Hepatogastroenterología, Farmacología y Terapéutica Clínica Traslacional

Lineas de Investigación

01. Spanish DILI Registry: grupo español para el estudio de las hepatopatías asociadas a medicamentos.

02. Hepatitis viral crónica: aspectos diagnósticos y terapéuticos. Trasplante hepático

03. Esteatohepatitis no alcohólica (nafld).

04. Inflamación gastrointestinal. Grupo malagueño de investigación en enfermedad inflamatoria intestinal (EII).

05. Farmacología, terapéutica y evaluación de medicamentos.

 



Proyectos de Investigación

MOV20-005 Nutrient sensitive OGlcNAcylation of TATA Box Binding protein induces upregulation of genes leading to early onset of colorectal cáncer. Candidato: Carlos López Gómez, Jefe de Grupo: Eduardo García Fuentes

Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
. 2020

Andrade Bellido, Raúl

IP Acciones Complementarias

GPC20-002 EASL Clinical Practice Guidelines: Drug-induced liver injury. EASL Clinical Practice Guidelines: Drug-induced liver injury. Journal of Hepatology2019; vol. 70:1222–1261

Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
. 2020

A1-0015-2020 Solicitud para el refuerzo anual de la actividad investigadora en las unidades asistenciales del servicio andaluz de Salud (SAS)

Servicio Andaluz de Salud (SAS)
. 2020

CD20/00083 ContratosSara Borrell 2020 Ismael Álvarez Álvarez. Jefe de Grupo: Raúl Jesús Andrade Bellido

Instituto de Salud Carlos III
. 2020

PI20/00455 Papel de la regulación circadiana y epigenética de los corticoides y sus receptores en la resistencia a estos fármacos en la enfermedad de Crohn

Instituto de Salud Carlos III
. 2020

RC-0005-2020 Renovación de la Acción C (Programa Nicolás Monardes) de la Convocatoria 2016.

Servicio Andaluz de Salud (SAS)
. 2020

Evaluación Integrada Mecanística, Diagnóstica y Pronóstica en Hepatotoxicidad

Junta de Andalucía
. 2019

PE-0098-2019. Nueva estrategia terapéutica en la obesidad basada en las vesículas extracelulares bacterianas

Consejería de Salud y Familias
. 2019

PE-0098-2019. Nueva estrategia terapéutica en la obesidad basada en las vesículas extracelulares bacterianas

ISCIII
. 2019

MV19-00057 Modelo dinamico in vitro y análisis metagenómico para el estudio de la enfermedad de Crohn y la infección por Clostridium difficile.

ISCIII
. 2019

A1-0051-2019 SOLICITUD PARA EL REFUERZO ANUAL DE LA ACTIVIDAD INVESTIGADORA EN LAS UNIDADES DE GESTIÓN CLÍNICA (UGC) DEL SERVICIO ANDALUZ DE SALUD (SAS)

Servicio Andaluz de Salud (SAS)
. 2019

PI18-01804 Evaluación del papel de la comedicación y la sucesión de enfermedades previas (trajectories diseases) en el daño hepático inducido por fármacos.

INSTITUTO DE SALUD CARLOS III
ACCIÓN ESTRATÉGICA EN SALUD - PROYECTOS DE INVESTIGACIÓN EN SALUD 2018

PI-0285-2016 Valoración de la Utilidad de la Determinación de Micrornas de Los Exosomas de Origen Hepático, Analisis del Perfil Inmunitario Adaptativo y de la Microbiota Intestinal en el Diagnóstico de Hepatotoxicidad Idiosincrásica y Su Utilidad en el Diagnóstico D

CONSEJERÍA DE SALUD
PROYECTOS DE INVESTIGACIÓN EN SALUD 2016

JR16/00015 Contrato Juan Rodés 2016 Mª Mercedes Robles Díaz

INSTITUTO DE SALUD CARLOS III
ACCIÓN ESTRATÉGICA EN SALUD - CONTRATOS JUAN RODÉS 2016

PI-0274-2016 Identificación de Biomarcadores Diagnósticos y Pronósticos en Hepatotoxicidad. Estudio Comparativo Con Controles Sanos y Hepatitis Aguda de Diferente Etiología

CONSEJERÍA DE SALUD
PROYECTOS DE INVESTIGACIÓN EN SALUD 2016

PI18-00901 Análisis de metabolómica y panel de biomarcadores en pacientes con hepatitis aguda. Búsqueda de un test diagnóstico en hepatotoxicidad.

INSTITUTO DE SALUD CARLOS III
ACCIÓN ESTRATÉGICA EN SALUD - PROYECTOS DE INVESTIGACIÓN EN SALUD 2018

CM17/00243 Rio Hortega Judith Adriana Sanabria Cabrera.Jefe de Grupo: Maria Isabel Lucena Gonzalez

INSTITUTO DE SALUD CARLOS III
ACCIÓN ESTRATÉGICA EN SALUD - CONTRATOS RÍO HORTEGA 2017

PI-0310-2018 ANÁLISIS INTEGRADO DE LAS PROPIEDADES FARMACOLÓGICAS, FACTORES DEL HUÉSPED, PERFIL EPIGENÉTICO Y SU INTERACCIÓN EN EL FENOTIPO CLÍNICO Y GRAVEDAD DEL DAÑO HEPÁTICO INDUCIDO POR FÁRMACOS

CONSEJERÍA DE SALUD
PROYECTOS DE INVESTIGACIÓN EN SALUD 2018

C-0031-2016 Nicolás Monardes 2016 Eduardo García Fuentes. Acciones para el refuerzo con recursos humanos de la actividad investigadora en las Unidades de Gestión Clinica del Servicio Andaluz de Salud 2016. Acción C. Vinculación de investigadores a las UGC del SAS. Programa Nicolás Monardes.

