Lineas de Investigación

01. Estudio de las bases embrionarias de la enfermedad cardiovascular. Estudio de los mecanismos celulares y moleculares de la fisiopatología cardiovascular

02. Desarrollo embrionario cardiovascular.

03. Reparación y regeneración cardiovascular.

04. Fibrosis en el contexto de las cardiomiopatías.

05. Histopatología cardiovascular.

06. Diferenciación de progenitores cardiovasculares.

07. Patología vascular.



Proyectos de Investigación

PIER-0084-2019. Origen embrionario del Síndrome de Canal Auriculoventricular Completo-Tetralogía de Fallot (CAVC-ToF) y del Defecto de la Comunicación Interauricular (CIA): Mecanismos Celulares y Moleculares.

Consejería de Salud y Familias
. 2019

PC-0066-2017 Funciones del Gen Wt1 en el Miocardio Embrionario y Adulto de Un Modelo Animal

CONSEJERÍA DE SALUD
PROYECTOS DE INVESTIGACIÓN COORDINADOS 2017

RD16/0011/0030 Red de Terapia Celular – TerCel

INSTITUTO DE SALUD CARLOS III
ACCIÓN ESTRATÉGICA EN SALUD - CONVOCATORIA DE REDES TEMÁTICAS DE INVESTIGACIÓN COOPERATIVA EN SALUD (RETICS) 2016

Publicaciones científicas

  • Todo
  • D1
  • Q1
  • Q2
  • Otro
Cellular identities in an unusual presentation of cyclopia in a chick embryo.

Palmquist-Gomes P, Pérez-Pomares JM, Guadix JA Journal of experimental zoology. Part B, Molecular and developmental evolution 2019 Sep;332(6):179-186

Development of the Myocardial Interstitium.

Pogontke C, Guadix JA, Ruiz-Villalba A, Pérez-Pomares JM Anatomical record (Hoboken, N.J. : 2007) 2019 Jan;302(1):58-68

Mesothelial-mesenchymal transitions in embryogenesis.

Carmona R, Ariza L, Cano E, Jiménez-Navarro M, Muñoz-Chápuli R Seminars in cell & developmental biology 2019 Aug;92():37-44

Platinum-Doped Dendritic Structure as a Phosphorescent Label for Bacteria in Two-Photon Excitation Microscopy.

Molina N, Cnudde M, Guadix JA, Perez-Pomares JM, Strassert CA, et al. ACS omega 2019 Aug 20;4(8):13027-13033

Principal Criteria for Evaluating the Quality, Safety and Efficacy of hMSC-Based Products in Clinical Practice: Current Approaches and Challenges.

Guadix JA, López-Beas J, Clares B, Soriano-Ruiz JL, Zugaza JL, et al. Pharmaceutics 2019 Oct 24;11(11):

Proepicardial Origin of Developing Coronary Vessels.

Palmquist-Gomes P, Pérez-Pomares JM, Guadix JA Revista espanola de cardiologia (English ed.) 2019 Feb;72(2):163

Synthesis of Amino Terminal Clicked Dendrimers. Approaches to the Application as a Biomarker.

Molina N, Nájera F, Guadix JA, Perez-Pomares JM, Vida Y, et al. The Journal of organic chemistry 2019 Aug 16;84(16):10197-10208

The Wilms’ tumor suppressor gene regulates pancreas homeostasis and repair.

Ariza L, Rojas A, Muñoz-Chápuli R, Carmona R PLoS genetics 2019 Feb;15(2):e1007971

Mesothelial-mesenchymal transitions in embryogenesis.

Carmona R, Ariza L, Cano E, Jiménez-Navarro M, Muñoz-Chápuli R Seminars in cell & developmental biology 2019 Aug;92():37-44

Avian embryonic coronary arterio-venous patterning involves the contribution of different endothelial and endocardial cell populations.

Palmquist-Gomes P, Guadix JA, Pérez-Pomares JM Developmental dynamics : an official publication of the American Association of Anatomists 2018 May;247(5):686-698

Bmi1-Progenitor Cell Ablation Impairs the Angiogenic Response to Myocardial Infarction.

Herrero D, Cañón S, Pelacho B, Salvador-Bernáldez M, Aguilar S, et al. Arteriosclerosis, thrombosis, and vascular biology 2018 Sep;38(9):2160-2173

Comparative developmental biology of the cardiac inflow tract.

Carmona R, Ariza L, Cañete A, Muñoz-Chápuli R Journal of molecular and cellular cardiology 2018 Mar;116():155-164

Myocardial Bmp2 gain causes ectopic EMT and promotes cardiomyocyte proliferation and immaturity.

