Lineas de Investigación

01. Estudio de los mecanismos implicados en la generación del cáncer de piel con búsqueda específica de nuevos factores pronósticos, así como el abordaje terapeútico de las mismas.

02. Prevención del cáncer cutáneo con investigaciones en el campo de la fotoprotección

03. Análisis de la etiopatogenia de la psoriasis y su tratamiento tanto por mecanismos inmunoterapeúticos y fototerapia.



Estudios Clínicos

I1F-MC-RHBA. Estudio multicéntrico, aleatorizado, en doble ciego y controlado con placebo, para comparar la eficacia y la seguridad de LY2439821 frente a etanercept y placebo en pacientes con psoriasis en placas de grado moderado a severo

ELI LILLY AND COMPANY
Fase: III ENSAYO CLINICO COMERCIAL

WA29330. Estudio multicéntrico, aleatorizado, doble ciego, con doble simulación y comparador activo para evaluar la eficacia y la seguridad de rituximab en comparación con MMF en pacientes con pénfigo vulgar

F. HOFFMANN LA ROCHE LTD
Fase: III ENSAYO CLINICO COMERCIAL

CAIN457A3401. Ensayo abierto, prospectivo, no aleatorizado, multicéntrico para evaluar el efecto de piel blanqueada en los resultados de calidad de vida relacionada con la salud a las 16 y 52 semanas en pacientes con psoriasis en placas de moderada a grave tratados con

NOVARTIS FARMACEUTICA, S.A.
Fase: IV ENSAYO CLINICO COMERCIAL

SP14019-18. Evaluación de la solución de uso cutáneo SP14019-F-01 para el tratamiento de la dermatitis atópica. Estudio piloto. Estudio Cyclatop

SPHERIUM BIOMED S.L (ANTES JANUS DEVELOPMENT)
Fase: II ENSAYO CLINICO COMERCIAL

CAIN457A2323. Estudio multicéntrico, aleatorizado, doble ciego, controlado con placebo, de 52 semanas de duración para demostrar la eficacia, seguridad y tolerabilidad de inyecciones subcutáneas de secukinumab con jeringas precargadas de 2 ml (300 mg) en pacientes adul

NOVARTIS FARMACEUTICA, S.A.
Fase: III ENSAYO CLINICO COMERCIAL

M-41008-41. Estudio clínico abierto para evaluar la eficacia y la seguridad a largo plazo de dimetilfumarato en adultos con psoriasis crónica en placas moderada-grave en la práctica clínica (Estudio DIMESKIN 1)

