Diabetes, Obesidad y otros Factores de Riesgo Vascular. Enfermedades Autoinmunes Sistémicas

Adherence to the Mediterranean Lifestyle and Desired Body Weight Loss in a Mediterranean Adult Population with Overweight: A PREDIMED-Plus Study

Bouzas C, Bibiloni MDM, Julibert A, Ruiz-Canela M, Salas-Salvadó J, Corella D, Zomeño MD, Romaguera D, Vioque J, Alonso-Gómez ÁM, Wärnberg J, Martínez JA, Serra-Majem L, Estruch R, Tinahones FJ, Lapetra J, Pintó X, García Ríos A, Bueno-Cavanillas A, Gaforio JJ, Matía-Martín P, Daimiel L, Martín-Sánchez V, Vidal J, Vázquez C, Ros E, Fernandez-Lázaro CI, Becerra-Tomás N, Gimenez-Alba IM, Muñoz J, Morey M, Oncina-Canovas A, Tojal-Sierra L, Pérez-López J, Abete I, Casañas-Quintana T, Castro-Barquero S, Bernal-López MR, Santos-Lozano JM, Galera A, Angullo-Martinez E, Basterra-Gortari FJ, Basora J, Saiz C, Castañer O, Martín M, Notario-Barandiarán L, Belló-Mora MC, Sayón-Orea C, García-Gavilán J, Goday A, Tur JA
Nutrients 2020 Jul 16;12(7):2114

Association of Hypertension with All-Cause Mortality among Hospitalized Patients with COVID-19

Rodilla E, Saura A, Jiménez I, Mendizábal A, Pineda-Cantero A, Lorenzo-Hernández E, Fidalgo-Montero MDP, López-Cuervo JF, Gil-Sánchez R, Rabadán-Pejenaute E, Abella-Vázquez L, Giner-Galvañ V, Solís-Marquínez MN, Boixeda R, Peña-Fernández A, Carrasco-Sánchez FJ, González-Moraleja J, Torres-Peña JD, Guisado-Espartero ME, Escobar-Sevilla J, Guzmán-García M, Martín-Escalante MD, Martínez-González ÁL, Casas-Rojo JM, Gómez-Huelgas R
J Clin Med 2020 Sep 28;9(10):3136

Cross-sectional association between non-soy legume consumption, serum uric acid and hyperuricemia: the PREDIMED-Plus study

Becerra-Tomás N, Mena-Sánchez G, Díaz-López A, Martínez-González MÁ, Babio N, Corella D, Freixer G, Romaguera D, Vioque J, Alonso-Gómez ÁM, Wärnberg J, Martínez JA, Serra-Majem L, Estruch R, Fernández-García JC, Lapetra J, Pintó X, Tur JA, López-Miranda J, Bueno-Cavanillas A, Gaforio JJ, Matía-Martín P, Daimiel L, Martín-Sánchez V, Vidal J, Vázquez C, Ros E, Razquin C, Abellán Cano I, Sorli JV, Torres L, Morey M, Navarrete-Muñoz EM, Tojal Sierra L, Crespo-Oliva E, Zulet MÁ, Sanchez-Villegas A, Casas R, Bernal-Lopez MR, Santos-Lozano JM, Corbella E, Del Mar Bibiloni M, Ruiz-Canela M, Fernández-Carrión R, Quifer M, Prieto RM, Fernandez-Brufal N, Salaverria Lete I, Cenoz JC, Llimona R, Salas-Salvadó J; PREDIMED-Plus Investigators
Eur J Nutr 2020 Aug;59(5):2195-2206

Differences between Clinical Protocols for the Treatment of Coronavirus Disease 2019 (COVID-19) in Andalusia, Spain

Pérez-Belmonte LM, López-Carmona MD, Quevedo-Marín JL, Ricci M, Martín-Carmona J, Sanz-Cánovas J, López-Sampalo A, Martín-Escalante MD, Bernal-López MR, Gómez-Huelgas R
Int J Environ Res Public Health 2020 Sep 19;17(18):6845

Effect of changes in adherence to Mediterranean diet on nutrient density after 1-year of follow-up: results from the PREDIMED-Plus Study

