Lineas de Investigación

01. Infección VIH.

02. Infección endovascular.

03. Gérmenes multirresistentes.

04. Identificación de MNT por MALDITOF



Proyectos de Investigación

EMG20-001 Ayudas para el fortalecimiento de grupos emergentes

Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
. 2020

PLAN PROPIO_AREA4 Optimización del diagnóstico de la infección por C. difficile y detección de marcadores microbiológicos de gravedad y mala evolución. María Dolores Rojo.

FIMABIS
. 2019

Estudios Clínicos

CDC-Ensayo clínico de Sarilumab en adultos hospitalizados con COVID-19 que presentan síndrome de liberación de citoquinas.

FIBICO. FUNDACION PARA LA INVESTIGACIÓN BIOMÉDICA DE CÓRDOBA
Fase: II Ensayo Clínico Comercial

CDC-Ensayo clínico fase I/II multicéntrico, aleatorizado y controlado para evaluar la eficacia del tratamiento con plasma hiperinmune obtenido de donantes convalecientes de la infección por COVID-19.

FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD
Fase: I Ensayo Clínico Comercial

Estudio Salutem: uso de hidroxicloroquina en profilaxis pre-exposición a la COVID-19 en trabajadores sanitarios.

AGENCIA PUBLICA EMPRESARIAL SANITARIA COSTA DEL SOL
Fase: III Ensayo Clínico Comercial

CDC-Estudio Prevención y tratamiento con Calcifediol del síndrome respiratorio agudo (SARS) inducido por Coronavirus COVID-19.

FIBICO. FUNDACION PARA LA INVESTIGACIÓN BIOMÉDICA DE CÓRDOBA
Fase: II Ensayo Clínico Comercial

Ensayo clínico abierto y multicéntrico para evaluar la efectividad y seguridad de tocilizumab intravenoso en el tratamiento de pacientes con neumonía por COVID-19: estudio BREATH-19.

FUNDACION SEIMC-GESIDA
Fase: II Ensayo Clínico Comercial

Temocilina vs Meropenem para el Tratamiento de la Bacteriemia por Enterobacteriales Resistentes a Cefalosporinas de Tercera Generación: Ensayo Aleatorizado y Pragmático..

FUNDACION PUBLICA ANDALUZA PARA LA GESTION DE LA INVESTIGACIÓN EN SALUD DE SEVILLA FISEVI
Fase: III Ensayo Clínico Comercial

Estudio de Fase 3 Aleatorizado para Evaluar la Seguridad y la Actividad Antiviral de Remdesivir (GS-5734™) en Participantes con infección moderada por el COVID-19 en comparación con el tratamiento de referencia.

GILEAD SCIENCES, INC
Fase: III Ensayo Clínico Comercial

Estudio de Fase 3 Aleatorizado para Evaluar la Seguridad y la Actividad Antiviral de Remdesivir (GS-5734™) en Participantes con infección grave por el COVID-19..

GILEAD SCIENCES, INC
Fase: III Ensayo Clínico Comercial

201585. Estudio Fase III aleatorizado, multicéntrico, abierto, de grupos paralelos, de no inferioridad, para evaluar la eficacia, seguridad y tolerabilidad del cambio de una terapiaantirretroviral basada en INI, ITINN o IP a una pauta de tratamiento intramuscular

LABORATORIOS VIIV HEALTHCARE S.L.
Fase: III ENSAYO CLINICO COMERCIAL

205543. Estudio de fase III, aleatorizado, doble ciego, multicéntrico, con grupos paralelos, de ausencia de inferioridad, para evaluar la eficacia, seguridad y tolerabilidad de dolutegravir más lamivudina en comparación con dolutegravir más tenofovir/emtricitabin