SERVICIO ANDALUZ DE SALUD
ACCIÓN C. VINCULACIÓN DE INVESTIGADORES A LAS UGC DEL SAS 2016

PI18-01652 Implicación de las vesículas extracelulares de origen bacteriano en la evolución de la enfermedad de Crohn

INSTITUTO DE SALUD CARLOS III
ACCIÓN ESTRATÉGICA EN SALUD - PROYECTOS DE INVESTIGACIÓN EN SALUD 2018

PI15/01845 Papel de los exosomas intestinales en el desarrollo de la obesidad/diabetes tipo 2

INSTITUTO DE SALUD CARLOS III
PROYECTOS DE INVESTIGACIÓN EN SALUD (FIS) 2015

IFI18-00047 I-PFIS 2018 Alejandro Cueto Sánchez Jefa de Grupo: Maria Isabel Lucena Gonzalez

INSTITUTO DE SALUD CARLOS III
ACCIÓN ESTRATÉGICA EN SALUD - CONTRATOS i-PFIS: DOCTORADOS IIS-EMPRESA EN CIENCIAS Y TECNOLOGÍAS DE LA SALUD 2018

FPU14/01972 Becas y ayudas para la formación de doctores del programa nacional de formación de profesorado universitario. Contratos Predoctorales de Formación de Profesorado Universitario. Solicitante: Ailec Ho Plagaro. Director de Tésis: Eduardo García Fuentes. Título del proyecto de tesis: Papel del intestino delgado en el desarrollo de la obesidad y diabetes tipo 2

MINISTERIO DE EDUCACIÓN Y FORMACIÓN PROFESIONAL
CONTRATOS PREDOCTORALES PARA LA FORMACIÓN DE PROFESORADO UNIVERSITARIO-FPU 2015

Estudios Clínicos

GS-EU-174-1403. Estudio farmacoepidemiológico para establecer el perfil de seguridad a largo plazo de tenofovir disoproxil fumarato (Tenofovir DF, Viread®) y describir el tratamiento de la toxicidad renal y ósea asociada a Tenofovir DF en adolescentes de 12 a <18 años co

GILEAD SCIENCES, INC
Fase: IV ENSAYO CLINICO COMERCIAL

AI444-046. Estudio de seguimiento a largo plazo de los sujetos que participaron en un ensayo clínico en el que se administró Asunaprevir (BMS-650032) y/o Daclatasvir (BMS-790052) para el tratamiento de la hepatitis C crónica

BRISTOL-MYERS SQUIBB, S.A.U.
Fase: III ENSAYO CLINICO COMERCIAL

64294178HPC2001. “Estudio de fase IIb, abierto, multicéntrico y aleatorizado para investigar la eficacia, seguridad y farmacocinética de diferentes pautas de tratamiento de AL-335, Odalasvir y Simeprevir en sujetos con hepatitis C crónica, con o sin Cirrosis, infectados p

JANSSEN-CILAG, S.A.
Fase: II ENSAYO CLINICO COMERCIAL

64294178HPC3001. Estudio prospectivo de seguimiento de 3 años de duración en pacientes tratados en un estudio anterior en fase II o III con una pauta posológica que contenga odalasvir y AL-335 con o sin simeprevir para el tratamiento de la infección por el virus de la hep

JANSSEN-CILAG INTERNATIONAL N.V.
Fase: III ENSAYO CLINICO COMERCIAL

747-303. Estudio de fase 3, multicéntrico, aleatorizado, con doble enmascaramiento, a largo plazo y controlado con placebo para evaluar la seguridad y la eficacia del ácido obeticólico en sujetos con esteatohepatitis no alcohólica.

INTERCEPT PHARMACEUTICALS, INC.
Fase: III ENSAYO CLINICO COMERCIAL

747-302. Estudio de fase 3b, multicéntrico, aleatorizado, con doble enmascaramiento y controlado con placebo para evaluar el efecto del ácido obeticólico en los resultados clínicos de pacientes con cirrosis biliar primaria

INTERCEPT PHARMACEUTICALS, INC.
Fase: III ENSAYO CLINICO COMERCIAL

GS-US-384-1944. Estudio en fase III, aleatorizado, doble ciego y controlado con placebo para evaluar la seguridad y la eficacia de selonsertib en pacientes con cirrosis compensada debida a esteatohepatitis no alcohólica (EHNA)

GILEAD SCIENCES, INC
Fase: III ENSAYO CLINICO COMERCIAL

GS-US-384-1943. Estudio de fase III, aleatorizado, doble ciego, controlado con placebo para evaluar la seguridad y eficacia de selonsertib en pacientes con esteatohepatitis no alcohólica (EHNA) y fibrosis en puentes (F3)

GILEAD SCIENCES, INC
Fase: III ENSAYO CLINICO COMERCIAL

1386.4. Ensayo fase II, multicéntrico, doble ciego, aleatorizado, de grupos paralelos y controlado con placebo para investigar la seguridad, tolerabilidad, farmacodinámica y farmacocinética de distintas dosis orales de BI 1467335 durante 12 semanas de tratamiento

BOEHRINGER INGELHEIM ESPAÑA, S.A.
Fase: II ENSAYO CLINICO COMERCIAL

GSN000300. Ensayo clínico doble ciego, aleatorizado y controlado con placebo para evaluar la eficacia y la seguridad de GKT137831 oral en pacientes con colangitis biliar primaria tratados con ácido ursodesoxicólico y con fosfatasa alcalina persistentemente elevada

GENKYOTEX S.A.
Fase: II ENSAYO CLINICO COMERCIAL

M16-133. Estudio multicéntrico, abierto y de un solo brazo para evaluar la eficacia y la seguridad de glecaprevir (GLE)/pibrentasvir (PIB) en adultos con infección crónica por el virus de la hepatitis C (VHC) de genotipos 1-6 y un índice aspartato aminotransferasa