Cano-Ibáñez N, Bueno-Cavanillas A, Martínez-González MÁ, Salas-Salvadó J, Corella D, Freixer GL, Romaguera D, Vioque J, Alonso-Gómez ÁM, Wärnberg J, Martínez JA, Serra-Majem L, Estruch R, Tinahones FJ, Lapetra J, Pintó X, Tur JA, García-Ríos A, García-Molina L, Delgado-Rodríguez M, Matía-Martín P, Daimiel L, Martín-Sánchez V, Vidal J, Vázquez C, Ros E, Bartolomé-Resano J, Palau-Galindo A, Portoles O, Torres L, Miquel-Fiol, Sánchez MTC, Sorto-Sánchez C, Moreno-Morales N, Abete I, Álvarez-Pérez J, Sacanella E, Bernal-López MR, Santos-Lozano JM, Fanlo-Maresma M, Bouzas C, Razquin C, Becerra-Tomás N, Ortega-Azorin C, LLimona R, Morey M, Román-Maciá J, Goicolea-Güemez L, Vázquez-Ruiz Z, Barrubés L, Fitó M, Gea A
Eur J Nutr 2020 Sep;59(6):2395-2409

Epigenetic approach in obesity: DNA methylation in a prepubertal population which underwent a lifestyle modification

Gallardo-Escribano C, Buonaiuto V, Ruiz-Moreno MI, Vargas-Candela A, Vilches-Perez A, Benitez-Porres J, Romance-Garcia AR, Ruiz-Moreno A, Gomez-Huelgas R, Bernal-Lopez MR
Clin Epigenetics 2020 Sep 23;12(1):144

Functional parameters indicative of mild cognitive impairment: a systematic review using instrumented kinematic assessment

Fuentes-Abolafio IJ, Stubbs B, Pérez-Belmonte LM, Bernal-López MR, Gómez-Huelgas R, Cuesta-Vargas A
BMC Geriatr 2020 Aug 10;20(1):282

Metabolic Syndrome Features and Excess Weight Were Inversely Associated with Nut Consumption after 1-Year Follow-Up in the PREDIMED-Plus Study

Julibert A, Del Mar Bibiloni M, Gallardo-Alfaro L, Abbate M, Martínez-González MÁ, Salas-Salvadó J, Corella D, Fitó M, Martínez JA, Alonso-Gómez ÁM, Wärnberg J, Vioque J, Romaguera D, Lopez-Miranda J, Estruch R, Tinahones FJ, Lapetra J, Serra-Majem L, Cano-Ibañez N, Martín-Sánchez V, Pintó X, Gaforio JJ, Matía-Martín P, Vidal J, Vázquez C, Daimiel L, Ros E, Sayon-Orea C, Becerra-Tomás N, Gimenez-Alba IM, Castañer O, Abete I, Tojal-Sierra L, Pérez-López J, Notario-Barandiaran L, Colom A, Garcia-Rios A, Castro-Barquero S, Bernal R, Santos-Lozano JM, Fernández-Lázaro CI, Hernández-Alonso P, Saiz C, Zomeño MD, Zulet MA, Belló-Mora MC, Basterra-Gortari J, Canudas S, Goday A, Tur JA; PREDIMED-PLUS investigators
J Nutr 2020 Dec 10;150(12):3161-3170

Metabolically Healthy Obesity: Presence of Arterial Stiffness in the Prepubescent Population

Ruiz-Moreno MI, Vilches-Perez A, Gallardo-Escribano C, Vargas-Candela A, Lopez-Carmona MD, Pérez-Belmonte LM, Ruiz-Moreno A, Gomez-Huelgas R, Bernal-Lopez MR
Int J Environ Res Public Health 2020 Sep 24;17(19):6995

Predicting Clinical Outcome with Phenotypic Clusters in COVID-19 Pneumonia: An Analysis of 12,066 Hospitalized Patients from the Spanish Registry SEMI-COVID-19

Rubio-Rivas M, Corbella X, Mora-Luján JM, Loureiro-Amigo J, López Sampalo A, Yera Bergua C, Esteve Atiénzar PJ, Díez García LF, Gonzalez Ferrer R, Plaza Canteli S, Pérez Piñeiro A, Cortés Rodríguez B, Jorquer Vidal L, Pérez Catalán I, León Téllez M, Martín Oterino JÁ, Martín González MC, Serrano Carrillo de Albornoz JL, García Sardon E, Alcalá Pedrajas JN, Martin-Urda Diez-Canseco A, Esteban Giner MJ, Tellería Gómez P, Ramos-Rincón JM, Gómez-Huelgas R
J Clin Med 2020 Oct 29;9(11):3488

