Basic and Applied Aspects of Neuropsychiatric and Neurodegenerative Diseases
Lineas de Investigación
This line of research studies everything from basic biomedical aspects of neurotransmission and regeneration of the central nervous system to applied clinical and therapeutic aspects. Different teams make up this multidisciplinary group, which allows for addressing neuropsychiatric and neurodegenerative diseases from different approaches that converge on the study of their basic mechanisms. This leads to the development of new diagnostic and therapeutic tools for the treatment of these diseases. This group is endorsed by its years of research and teaching.
01. Study of the role of neuropeptides in the central nervous system (CNS) in key areas for the mediation of behavioural functions associated with anxiety, depression, and fear.
02. Analysis of the functional interaction of the opioid and dopaminergic systems during opiate dependence in areas related to learning and consolidation of the habits of addictive behaviour.
03. Further research into the molecular and cellular bases (such as oxidative stress) involved in the genesis of neurodegenerative processes such as ageing and Parkinson’s disease as well as the study of the neuroprotective effects of IGF-II.
04. Early diagnosis, monitoring, and intervention in neurodegenerative and neuropsychiatric diseases and through techniques for autonomic and cognitive evaluation. Basic and applied aspects.
Miembros del grupo
- Todos
- IR
- Co-IR
- Investigador
- Tecnico Laboratorio
- Otro
Proyectos de Investigación
GALANINA(1-15) Y ANHEDONIA: NUEVA INTERVENCIÓN TERAPÉUTICA ANTIDEPRESIVA
Fondos Feder - Junta de Andalucía
.
2019
COMBINACIÓN GALANINA(1-15)-FLUOXETINA: NUEVA ESTRATEGIA DE POTENCIACIÓN EN EL TRATAMIENTO DE LA DEPRESIÓN
Junta de Andalucía
.
2021
DEPRESION RESISTENTE AL TRATAMIENTO: UNA NUEVA ESTRATEGIA FARMACOLOGICA UTILIZANDO GALANINA(1-15)
Ministerio de Ciencia e Innovación
.
2021
NUEVA TERAPIA DE POTENCIACION: GALANINA(1-15) Y LOS INHIBIDORES DE LA RECAPTACION DE SEROTONINA PARA EL TRATAMIENTO DE LA DEPRESION Y OTROS DESORDENES PSICOTICOS 
Ministerio de Ciencia e Innovación
.
2021
PI-0083-2019. ESTUDIO TRASLACIONAL DE LA PARTICIPACIÓN DEL FRAGMENTO N-TERMINAL 1-15 DE LA GALANINA EN LA DEPENDENCIA ALCOHOLICA: NUEVAS ESTRATEGIAS TERAPÉUTICAS Y EVALUACIÓN DE BIOMARCADORES EN ADICCIÓN.
Consejería de Salud y Familias
.
2019
Papel del heteromero GALR2/NPYY1R en la neurogenesis hipocampal: Una posible estrategia terapeutica para la enfermedad de Alzheimer
Programa Operativo FEDER Andalucía 2014-2020
Programa Operativo FEDER Andalucía 2014-2020 (convocatoria 2018) de generación de conocimiento "frontera" (consolidados y emergentes)
2018
Papel del heteromero GALR2/NPYY1R en la neurogenesis hipocampal: Una posible estrategia terapeutica para la enfermedad de Alzheimer
Programa Operativo FEDER Andalucía 2014-2020 (convocatoria 2018) de generación de conocimiento "frontera" (consolidados y emergentes)
2018
2014
Patentes y Tecnologías
Publicaciones científicas
- Todo
- D1
- Q1
- Q2
- Otro
Effects of Long-Term Alcohol Drinking on the Dopamine D2 Receptor: Gene Expression and Heteroreceptor Complexes in the Striatum in Rats
Feltmann, K; Borroto-Escuela, DO; Ruegg, J; Pinton, L; Sergio TD; Narvaez, M; Jimenez-Beristain, A; Ekstrom, TJ; Fuxe, K; Steensland, P
Alcoholism-Clinical And Experimental Research 2018
Synthesis and dopaminergic activity of a series of new 1-aryl tetrahydroisoquinolines and 2-substituted 1-aryl-3-tetrahydrobenzazepines
Lucena-Serrano, C; Lucena-Serrano, A; Rivera, A; Lopez-Romero, JM; Valpuesta, M; Diaz, A
Bioorganic Chemistry 2018
Immunohistochemical mapping of neurotensin in the alpaca diencephalon
Sanchez, ML; Mangas, A; Medina, LE; Aguilar, LA; Diaz-Cabiale, Z; Narvaez, JA; Covenas, R
Folia Histochemica Et Cytobiologica 2018
A Novel Integrative Mechanism in Anxiolytic Behavior Induced by Galanin 2/Neuropeptide Y Y1 Receptor Interactions on Medial Paracapsular Intercalated Amygdala in Rats
Narvaez, M; Borroto-Escuela, DO; Santin, L; Millon, C; Gago, B; Flores-Burgess, A; Barbancho, MA; de la Mora, MP; Narvaez, JA; Diaz-Cabiale, Z; Fuxe, K
Frontiers In Cellular Neuroscience 2018
Oral Photoprotection: Effective Agents and Potential Candidates
Parrado, C; Philips, N; Gilaberte, Y; Juarranz, A; Gonzalez, S
Frontiers In Medicine 2018
Brain Dopamine Transmission in Health and Parkinson’s Disease: Modulation of Synaptic Transmission and Plasticity Through Volume Transmission and Dopamine Heteroreceptors
Borroto-Escuela, DO; De la Mora, MP; Manger, P; Narvaez, M; Beggiato, S; Crespo-Ramirez, M; Navarro, G; Wydra, K; Diaz-Cabiale, Z; Rivera, A; Ferraro, L; Tanganelli, S; Filip, G; Franco, R; Fuxe, K
Frontiers In Synaptic Neuroscience 2018
Excessive habit formation in schedule-induced polydipsia: Microstructural analysis of licking among rat strains and involvement of the orbitofrontal cortex.