ABBVIE DEUTCHSLAND GMBH & CON K. G
Fase: III ENSAYO CLINICO COMERCIAL

GA29145. ESTUDIO ABIERTO DE EXTENSIÓN Y SUPERVISIÓN DE LA SEGURIDAD DE PACIENTES CON ENFERMEDAD DE CROHN CON ACTIVIDAD DE MODERADA A GRAVE PREVIAMENTE INSCRITOS EN EL PROTOCOLO DE FASE III CON ETROLIZUMAB, GA29144

F. HOFFMANN LA ROCHE LTD
Fase: III ENSAYO CLINICO COMERCIAL

GA29144. ESTUDIO MULTICÉNTRICO DE FASE III ALEATORIZADO, DOBLE CIEGO Y CONTROLADO CON PLACEBO PARA EVALUAR LA EFICACIA Y LA SEGURIDAD DEL ETROLIZUMAB COMO TRATAMIENTO DE INDUCCIÓN Y MANTENIMIENTO EN PACIENTES CON ENFERMEDAD DE CROHN ACTIVA DE MODERADA A GRAVE

F. HOFFMANN LA ROCHE LTD
Fase: III ENSAYO CLINICO COMERCIAL

M14-423. Estudio abierto y multicéntrico para evaluar los resultados a largo plazo con ABT-450/ritonavir/ABT-267 (ABT-450/r/ABT-267) y ABT-333 con o sin ribavirina (RBV) en adultos con infección crónica por el virus de la hepatitis C (VHC) de genotipo 1(TOPAZ-I)

ABBVIE DEUTCHSLAND GMBH & CON K. G
Fase: III ENSAYO CLINICO COMERCIAL

IVA_01_337_HNAS_16_002. A randomized, double-blind, placebo-controlled, multicenter, dose-range, proof-of-concept, 24-week treatment study of IVA337 in adult subjects with nonalcoholic steatohepatitis (NASH)

INVENTIVA
Fase: II ENSAYO CLINICO COMERCIAL

GFT505-315-1. Estudio de fase III, multicéntrico, aleatorizado, doble ciego, controlado con placebo para evaluar la eficacia y seguridad de elafibranor en pacientes con esteatohepatitis no alcohólica (EHNA) y fibrosis

GENFIT
Fase: III ENSAYO CLINICO COMERCIAL

GS-US-342-2097. Estudio de fase II, multicéntrico, aleatorizado, abierto, para evaluar la eficacia y seguridad de la combinación a dosis fija de sofosbuvir/velpatasvir (CDF) y sofosbuvir/velpatasvir en CDF y ribavirina en pacientes con infección crónica por el genotipo 3

GILEAD SCIENCES, INC
Fase: II ENSAYO CLINICO COMERCIAL

3152-301-002. Estudio de fase III, multicéntrico, aleatorizado, con doble enmascaramiento, controlado con placebo, para evaluar la eficacia y seguridad de cenicriviroc para el tratamiento de la fibrosis hepática en pacientes adultos con esteatohepatitis no alcohólica

TOBIRA THERAPEUTICS
Fase: III ENSAYO CLINICO COMERCIAL

TROMBOXABAN. Estudio prospectivo multicéntrico, aleatorizado, para valorar el efecto de rivaroxaban en la recanalización de la trombosis venosa portal y en la supervivencia en pacientes con cirrosis y trombosis venosa portal

FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL RAMÓN Y CAJAL
Fase: II ENSAYO CLINICO INDEPENDIENTE

CIRROXABAN. Estudio prospectivo multicéntrico, aleatorizado del efecto de Rivaroxaban sobre la supervivencia y el desarrollo de complicaciones de la hipertensión portal en pacientes con cirrosis

INSTITUT D`INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER IDIBAPS
Fase: III ENSAYO CLINICO INDEPENDIENTE

GIS-SUSANTI-TNF-2015. SUSPENSIÓN DEL TRATAMIENTO ANTI-TNF EN PACIENTES CON ENFERMEDAD INFLAMATORIA INTESTINAL: ENSAYO CLÍNICO MULTICÉNTRICO, PROSPECTIVO Y ALEATORIZADO

FUNDACIÓN DE INVESTIG. BIOMEDICA DEL HOSPITAL UNIVERSITARIO LA PRINCESA
Fase: IV ENSAYO CLINICO INDEPENDIENTE

Publicaciones científicas

  • Todo
  • D1
  • Q1
  • Q2
  • Otro
Heterologous COVID-19 Vaccination in Spain: A Case Study of Individual Autonomy in the Real World

Dal-Re, Rafael; Farre, Magi; Lucena, M Isabel Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 2022

Advanced preclinical models for evaluation of drug-induced liver injury – consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET]

Fernandez-Checa JC, Bagnaninchi P, Ye H, Sancho-Bru P, Falcon-Perez JM, et al. Journal of hepatology 2021 Oct;75(4):935-959

Advances in mt-tRNA Mutation-Caused Mitochondrial Disease Modeling: Patients’ Brain in a Dish

Povea-Cabello S, Villanueva-Paz M, Suárez-Rivero JM, Álvarez-Córdoba M, Villalón-García I, et al. Frontiers in genetics 2020;11():610764

An Isolated Dose of Extra-Virgin Olive Oil Produces a Better Postprandial Gut Hormone Response, Lipidic, and Anti-Inflammatory Profile that Sunflower Oil: Effect of Morbid Obesity

Garcia-Serrano S, Ho-Plagaro A, Santiago-Fernandez C, Rodríguez-Díaz C, Martín-Reyes F, et al. Molecular nutrition & food research 2021 Nov;65(22):e2100071

Assessing Prevalence and Factors Related to Frailty in Community-Dwelling Older Adults: A Multinomial Logistic Analysis