ALMIRALL S.A.
Fase: IV ENSAYO CLINICO COMERCIAL


Publicaciones científicas

  • Todo
  • D1
  • Q1
  • Q2
  • Otro
  1. Dirschka, T, Ekanayake-Bohlig, S, Dominicus, R, Aschoff, R, Herrera-Ceballos, E, Botella-Estrada, R et al.. A randomized, intraindividual, non-inferiority, Phase III study comparing daylight photodynamic therapy with BF-200 ALA gel and MAL cream for the treatment of actinic keratosis. J Eur Acad Dermatol Venereol. 2019;33 (2):288-297. doi: 10.1111/jdv.15185. PubMed PMID:30022544 PubMed Central PMC6585804.
Search PubMed
  1. Valencia-Vera, E, Aguilera, J, Cobos, A, Bernabó, JL, Pérez-Valero, V, Herrera-Ceballos, E et al.. Association between seasonal serum folate levels and ultraviolet radiation. J. Photochem. Photobiol. B, Biol. 2019;190 :66-71. doi: 10.1016/j.jphotobiol.2018.10.012. PubMed PMID:30502586 .
Search PubMed
  1. Aterido, A, Cañete, JD, Tornero, J, Ferrándiz, C, Pinto, JA, Gratacós, J et al.. Genetic variation at the glycosaminoglycan metabolism pathway contributes to the risk of psoriatic arthritis but not psoriasis. Ann. Rheum. Dis. 2019;78 (3):. doi: 10.1136/annrheumdis-2018-214158. PubMed PMID:30552173 .
Search PubMed
  1. Montes-Torres, A, Aparicio, G, Rivera, R, Vilarrasa, E, Marcellán, M, Notario, J et al.. Safety and effectiveness of conventional systemic therapy and biological drugs in patients with moderate to severe psoriasis and HIV infection: a retrospective multicenter study. J Dermatolog Treat. 2019;30 (5):461-465. doi: 10.1080/09546634.2018.1535690. PubMed PMID:30307344 .
Search PubMed
  1. López Jiménez, P, Suárez Pérez, J, Herrera Acosta, E, Aguilera Arjona, J, Mendiola Fernández, MV, Bosch García, R et al.. Secukinumab versus ustekinumab for skin clearance in patients with moderate to severe psoriasis after a year of treatment: Real-world practice. Dermatol Ther. 2019;32 (4):e12937. doi: 10.1111/dth.12937. PubMed PMID:30983098 .
Search PubMed
  1. de la Coba, F, Aguilera, J, Korbee, N, de Gálvez, MV, Herrera-Ceballos, E, Álvarez-Gómez, F et al.. UVA and UVB Photoprotective Capabilities of Topical Formulations Containing Mycosporine-like Amino Acids (MAAs) through Different Biological Effective Protection Factors (BEPFs). Mar Drugs. 2019;17 (1):. doi: 10.3390/md17010055. PubMed PMID:30646557 PubMed Central PMC6356945.
Search PubMed
  1. de Gálvez, MV, Aguilera, J, Sánchez-Roldán, C, Herrera-Acosta, E, Herrera-Ceballos, E. Water-Filtered Infrared Radiation Decreases the Generation of Photodermatoses Dependent on Ultraviolet and Visible Radiation. Photochem. Photobiol. 2019;95 (3):874-878. doi: 10.1111/php.13049. PubMed PMID:30447157 .
Search PubMed
  1. Baños-Arévalo, AJ, López-Navarro, N, Gallego-Domínguez, E, Herrera, E. Acral Metastasis of the Fingers: Report of 2 Cases. Actas Dermosifiliogr. 2018;109 (10):e1-e4. doi: 10.1016/j.ad.2017.03.024. PubMed PMID:29724431 .
Search PubMed
  1. Garcia-Doval, I, Descalzo, MA, Mason, KJ, Cohen, AD, Ormerod, AD, Gómez-García, FJ et al.. Cumulative exposure to biological therapy and risk of cancer in patients with psoriasis: a meta-analysis of Psonet studies from Israel, Italy, Spain, the U.K. and Republic of Ireland. Br. J. Dermatol. 2018;179 (4):863-871. doi: 10.1111/bjd.16715. PubMed PMID:29723914 .