Merchan, A; Mora, S; Gago, B; Rodriguez-Ortega, E; Fernandez-Teruel, A; Puga, J L; Sanchez-Santed, F; Moreno, M; Flores, P
Genes, Brain, And Behavior 2018
Glutamate receptors of the A5 region modulate cardiovascular responses evoked from the dorsomedial hypothalamic nucleus and perifornical area
Lopez-Gonzalez, MV; Diaz-Casares, A; Gonzalez-Garcia, M; Peinado-Aragones, CA; Barbancho, MA; de Albornoz, MC; Dawid-Milner, MS
Journal Of Physiology And Biochemistry 2018
Doppler Resistivity and Cerebral Small Vessel Disease: Hemodynamic Structural Correlation and Usefulness for the Etiological Classification of Acute Ischemic Stroke
de la Cruz-Cosme, C; Dawid-Milner, MS; Ojeda-Burgos, G; Gallardo-Tur, A; Segura, T
Journal Of Stroke & Cerebrovascular Diseases 2018
Receptor-Receptor Interactions in Multiple 5-HT1A Heteroreceptor Complexes in Raphe-Hippocampal 5-HT Transmission and Their Relevance for Depression and Its Treatment
Borroto-Escuela, DO; Narvaez, M; Ambrogini, P; Ferraro, L; Brito, I; Romero-Fernandez, W; Andrade-Talavera, Y; Flores-Burgess, A; Millon, C; Gago, B; Narvaez, JA; Odagaki, Y; Palkovits, M; Diaz-Cabiale, Z; Fuxe, K
Molecules 2018
Ratios of proteins in cerebrospinal fluid in Parkinson’s disease cognitive decline: prospective study
Delgado-Alvarado, M; Dacosta-Aguayo, R; Navalpotro-Gomez, I; Gago, B; Gorostidi, A; Jimenez-Urbieta, H; Quiroga-Varela, A; Ruiz-Martinez, J; Bergareche, A; Rodriguez-Oroz, MC
Movement Disorders 2018
Selective ablation of striatal striosomes produces the deregulation of dopamine nigrostriatal pathway
Shumilov, K; Real, MA; Valderrama-Carvajal, A; Rivera, A
Plos One 2018
Predicted change in the number of permanent medical teachers from 2017 to 2026. The training of future physicians in critical condition.
Lara, J P; Compan, A; Vargas-Nunez, J A; Cardellach, F; Fernandez-Gonzalez, S; Lopez-Muniz, A; Alvarez-Sala, J L
Revista Clinica Espanola 2018
Transcriptomic integration of D4R and MOR signaling in the rat caudate putamen
Valderrama-Carvajal, A; Irizar, H; Gago, B; Jimenez-Urbieta, H; Fuxe, K; Rodriguez-Oroz, MC; Otaegui, D; Rivera, A
Scientific Reports 2018
Cell survival and differentiation with nanocrystalline glass-like carbon using substantia nigra dopaminergic cells derived from transgenic mouse embryos
Rodriguez-Losada, N; Romero, P; Estivill-Torrus, G; de Villoria, RG; Aguirre, JAPlos One. 2017
Disturbances in the FGFR1-5-HT1A Heteroreceptor Complexes in the Raphe-Hippocampal 5-HT System Develop in a Genetic Rat Model of Depression
Borroto-Escuela, DO; DuPont, CM; Li, X; Savelli, D; Lattanzi, D; Srivastava, I; Narvaez, M; Di Palma, M; Barbieri, E; Andrade-Talavera, Y; Cuppini, R; Odagaki, Y; Palkovits, M; Ambrogini, P; Lindskog, M; Fuxe, KFrontiers In Cellular Neuroscience. 2017
Dopamine D-4 receptor stimulation prevents nigrostriatal dopamine pathway activation by morphine: relevance for drug addiction
Rivera, A; Gago, B; Suarez-Boomgaard, D; Yoshitake, T; Roales-Bujan, R; Valderrama-Carvajal, A; Bilbao, A; Medina-Luque, J; Diaz-Cabiale, Z; Van Craenenbroeck, K; Borroto-Escuela, DO; Kehr, J; de Fonseca, FR; Santin, L; de la Calle, A; Fuxe, KAddiction Biology. 2017
Galanin (1-15) enhancement of the behavioral effects of Fluoxetine in the forced swimming test gives a new therapeutic strategy against depression
Flores-Burgess, A; Millon, C; Gago, B; Narvaez, M; Borroto-Escuela, DO; Mengod, G; Narvaez, JA; Fuxe, K; Santin, L; Diaz-Cabiale, ZNeuropharmacology. 2017
IGF-II promotes neuroprotection and neuroplasticity recovery in a long-lasting model of oxidative damage induced by glucocorticoids