Blanco-Reina E, Aguilar-Cano L, García-Merino MR, Ocaña-Riola R, Valdellós J, et al. Journal of clinical medicine 2021 Aug 14;10(16):

Association between the Mediterranean Diet and Metabolic Syndrome with Serum Levels of miRNA in Morbid Obesity

Fontalba-Romero MI, Lopez-Enriquez S, Lago-Sampedro A, García-Escobar E, Pastori RL, et al. Nutrients 2021 Jan 29;13(2):

Biomarkers of idiosyncratic drug-induced liver injury (DILI)-a systematic review

Atallah E, Freixo C, Alvarez-Alvarez I, Cubero FJ, Gerbes AL, et al. Expert opinion on drug metabolism & toxicology 2021 Nov;17(11):1327-1343

Characterizing Highly Cited Papers in Mass Cytometry through H-Classics

Di Zeo-Sánchez DE, Sánchez-Núñez P, Stephens C, Lucena MI Biology 2021 Feb 2;10(2):

Clinical Characteristics and Outcome of Drug-Induced Liver Injury in the Older Patients: From the Young-Old to the Oldest-Old

Weersink RA, Alvarez-Alvarez I, Medina-Cáliz I, Sanabria-Cabrera J, Robles-Díaz M, et al. Clinical pharmacology and therapeutics 2021 Apr;109(4):1147-1158

Combination of Tocilizumab and Steroids to Improve Mortality in Patients with Severe COVID-19 Infection: A Spanish, Multicenter, Cohort Study.

Ruiz-Antorán B, Sancho-López A, Torres F, Moreno-Torres V, de Pablo-López I, et al. Infectious diseases and therapy 2021 Mar;10(1):347-362

Comprehensive analysis and insights gained from long-term experience of the Spanish DILI Registry

Stephens C, Robles-Diaz M, Medina-Caliz I, Garcia-Cortes M, Ortega-Alonso A, et al. Journal of hepatology 2021 Jul;75(1):86-97

Critical Review of Gaps in the Diagnosis and Management of Drug-Induced Liver Injury Associated with Severe Cutaneous Adverse Reactions

Villanueva-Paz M, Niu H, Segovia-Zafra A, Medina-Caliz I, Sanabria-Cabrera J, et al. Journal of clinical medicine 2021 Nov 15;10(22):

Definite and indeterminate nonalcoholic steatohepatitis share similar clinical features and prognosis: A longitudinal study of 1893 biopsy-proven nonalcoholic fatty liver disease subjects

Ampuero J, Aller R, Gallego-Durán R, Crespo J, Abad J, et al. Liver international : official journal of the International Association for the Study of the Liver 2021 Sep;41(9):2076-2086

Drug properties and host factors contribute to biochemical presentation of drug-induced liver injury: a prediction model from a machine learning approach

Gonzalez-Jimenez A, Suzuki A, Chen M, Ashby K, Alvarez-Alvarez I, et al. Archives of toxicology 2021 May;95(5):1793-1803

Elevated bilirubin, alkaline phosphatase at onset, and drug metabolism are associated with prolonged recovery from DILI

Ashby K, Zhuang W, González-Jimenez A, Alvarez-Alvarez I, Lucena MI, et al. Journal of hepatology 2021 Aug;75(2):333-341

Endoscopic intragastric injection of botulinum toxin A in obese patients on bariatric surgery waiting lists: A randomised double-blind study (IntraTox study)

Sánchez Torralvo FJ, Vázquez Pedreño L, Gonzalo Marín M, Tapia MJ, Lima F, et al. Clinical nutrition (Edinburgh, Scotland) 2021 Apr;40(4):1834-1842

Extraintestinal Manifestations in Patients with Inflammatory Bowel Disease: Study Based on the ENEIDA Registry

Algaba A, Guerra I, Ricart E, Iglesias E, Mañosa M, et al. Digestive diseases and sciences 2021 Jun;66(6):2014-2023

First isolation of Clostridioides difficile from smoked and dried freshwater fish in Cambodia

Rodriguez, C; Mith, H; Taminiau, B; Bouchafa, L; Van Broeck, J; Soumillion, K; Ngyuvula, E; Garcia-Fuentes, E; Korsak, N; Delmee, M; Daube, G FOOD CONTROL 2021

Genetic Risk Factors in Drug-Induced Liver Injury Due to Isoniazid-Containing Antituberculosis Drug Regimens

Nicoletti P, Devarbhavi H, Goel A, Venkatesan R, Eapen CE, et al. Clinical pharmacology and therapeutics 2021 Apr;109(4):1125-1135

Genetic risk factors in the development of idiosyncratic drug-induced liver injury

Stephens C, Lucena MI, Andrade RJ Expert opinion on drug metabolism & toxicology 2021 Feb;17(2):153-169

Gut Microbiota Metabolism of Bile Acids Could Contribute to the Bariatric Surgery Improvements in Extreme Obesity

Ocaña-Wilhelmi L, Martín-Núñez GM, Ruiz-Limón P, Alcaide J, García-Fuentes E, et al. Metabolites 2021 Oct 27;11(11):

Immune-Mediated Drug-Induced Liver Injury: Immunogenetics and Experimental Models

Gerussi A, Natalini A, Antonangeli F, Mancuso C, Agostinetto E, et al. International journal of molecular sciences 2021 Apr 27;22(9):

Incidence and prevalence of acute hepatitis E virus infection in patients with suspected Drug-Induced Liver Injury in the Spanish DILI Registry

Sanabria-Cabrera J, Sanjuán-Jiménez R, Clavijo E, Medina-Cáliz I, González-Jiménez A, et al. Liver international : official journal of the International Association for the Study of the Liver 2021 Jul;41(7):1523-1531

Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain: Large-Scale Epidemiological Study

Chaparro M, Garre A, Núñez Ortiz A, Diz-Lois Palomares MT, Rodríguez C, et al. Journal of clinical medicine 2021 Jun 29;10(13):

Influence of Factors Altering Gastric Microbiota on Bariatric Surgery Metabolic Outcomes

Gutiérrez-Repiso C, Moreno-Indias I, Martín-Núñez GM, Ho-Plagaro A, Ocaña-Wilhelmi L, et al. Microbiology spectrum 2021 Dec 22;9(3):e0053521

Late presentation of chronic HBV and HCV patients seeking first time specialist care in Spain: a 2-year registry review

Picchio CA, Lens S, Hernandez-Guerra M, Arenas J, Andrade RJ, et al. Scientific reports 2021 Dec 17;11(1):24133

Listeria monocytogenes dissemination in farming and primary production: Sources, shedding and control measures

Rodriguez, C; Taminiau, B; Garcia-Fuentes, E; Daube, G; Korsak, N FOOD CONTROL 2021

Lymphocyte Profile and Immune Checkpoint Expression in Drug-Induced Liver Injury: An Immunophenotyping Study

Cueto-Sanchez A, Niu H, Del Campo-Herrera E, Robles-Díaz M, Sanabria-Cabrera J, et al. Clinical pharmacology and therapeutics 2021 Dec;110(6):1604-1612

Microbiota composition and intestinal integrity remain unaltered after the inclusion of hydrolysed Nannochloropsis gaditana in Sparus aurata diet

Cerezo-Ortega IM, Di Zeo-Sánchez DE, García-Márquez J, Ruiz-Jarabo I, Sáez-Casado MI, et al. Scientific reports 2021 Sep 21;11(1):18779

miR-21 mimic blocks obesity in mice: A novel therapeutic option

Lhamyani S, Gentile AM, Giráldez-Pérez RM, Feijóo-Cuaresma M, Romero-Zerbo SY, et al. Molecular therapy. Nucleic acids 2021 Dec 3;26():401-416

NGS of microRNAs Involved in Cardioprotection Induced by Sevoflurane Compared to Propofol in Myocardial Revascularization Surgery: The ACDHUVV-16 Clinical Trial

Orriach JLG, Belmonte JJE, Aliaga MR, Fernandez AR, Capitan MJR, et al. Current medicinal chemistry 2021;28(20):4074-4086

Obeticholic Acid and Fibrates in Primary Biliary Cholangitis: Comparative Effects in a Multicentric Observational Study

Reig A, Álvarez-Navascués C, Vergara M, Gómez-Domínguez E, Gallego-Moya A, et al. The American journal of gastroenterology 2021 Nov 1;116(11):2250-2257

Oleic acid restores the rhythmicity of the disrupted circadian rhythm found in gastrointestinal explants from patients with morbid obesity

Lago-Sampedro A, Ho-Plagaro A, Garcia-Serrano S, Santiago-Fernandez C, Rodríguez-Díaz C, et al. Clinical nutrition (Edinburgh, Scotland) 2021 Jun;40(6):4324-4333

Overview of Causality Assessment for Drug-Induced Liver Injury (DILI) in Clinical Trials

Hey-Hadavi J, Seekins D, Palmer M, Coffey D, Caminis J, et al. Drug safety 2021 Jun;44(6):619-634

Oxidative Stress in Drug-Induced Liver Injury (DILI): From Mechanisms to Biomarkers for Use in Clinical Practice

Villanueva-Paz M, Morán L, López-Alcántara N, Freixo C, Andrade RJ, et al. Antioxidants (Basel, Switzerland) 2021 Mar 5;10(3):

Oxidized LDL Increase the Proinflammatory Profile of Human Visceral Adipocytes Produced by Hypoxia

Santiago-Fernández C, Martín-Reyes F, Tome M, Gutierrez-Repiso C, Fernandez-Garcia D, et al. Biomedicines 2021 Nov 18;9(11):

Preclinical models of idiosyncratic drug-induced liver injury (iDILI): Moving towards prediction

Segovia-Zafra A, Di Zeo-Sánchez DE, López-Gómez C, Pérez-Valdés Z, García-Fuentes E, et al. Acta pharmaceutica Sinica. B 2021 Dec;11(12):3685-3726

Prevention and management of idiosyncratic drug-induced liver injury: Systematic review and meta-analysis of randomised clinical trials

Niu H, Sanabria-Cabrera J, Alvarez-Alvarez I, Robles-Diaz M, Stankeviciute S, et al. Pharmacological research 2021 Feb;164():105404

Profile of herbal and dietary supplements induced liver injury in Latin America: A systematic review of published reports

Santos G, Gasca J, Parana R, Nunes V, Schinnoni M, et al. Phytotherapy research : PTR 2021 Jan;35(1):6-19

Promoting exercise, reducing sedentarism or both for diabetes prevention: The Seguimiento Universidad De Navarra (SUN) cohort

Llavero-Valero M, Escalada San Martín J, Martínez-González MA, Alvarez-Mon MA, Alvarez-Alvarez I, et al. Nutrition, metabolism, and cardiovascular diseases : NMCD 2021 Feb 8;31(2):411-419

Role of Ursodeoxycholic Acid in Treating and Preventing Idiosyncratic Drug-Induced Liver Injury. A Systematic Review

Robles-Díaz M, Nezic L, Vujic-Aleksic V, Björnsson ES Frontiers in pharmacology 2021;12():744488

Serious liver injury induced by Nimesulide: an international collaborative study

Bessone F, Hernandez N, Mendizabal M, Ridruejo E, Gualano G, et al. Archives of toxicology 2021 Apr;95(4):1475-1487

