Lineas de Investigación

01. Estudio de las bases embrionarias de la enfermedad cardiovascular. Estudio de los mecanismos celulares y moleculares de la fisiopatología cardiovascular

02. Desarrollo embrionario cardiovascular.

03. Reparación y regeneración cardiovascular.

04. Fibrosis en el contexto de las cardiomiopatías.

05. Histopatología cardiovascular.

06. Diferenciación de progenitores cardiovasculares.

07. Patología vascular.



Proyectos de Investigación

PIER-0084-2019. Origen embrionario del Síndrome de Canal Auriculoventricular Completo-Tetralogía de Fallot (CAVC-ToF) y del Defecto de la Comunicación Interauricular (CIA): Mecanismos Celulares y Moleculares.

Consejería de Salud y Familias
. 2019

PC-0066-2017 Funciones del Gen Wt1 en el Miocardio Embrionario y Adulto de Un Modelo Animal

CONSEJERÍA DE SALUD
PROYECTOS DE INVESTIGACIÓN COORDINADOS 2017

RD16/0011/0030 Red de Terapia Celular – TerCel

INSTITUTO DE SALUD CARLOS III
ACCIÓN ESTRATÉGICA EN SALUD - CONVOCATORIA DE REDES TEMÁTICAS DE INVESTIGACIÓN COOPERATIVA EN SALUD (RETICS) 2016