The Effect of Physical Activity and High Body Mass Index on Health-Related Quality of Life in Individuals with Metabolic Syndrome

Marcos-Delgado A, Fernández-Villa T, Martínez-González MÁ, Salas-Salvadó J, Corella D, Castañer O, Martínez JA, Alonso-Gómez ÁM, Wärnberg J, Vioque J, Romaguera D, López-Miranda J, Estruch R, Tinahones FJ, Lapetra J, Serra-Majem JL, García-Molina L, Tur JA, de Paz JA, Pintó X, Delgado-Rodríguez M, Matía-Martín P, Vidal J, Vázquez C, Daimiel L, Ros E, Babio N, Gimenez-Alba IM, Toledo E, Zomeño MD, Zulet MA, Vaquero-Luna J, Pérez-López J, Pastor-Morel A, Galmes-Panades AM, García-Rios A, Casas R, Bernal-López MR, Santos-Lozano JM, Becerra-Tomás N, Ortega-Azorin C, Vázquez-Ruiz Z, Pérez-Vega KA, Abete I, Sorto-Sánchez C, Palau-Galindo A, Galilea-Zabalza I, Muñoz-Martínez J, Martín V
Int J Environ Res Public Health 2020 May 25;17(10):3728

Utility of Liver Function Tests and Fatty Liver Index to Categorize Metabolic Phenotypes in a Mediterranean Population

Narankiewicz D, Ruiz-Nava J, Buonaiuto V, Ruiz-Moreno MI, López-Carmona MD, Pérez-Belmonte LM, Gómez-Huelgas R, Bernal-López MR
Int J Environ Res Public Health 2020 May 18;17(10):3518

1. Zapatero-Gaviria, A, Gómez-Huelgas, R, Canora-Lebrato, J, Ena-Muñoz, J, Romero-Sánchez, M, Mendez-Bailón, M et al.. Analysis of hospitalizations by cardiovascular disease in the population with diabetes in Spain. Rev Clin Esp (Barc). 2019;219 (3):124-129. doi: 10.1016/j.rce.2018.09.012. PubMed PMID:30447849 .

1. Roca Villanueva, B, Beltrán Salvador, M, Gómez Huelgas, R. Change climate and health. Rev Clin Esp (Barc). ;219 (5):260-265. doi: 10.1016/j.rce.2019.01.004. PubMed PMID:30795848 .

1. Carretero Gómez, J, Arévalo Lorido, JC, Gómez Huelgas, R, García de Lucas, D, Mateos Polo, L, Varela Aguilar, JM et al.. Combination Therapy With Glucagon-Like Peptide-1 Receptor Agonists and Sodium-Glucose Cotransporter 2 Inhibitors in Older Patients With Type 2 Diabetes: A Real-World Evidence Study. Can J Diabetes. 2019;43 (3):186-192. doi: 10.1016/j.jcjd.2018.09.001. PubMed PMID:30415909 .

1. León Jiménez, D, Gómez Huelgas, R, Fernández Romero, AJ, López Chozas, JM, Pérez de Isla, L, Miramontes González, JP et al.. Diuretic treatment of the patient with diabetes and heart failure. Role of SGLT2 inhibitors and similarities with carbonic anhydrase inhibitors. Rev Clin Esp (Barc). 2019;219 (4):208-217. doi: 10.1016/j.rce.2018.09.021. PubMed PMID:30553441 .

1. Pérez-Belmonte, LM, Osuna-Sánchez, J, Millán-Gómez, M, López-Carmona, MD, Gómez-Doblas, JJ, Cobos-Palacios, L et al.. Glycaemic efficacy and safety of linagliptin for the management of non-cardiac surgery patients with type 2 diabetes in a real-world setting: Lina-Surg study. Ann Med. ;51 (3-4):252-261. doi: 10.1080/07853890.2019.1613672. PubMed PMID:31037970 PubMed Central PMC7877876.

1. Gomez-Huelgas, R, Ruiz-Nava, J, Santamaria-Fernandez, S, Vargas-Candela, A, Alarcon-Martin, AV, Tinahones, FJ et al.. Impact of Intensive Lifestyle Modification on Levels of Adipokines and Inflammatory Biomarkers in Metabolically Healthy Obese Women. Mediators Inflamm. 2019;2019 :4165260. doi: 10.1155/2019/4165260. PubMed PMID:31093012 PubMed Central PMC6481026.