SOME MIXED WEAK TYPE INEQUALITIES

Lorente, M; Martin-Reyes, FJ JOURNAL OF MATHEMATICAL INEQUALITIES 2021

Sudden cessation of fluoxetine before alcohol drinking reinstatement alters microglial morphology and TLR4/inflammatory neuroadaptation in the rat brain

Aranda J, Fernández-Arjona MDM, Alén F, Rivera P, Rubio L, et al. Brain structure & function 2021 Sep;226(7):2243-2264

Synergistic Deoxynucleoside and Gene Therapies for Thymidine Kinase 2 Deficiency

Lopez-Gomez C, Sanchez-Quintero MJ, Lee EJ, Kleiner G, Tadesse S, et al. Annals of neurology 2021 Oct;90(4):640-652

The metabesity factor HMG20A potentiates astrocyte survival and reactive astrogliosis preserving neuronal integrity

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Santiago-Fernández C, García-Serrano S, Tome M, Valdes S, Ocaña-Wilhelmi L, et al. Endocrinologia, diabetes y nutricion 2017 Aug – Sep;64(7):355-362

Growth hormone-releasing hormone is produced by adipocytes and regulates lipolysis through growth hormone receptor

Rodríguez-Pacheco F, Gutierrez-Repiso C, García-Serrano S, Ho-Plagaro A, Gómez-Zumaquero JM, et al. International journal of obesity (2005) 2017 Oct;41(10):1547-1555

Human immunodeficiency virus-infected liver transplant recipients with incidental hepatocellular carcinoma: A prospective multicenter nationwide cohort study

Agüero F, Forner A, Valdivieso A, Blanes M, Barcena R, et al. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2017 May;23(5):645-651

Inflammatory Bowel Disease: New Therapeutic Options in the Post Anti-TNF alpha Era

Jiménez-Pérez M, Olmedo-Martín RV, Amo-Trillo VM, González-Gande R Current drug metabolism 2017;18(7):666-679

Iodine is associated to semen quality in men who undergo consultations for infertility

Partal-Lorente AB, Maldonado-Ezequiel V, Martinez-Navarro L, Herrera-Contreras I, Gutierrez-Repiso C, et al. Reproductive toxicology (Elmsford, N.Y.) 2017 Oct;73():1-7

Jejunal gluconeogenesis associated with insulin resistance level and its evolution after Roux-en-Y gastric bypass

Gutierrez-Repiso C, Garcia-Serrano S, Moreno-Ruiz FJ, Alcain-Martinez G, Rodriguez-Pacheco F, et al. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery 2017 Apr;13(4):623-630

Medium to long-term efficacy and safety of oral tacrolimus in moderate to severe steroid refractory ulcerative colitis

Olmedo Martín RV, Amo Trillo V, González Grande R, Jiménez Pérez M Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva 2017 Aug;109(8):559-565

Methylation patterns of Vegfb promoter are associated with gene and protein expression levels: the effects of dietary fatty acids

Monastero R, García-Serrano S, Lago-Sampedro A, Rodríguez-Pacheco F, Colomo N, et al. European journal of nutrition 2017 Mar;56(2):715-726

Population-Based National Prevalence of Thyroid Dysfunction in Spain and Associated Factors: Di@bet.es Study

Valdés S, Maldonado-Araque C, Lago-Sampedro A, Lillo JA, Garcia-Fuentes E, et al. Thyroid : official journal of the American Thyroid Association 2017 Feb;27(2):156-166

Reference Values for TSH may be Inadequate to Define Hypothyroidism in Persons with Morbid Obesity: Di@bet.es Study

Valdés S, Maldonado-Araque C, Lago-Sampedro A, Lillo-Muñoz JA, Garcia-Fuentes E, et al. Obesity (Silver Spring, Md.) 2017 Apr;25(4):788-793

Selenium, selenoproteins and selenometabolites in mothers and babies at the time of birth

Santos C, García-Fuentes E, Callejón-Leblic B, García-Barrera T, Gómez-Ariza JL, et al. The British journal of nutrition 2017 May;117(9):1304-1311

The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury

Barbier-Torres L, Iruzubieta P, Fernández-Ramos D, Delgado TC, Taibo D, et al. Nature communications 2017 Dec 12;8(1):2068

The pro-/anti-inflammatory effects of different fatty acids on visceral adipocytes are partially mediated by GPR120

Rodriguez-Pacheco F, Gutierrez-Repiso C, Garcia-Serrano S, Alaminos-Castillo MA, Ho-Plagaro A, et al. European journal of nutrition 2017 Jun;56(4):1743-1752

Adverse effects of the proton pump inhibitors: review of evidences and position of the Spanish Society of Digestive Pathology

de la Coba Ortiz C, Argüelles Arias F, Martín de Argila de Prados C, Júdez Gutiérrez J, Linares Rodríguez A, et al. Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva 2016 Apr;108(4):207-24

Autoantibody presentation in drug-induced liver injury and idiopathic autoimmune hepatitis: the influence of human leucocyte antigen alleles

Stephens C, Castiella A, Gomez-Moreno EM, Otazua P, López-Nevot MÁ, et al. Pharmacogenetics and genomics 2016 Sep;26(9):414-22

Bioactive Components in Human Milk Along the First Month of Life: Effects of Iodine Supplementation during Pregnancy

Velasco I, Santos C, Limón J, Pascual E, Zarza L, et al. Annals of nutrition & metabolism 2016;68(2):130-6

Biomarkers in DILI: One More Step Forward

Robles-Díaz M, Medina-Caliz I, Stephens C, Andrade RJ, Lucena MI Frontiers in pharmacology 2016;7():267

Case Characterization, Clinical Features and Risk Factors in Drug-Induced Liver Injury

Ortega-Alonso A, Stephens C, Lucena MI, Andrade RJ International journal of molecular sciences 2016 May 12;17(5):