LABORATORIOS VIIV HEALTHCARE S.L.
Fase: III ENSAYO CLINICO COMERCIAL

GS-US-292-1823. Estudio de fase 3b, aleatorizado y abierto para evaluar la seguridad y la eficacia del cambio de una pauta de abacavir/lamivudina (ABC/3TC) más un tercer antirretroviral a la combinación de dosis fijas (CDF) elvitegravir/cobicistat/emtricitabina/tenofovir

GILEAD SCIENCES, INC
Fase: III ENSAYO CLINICO COMERCIAL

GS-US-292-1824. Estudio piloto de fase 3b abierto para evaluar el cambio a la combinación de dosis fijas (CDF) elvitegravir/cobicistat/emtricitabina/tenofovir alafenamida (E/C/F/TAF) en sujetos adultos infectados por el VIH-1 con supresión virológica que tienen la mutaci

GILEAD SCIENCES, INC
Fase: III ENSAYO CLINICO COMERCIAL

SIMPLIFY. Ensayo clínico aleatorizado, multicéntrico, abierto, controlado, en fase III, para demostrar la no inferioridad del tratamiento antibiótico dirigido de espectro reducido frente al tratamiento de amplio espectro con un betalactámico antipseudomónico en el

FUNDACION PUBLICA ANDALUZA PARA LA GESTION DE LA INVESTIGACIÓN EN SALUD DE SEVILLA. FISEVI FISEVI
Fase: III ENSAYO CLINICO INDEPENDIENTE

FOREST. Ensayo clínico aleatorizado, multicéntrico, abierto, controlado, en fase III, para evaluar la eficacia de fosfomicina vs meropenem en el tratamiento dirigido de la infección urinaria bacteriémica por Escherichia coli productor de betalactamasas de espectr

FUNDACION PUBLICA ANDALUZA PARA LA GESTION DE LA INVESTIGACIÓN EN SALUD DE SEVILLA. FISEVI FISEVI
Fase: III ENSAYO CLINICO INDEPENDIENTE

Publicaciones científicas

  • Todo
  • D1
  • Q1
  • Q2
  • Otro
Blood culture-negative infective endocarditis: a worse outcome? Results from a large multicentre retrospective Spanish cohort study

Suardi LR, de Alarcón A, García MV, Ciezar AP, Hidalgo Tenorio C, et al. Infectious diseases (London, England) 2021 Oct;53(10):755-763

Clinical Factors Associated with Reinfection versus Relapse in Infective Endocarditis: Prospective Cohort Study

Calderón-Parra J, Kestler M, Ramos-Martínez A, Bouza E, Valerio M, et al. Journal of clinical medicine 2021 Feb 13;10(4):

Co-infections and superinfections complicating COVID-19 in cancer patients: A multicentre, international study

Gudiol C, Durà-Miralles X, Aguilar-Company J, Hernández-Jiménez P, Martínez-Cutillas M, et al. The Journal of infection 2021 Sep;83(3):306-313

Do specific antimicrobial stewardship interventions have an impact on carbapenem resistance in Gram-negative bacilli? A multicentre quasi-experimental ecological study: time-trend analysis and characterization of carbapenemases

Álvarez-Marín R, López-Cerero L, Guerrero-Sánchez F, Palop-Borras B, Rojo-Martín MD, et al. The Journal of antimicrobial chemotherapy 2021 Jun 18;76(7):1928-1936

Epidemiologic changes in bloodstream infections in Andalucia (Spain) during the last decade

Martínez Pérez-Crespo PM, López-Cortés LE, Retamar-Gentil P, García JFL, Vinuesa García D, et al. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2021 Feb;27(2):283.e9-283.e16

Infections after spine instrumentation: effectiveness of short antibiotic treatment in a large multicentre cohort

Benavent E, Rodríguez-Pardo D, Ulldemolins M, Sobrino-Diaz B, Bustinduy MJ, et al. The Journal of antimicrobial chemotherapy 2021 Mar 12;76(4):1085-1093

Linezolid for infective endocarditis A structured approach based on a national database experience