Martin-Montanez, E; Millon, C; Boraldi, F; Garcia-Guirado, F; Pedraza, C; Lara, E; Santin, LJ; Pavia, J; Garcia-Fernandez, MRedox Biology. 2017
Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis
de Guevara-Miranda, DL; Millon, C; Rosell-Valle, C; Perez-Fernandez, M; Missiroli, M; Serrano, A; Pavon, FJ; de Fonseca, FR; Martinez-Losa, M; Alvarez-Dolado, M; Santin, LJ; Castilla-Ortega, EDisease Models & Mechanisms. 2017
maLPA1-null mice as an endophenotype of anxious depression
Moreno-Fernandez, RD; Perez-Martin, M; Castilla-Ortega, E; del Valle, CR; Garcia-Fernandez, MI; Chun, J; Estivill-Torrus, G; de Fonseca, FR; Santin, LJ; Pedraza, CTranslational Psychiatry. 2017
Non-linear classifiers applied to EEG analysis for epilepsy seizure detection
Martinez-Del-Rincon, J; Santofimia, MJ; del Toro, X; Barba, J; Romero, F; Navas, P; Lopez, JCExpert Systems With Applications. 2017
Understanding the Role of GPCR Heteroreceptor Complexes in Modulating the Brain Networks in Health and Disease
Borroto-Escuela, DO; Carlsson, J; Ambrogini, P; Narvaez, M; Wydra, K; Tarakanov, AO; Li, X; Millon, C; Ferraro, L; Cuppini, R; Tanganelli, S; Liu, F; Filip, M; Diaz-Cabiale, Z; Fuxe, KFrontiers In Cellular Neuroscience. 2017
Cocaine self-administration specifically increases A2AR-D2R and D2R-sigma1 R heteroreceptor complexes in the rat nucleus accumbens shell. Relevance for cocaine use disorder
Borroto-Escuela, DO; Narvaez, M; Wydra, K; Pintsuk, J; Pinton, L; Jimenez-Beristain, A; Di Palma, M; Jastrzebska, J; Filip, M; Fuxe, KPharmacology Biochemistry And Behavior. 2017
Cryptomphalus aspersa Mollusc Egg Extract Promotes Regenerative Effects in Human Dermal Papilla Stem Cells
Alameda, MT; Morel, E; Parrado, C; Gonzalez, S; Juarranz, AInternational Journal Of Molecular Sciences. 2017
The neuropeptides Galanin and Galanin(1-15) in depression-like behaviours
Millon, C; Flores-Burgess, A; Narvaez, M; Borroto-Escuela, DO; Gago, B; Santin, L; Castilla-Ortega, E; Narvaez, JA; Fuxe, K; Diaz-Cabiale, ZNeuropeptides. 2017
Acute polyneuropathies in a hospital in the south of Spain: ten years” experience
Alonso-Montejo, MM; Pradillo, MC; Moreno-Medinilla, EE; Navas-Sanchez, P; Martinez-Anton, JLRevista De Neurologia. 2017
Evaluation and treatment of sleep problems in children diagnosed with attention deficit hyperactivity disorder: an update of the evidence
Chamorro, M; Lara, JP; Insa, I; Espadas, M; Alda-Diez, JARevista De Neurologia. 2017
Mapping of enkephalins and adrenocorticotropic hormone in the squirrel monkey brainstem
Duque-Diaz, E; Diaz-Cabiale, Z; Narvaez, J; Covenas, RAnatomical Science International. 2017
The impact of graphene on neural regenerative medicine
Rodriguez-Losada, N; Aguirre, JANeural Regeneration Research. 2017
Existence of Brain 5-HT1A-5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor-Receptor Interactions Regulating 5-HT1A Receptor Recognition
Borroto-Escuela, DO; Li, X; Tarakanov, AO; Savelli, D; Narvaez, M; Shumilov, K; Andrade-Talavera, Y; Jimenez-Beristain, A; Pomierny, B; Diaz-Cabiale, Z; Cuppini, R; Ambrogini, P; Lindskog, M; Fuxe, KAcs Omega. 2017
Brainstem and Autonomic Nervous System Dysfunction: A Neurosurgical Point of View
Martin-Gallego, A; Gonzalez-Garcia, L; Carrasco-Brenes, A; Segura-Fernandez-Nogueras, M; Delgado-Babiano, A; Ros-Sanjuan, A; Romero-Moreno, L; Dominguez-Paez, M; Dawid-Milner, M S; Arraez-Sanchez, M AActa Neurochirurgica. Supplement. 2017
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