Lineas de Investigación

1. Genómica Funcional y Proteómica del Cáncer

2. Bases celulares y moleculares de la síntesis de glutamato en cerebro

3. Modelos animales transgénicos con déficits en el metabolismo de aminoácidos

4. Expresión heteróloga de proteínas humanas recombinantes con valor terapéutico y biotecnológico



Proyectos de Investigación

Terapia metabólica del cáncer: supresión tumoral inducida por desregulación de glutaminasa (RTI2018-096866-B-I00).

Ministerio de Ciencia, Innovación y Universidades
Ministerio de Ciencia, Innovación y Universidades 2019

Publicaciones científicas

  • Todo
  • D1
  • Q1
  • Q2
  • Otro
A problem-/case-based learning approach as an useful tool for studying glycogen metabolism and its regulation

García-Ponce ÁL, Martínez-Poveda B, Blanco-López Á, Quesada AR, Suárez F, et al. Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology 2021 Mar;49(2):236-241

Antioxidant responses related to temozolomide resistance in glioblastoma

Campos-Sandoval JA, Gómez-García MC, Santos-Jiménez JL, Matés JM, Alonso FJ, et al. Neurochemistry international 2021 Oct;149():105136

Glutaminase isoforms expression switches microRNA levels and oxidative status in glioblastoma cells

de Los Santos-Jiménez J, Campos-Sandoval JA, Márquez-Torres C, Urbano-Polo N, Brøndegaard D, et al. Journal of biomedical science 2021 Feb 20;28(1):14

Identification of key molecular biomarkers involved in reactive and neurodegenerative processes present in inherited congenital hydrocephalus

Ojeda-Pérez B, Campos-Sandoval JA, García-Bonilla M, Cárdenas-García C, Páez-González P, et al. Fluids and barriers of the CNS 2021 Jul 2;18(1):30

Glutaminases regulate glutathione and oxidative stress in cancer

Matés JM, Campos-Sandoval JA, de Los Santos-Jiménez J, Márquez J Archives of toxicology 2020 Aug;94(8):2603-2623

Metabolic Reprogramming of Cancer by Chemicals that Target Glutaminase Isoenzymes

Matés JM, Campos-Sandoval JA, de Los Santos-Jiménez J, Segura JA, Alonso FJ, et al. Current medicinal chemistry 2020;27(32):5317-5339

Nuclear Translocation of Glutaminase GLS2 in Human Cancer Cells Associates with Proliferation Arrest and Differentiation

López de la Oliva AR, Campos-Sandoval JA, Gómez-García MC, Cardona C, Martín-Rufián M, et al. Scientific reports 2020 Feb 10;10(1):2259

Therapeutic targeting of glutaminolysis as an essential strategy to combat cancer

Matés JM, Di Paola FJ, Campos-Sandoval JA, Mazurek S, Márquez J Seminars in cell & developmental biology 2020 Feb;98():34-43

Dysregulation of glutaminase and glutamine synthetase in cancer

Matés JM, Campos-Sandoval JA, Santos-Jiménez JL, Márquez J Cancer letters 2019 Dec 28;467():29-39

Lysophosphatidic Acid and Glutamatergic Transmission

Roza C, Campos-Sandoval JA, Gómez-García MC, Peñalver A, Márquez J Frontiers in molecular neuroscience 2019;12():138

The Epithelial to Mesenchymal Transition Promotes Glutamine Independence by Suppressing GLS2 Expression

Ramirez-Peña E, Arnold J, Shivakumar V, Joseph R, Vidhya Vijay G, et al. Cancers 2019 Oct 22;11(10):

A Distinct Metabolite Profile Correlates with Neurodegenerative Conditions and the Severity of Congenital Hydrocephalus.

García-Bonilla M, García-Martín ML, Muñoz-Hernández MC, Domínguez-Pinos D, Martínez-León MI, et al. Journal of neuropathology and experimental neurology 2018 Dec 1;77(12):1122-1136

Glutaminase isoenzymes in the metabolic therapy of cancer

Matés JM, Campos-Sandoval JA, Márquez J Biochimica et biophysica acta. Reviews on cancer 2018 Dec;1870(2):158-164

Glutamate and Brain Glutaminases in Drug Addiction

Márquez J, Campos-Sandoval JA, Peñalver A, Matés JM, Segura JA, et al. Neurochemical research 2017 Mar;42(3):846-857

Glutaminase and MMP-9 Downregulation in Cortex and Hippocampus of LPA(1) Receptor Null Mice Correlate with Altered Dendritic Spine Plasticity

Peñalver A, Campos-Sandoval JA, Blanco E, Cardona C, Castilla L, et al. Frontiers in molecular neuroscience 2017;10():278

Glutamine Addiction In Gliomas

Márquez J, Alonso FJ, Matés JM, Segura JA, Martín-Rufián M, et al. Neurochemical research 2017 Jun;42(6):1735-1746

MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer

Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, et al. Cancer cell 2017 Jul 10;32(1):71-87.e7

TRANSCRIPTION FACTOR GATA3 EXPRESSION IS INDUCED BY GLS2 OVEREXPRESSION IN A GLIOBLASTOMA CELL LINE BUT IS GLS2-INDEPENDENT IN PATIENT-DERIVED GLIOBLASTOMA

Majewska E, Rola R, Barczewska M, Marquez J, Albrecht J, et al. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2017 Apr;68(2):209-214

Synthesis and Covalent Grafting of Tripod-Shaped Oligo(p-phenylene)s End-Capped with Azide Groups

Sanchez-Molina, M; Lopez-Romero, JM; Hierrezuelo-Leon, J; Martin-Rufian, M; Diaz, A; Valpuesta, M; Contreras-Caceres, R ASIAN JOURNAL OF ORGANIC CHEMISTRY 2016

Expression of Gls and Gls2 Glutaminase Isoforms in Astrocytes

Cardona C, Sánchez-Mejías E, Dávila JC, Martín-Rufián M, Campos-Sandoval JA, et al. Glia 2015 Mar;63(3):365-82

Glutaminases in brain: Multiple isoforms for many purposes

Campos-Sandoval JA, Martín-Rufián M, Cardona C, Lobo C, Peñalver A, et al. Neurochemistry international 2015 Sep;88():1-5

Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia

Herranz D, Ambesi-Impiombato A, Sudderth J, Sánchez-Martín M, Belver L, et al. Nature medicine 2015 Oct;21(10):1182-9

Pharmacological Blockade of Cannabinoid CB1 Receptors in Diet-Induced Obesity Regulates Mitochondrial Dihydrolipoamide Dehydrogenase in Muscle

Arrabal S, Lucena MA, Canduela MJ, Ramos-Uriarte A, Rivera P, et al. PloS one 2015;10(12):e0145244


Consulta el histórico de Newsletter:

Calle Severo Ochoa, 35
Parque Tecnolgico de Andaluca (PTA) Campanillas, Mlaga 29590

(+34) 951 440 260
Fax: (+34) 951 440 263