Muñoz P, De la Villa S, Martínez-Sellés M, Goenaga MA, Reviejo-Jaka K, et al. Medicine 2021 Dec 23;100(51):e27597

Mural Endocarditis: The GAMES Registry Series and Review of the Literature

Gutiérrez-Villanueva A, Muñoz P, Delgado-Montero A, Olmedo-Samperio M, de Alarcón A, et al. Infectious diseases and therapy 2021 Dec;10(4):2749-2764

Plasma concentrations of granulocyte colony-stimulating factor (G-CSF) in patients with substance use disorders and comorbid major depressive disorder

Galván ST, Flores-López M, Romero-Sanchiz P, Requena-Ocaña N, Porras-Perales O, et al. Scientific reports 2021 Jul 1;11(1):13629

Plasma Concentrations of Lysophosphatidic Acid and Autotaxin in Abstinent Patients with Alcohol Use Disorder and Comorbid Liver Disease

Flores-López M, García-Marchena N, Pavon FJ, Lara E, Porras-Perales O, et al. Biomedicines 2021 Sep 13;9(9):

Revisiting the epidemiology of bloodstream infections and healthcare-associated episodes: results from a multicentre prospective cohort in Spain (PRO-BAC Study)

Pérez-Crespo PMM, Lanz-García JF, Bravo-Ferrer J, Cantón-Bulnes ML, Sousa Domínguez A, et al. International journal of antimicrobial agents 2021 Jul;58(1):106352

Skin lesions in children during the first wave of the SARS-CoV-2 pandemic

Carazo Gallego B, Martín Pedraz L, Galindo Zavala R, Rivera Cuello M, Mediavilla Gradolph C, et al. Medicina clinica 2021 Jul 9;157(1):33-37

Skin manifestations during the COVID-19 pandemic in the pediatric emergency department

Oliva Rodríguez-Pastor S, Martín Pedraz L, Carazo Gallego B, Galindo Zavala R, Lozano Sánchez G, et al. Pediatrics international : official journal of the Japan Pediatric Society 2021 Sep;63(9):1033-1037

The first wave of the COVID-19 epidemic in Spain was associated with early introductions and fast spread of a dominating genetic variant

López MG, Chiner-Oms Á, García de Viedma D, Ruiz-Rodriguez P, Bracho MA, et al. Nature genetics 2021 Oct;53(10):1405-1414

Update in Diagnostics of Toscana Virus Infection in a Hyperendemic Region (Southern Spain)

Sanbonmatsu-Gámez S, Pedrosa-Corral I, Navarro-Marí JM, Pérez-Ruiz M Viruses 2021 Jul 23;13(8):

Catheter-related bloodstream infections: predictive factors for Gram-negative bacteria aetiology and 30 day mortality in a multicentre prospective cohort

Calò F, Retamar P, Martínez Pérez-Crespo PM, Lanz-García J, Sousa A, et al. The Journal of antimicrobial chemotherapy 2020 Oct 1;75(10):3056-3061

Clinical and prognostic differences between methicillin-resistant and methicillin-susceptible Staphylococcus aureus infective endocarditis

Hidalgo-Tenorio C, Gálvez J, Martínez-Marcos FJ, Plata-Ciezar A, De La Torre-Lima J, et al. BMC infectious diseases 2020 Feb 21;20(1):160

Clinical Predictive Model of Multidrug Resistance in Neutropenic Cancer Patients with Bloodstream Infection Due to Pseudomonas aeruginosa

Gudiol C, Albasanz-Puig A, Laporte-Amargós J, Pallarès N, Mussetti A, et al. Antimicrobial agents and chemotherapy 2020 Mar 24;64(4):

Four weeks versus six weeks of ampicillin plus ceftriaxone in Enterococcus faecalis native valve endocarditis: A prospective cohort study

Ramos-Martínez A, Pericàs JM, Fernández-Cruz A, Muñoz P, Valerio M, et al. PloS one 2020;15(8):e0237011