1. Pérez, A, Ramos, A, Reales, P, Tobares, N, Gómez-Huelgas, R, en nombre del Grupo de estudio AL ALTA et al.. Indicator performance after the implementation of the Spanish Consensus Document for the control of hyperglycemia in the hospital and at discharge. Rev Clin Esp (Barc). ;219 (1):18-25. doi: 10.1016/j.rce.2018.05.010. PubMed PMID:30049416 .

1. Pérez-Cabeza, MI, Borrás, F, Moreno-Medinilla, EE, Bardán-Rebollar, D, Ferrer-López, I, Rodríguez-García, E et al.. Infantile sialidosis: natural history in a preterm infant with two new pathogenic mutations and new ocular findings. J AAPOS. 2019;23 (2):102-104. doi: 10.1016/j.jaapos.2018.08.008. PubMed PMID:30445145 .

1. Lara-Rojas, CM, Pérez-Belmonte, LM, López-Carmona, MD, Guijarro-Merino, R, Bernal-López, MR, Gómez-Huelgas, R et al.. National trends in diabetes mellitus hospitalization in Spain 1997-2010: Analysis of over 5.4 millions of admissions. Eur J Intern Med. 2019;60 :83-89. doi: 10.1016/j.ejim.2018.04.005. PubMed PMID:30100217 .

1. Santiago-Fernández, C, Pérez-Belmonte, LM, Millán-Gómez, M, Moreno-Santos, I, Carrasco-Chinchilla, F, Ruiz-Salas, A et al.. Overexpression of scavenger receptor and infiltration of macrophage in epicardial adipose tissue of patients with ischemic heart disease and diabetes. J Transl Med. 2019;17 (1):95. doi: 10.1186/s12967-019-1842-2. PubMed PMID:30894181 PubMed Central PMC6425581.

1. Tinahones, FJ, Molina-Vega, M, Parra-Barona, J, Flores-Le Roux, J, Gómez-Huelgas, R. Prevalence of postprandial hyperglycaemia in basal insulin-treated patients with type 2 diabetes mellitus with controlled fasting glycaemia and elevated glycosylated haemoglobin. Diabetol Metab Syndr. 2019;11 :59. doi: 10.1186/s13098-019-0452-8. PubMed PMID:31367236 PubMed Central PMC6657157.

1. Zapatero-Gaviria, A, Gomez-Huelgas, R, Diez-Manglano, J, Barba-Martín, R, Carretero-Gomez, J, Maestre-Peiró, A et al.. RECALMIN. Four years of growth of the internal medicine units of the Spanish National Health System (2013-2016). Rev Clin Esp (Barc). 2019;219 (4):171-176. doi: 10.1016/j.rce.2018.11.005. PubMed PMID:30808505 .

1. Julibert, A, Bibiloni, MDM, Bouzas, C, Martínez-González, MÁ, Salas-Salvadó, J, Corella, D et al.. Total and Subtypes of Dietary Fat Intake and Its Association with Components of the Metabolic Syndrome in a Mediterranean Population at High Cardiovascular Risk. Nutrients. 2019;11 (7):. doi: 10.3390/nu11071493. PubMed PMID:31261967 PubMed Central PMC6682917.

1. García-Alfonso, P, Cavanagh Podesta, M, Muñoz Martín, A, Blanco Codeisido, M, Calvo, A, Peligros, I et al.. Chemotherapy Plus Bevacizumab as Neoadjuvant or Conversion Treatment in Patients with Colorectal Liver Metastases. Anticancer Res. 2018;38 (5):3069-3077. doi: 10.21873/anticanres.12564. PubMed PMID:29715142 .

1. Ena, J, Gaviria, AZ, Romero-Sánchez, M, Carretero-Gómez, J, Carrasco-Sánchez, FJ, Segura-Heras, JV et al.. Derivation and validation model for hospital hypoglycemia. Eur J Intern Med. 2018;47 :43-48. doi: 10.1016/j.ejim.2017.08.024. PubMed PMID:28882417 .

