la neurogenesis hipocampal: Una posible estrategia terapeutica para la enfermedad de Alzheimer

Programa Operativo FEDER Andalucía 2014-2020 (convocatoria 2018) de generación de conocimiento "frontera" (consolidados y emergentes)
2018 2014

Publicaciones científicas

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Effects of Long-Term Alcohol Drinking on the Dopamine D2 Receptor: Gene Expression and Heteroreceptor Complexes in the Striatum in Rats

Feltmann, K; Borroto-Escuela, DO; Ruegg, J; Pinton, L; Sergio TD; Narvaez, M; Jimenez-Beristain, A; Ekstrom, TJ; Fuxe, K; Steensland, P
Alcoholism-Clinical And Experimental Research 2018

Synthesis and dopaminergic activity of a series of new 1-aryl tetrahydroisoquinolines and 2-substituted 1-aryl-3-tetrahydrobenzazepines

Lucena-Serrano, C; Lucena-Serrano, A; Rivera, A; Lopez-Romero, JM; Valpuesta, M; Diaz, A
Bioorganic Chemistry 2018

Immunohistochemical mapping of neurotensin in the alpaca diencephalon

Sanchez, ML; Mangas, A; Medina, LE; Aguilar, LA; Diaz-Cabiale, Z; Narvaez, JA; Covenas, R
Folia Histochemica Et Cytobiologica 2018

A Novel Integrative Mechanism in Anxiolytic Behavior Induced by Galanin 2/Neuropeptide Y Y1 Receptor Interactions on Medial Paracapsular Intercalated Amygdala in Rats

Narvaez, M; Borroto-Escuela, DO; Santin, L; Millon, C; Gago, B; Flores-Burgess, A; Barbancho, MA; de la Mora, MP; Narvaez, JA; Diaz-Cabiale, Z; Fuxe, K
Frontiers In Cellular Neuroscience 2018

Oral Photoprotection: Effective Agents and Potential Candidates

Parrado, C; Philips, N; Gilaberte, Y; Juarranz, A; Gonzalez, S
Frontiers In Medicine 2018

Brain Dopamine Transmission in Health and Parkinson’s Disease: Modulation of Synaptic Transmission and Plasticity Through Volume Transmission and Dopamine Heteroreceptors

Borroto-Escuela, DO; De la Mora, MP; Manger, P; Narvaez, M; Beggiato, S; Crespo-Ramirez, M; Navarro, G; Wydra, K; Diaz-Cabiale, Z; Rivera, A; Ferraro, L; Tanganelli, S; Filip, G; Franco, R; Fuxe, K
Frontiers In Synaptic Neuroscience 2018

Excessive habit formation in schedule-induced polydipsia: Microstructural analysis of licking among rat strains and involvement of the orbitofrontal cortex.

Merchan, A; Mora, S; Gago, B; Rodriguez-Ortega, E; Fernandez-Teruel, A; Puga, J L; Sanchez-Santed, F; Moreno, M; Flores, P
Genes, Brain, And Behavior 2018

Glutamate receptors of the A5 region modulate cardiovascular responses evoked from the dorsomedial hypothalamic nucleus and perifornical area

Lopez-Gonzalez, MV; Diaz-Casares, A; Gonzalez-Garcia, M; Peinado-Aragones, CA; Barbancho, MA; de Albornoz, MC; Dawid-Milner, MS
Journal Of Physiology And Biochemistry 2018

Doppler Resistivity and Cerebral Small Vessel Disease: Hemodynamic Structural Correlation and Usefulness for the Etiological Classification of Acute Ischemic Stroke

de la Cruz-Cosme, C; Dawid-Milner, MS; Ojeda-Burgos, G; Gallardo-Tur, A; Segura, T
Journal Of Stroke & Cerebrovascular Diseases 2018

Receptor-Receptor Interactions in Multiple 5-HT1A Heteroreceptor Complexes in Raphe-Hippocampal 5-HT Transmission and Their Relevance for Depression and Its Treatment

Borroto-Escuela, DO; Narvaez, M; Ambrogini, P; Ferraro, L; Brito, I; Romero-Fernandez, W; Andrade-Talavera, Y; Flores-Burgess, A; Millon, C; Gago, B; Narvaez, JA; Odagaki, Y; Palkovits, M; Diaz-Cabiale, Z; Fuxe, K
Molecules 2018

Ratios of proteins in cerebrospinal fluid in Parkinson’s disease cognitive decline: prospective study

Delgado-Alvarado, M; Dacosta-Aguayo, R; Navalpotro-Gomez, I; Gago, B; Gorostidi, A; Jimenez-Urbieta, H; Quiroga-Varela, A; Ruiz-Martinez, J; Bergareche, A; Rodriguez-Oroz, MC
Movement Disorders 2018

Selective ablation of striatal striosomes produces the deregulation of dopamine nigrostriatal pathway

Shumilov, K; Real, MA; Valderrama-Carvajal, A; Rivera, A
Plos One 2018

Predicted change in the number of permanent medical teachers from 2017 to 2026. The training of future physicians in critical condition.