Search PubMed
  1. Skröder, H, Pettersson, H, Norlén, F, Gustavsson, P, Rylander, L, Albin, M et al.. Occupational exposure to whole body vibrations and birth outcomes - A nationwide cohort study of Swedish women. Sci. Total Environ. 2020;751 :141476. doi: 10.1016/j.scitotenv.2020.141476. PubMed PMID:32871309 .
  2. Tudi, M, Ruan, HD, Yu, Y, Wang, L, Wei, B, Tong, S et al.. Bioaccumulation and translocation of trace elements in soil-irrigation water-wheat in arid agricultural areas of Xin Jiang, China. Ecotoxicology. 2020; :. doi: 10.1007/s10646-020-02267-4. PubMed PMID:32860622 .
  3. Kim, SJ, Oh, MJ. Potentiality to natural immunization inducement against VHS in olive flounder by live VHSV immersion vaccination at temperature controlled culture condition. Virus Res. 2020;288 :198140. doi: 10.1016/j.virusres.2020.198140. PubMed PMID:32846195 .
  4. Wallentine, S, Bandaranayake, S, Biswas, S, Baker, LR. Plasmon-Resonant Vibrational Sum Frequency Generation of Electrochemical Interfaces: Direct Observation of Carbon Dioxide Electroreduction on Gold. J Phys Chem A. 2020; :. doi: 10.1021/acs.jpca.0c04268. PubMed PMID:32846085 .
  5. Tirloni, E, Nauta, M, Vasconi, M, Di Pietro, V, Bernardi, C, Stella, S et al.. Growth of Listeria monocytogenes in ready-to-eat "shrimp cocktail": Risk assessment and possible preventive interventions. Int. J. Food Microbiol. 2020;334 :108800. doi: 10.1016/j.ijfoodmicro.2020.108800. PubMed PMID:32829187 .
  6. Dey Bhowmik, A, Podder, S, Mondal, P, Shaw, P, Bandyopadhyay, A, Das, A et al.. Chronic exposure to environmentally relevant concentration of fluoride alters Ogg1 and Rad51 expressions in mice: Involvement of epigenetic regulation. Ecotoxicol. Environ. Saf. 2020;202 :110962. doi: 10.1016/j.ecoenv.2020.110962. PubMed PMID:32800233 .
  7. Mahfooz, Y, Yasar, A, Guijian, L, Islam, QU, Akhtar, ABT, Rasheed, R et al.. Critical risk analysis of metals toxicity in wastewater irrigated soil and crops: a study of a semi-arid developing region. Sci Rep. 2020;10 (1):12845. doi: 10.1038/s41598-020-69815-0. PubMed PMID:32733057 PubMed Central PMC7393170.
  8. Han, L, Peng, R, Jiang, W, Xu, T, Zhang, C, Chen, K et al.. Coordination-driven reversible surfaces with site-specifically immobilized nanobody for dynamic cancer cell capture and release. J Mater Chem B. 2020;8 (33):7511-7520. doi: 10.1039/d0tb00574f. PubMed PMID:32677632 .
  9. Zhao, ML, Zeng, WJ, Chai, YQ, Yuan, R, Zhuo, Y. An Affinity-Enhanced DNA Intercalator with Intense ECL Embedded in DNA Hydrogel for Biosensing Applications. Anal. Chem. 2020;92 (16):11044-11052. doi: 10.1021/acs.analchem.0c00152. PubMed PMID:32677426 .
  10. Yu, H, McCuller, L, Tse, M, Kijbunchoo, N, Barsotti, L, Mavalvala, N et al.. Quantum correlations between light and the kilogram-mass mirrors of LIGO. Nature. 2020;583 (7814):43-47. doi: 10.1038/s41586-020-2420-8. PubMed PMID:32612226 .
  11. Souza Neto, HF, Pereira, WVDS, Dias, YN, Souza, ES, Teixeira, RA, Lima, MW et al.. Environmental and human health risks of arsenic in gold mining areas in the eastern Amazon. Environ. Pollut. 2020;265 (Pt B):114969. doi: 10.1016/j.envpol.2020.114969. PubMed PMID:32559696 .