1. Ena, J, Gómez-Huelgas, R, Gracia-Tello, BC, Vázquez-Rodríguez, P, Alcalá-Pedrajas, JN, Carrasco-Sánchez, FJ et al.. Derivation and validation of a predictive model for the readmission of patients with diabetes mellitus treated in internal medicine departments. Rev Clin Esp (Barc). ;218 (6):271-278. doi: 10.1016/j.rce.2018.03.010. PubMed PMID:29731294 .

1. Manzano-Gamero, V, Pardo-Cabello, AJ, Vargas-Hitos, JA, Zamora-Pasadas, M, Navarrete-Navarrete, N, Sabio, JM et al.. Effect of ethnicity on clinical presentation and risk of antiphospholipid syndrome in Roma and Caucasian patients with systemic lupus erythematosus: a multicenter cross-sectional study. Int J Rheum Dis. 2018;21 (11):2028-2035. doi: 10.1111/1756-185X.13117. PubMed PMID:28593703 .

1. Garcia de Lucas, MD, Pérez Belmonte, LM, Suárez Tembra, M, Olalla Sierra, J, Gómez Huelgas, R. Efficacy and safety of replacing sitagliptin with canagliflozin in real-world patients with type 2 diabetes uncontrolled with sitagliptin combined with metformin and/or gliclazide: The SITA-CANA Switch Study. Diabetes Metab. 2018;44 (4):373-375. doi: 10.1016/j.diabet.2018.05.005. PubMed PMID:29859992 .

1. Carretero-Gómez, J, Arévalo Lorido, JC, Gómez Huelgas, R, De Escalante Yangüela, B, Gracia Tello, B, Pérez Belmonte, L et al.. Hydration and obesity among outpatient-based population: H2Ob study. J Investig Med. 2018;66 (4):780-783. doi: 10.1136/jim-2017-000641. PubMed PMID:29367255 .

1. Almanza-Aguilera, E, Brunius, C, Bernal-Lopez, MR, Garcia-Aloy, M, Madrid-Gambin, F, Tinahones, FJ et al.. Impact in Plasma Metabolome as Effect of Lifestyle Intervention for Weight-Loss Reveals Metabolic Benefits in Metabolically Healthy Obese Women. J Proteome Res. 2018;17 (8):2600-2610. doi: 10.1021/acs.jproteome.8b00042. PubMed PMID:29877711 .

1. Rodriguez-Garcia, E, Ruiz-Nava, J, Santamaria-Fernandez, S, Fernandez-Garcia, JC, Vargas-Candela, A, Yahyaoui, R et al.. Implications of the Mediterranean diet and physical exercise on the lipid profile of metabolically healthy obese women as measured by nuclear magnetic resonance spectroscopy (¹H NMR). Chem Phys Lipids. 2018;213 :68-75. doi: 10.1016/j.chemphyslip.2018.03.007. PubMed PMID:29580835 .

1. Carrasco-Sánchez, FJ, Carretero-Gómez, J, Gómez-Huelgas, R, Garcia-Ordoñez, MA, Pardo-Ortega, MV, de Escalante-Yanguela, B et al.. Stress-induced hyperglycemia on complications in non-critically elderly hospitalized patients. Rev Clin Esp (Barc). ;218 (5):223-231. doi: 10.1016/j.rce.2018.02.017. PubMed PMID:29661504 .

1. Gómez-Huelgas, R, Gómez Peralta, F, Rodríguez Mañas, L, Formiga, F, Puig Domingo, M, Mediavilla Bravo, JJ et al.. Treatment of type 2 diabetes mellitus in elderly patients. Rev Clin Esp (Barc). 2018;218 (2):74-88. doi: 10.1016/j.rce.2017.12.003. PubMed PMID:29366502 .

1. Oliva-Olivera, W, Coín-Aragüez, L, Lhamyani, S, Clemente-Postigo, M, Torres, JA, Bernal-López, MR et al.. Adipogenic Impairment of Adipose Tissue-Derived Mesenchymal Stem Cells in Subjects With Metabolic Syndrome: Possible Protective Role of FGF2. J Clin Endocrinol Metab. 2017;102 (2):478-487. doi: 10.1210/jc.2016-2256. PubMed PMID:27967316 .

1. Jiménez-Navarro, MF, Lopez-Jimenez, F, Pérez-Belmonte, LM, Lennon, RJ, Diaz-Melean, C, Rodriguez-Escudero, JP et al.. Benefits of Cardiac Rehabilitation on Cardiovascular Outcomes in Patients With Diabetes Mellitus After Percutaneous Coronary Intervention. J Am Heart Assoc. 2017;6 (10):. doi: 10.1161/JAHA.117.006404. PubMed PMID:29021270 PubMed Central PMC5721849.