Creating an effective clinical registry for rare diseases

D’Agnolo HM, Kievit W, Andrade RJ, Karlsen TH, Wedemeyer H, et al. United European gastroenterology journal 2016 Jun;4(3):333-8

Cyproterone acetate induces a wide spectrum of acute liver damage including corticosteroid-responsive hepatitis: report of 22 cases

Bessone F, Lucena MI, Roma MG, Stephens C, Medina-Cáliz I, et al. Liver international : official journal of the International Association for the Study of the Liver 2016 Feb;36(2):302-10

Definition and risk factors for chronicity following acute idiosyncratic drug-induced liver injury

Medina-Caliz I, Robles-Diaz M, Garcia-Muñoz B, Stephens C, Ortega-Alonso A, et al. Journal of hepatology 2016 Sep;65(3):532-42

Drug utilization pattern in children and off-label use of medicines in a pediatric intensive care unit

Blanco-Reina E, Medina-Claros AF, Vega-Jiménez MA, Ocaña-Riola R, Márquez-Romero EI, et al. Medicina intensiva 2016 Jan-Feb;40(1):1-8

Effect of Roux-en-Y gastric bypass-induced weight loss on the transcriptomic profiling of subcutaneous adipose tissue

González-Plaza JJ, Gutiérrez-Repiso C, García-Serrano S, Rodriguez-Pacheco F, Garrido-Sánchez L, et al. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery 2016 Feb;12(2):257-63

Endoscopic Management of Post-Liver Transplantation Biliary Strictures With the Use of Fully Covered Metallic Stents

Jiménez-Pérez M, Melgar Simón JM, Durán Campos A, González Grande R, Rodrigo López JM, et al. Transplantation proceedings 2016 Sep;48(7):2510-2514

Genetic variants associated with antithyroid drug-induced agranulocytosis: a genome-wide association study in a European population

Hallberg P, Eriksson N, Ibañez L, Bondon-Guitton E, Kreutz R, et al. The lancet. Diabetes & endocrinology 2016 Jun;4(6):507-16

Hepatic Safety of Atypical Antipsychotics: Current Evidence and Future Directions

Slim M, Medina-Caliz I, Gonzalez-Jimenez A, Cabello MR, Mayoral-Cleries F, et al. Drug safety 2016 Oct;39(10):925-43

Hepatotoxicity by Dietary Supplements: A Tabular Listing and Clinical Characteristics

García-Cortés M, Robles-Díaz M, Ortega-Alonso A, Medina-Caliz I, Andrade RJ International journal of molecular sciences 2016 Apr 9;17(4):537

Hepatotoxicity induced by coxibs: how concerned should we be?

Bessone F, Hernandez N, Roma MG, Ridruejo E, Mendizabal M, et al. Expert opinion on drug safety 2016 Nov;15(11):1463-1475

Human Immunodeficiency Virus Infection Does Not Worsen Prognosis of Liver Transplantation for Hepatocellular Carcinoma

Agüero F, Forner A, Manzardo C, Valdivieso A, Blanes M, et al. Hepatology (Baltimore, Md.) 2016 Feb;63(2):488-98

Imaging biomarkers for steatohepatitis and fibrosis detection in non-alcoholic fatty liver disease

Gallego-Durán R, Cerro-Salido P, Gomez-Gonzalez E, Pareja MJ, Ampuero J, et al. Scientific reports 2016 Aug 12;6():31421

Insulin resistance is associated with specific gut microbiota in appendix samples from morbidly obese patients

Moreno-Indias I, Sánchez-Alcoholado L, García-Fuentes E, Cardona F, Queipo-Ortuño MI, et al. American journal of translational research 2016;8(12):5672-5684

Iodine status and thyroid function among Spanish schoolchildren aged 6-7 years: the Tirokid study

Vila L, Donnay S, Arena J, Arrizabalaga JJ, Pineda J, et al. The British journal of nutrition 2016 May;115(9):1623-31

Killer Immunoglobulin-Like Receptor Profiles Are not Associated with Risk of Amoxicillin-Clavulanate-Induced Liver Injury in Spanish Patients

Stephens C, Moreno-Casares A, López-Nevot MÁ, García-Cortés M, Medina-Cáliz I, et al. Frontiers in pharmacology 2016;7():280

Metabolic complications in liver transplant recipients

Jiménez-Pérez M, González-Grande R, Omonte Guzmán E, Amo Trillo V, Rodrigo López JM World journal of gastroenterology 2016 Jul 28;22(28):6416-23

New approaches in the treatment of hepatitis C

González-Grande R, Jiménez-Pérez M, González Arjona C, Mostazo Torres J World journal of gastroenterology 2016 Jan 28;22(4):1421-32

Oxidized low-density lipoprotein antibodies/high-density lipoprotein cholesterol ratio is linked to advanced non-alcoholic fatty liver disease lean patients

Ampuero J, Ranchal I, Gallego-Durán R, Pareja MJ, Del Campo JA, et al. Journal of gastroenterology and hepatology 2016 Sep;31(9):1611-8

The Latin American DILI Registry Experience: A Successful Ongoing Collaborative Strategic Initiative

Bessone F, Hernandez N, Lucena MI, Andrade RJ, Latin Dili Network Latindilin And Spanish Dili Registry. International journal of molecular sciences 2016 Feb 29;17(3):313

Thyroid Function and Thyroid Autoimmunity in Relation to Weight Status and Cardiovascular Risk Factors in Children and Adolescents: A Population-Based Study

García-García E, Vázquez-López MA, García-Fuentes E, Galera-Martínez R, Gutiérrez-Repiso C, et al. Journal of clinical research in pediatric endocrinology 2016 Jun 5;8(2):157-62

Treatment of chronic hepatitis C with direct-acting antivirals: The role of resistance