  12. Ge, R, Zhao, H, Wei, JX, Duan, YQ, Bai, Z, Li, C et al.. Improved two-step optimization procedure used for designing an apodizer and Lyot stop in the Lyot coronagraph. Appl Opt. 2020;59 (16):4939-4952. doi: 10.1364/AO.391959. PubMed PMID:32543491 .
  13. Akshaya, KB, Anitha, V, Nidhin, M, Sudhakar, YN, Louis, G. Electrochemical sensing of vitamin B12 deficiency marker methylmalonic acid using PdAu-PPy tailored carbon fiber paper electrode. Talanta. 2020;217 :121028. doi: 10.1016/j.talanta.2020.121028. PubMed PMID:32498897 .
  14. Tamele, IJ, Vasconcelos, V. Microcystin Incidence in the Drinking Water of Mozambique: Challenges for Public Health Protection. Toxins (Basel). 2020;12 (6):. doi: 10.3390/toxins12060368. PubMed PMID:32498435 PubMed Central PMC7354522.
  15. Bandi, R, Alle, M, Park, CW, Han, SY, Kwon, GJ, Kim, JC et al.. Rapid synchronous synthesis of Ag nanoparticles and Ag nanoparticles/holocellulose nanofibrils: Hg(II) detection and dye discoloration. Carbohydr Polym. 2020;240 :116356. doi: 10.1016/j.carbpol.2020.116356. PubMed PMID:32475600 .
  16. Zhao, X, Yang, Y, Chiribella, G. Quantum Metrology with Indefinite Causal Order. Phys. Rev. Lett. 2020;124 (19):190503. doi: 10.1103/PhysRevLett.124.190503. PubMed PMID:32469602 .
  17. Ayres Cacciatore, F, Dalmás, M, Maders, C, Ataíde Isaía, H, Brandelli, A, da Silva Malheiros, P et al.. Carvacrol encapsulation into nanostructures: Characterization and antimicrobial activity against foodborne pathogens adhered to stainless steel. Food Res. Int. 2020;133 :109143. doi: 10.1016/j.foodres.2020.109143. PubMed PMID:32466924 .
  18. Wang, Y, Yu, J, Mao, YF, Chen, J, Wang, S, Chen, HZ et al.. Stable, high-performance sodium-based plasmonic devices in the near infrared. Nature. 2020;581 (7809):401-405. doi: 10.1038/s41586-020-2306-9. PubMed PMID:32461649 .
  19. Löfgren, L, Forsberg, GB, Davidsson, P, Eketjäll, S, Whatling, C. Development of a highly sensitive liquid chromatography-mass spectrometry method to quantify plasma leukotriene E4 and demonstrate pharmacological suppression of endogenous 5-LO pathway activity in man. Prostaglandins Other Lipid Mediat. 2020;150 :106463. doi: 10.1016/j.prostaglandins.2020.106463. PubMed PMID:32450304 .
  20. Obasi, NA, Aloke, C, Obasi, SE, Famurewa, AC, Ogbu, PN, Onyeji, GN et al.. Elemental Composition and Associated Health Risk of Honey Obtained from Apiary Farms in Southeast Nigeria. J. Food Prot. 2020;83 (10):1745-1756. doi: 10.4315/JFP-20-072. PubMed PMID:32421795 .
Search PubMed
  1. de Troya-Martín, M, de Gálvez-Aranda, MV, Rivas-Ruiz, F, Blázquez-Sánchez, N, Fernández-Morano, MT, Padilla-España, L et al.. Prevalence and predictors of sunburn among beachgoers. Photodermatol Photoimmunol Photomed. 2018;34 (2):122-129. doi: 10.1111/phpp.12354. PubMed PMID:28976044 .
Search PubMed
  1. Belinchón, I, Ramos, JM, Carretero, G, Ferrándiz, C, Rivera, R, Daudén, E et al.. Adverse events associated with discontinuation of the biologics/classic systemic treatments for moderate-to-severe plaque psoriasis: data from the Spanish Biologics Registry, Biobadaderm. J Eur Acad Dermatol Venereol. 2017;31 (10):1700-1708. doi: 10.1111/jdv.14314. PubMed PMID:28485816 .