1. García-Casares, N, Bernal-López, MR, Roé-Vellvé, N, Gutiérrez-Bedmar, M, Fernández-García, JC, García-Arnés, JA et al.. Brain Functional Connectivity Is Modified by a Hypocaloric Mediterranean Diet and Physical Activity in Obese Women. Nutrients. 2017;9 (7):. doi: 10.3390/nu9070685. PubMed PMID:28671558 PubMed Central PMC5537800.

1. Lopez-Carmona, MD, Plaza-Seron, MC, Vargas-Candela, A, Tinahones, FJ, Gomez-Huelgas, R, Bernal-Lopez, MR et al.. CD36 overexpression: a possible etiopathogenic mechanism of atherosclerosis in patients with prediabetes and diabetes. Diabetol Metab Syndr. 2017;9 :55. doi: 10.1186/s13098-017-0253-x. PubMed PMID:28729885 PubMed Central PMC5516302.

1. Rodriguez-Garcia, E, Ruiz-Nava, J, Santamaria-Fernandez, S, Fernandez-Garcia, JC, Vargas-Candela, A, Yahyaoui, R et al.. Characterization of lipid profile by nuclear magnetic resonance spectroscopy (1H NMR) of metabolically healthy obese women after weight loss with Mediterranean diet and physical exercise. Medicine (Baltimore). 2017;96 (27):e7040. doi: 10.1097/MD.0000000000007040. PubMed PMID:28682864 PubMed Central PMC5502137.

1. Gómez-Huelgas, R, López-Carmona, MD. Diabetes in the elderly: primum non nocere. Rev Clin Esp (Barc). 2017;217 (9):518-519. doi: 10.1016/j.rce.2017.10.003. PubMed PMID:29122208 .

1. Gómez-Moyano, E, Ureña-Garnica, I, Manrique-Arija, S, Perez-Belmonte, LM. Erythematous patches with keratotic annular borders on the glans penis. Cleve Clin J Med. 2017;84 (1):23-24. doi: 10.3949/ccjm.84a.15145. PubMed PMID:28084979 .

1. Pérez-Belmonte, LM, Moreno-Santos, I, Gómez-Doblas, JJ, García-Pinilla, JM, Morcillo-Hidalgo, L, Garrido-Sánchez, L et al.. Expression of epicardial adipose tissue thermogenic genes in patients with reduced and preserved ejection fraction heart failure. Int J Med Sci. 2017;14 (9):891-895. doi: 10.7150/ijms.19854. PubMed PMID:28824327 PubMed Central PMC5562197.

1. Pérez-Belmonte, LM, Moreno-Santos, I, Cabrera-Bueno, F, Sánchez-Espín, G, Castellano, D, Such, M et al.. Expression of Sterol Regulatory Element-Binding Proteins in epicardial adipose tissue in patients with coronary artery disease and diabetes mellitus: preliminary study. Int J Med Sci. 2017;14 (3):268-274. doi: 10.7150/ijms.17821. PubMed PMID:28367087 PubMed Central PMC5370289.

1. Carretero Gómez, J, Arévalo Lorido, JC, Gómez Huelgas, R, Sánchez Vidal, MT, Suárez Tembra, M, Varela Aguilar, JM et al.. Prevalence of obesity according to Edmonton staging in the Internal Medicine consultations. Results of the OBEMI study. Rev Clin Esp (Barc). 2017;217 (2):71-78. doi: 10.1016/j.rce.2016.11.003. PubMed PMID:27939027 .

1. Zapatero-Gaviria, A, Barba-Martín, R, Canora Lebrato, J, Fernández-Pérez, C, Gómez-Huelgas, R, Bernal-Sobrino, JL et al.. RECALMIN II. Eight years of hospitalisation in Internal Medicine Units (2007-2014). What has changed?. Rev Clin Esp (Barc). 2017;217 (8):446-453. doi: 10.1016/j.rce.2017.07.008. PubMed PMID:28851485 .