Publicaciones científicas

  • Todo
  • D1
  • Q1
  • Q2
  • Otro
  1. Bajaj, S, Jain, V, Sharma, N, Tiwari, S, Saxena, R. Efficient lead preconcentration using two chemically functionalized carbon nanotubes in hyphenated flow injection-flame atomic absorption spectrometry system. J Chromatogr A. 2021;1638 :461888. doi: 10.1016/j.chroma.2021.461888. PubMed PMID:33482614 .
  2. Long, L, He, J, Yang, X. Characteristics, emission sources and health risk assessment of trace elements in size-segregated aerosols during haze and non-haze periods at Ningbo, China. Environ Geochem Health. 2021; :. doi: 10.1007/s10653-020-00757-2. PubMed PMID:33459888 .
  3. Otal, EH, Kim, ML, Dietrich, S, Takada, R, Nakaya, S, Kimura, M et al.. Open-Source Portable Device for the Determination of Fluoride in Drinking Water. ACS Sens. 2021;6 (1):259-266. doi: 10.1021/acssensors.0c02273. PubMed PMID:33415970 .
  4. Gu, G, Bolten, S, Mendes-Oliveira, G, Zhou, B, Teng, Z, Pearlstein, D et al.. Salmonella inactivation and sponge/microfiber mediated cross-contamination during papaya wash with chlorine or peracetic acid as sanitizer. Food Microbiol. 2021;95 :103677. doi: 10.1016/j.fm.2020.103677. PubMed PMID:33397611 .
  5. Lu, Q, Xu, Z, Xu, X, Liu, L, Liang, L, Chen, Z et al.. Cadmium exposure as a key risk factor for residents in a world large-scale barite mining district, southwestern China. Chemosphere. 2020;269 :129387. doi: 10.1016/j.chemosphere.2020.129387. PubMed PMID:33387789 .
  6. Cai, J, Shen, H, Wang, Y, Peng, Y, Tang, S, Zhu, Y et al.. A dual recognition strategy for accurate detection of CTCs based on novel branched PtAuRh trimetallic nanospheres. Biosens Bioelectron. 2021;176 :112893. doi: 10.1016/j.bios.2020.112893. PubMed PMID:33342693 .
  7. Wang, J, Wang, W, Xiong, J, Li, L, Zhao, B, Sohail, I et al.. A constructed wetland system with aquatic macrophytes for cleaning contaminated runoff/storm water from urban area in Florida. J Environ Manage. 2021;280 :111794. doi: 10.1016/j.jenvman.2020.111794. PubMed PMID:33341472 .
  8. Mansouri, S, Pajohi-Alamoti, M, Aghajani, N, Bazargani-Gilani, B, Nourian, A. Stability and antibacterial activity of Thymus daenensis L. essential oil nanoemulsion in mayonnaise. J Sci Food Agric. 2020; :. doi: 10.1002/jsfa.11026. PubMed PMID:33336802 .
  9. Gao, Y, Wang, S, Yin, F, Hu, P, Wang, X, Liu, Y et al.. Enhancing sensitivity of microbial fuel cell sensors for low concentration biodegradable organic matter detection: Regulation of substrate concentration, anode area and external resistance. J Environ Sci (China). 2021;101 :227-235. doi: 10.1016/j.jes.2020.08.020. PubMed PMID:33334518 .
  10. Georgiev, S, Hirnschall, N, Dana-Fisus, A, Ruiss, M, Hienert, J, Leisser, C et al.. Repeatability of intraoperative Shack-Hartmann wavefront sensing in cataract surgery. J Cataract Refract Surg. 2020; :. doi: 10.1097/j.jcrs.0000000000000550. PubMed PMID:33315741 .
  11. Montso, PK, Mlambo, V, Ateba, CN. Efficacy of novel phages for control of multi-drug resistant Escherichia coli O177 on artificially contaminated beef and their potential to disrupt biofilm formation. Food Microbiol. 2021;94 :103647. doi: 10.1016/j.fm.2020.103647. PubMed PMID:33279072 .
  12. Aslam, I, Mumtaz, M, Qadir, A, Jamil, N, Baqar, M, Mahmood, A et al.. Organochlorine pesticides (OCPs) in air-conditioner filter dust of indoor urban setting: Implication for health risk in a developing country. Indoor Air. 2020; :. doi: 10.1111/ina.12772. PubMed PMID:33247439 .
  13. Mackenzie, IS, Ford, I, Nuki, G, Hallas, J, Hawkey, CJ, Webster, J et al.. Long-term cardiovascular safety of febuxostat compared with allopurinol in patients with gout (FAST): a multicentre, prospective, randomised, open-label, non-inferiority trial. Lancet. 2020;396 (10264):1745-1757. doi: 10.1016/S0140-6736(20)32234-0. PubMed PMID:33181081 .