Search PubMed
  1. Pérez-Plaza, A, Carretero, G, Ferrandiz, C, Vanaclocha, F, Gómez-García, FJ, Herrera-Ceballos, E et al.. Comparison of phenotype, comorbidities, therapy and adverse events between psoriatic patients with and without psoriatic arthritis. Biobadaderm registry. J Eur Acad Dermatol Venereol. 2017;31 (6):1021-1028. doi: 10.1111/jdv.14188. PubMed PMID:28252811 .
Search PubMed
  1. Dávila-Seijo, P, Dauden, E, Descalzo, MA, Carretero, G, Carrascosa, JM, Vanaclocha, F et al.. Infections in Moderate to Severe Psoriasis Patients Treated with Biological Drugs Compared to Classic Systemic Drugs: Findings from the BIOBADADERM Registry. J. Invest. Dermatol. 2017;137 (2):313-321. doi: 10.1016/j.jid.2016.08.034. PubMed PMID:27677836 .
Search PubMed
  1. Tejera-Vaquerizo, A, Pérez-Cabello, G, Marínez-Leborans, L, Gallego, E, Oliver-Martínez, V, Martín-Cuevas, P et al.. Is mitotic rate still useful in the management of patients with thin melanoma?. J Eur Acad Dermatol Venereol. 2017;31 (12):2025-2029. doi: 10.1111/jdv.14485. PubMed PMID:28750139 .
Search PubMed
  1. Losantos, R, Funes-Ardoiz, I, Aguilera, J, Herrera-Ceballos, E, García-Iriepa, C, Campos, PJ et al.. Rational Design and Synthesis of Efficient Sunscreens To Boost the Solar Protection Factor. Angew. Chem. Int. Ed. Engl. 2017;56 (10):2632-2635. doi: 10.1002/anie.201611627. PubMed PMID:28128519 .
Search PubMed
  1. Belinchón, I, Ramos, JM, Carretero, G, Ferrándiz, C, Rivera, R, Daudén, E et al.. Adverse events associated with discontinuation of the biologics/classic systemic treatments for moderate-to-severe plaque psoriasis: data from the Spanish Biologics Registry, Biobadaderm. J Eur Acad Dermatol Venereol. 2017;31 (10):1700-1708. doi: 10.1111/jdv.14314. PubMed PMID:28485816 .
Search PubMed
  1. Pérez-Plaza, A, Carretero, G, Ferrandiz, C, Vanaclocha, F, Gómez-García, FJ, Herrera-Ceballos, E et al.. Comparison of phenotype, comorbidities, therapy and adverse events between psoriatic patients with and without psoriatic arthritis. Biobadaderm registry. J Eur Acad Dermatol Venereol. 2017;31 (6):1021-1028. doi: 10.1111/jdv.14188. PubMed PMID:28252811 .
Search PubMed
  1. Dávila-Seijo, P, Dauden, E, Descalzo, MA, Carretero, G, Carrascosa, JM, Vanaclocha, F et al.. Infections in Moderate to Severe Psoriasis Patients Treated with Biological Drugs Compared to Classic Systemic Drugs: Findings from the BIOBADADERM Registry. J. Invest. Dermatol. 2017;137 (2):313-321. doi: 10.1016/j.jid.2016.08.034. PubMed PMID:27677836 .
Search PubMed
  1. Tejera-Vaquerizo, A, Pérez-Cabello, G, Marínez-Leborans, L, Gallego, E, Oliver-Martínez, V, Martín-Cuevas, P et al.. Is mitotic rate still useful in the management of patients with thin melanoma?. J Eur Acad Dermatol Venereol. 2017;31 (12):2025-2029. doi: 10.1111/jdv.14485. PubMed PMID:28750139 .
Search PubMed
  1. Losantos, R, Funes-Ardoiz, I, Aguilera, J, Herrera-Ceballos, E, García-Iriepa, C, Campos, PJ et al.. Rational Design and Synthesis of Efficient Sunscreens To Boost the Solar Protection Factor. Angew. Chem. Int. Ed. Engl. 2017;56 (10):2632-2635. doi: 10.1002/anie.201611627. PubMed PMID:28128519 .