1. Zapatero-Gaviria, A, Javier Elola-Somoza, F, Casariego-Vales, E, Fernandez-Perez, C, Gomez-Huelgas, R, Bernal, JL et al.. RECALMIN: The association between management of Spanish National Health Service Internal Medical Units and health outcomes. Int J Qual Health Care. 2017;29 (4):507-511. doi: 10.1093/intqhc/mzx055. PubMed PMID:28541515 .

1. Gómez-Huelgas, R, Sabán-Ruiz, J, García-Román, FJ, Quintela-Fernández, N, Seguí-Ripoll, JM, Bonilla-Hernández, MV et al.. Safety and efficacy of a basal-plus regimen with insulin glargine and insulin glulisine for elderly patients with high cardiovascular risk and type 2 diabetes mellitus. Rev Clin Esp (Barc). 2017;217 (4):201-206. doi: 10.1016/j.rce.2017.02.005. PubMed PMID:28314656 .

1. Gómez-Huelgas, R, Artola-Menéndez, S, Menéndez-Torre, E. Analysis of the healthcare process of patients with type 2 diabetes mellitus and associated comorbidity treated in Spain's National Health System: A perspective of medical professionals. IMAGINE study. Rev Clin Esp (Barc). 2016;216 (3):113-20. doi: 10.1016/j.rce.2015.11.009. PubMed PMID:26772868 .

1. Martínez-Sellés, M, Gómez Huelgas, R, Abu-Assi, E, Calderón, A, Vidán, MT. [Chronic ischaemic heart disease in the elderly]. Med Clin (Barc). 2016;146 (8):372.e1-372.e10. doi: 10.1016/j.medcli.2016.01.014. PubMed PMID:26965220 .

1. Ena, J, Gómez-Huelgas, R, Zapatero-Gaviria, A, Vázquez-Rodriguez, P, González-Becerra, C, Romero-Sánchez, M et al.. Effect of an intervention on quality indicators for improving the treatment of hyperglycemia in patients hospitalized in noncritical areas. Rev Clin Esp (Barc). 2016;216 (7):352-360. doi: 10.1016/j.rce.2016.05.006. PubMed PMID:27318510 .

1. Calvo Gómez, C, Gómez-Huelgas, R, Lima Ruiz, J, Masmiquel Comas, L, Michán Doña, A, Zapatero Gaviria, A et al.. Expert consensus on the use of liraglutide in the treatment of diabetes in internal medicine. Int J Clin Pharmacol Ther. 2016;54 (11):880-890. doi: 10.5414/CP202428. PubMed PMID:27487367 .

1. Ortiz-Fernández, L, Carmona, FD, Montes-Cano, MA, García-Lozano, JR, Conde-Jaldón, M, Ortego-Centeno, N et al.. Genetic Analysis with the Immunochip Platform in Behçet Disease. Identification of Residues Associated in the HLA Class I Region and New Susceptibility Loci. PLoS One. 2016;11 (8):e0161305. doi: 10.1371/journal.pone.0161305. PubMed PMID:27548383 PubMed Central PMC4993481.

1. Ena, J, Gómez-Huelgas, R, Sánchez-Fuentes, D, Camafort-Babkowsk, M, Formiga, F, Michán-Doña, A et al.. Management of patients with type 2 diabetes and multiple chronic conditions: A Delphi consensus of the Spanish Society of Internal Medicine. Eur J Intern Med. 2016;27 :31-6. doi: 10.1016/j.ejim.2015.10.015. PubMed PMID:26586286 .

1. Tulipani, S, Griffin, J, Palau-Rodriguez, M, Mora-Cubillos, X, Bernal-Lopez, RM, Tinahones, FJ et al.. Metabolomics-guided insights on bariatric surgery versus behavioral interventions for weight loss. Obesity (Silver Spring). 2016;24 (12):2451-2466. doi: 10.1002/oby.21686. PubMed PMID:27891833 .

1. Ortiz-Fernández, L, Montes-Cano, MA, García-Lozano, JR, Conde-Jaldón, M, Ortego-Centeno, N, González-Leon, R et al.. PTPN22 is not associated with Behçet's disease. Study spanning the complete gene region in the Spanish population and meta-analysis of the functional variant R620W. Clin Exp Rheumatol. ;34 (6 Suppl 102):S41-S45. . PubMed PMID:27050764 .