  14. Tsunoda, N, Otsuka, T, Takayanagi, K, Shimizu, N, Suzuki, T, Utsuno, Y et al.. The impact of nuclear shape on the emergence of the neutron dripline. Nature. 2020;587 (7832):66-71. doi: 10.1038/s41586-020-2848-x. PubMed PMID:33149291 .
  15. Rusinaru, D, Bohbot, Y, Djelaili, F, Delpierre, Q, Altes, A, Serbout, S et al.. Normative Reference Values of Cardiac Output by Pulsed-Wave Doppler Echocardiography in Adults. Am J Cardiol. 2021;140 :128-133. doi: 10.1016/j.amjcard.2020.10.046. PubMed PMID:33144167 .
  16. Dalkıran, B, Fernandes, IPG, David, M, Brett, CMA. Electrochemical synthesis and characterization of poly(thionine)-deep eutectic solvent/carbon nanotube-modified electrodes and application to electrochemical sensing. Mikrochim Acta. 2020;187 (11):609. doi: 10.1007/s00604-020-04588-x. PubMed PMID:33057990 .
  17. Dey Bhowmik, A, Shaw, P, Mondal, P, Chakraborty, A, Sudarshan, M, Chattopadhyay, A et al.. Calcium and Vitamin D Supplementation Effectively Alleviates Dental and Skeletal Fluorosis and Retain Elemental Homeostasis in Mice. Biol Trace Elem Res. 2020; :. doi: 10.1007/s12011-020-02435-x. PubMed PMID:33057951 .
  18. Tang, J, Li, Z, Xie, M, Zhang, Y, Long, W, Long, S et al.. Optical fiber bio-sensor for phospholipase using liquid crystal. Biosens Bioelectron. 2020;170 :112547. doi: 10.1016/j.bios.2020.112547. PubMed PMID:33010707 .
  19. Cao, L, Xiao, H, Fang, C, Zhao, F, Chen, Z. Electrochemical immunosensor based on binary nanoparticles decorated rGO-TEPA as magnetic capture and Au@PtNPs as probe for CEA detection. Mikrochim Acta. 2020;187 (10):584. doi: 10.1007/s00604-020-04559-2. PubMed PMID:32990786 .
  20. Meng, L, Dai, J, Rong, S, Gao, H, Zhang, Z, Zhang, Y et al.. One-step electrodeposition preparation of polyaniline/f-MWCNTs as electrochemical sensors for detection of 10-hydroxycamptothecine. Biotechnol Appl Biochem. 2020; :. doi: 10.1002/bab.2041. PubMed PMID:32970340 .
Search PubMed
  1. Palmquist-Gomes, P, Pérez-Pomares, JM, Guadix, JA. Cell-based therapies for the treatment of myocardial infarction: lessons from cardiac regeneration and repair mechanisms in non-human vertebrates. Heart Fail Rev. 2019;24 (1):133-142. doi: 10.1007/s10741-018-9750-8. PubMed PMID:30421074 .
Search PubMed
  1. Palmquist-Gomes, P, Pérez-Pomares, JM, Guadix, JA. Cellular identities in an unusual presentation of cyclopia in a chick embryo. J Exp Zool B Mol Dev Evol. 2019;332 (6):179-186. doi: 10.1002/jez.b.22893. PubMed PMID:31298492 .
Search PubMed
  1. Pogontke, C, Guadix, JA, Ruiz-Villalba, A, Pérez-Pomares, JM. Development of the Myocardial Interstitium. Anat Rec (Hoboken). 2019;302 (1):58-68. doi: 10.1002/ar.23915. PubMed PMID:30288955 .
Search PubMed
  1. Carmona, R, Ariza, L, Cano, E, Jiménez-Navarro, M, Muñoz-Chápuli, R. Mesothelial-mesenchymal transitions in embryogenesis. Semin Cell Dev Biol. 2019;92 :37-44. doi: 10.1016/j.semcdb.2018.09.006. PubMed PMID:30243860 .
Search PubMed
  1. Molina, N, Cnudde, M, Guadix, JA, Perez-Pomares, JM, Strassert, CA, Vida, Y et al.. Platinum-Doped Dendritic Structure as a Phosphorescent Label for Bacteria in Two-Photon Excitation Microscopy. ACS Omega. 2019;4 (8):13027-13033. doi: 10.1021/acsomega.9b00639. PubMed PMID:31460429 PubMed Central PMC6704438.
Search PubMed
  1. Guadix, JA, López-Beas, J, Clares, B, Soriano-Ruiz, JL, Zugaza, JL, Gálvez-Martín, P et al.. Principal Criteria for Evaluating the Quality, Safety and Efficacy of hMSC-Based Products in Clinical Practice: Current Approaches and Challenges. Pharmaceutics. 2019;11 (11):. doi: 10.3390/pharmaceutics11110552. PubMed PMID:31652984 PubMed Central PMC6921040.
Search PubMed
  1. Palmquist-Gomes, P, Pérez-Pomares, JM, Guadix, JA. Proepicardial Origin of Developing Coronary Vessels. Rev Esp Cardiol (Engl Ed). 2019;72 (2):163. doi: 10.1016/j.rec.2018.01.028. PubMed PMID:29735303 .
Search PubMed
