Lineas de Investigación

1. Functional genomics and proteomics of cancer.

2.Cellular and molecular bases of glutamate synthesis in the brain.

3. Transgenic animal models with amino acid metabolism deficiency.

4. Heterologous expression of recombinant human proteins of therapeutic and biotechnological value.



Proyectos de Investigación

Terapia metabólica del cáncer: supresión tumoral inducida por desregulación de glutaminasa (RTI2018-096866-B-I00).

Ministerio de Ciencia, Innovación y Universidades
Ministerio de Ciencia, Innovación y Universidades 2019

Publicaciones científicas

  • Todo
  • D1
  • Q1
  • Q2
  • Otro

Glutaminase isoenzymes in the metabolic therapy of cancer

Mates, JM; Campos-Sandoval, JA; Marquez, J
Biochimica Et Biophysica Acta-Reviews On Cancer 2018


A Distinct Metabolite Profile Correlates with Neurodegenerative Conditions and the Severity of Congenital Hydrocephalus.

Garcia-Bonilla, Maria; Garcia-Martin, Maria L; Munoz-Hernandez, M Carmen; Dominguez-Pinos, Dolores; Martinez-Leon, Maria I; Penalver, Ana; Castilla, Laura; Alonso, Francisco J; Marquez, Javier; Shumilov, Kirill; Hidalgo-Sanchez, Ramon; Gutierrez, Antonia; Paez-Gonzalez, Patricia; Jimenez, Antonio J
Journal Of Neuropathology And Experimental Neurology 2018

Glutaminase and MMP-9 Downregulation in Cortex and Hippocampus of LPA(1) Receptor Null Mice Correlate with Altered Dendritic Spine Plasticity

Penalver, A; Campos-Sandoval, JA; Blanco, E; Cardona, C; Castilla, L; Martin-Rufian, M; Estivill-Torrus, G; Sanchez-Varo, R; Alonso, FJ; Perez-Hernandez, M; Colado, MI; Gutierrez, A; de Fonseca, FR; Marquez, JFrontiers In Molecular Neuroscience. 2017

MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer

Shukla, SK; Purohit, V; Mehla, K; Gunda, V; Chaika, NV; Vernucci, E; King, RJ; Abrego, J; Goode, GD; Dasgupta, A; Illies, AL; Gebregiworgis, T; Dai, BB; Augustine, JJ; Murthy, D; Attri, KS; Mashadova, O; Grandgenett, PM; Powers, R; Ly, QP; Lazenby, AJ; Grem, JL; Yu, F; Mates, JM; Asara, JM; Kim, JW; Hankins, JH; Weekes, C; Hollingsworth, MA; Sarkova, NJ; Sasson, AR; Fleming, JB; Oliveto, JM; Lyssiotis, CA; Cantley, LC; Berim, L; Singh, PKCancer Cell. 2017

TRANSCRIPTION FACTOR GATA3 EXPRESSION IS INDUCED BY GLS2 OVEREXPRESSION IN A GLIOBLASTOMA CELL LINE BUT IS GLS2-INDEPENDENT IN PATIENT-DERIVED GLIOBLASTOMA

Majewska, E; Rola, R; Barczewska, M; Marquez, J; Albrecht, J; Szeliga, MJournal Of Physiology And Pharmacology. 2017

Glutamate and Brain Glutaminases in Drug Addiction

Marquez, J; Campos-Sandoval, JA; Penalver, A; Mates, JM; Segura, JA; Blanco, E; Alonso, FJ; de Fonseca, FRNeurochemical Research. 2017

Glutamine Addiction In Gliomas

Marquez, J; Alonso, FJ; Mates, JM; Segura, JA; Martin-Rufian, M; Campos-Sandoval, JANeurochemical Research. 2017


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