1. Guijarro, R, de Miguel-Diez, J, Jimenez, D, Trujillo-Santos, J, Otero, R, Barba, R et al.. Pulmonary embolism, acute coronary syndrome and ischemic stroke in the Spanish National Discharge Database. Eur J Intern Med. 2016;28 :65-9. doi: 10.1016/j.ejim.2015.10.006. PubMed PMID:26603210 .

1. de Miguel-Díez, J, Muñoz-Rivas, N, Jiménez-García, R, Hernández-Barrera, V, Carrasco-Garrido, P, Monreal, M et al.. Type 2 diabetes is associated with a higher incidence of hospitalization for pulmonary embolism in Spain: Analysis of hospital discharge data during 2004-2013. Respirology. 2016;21 (7):1277-84. doi: 10.1111/resp.12847. PubMed PMID:27377690 .

1. Rojas, CM, Borella, E, Palma, L, Ragozzino, S, De Ramón, E, Gomez-Huelgas, R et al.. Bronchiolitis obliterans organizing pneumonia in patients with autoimmune rheumatic diseases. Immunol Res. 2015;61 (1-2):97-103. doi: 10.1007/s12026-014-8607-z. PubMed PMID:25480740 .

1. Bernal-Lopez, MR, Peña, D, Gomez-Martin, P, Tinahones, FJ, Gomez-Huelgas, R. Cilostazol does not improve peripheral arterial disease-linked oxidative stress. Cardiovasc Ther. 2015;33 (1):15-9. doi: 10.1111/1755-5922.12100. PubMed PMID:25393963 .

1. Gomez-Huelgas, R, Jansen-Chaparro, S, Baca-Osorio, AJ, Mancera-Romero, J, Tinahones, FJ, Bernal-López, MR et al.. Effects of a long-term lifestyle intervention program with Mediterranean diet and exercise for the management of patients with metabolic syndrome in a primary care setting. Eur J Intern Med. 2015;26 (5):317-23. doi: 10.1016/j.ejim.2015.04.007. PubMed PMID:25907985 .

1. Gómez-Huelgas, R, Azriel, S, Puig-Domingo, M, Vidal, J, de Pablos-Velasco, P. Glucagon-like peptide-1 receptor agonists as insulin add-on therapy in patients with inadequate glycemic control in type 2 diabetes mellitus: lixisenatide as a new therapeutic option. Int J Clin Pharmacol Ther. 2015;53 (3):230-40. doi: 10.5414/CP202052. PubMed PMID:25066229 .

1. Ena, J, Gómez-Huelgas, R, Romero-Sánchez, M, Gaviria, AZ, Calzada-Valle, A, Varela-Aguilar, JM et al.. Hyperglycemia management in patients admitted to internal medicine in Spain: A point-prevalence survey examining adequacy of glycemic control and guideline adherence. Eur J Intern Med. 2015;26 (6):392-8. doi: 10.1016/j.ejim.2015.04.020. PubMed PMID:25962558 .

1. Arcelus, JI, Domènech, P, Fernández-Capitan, Mdel C, Guijarro, R, Jiménez, D, Jiménez, S et al.. Rivaroxaban in the treatment of venous thromboembolism and the prevention of recurrences: a practical approach. Clin Appl Thromb Hemost. 2015;21 (4):297-308. doi: 10.1177/1076029614561321. PubMed PMID:25504999 .

1. Clemente-Postigo, M, Muñoz-Garach, A, Serrano, M, Garrido-Sánchez, L, Bernal-López, MR, Fernández-García, D et al.. Serum 25-hydroxyvitamin D and adipose tissue vitamin D receptor gene expression: relationship with obesity and type 2 diabetes. J Clin Endocrinol Metab. 2015;100 (4):E591-5. doi: 10.1210/jc.2014-3016. PubMed PMID:25706239 .

1. Gómez-Huelgas, R, Guijarro-Merino, R, Zapatero, A, Barba, R, Guijarro-Contreras, A, Tinahones, F et al.. The frequency and impact of hypoglycemia among hospitalized patients with diabetes: A population-based study. J Diabetes Complications. ;29 (8):1050-5. doi: 10.1016/j.jdiacomp.2015.07.018. PubMed PMID:26279321 .

1. Gómez Carrillo, V, Márquez Gómez, I, Pérez de Pedro, I. [Tumor mass in the right upper limb]. Med Clin (Barc). 2015;145 (11):510. doi: 10.1016/j.medcli.2015.04.001. PubMed PMID:26051433 .