  1. Bajaj, S, Jain, V, Sharma, N, Tiwari, S, Saxena, R. Efficient lead preconcentration using two chemically functionalized carbon nanotubes in hyphenated flow injection-flame atomic absorption spectrometry system. J Chromatogr A. 2021;1638 :461888. doi: 10.1016/j.chroma.2021.461888. PubMed PMID:33482614 .
  2. Long, L, He, J, Yang, X. Characteristics, emission sources and health risk assessment of trace elements in size-segregated aerosols during haze and non-haze periods at Ningbo, China. Environ Geochem Health. 2021; :. doi: 10.1007/s10653-020-00757-2. PubMed PMID:33459888 .
  3. Otal, EH, Kim, ML, Dietrich, S, Takada, R, Nakaya, S, Kimura, M et al.. Open-Source Portable Device for the Determination of Fluoride in Drinking Water. ACS Sens. 2021;6 (1):259-266. doi: 10.1021/acssensors.0c02273. PubMed PMID:33415970 .
  4. Gu, G, Bolten, S, Mendes-Oliveira, G, Zhou, B, Teng, Z, Pearlstein, D et al.. Salmonella inactivation and sponge/microfiber mediated cross-contamination during papaya wash with chlorine or peracetic acid as sanitizer. Food Microbiol. 2021;95 :103677. doi: 10.1016/j.fm.2020.103677. PubMed PMID:33397611 .
  5. Lu, Q, Xu, Z, Xu, X, Liu, L, Liang, L, Chen, Z et al.. Cadmium exposure as a key risk factor for residents in a world large-scale barite mining district, southwestern China. Chemosphere. 2020;269 :129387. doi: 10.1016/j.chemosphere.2020.129387. PubMed PMID:33387789 .
  6. Cai, J, Shen, H, Wang, Y, Peng, Y, Tang, S, Zhu, Y et al.. A dual recognition strategy for accurate detection of CTCs based on novel branched PtAuRh trimetallic nanospheres. Biosens Bioelectron. 2021;176 :112893. doi: 10.1016/j.bios.2020.112893. PubMed PMID:33342693 .
  7. Wang, J, Wang, W, Xiong, J, Li, L, Zhao, B, Sohail, I et al.. A constructed wetland system with aquatic macrophytes for cleaning contaminated runoff/storm water from urban area in Florida. J Environ Manage. 2021;280 :111794. doi: 10.1016/j.jenvman.2020.111794. PubMed PMID:33341472 .
  8. Mansouri, S, Pajohi-Alamoti, M, Aghajani, N, Bazargani-Gilani, B, Nourian, A. Stability and antibacterial activity of Thymus daenensis L. essential oil nanoemulsion in mayonnaise. J Sci Food Agric. 2020; :. doi: 10.1002/jsfa.11026. PubMed PMID:33336802 .
  9. Gao, Y, Wang, S, Yin, F, Hu, P, Wang, X, Liu, Y et al.. Enhancing sensitivity of microbial fuel cell sensors for low concentration biodegradable organic matter detection: Regulation of substrate concentration, anode area and external resistance. J Environ Sci (China). 2021;101 :227-235. doi: 10.1016/j.jes.2020.08.020. PubMed PMID:33334518 .
  10. Georgiev, S, Hirnschall, N, Dana-Fisus, A, Ruiss, M, Hienert, J, Leisser, C et al.. Repeatability of intraoperative Shack-Hartmann wavefront sensing in cataract surgery. J Cataract Refract Surg. 2020; :. doi: 10.1097/j.jcrs.0000000000000550. PubMed PMID:33315741 .
  11. Montso, PK, Mlambo, V, Ateba, CN. Efficacy of novel phages for control of multi-drug resistant Escherichia coli O177 on artificially contaminated beef and their potential to disrupt biofilm formation. Food Microbiol. 2021;94 :103647. doi: 10.1016/j.fm.2020.103647. PubMed PMID:33279072 .
  12. Aslam, I, Mumtaz, M, Qadir, A, Jamil, N, Baqar, M, Mahmood, A et al.. Organochlorine pesticides (OCPs) in air-conditioner filter dust of indoor urban setting: Implication for health risk in a developing country. Indoor Air. 2020; :. doi: 10.1111/ina.12772. PubMed PMID:33247439 .
  13. Mackenzie, IS, Ford, I, Nuki, G, Hallas, J, Hawkey, CJ, Webster, J et al.. Long-term cardiovascular safety of febuxostat compared with allopurinol in patients with gout (FAST): a multicentre, prospective, randomised, open-label, non-inferiority trial. Lancet. 2020;396 (10264):1745-1757. doi: 10.1016/S0140-6736(20)32234-0. PubMed PMID:33181081 .
  14. Tsunoda, N, Otsuka, T, Takayanagi, K, Shimizu, N, Suzuki, T, Utsuno, Y et al.. The impact of nuclear shape on the emergence of the neutron dripline. Nature. 2020;587 (7832):66-71. doi: 10.1038/s41586-020-2848-x. PubMed PMID:33149291 .