Lara, J P; Compan, A; Vargas-Nunez, J A; Cardellach, F; Fernandez-Gonzalez, S; Lopez-Muniz, A; Alvarez-Sala, J L
Revista Clinica Espanola 2018

Transcriptomic integration of D4R and MOR signaling in the rat caudate putamen

Valderrama-Carvajal, A; Irizar, H; Gago, B; Jimenez-Urbieta, H; Fuxe, K; Rodriguez-Oroz, MC; Otaegui, D; Rivera, A
Scientific Reports 2018

Disturbances in the FGFR1-5-HT1A Heteroreceptor Complexes in the Raphe-Hippocampal 5-HT System Develop in a Genetic Rat Model of Depression

Borroto-Escuela, DO; DuPont, CM; Li, X; Savelli, D; Lattanzi, D; Srivastava, I; Narvaez, M; Di Palma, M; Barbieri, E; Andrade-Talavera, Y; Cuppini, R; Odagaki, Y; Palkovits, M; Ambrogini, P; Lindskog, M; Fuxe, KFrontiers In Cellular Neuroscience. 2017

Dopamine D-4 receptor stimulation prevents nigrostriatal dopamine pathway activation by morphine: relevance for drug addiction

Rivera, A; Gago, B; Suarez-Boomgaard, D; Yoshitake, T; Roales-Bujan, R; Valderrama-Carvajal, A; Bilbao, A; Medina-Luque, J; Diaz-Cabiale, Z; Van Craenenbroeck, K; Borroto-Escuela, DO; Kehr, J; de Fonseca, FR; Santin, L; de la Calle, A; Fuxe, KAddiction Biology. 2017

Galanin (1-15) enhancement of the behavioral effects of Fluoxetine in the forced swimming test gives a new therapeutic strategy against depression

Flores-Burgess, A; Millon, C; Gago, B; Narvaez, M; Borroto-Escuela, DO; Mengod, G; Narvaez, JA; Fuxe, K; Santin, L; Diaz-Cabiale, ZNeuropharmacology. 2017

IGF-II promotes neuroprotection and neuroplasticity recovery in a long-lasting model of oxidative damage induced by glucocorticoids

Martin-Montanez, E; Millon, C; Boraldi, F; Garcia-Guirado, F; Pedraza, C; Lara, E; Santin, LJ; Pavia, J; Garcia-Fernandez, MRedox Biology. 2017

Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis

de Guevara-Miranda, DL; Millon, C; Rosell-Valle, C; Perez-Fernandez, M; Missiroli, M; Serrano, A; Pavon, FJ; de Fonseca, FR; Martinez-Losa, M; Alvarez-Dolado, M; Santin, LJ; Castilla-Ortega, EDisease Models & Mechanisms. 2017

maLPA1-null mice as an endophenotype of anxious depression

Moreno-Fernandez, RD; Perez-Martin, M; Castilla-Ortega, E; del Valle, CR; Garcia-Fernandez, MI; Chun, J; Estivill-Torrus, G; de Fonseca, FR; Santin, LJ; Pedraza, CTranslational Psychiatry. 2017

Non-linear classifiers applied to EEG analysis for epilepsy seizure detection

Martinez-Del-Rincon, J; Santofimia, MJ; del Toro, X; Barba, J; Romero, F; Navas, P; Lopez, JCExpert Systems With Applications. 2017

Understanding the Role of GPCR Heteroreceptor Complexes in Modulating the Brain Networks in Health and Disease

Borroto-Escuela, DO; Carlsson, J; Ambrogini, P; Narvaez, M; Wydra, K; Tarakanov, AO; Li, X; Millon, C; Ferraro, L; Cuppini, R; Tanganelli, S; Liu, F; Filip, M; Diaz-Cabiale, Z; Fuxe, KFrontiers In Cellular Neuroscience. 2017

Cocaine self-administration specifically increases A2AR-D2R and D2R-sigma1 R heteroreceptor complexes in the rat nucleus accumbens shell. Relevance for cocaine use disorder

Borroto-Escuela, DO; Narvaez, M; Wydra, K; Pintsuk, J; Pinton, L; Jimenez-Beristain, A; Di Palma, M; Jastrzebska, J; Filip, M; Fuxe, KPharmacology Biochemistry And Behavior. 2017

Cryptomphalus aspersa Mollusc Egg Extract Promotes Regenerative Effects in Human Dermal Papilla Stem Cells

Alameda, MT; Morel, E; Parrado, C; Gonzalez, S; Juarranz, AInternational Journal Of Molecular Sciences. 2017

The neuropeptides Galanin and Galanin(1-15) in depression-like behaviours

Millon, C; Flores-Burgess, A; Narvaez, M; Borroto-Escuela, DO; Gago, B; Santin, L; Castilla-Ortega, E; Narvaez, JA; Fuxe, K; Diaz-Cabiale, ZNeuropeptides. 2017

Acute polyneuropathies in a hospital in the south of Spain: ten years” experience

Alonso-Montejo, MM; Pradillo, MC; Moreno-Medinilla, EE; Navas-Sanchez, P; Martinez-Anton, JLRevista De Neurologia. 2017

Mapping of enkephalins and adrenocorticotropic hormone in the squirrel monkey brainstem

Duque-Diaz, E; Diaz-Cabiale, Z; Narvaez, J; Covenas, RAnatomical Science International. 2017

The impact of graphene on neural regenerative medicine

Rodriguez-Losada, N; Aguirre, JANeural Regeneration Research. 2017

Existence of Brain 5-HT1A-5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor-Receptor Interactions Regulating 5-HT1A Receptor Recognition

Borroto-Escuela, DO; Li, X; Tarakanov, AO; Savelli, D; Narvaez, M; Shumilov, K; Andrade-Talavera, Y; Jimenez-Beristain, A; Pomierny, B; Diaz-Cabiale, Z; Cuppini, R; Ambrogini, P; Lindskog, M; Fuxe, KAcs Omega. 2017

Brainstem and Autonomic Nervous System Dysfunction: A Neurosurgical Point of View

Martin-Gallego, A; Gonzalez-Garcia, L; Carrasco-Brenes, A; Segura-Fernandez-Nogueras, M; Delgado-Babiano, A; Ros-Sanjuan, A; Romero-Moreno, L; Dominguez-Paez, M; Dawid-Milner, M S; Arraez-Sanchez, M AActa Neurochirurgica. Supplement. 2017

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