Search PubMed
  1. de Troya-Martín, M, Padilla-España, L, Férnandez-Morano, T, Delgado-Sánchez, N, Blázquez Sánchez, N, Rivas-Ruiz, F et al.. Sun Protection Habits and Attitudes Among Healthcare Personnel in a Mediterranean Population. J Cancer Educ. 2016;31 (4):789-795. doi: 10.1007/s13187-015-0913-1. PubMed PMID:26370806 .
Search PubMed
  1. Dávila-Seijo, P, Dauden, E, Carretero, G, Ferrandiz, C, Vanaclocha, F, Gómez-García, FJ et al.. Survival of classic and biological systemic drugs in psoriasis: results of the BIOBADADERM registry and critical analysis. J Eur Acad Dermatol Venereol. 2016;30 (11):1942-1950. doi: 10.1111/jdv.13682. PubMed PMID:27329511 .
Search PubMed
  1. Julià, A, Pinto, JA, Gratacós, J, Queiró, R, Ferrándiz, C, Fonseca, E et al.. A deletion at ADAMTS9-MAGI1 locus is associated with psoriatic arthritis risk. Ann. Rheum. Dis. 2015;74 (10):1875-81. doi: 10.1136/annrheumdis-2014-207190. PubMed PMID:25990289 .
Search PubMed
  1. Julià, A, Ferrándiz, C, Dauden, E, Fonseca, E, Fernández-López, E, Sanchez-Carazo, JL et al.. Association of the PDE3A-SLCO1C1 locus with the response to anti-TNF agents in psoriasis. Pharmacogenomics J. 2015;15 (4):322-5. doi: 10.1038/tpj.2014.71. PubMed PMID:25403996 .
Search PubMed
  1. Tejera-Vaquerizo, A, Arias-Santiago, S, Nagore, E, Martín-Cuevas, P, Orgaz-Molina, J, Traves, V et al.. Defining the dermoscopic characteristics of fast-growing cutaneous melanomas. Melanoma Res. 2015;25 (3):269-72. doi: 10.1097/CMR.0000000000000157. PubMed PMID:25919929 .
Search PubMed
  1. Tejera-Vaquerizo, A, Nagore, E, Puig, S, Robert, C, Saiag, P, Martín-Cuevas, P et al.. Effect of time to sentinel-node biopsy on the prognosis of cutaneous melanoma. Eur. J. Cancer. 2015;51 (13):1780-93. doi: 10.1016/j.ejca.2015.05.023. PubMed PMID:26072362 PubMed Central PMC4768477.
Search PubMed
  1. de Gálvez, MV, Aguilera, J, Bernabó, JL, Sánchez-Roldán, C, Herrera-Ceballos, E. Human Hair as a Natural Sun Protection Agent: A Quantitative Study. Photochem. Photobiol. ;91 (4):966-70. doi: 10.1111/php.12433. PubMed PMID:25682789 .
Search PubMed
  1. Carretero, G, Ferrandiz, C, Dauden, E, Vanaclocha Sebastián, F, Gómez-García, FJ, Herrera-Ceballos, E et al.. Risk of adverse events in psoriasis patients receiving classic systemic drugs and biologics in a 5-year observational study of clinical practice: 2008-2013 results of the Biobadaderm registry. J Eur Acad Dermatol Venereol. 2015;29 (1):156-63. doi: 10.1111/jdv.12492. PubMed PMID:24684267 .
Search PubMed
  1. Medina, C, Carretero, G, Ferrandiz, C, Dauden, E, Vanaclocha, F, Gómez-García, FJ et al.. Safety of classic and biologic systemic therapies for the treatment of psoriasis in elderly: an observational study from national BIOBADADERM registry. J Eur Acad Dermatol Venereol. 2015;29 (5):858-64. doi: 10.1111/jdv.12688. PubMed PMID:25185962 .
Search PubMed

Subscribe

Suscríbete a nuestro Newsletter y recibe en tu correo todas las últimas novedades del Instituto.
Consulta el histórico de Newsletter:

Calle Doctor Miguel Díaz Recio , 28 Málaga 29010

(+34) 951 440 260
Fax: (+34) 951 440 263