  15. Rusinaru, D, Bohbot, Y, Djelaili, F, Delpierre, Q, Altes, A, Serbout, S et al.. Normative Reference Values of Cardiac Output by Pulsed-Wave Doppler Echocardiography in Adults. Am J Cardiol. 2021;140 :128-133. doi: 10.1016/j.amjcard.2020.10.046. PubMed PMID:33144167 .
  16. Dalkıran, B, Fernandes, IPG, David, M, Brett, CMA. Electrochemical synthesis and characterization of poly(thionine)-deep eutectic solvent/carbon nanotube-modified electrodes and application to electrochemical sensing. Mikrochim Acta. 2020;187 (11):609. doi: 10.1007/s00604-020-04588-x. PubMed PMID:33057990 .
  17. Dey Bhowmik, A, Shaw, P, Mondal, P, Chakraborty, A, Sudarshan, M, Chattopadhyay, A et al.. Calcium and Vitamin D Supplementation Effectively Alleviates Dental and Skeletal Fluorosis and Retain Elemental Homeostasis in Mice. Biol Trace Elem Res. 2020; :. doi: 10.1007/s12011-020-02435-x. PubMed PMID:33057951 .
  18. Tang, J, Li, Z, Xie, M, Zhang, Y, Long, W, Long, S et al.. Optical fiber bio-sensor for phospholipase using liquid crystal. Biosens Bioelectron. 2020;170 :112547. doi: 10.1016/j.bios.2020.112547. PubMed PMID:33010707 .
  19. Cao, L, Xiao, H, Fang, C, Zhao, F, Chen, Z. Electrochemical immunosensor based on binary nanoparticles decorated rGO-TEPA as magnetic capture and Au@PtNPs as probe for CEA detection. Mikrochim Acta. 2020;187 (10):584. doi: 10.1007/s00604-020-04559-2. PubMed PMID:32990786 .
  20. Meng, L, Dai, J, Rong, S, Gao, H, Zhang, Z, Zhang, Y et al.. One-step electrodeposition preparation of polyaniline/f-MWCNTs as electrochemical sensors for detection of 10-hydroxycamptothecine. Biotechnol Appl Biochem. 2020; :. doi: 10.1002/bab.2041. PubMed PMID:32970340 .
Search PubMed
  1. Cañete, A, Carmona, R, Ariza, L, Sánchez, MJ, Rojas, A, Muñoz-Chápuli, R et al.. A population of hematopoietic stem cells derives from GATA4-expressing progenitors located in the placenta and lateral mesoderm of mice. Haematologica. 2017;102 (4):647-655. doi: 10.3324/haematol.2016.155812. PubMed PMID:28057738 PubMed Central PMC5395105.
Search PubMed
  1. Ruiz-Villalba, A, Mattiotti, A, Gunst, QD, Cano-Ballesteros, S, van den Hoff, MJ, Ruijter, JM et al.. Reference genes for gene expression studies in the mouse heart. Sci Rep. 2017;7 (1):24. doi: 10.1038/s41598-017-00043-9. PubMed PMID:28154421 PubMed Central PMC5428317.
Search PubMed
  1. Théveniau-Ruissy, M, Pérez-Pomares, JM, Parisot, P, Baldini, A, Miquerol, L, Kelly, RG et al.. Coronary stem development in wild-type and Tbx1 null mouse hearts. Dev Dyn. 2016;245 (4):445-59. doi: 10.1002/dvdy.24380. PubMed PMID:26708418 .
Search PubMed
  1. Cano, E, Carmona, R, Ruiz-Villalba, A, Rojas, A, Chau, YY, Wagner, KD et al.. Extracardiac septum transversum/proepicardial endothelial cells pattern embryonic coronary arterio-venous connections. Proc Natl Acad Sci U S A. 2016;113 (3):656-61. doi: 10.1073/pnas.1509834113. PubMed PMID:26739565 PubMed Central PMC4725486.
Search PubMed
  1. Villa Del Campo, C, Lioux, G, Carmona, R, Sierra, R, Muñoz-Chápuli, R, Clavería, C et al.. Myc overexpression enhances of epicardial contribution to the developing heart and promotes extensive expansion of the cardiomyocyte population. Sci Rep. 2016;6 :35366. doi: 10.1038/srep35366. PubMed PMID:27752085 PubMed Central PMC5082763.
Search PubMed
  1. Ruiz-Villalba, A, Simón, AM, Pogontke, C, Castillo, MI, Abizanda, G, Pelacho, B et al.. Interacting resident epicardium-derived fibroblasts and recruited bone marrow cells form myocardial infarction scar. J Am Coll Cardiol. 2015;65 (19):2057-66. doi: 10.1016/j.jacc.2015.03.520. PubMed PMID:25975467 .
Search PubMed
  1. Cano, E, Carmona, R, Velecela, V, Martínez-Estrada, O, Muñoz-Chápuli, R. The proepicardium keeps a potential for glomerular marker expression which supports its evolutionary origin from the pronephros. Evol Dev. ;17 (4):224-30. doi: 10.1111/ede.12130. PubMed PMID:26174098 .
Search PubMed

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