Prados B, Gómez-Apiñániz P, Papoutsi T, Luxán G, Zaffran S, et al. Cell death & disease 2018 Mar 14;9(3):399

Role of the Wilms’ tumor suppressor gene Wt1 in pancreatic development.

Ariza L, Cañete A, Rojas A, Muñoz-Chápuli R, Carmona R Developmental dynamics : an official publication of the American Association of Anatomists 2018 Jul;247(7):924-933

A population of hematopoietic stem cells derives from GATA4-expressing progenitors located in the placenta and lateral mesoderm of mice.

Cañete A, Carmona R, Ariza L, Sánchez MJ, Rojas A, et al. Haematologica 2017 Apr;102(4):647-655

A right-handed signalling pathway drives heart looping in vertebrates.

Ocaña OH, Coskun H, Minguillón C, Murawala P, Tanaka EM, et al. Nature 2017 Sep 6;549(7670):86-90

Characteristics, applications and prospects of mesenchymal stem cells in cell therapy.

Guadix JA, Zugaza JL, Gálvez-Martín P Medicina clinica 2017 May 10;148(9):408-414

Human Pluripotent Stem Cell Differentiation into Functional Epicardial Progenitor Cells.

Guadix JA, Orlova VV, Giacomelli E, Bellin M, Ribeiro MC, et al. Stem cell reports 2017 Dec 12;9(6):1754-1764

Reference genes for gene expression studies in the mouse heart.

Ruiz-Villalba A, Mattiotti A, Gunst QD, Cano-Ballesteros S, van den Hoff MJ, et al. Scientific reports 2017 Feb 2;7(1):24

Role of Vitamin A/Retinoic Acid in Regulation of Embryonic and Adult Hematopoiesis.

Cañete A, Cano E, Muñoz-Chápuli R, Carmona R Nutrients 2017 Feb 20;9(2):

A chick embryo cryoinjury model for the study of embryonic organ development and repair.

Palmquist-Gomes P, Guadix JA, Pérez-Pomares JM Differentiation; research in biological diversity 2016 Apr-Jun;91(4-5):72-7

Cardiac electrical defects in progeroid mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations.

Rivera-Torres J, Calvo CJ, Llach A, Guzmán-Martínez G, Caballero R, et al. Proceedings of the National Academy of Sciences of the United States of America 2016 Nov 15;113(46):E7250-E7259

Coelomic epithelium-derived cells in visceral morphogenesis.

Ariza L, Carmona R, Cañete A, Cano E, Muñoz-Chápuli R Developmental dynamics : an official publication of the American Association of Anatomists 2016 Mar;245(3):307-22

Conditional deletion of WT1 in the septum transversum mesenchyme causes congenital diaphragmatic hernia in mice.

Carmona R, Cañete A, Cano E, Ariza L, Rojas A, et al. eLife 2016 Sep 19;5():

Congenital coronary artery anomalies: a bridge from embryology to anatomy and pathophysiology–a position statement of the development, anatomy, and pathology ESC Working Group.

Pérez-Pomares JM, de la Pompa JL, Franco D, Henderson D, Ho SY, et al. Cardiovascular research 2016 Feb 1;109(2):204-16

Coronary stem development in wild-type and Tbx1 null mouse hearts.

Théveniau-Ruissy M, Pérez-Pomares JM, Parisot P, Baldini A, Miquerol L, et al. Developmental dynamics : an official publication of the American Association of Anatomists 2016 Apr;245(4):445-59

Extracardiac septum transversum/proepicardial endothelial cells pattern embryonic coronary arterio-venous connections.

Cano E, Carmona R, Ruiz-Villalba A, Rojas A, Chau YY, et al. Proceedings of the National Academy of Sciences of the United States of America 2016 Jan 19;113(3):656-61

Myc overexpression enhances of epicardial contribution to the developing heart and promotes extensive expansion of the cardiomyocyte population.

Villa Del Campo C, Lioux G, Carmona R, Sierra R, Muñoz-Chápuli R, et al. Scientific reports 2016 Oct 18;6():35366

Interacting resident epicardium-derived fibroblasts and recruited bone marrow cells form myocardial infarction scar.

Ruiz-Villalba A, Simón AM, Pogontke C, Castillo MI, Abizanda G, et al. Journal of the American College of Cardiology 2015 May 19;65(19):2057-66

The proepicardium keeps a potential for glomerular marker expression which supports its evolutionary origin from the pronephros.

Cano E, Carmona R, Velecela V, Martínez-Estrada O, Muñoz-Chápuli R Evolution & development 2015 Jul-Aug;17(4):224-30


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