Jiménez-Pérez M, González-Grande R, España Contreras P, Pinazo Martínez I, de la Cruz Lombardo J, et al. World journal of gastroenterology 2016 Aug 7;22(29):6573-81

Age, Period, and Cohort Effects on Mortality From Ischemic Heart Disease in Southern Spain

Ocaña-Riola R, Mayoral-Cortés JM, Fernández-Ajuria A, Sánchez-Cantalejo C, Martín-Olmedo P, et al. Revista espanola de cardiologia (English ed.) 2015 May;68(5):373-81

Cases report of drug-induced liver injury in a reference hospital of Zulia state, Venezuela

Mengual-Moreno E, Lizarzábal-García M, Ruiz-Soler M, Silva-Suarez N, Andrade-Bellido R, et al. Investigacion clinica 2015 Mar;56(1):3-12

C-peptide modifies leptin and visfatin secretion in human adipose tissue

Garcia-Serrano S, Gutiérrez-Repiso C, Gonzalo M, Garcia-Arnes J, Valdes S, et al. Obesity (Silver Spring, Md.) 2015 Aug;23(8):1607-15

Distinct phenotype of hepatotoxicity associated with illicit use of anabolic androgenic steroids

Robles-Diaz M, Gonzalez-Jimenez A, Medina-Caliz I, Stephens C, García-Cortes M, et al. Alimentary pharmacology & therapeutics 2015 Jan;41(1):116-25

Drug prescriptions study in the outpatient setting: assessment of off-label uses in children

Blanco-Reina E, Vega-Jiménez MA, Ocaña-Riola R, Márquez-Romero EI, Bellido-Estévez I Atencion primaria 2015 Jun-Jul;47(6):344-50

Drug-induced liver injury: Interactions between drug properties and host factors

Chen M, Suzuki A, Borlak J, Andrade RJ, Lucena MI Journal of hepatology 2015 Aug;63(2):503-14

Entecavir has high efficacy and safety in white patients with chronic hepatitis B and comorbidities

Buti M, Morillas RM, Pérez J, Prieto M, Solà R, et al. European journal of gastroenterology & hepatology 2015 Jan;27(1):46-54

Everolimus Plus Mycophenolate Mofetil as Initial Immunosuppression in Liver Transplantation

Jiménez-Pérez M, González Grande R, Rando Muñoz FJ, de la Cruz Lombardo J, Muñoz Suárez MA, et al. Transplantation proceedings 2015 Jan-Feb;47(1):90-2

Exposure to tobacco, alcohol and drugs of abuse during pregnancy. A study of prevalence among pregnant women in Malaga (Spain)

Blasco-Alonso M, González-Mesa E, Gálvez Montes M, Lozano Bravo I, Merino Galdón F, et al. Adicciones 2015 Jun 17;27(2):99-108

Fine-mapping butyrophilin family genes revealed several polymorphisms influencing viral genotype selection in hepatitis C infection

Ampuero J, del Campo JA, Rojas L, García-Lozano RJ, Buti M, et al. Genes and immunity 2015 Jul-Aug;16(5):297-300

Forum for debate: Safety of allogeneic blood transfusion alternatives in the surgical/critically ill patient

Muñoz Gómez M, Bisbe Vives E, Basora Macaya M, García Erce JA, Gómez Luque A, et al. Medicina intensiva 2015 Dec;39(9):552-62

In 1-ghrelin splicing variant is overexpressed in pituitary adenomas and increases their aggressive features

Ibáñez-Costa A, Gahete MD, Rivero-Cortés E, Rincón-Fernández D, Nelson R, et al. Scientific reports 2015 Mar 4;5():8714

Management of hepatitis B virus infection after liver transplantation

Jiménez-Pérez M, González-Grande R, Mostazo Torres J, González Arjona C, Rando-Muñoz FJ World journal of gastroenterology 2015 Nov 14;21(42):12083-90

Optimizing elderly pharmacotherapy: polypharmacy vs. undertreatment. Are these two concepts related?

Blanco-Reina E, Ariza-Zafra G, Ocaña-Riola R, León-Ortíz M, Bellido-Estévez I European journal of clinical pharmacology 2015 Feb;71(2):199-207

Prognosis of Patients with Ulcerative Colitis in Sustained Remission After Thiopurines Withdrawal

Moreno-Rincón E, Benítez JM, Serrano-Ruiz FJ, Vázquez-Morón JM, Pallarés-Manrique H, et al. Inflammatory bowel diseases 2015 Jul;21(7):1564-71

Role of ITPA and SLC28A2 genes in the prediction of anaemia associated with protease inhibitor plus ribavirin and peginterferon in hepatitis C treatment

Ampuero J, Del Campo JA, Rojas L, Calleja JL, Cabezas J, et al. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2015 Jul;68():56-60

The expression of genes involved in jejunal lipogenesis and lipoprotein synthesis is altered in morbidly obese subjects with insulin resistance

Gutierrez-Repiso C, Rodriguez-Pacheco F, Garcia-Arnes J, Valdes S, Gonzalo M, et al. Laboratory investigation; a journal of technical methods and pathology 2015 Dec;95(12):1409-17

The value of serum aspartate aminotransferase and gamma-glutamyl transpetidase as biomarkers in hepatotoxicity

Robles-Diaz M, Garcia-Cortes M, Medina-Caliz I, Gonzalez-Jimenez A, Gonzalez-Grande R, et al. Liver international : official journal of the International Association for the Study of the Liver 2015 Nov;35(11):2474-82

Therapeutic decisions in the treatment of hepatocellular carcinoma and patterns of sorafenib use. Results of the international observational GIDEON trial in Spain

Turnes J, Díaz R, Hernandez-Guerra M, Gómez M, Castells L, et al. Gastroenterologia y hepatologia 2015 Apr;38(4):263-73


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