Impact of HIV on the survival of hepatocellular carcinoma in hepatitis C virus-infected patients

Merchante N, Rodríguez-Fernández M, Figueruela B, Rodríguez-Arrondo F, Revollo B, et al. AIDS (London, England) 2020 Aug 1;34(10):1497-1507

Outcomes of the PIRASOA programme, an antimicrobial stewardship programme implemented in hospitals of the Public Health System of Andalusia, Spain: an ecologic study of time-trend analysis

Rodríguez-Baño J, Pérez-Moreno MA, Peñalva G, Garnacho-Montero J, Pinto C, et al. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2020 Mar;26(3):358-365

Quasiexperimental intervention study protocol to optimise the use of new antibiotics in Spain: the NEW_SAFE project

Palacios-Baena ZR, Valiente de Santis L, Maldonado N, Rosso-Fernández CM, Borreguero I, et al. BMJ open 2020 Jul 31;10(7):e035460

What is needed to achieve HCV microelimination among HIV-infected populations in Andalusia, Spain: a modeling analysis

Skaathun B, Borquez A, Rivero-Juarez A, Mehta SR, Tellez F, et al. BMC infectious diseases 2020 Aug 8;20(1):588

A prospective survey of Aspergillus spp. in respiratory tract samples: Species identification and susceptibility patterns

Castro C, Galán-Sanchez F, Linares MJ, Tejero R, Ruiz M, et al. Medical mycology 2019 Jun 1;57(4):412-420

DALBACEN cohort: dalbavancin as consolidation therapy in patients with endocarditis and/or bloodstream infection produced by gram-positive cocci

Hidalgo-Tenorio C, Vinuesa D, Plata A, Martin Dávila P, Iftimie S, et al. Annals of clinical microbiology and antimicrobials 2019 Oct 19;18(1):30

Evaluation of a rapid assay for detection of PBP2a Staphylococcus aureus

Sáinz-Rodríguez R, de Toro-Peinado I, Valverde-Troya M, Bermúdez Ruíz MP, Palop-Borrás B Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 2019 Aug;32(4):370-374

Evaluation of hepatitis C viral RNA persistence in HIV-infected patients with long-term sustained virological response by droplet digital PCR

Frías M, Rivero-Juárez A, Téllez F, Palacios R, Jiménez-Arranz Á, et al. Scientific reports 2019 Aug 29;9(1):12507

Left-sided infective endocarditis caused by Streptococcus agalactiae: rare and serious

Ivanova-Georgieva R, Ruiz-Morales J, García-Cabrera E, García-López MV, Gálvez-Acebal J, et al. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2019 Feb;38(2):265-275

Losses to follow-up of HIV-infected people in the Spanish VACH cohort over the period between 2013 and 2014: The importance of sociodemographic factors

Teira R, Espinosa N, Gutiérrez MM, Montero M, Martínez E, et al. Enfermedades infecciosas y microbiologia clinica (English ed.) 2019 Jun – Jul;37(6):361-366

Low performance of ultrasound surveillance for the diagnosis of hepatocellular carcinoma in HIV-infected patients

Merchante N, Figueruela B, Rodríguez-Fernández M, Rodríguez-Arrondo F, Revollo B, et al. AIDS (London, England) 2019 Feb 1;33(2):269-278

Outpatient Parenteral Antibiotic Treatment for Infective Endocarditis: A Prospective Cohort Study From the GAMES Cohort

Pericà S JM, Llopis J, González-Ramallo V, Goenaga MÁ, Muñoz P, et al. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2019 Oct 30;69(10):1690-1700

OXA-48-Like-Producing Klebsiella pneumoniae in Southern Spain in 2014-2015

Machuca J, López-Cerero L, Fernández-Cuenca F, Mora-Navas L, Mediavilla-Gradolph C, et al. Antimicrobial agents and chemotherapy 2019 Jan;63(1):

Parenteral drug use as the main barrier to hepatitis C treatment uptake in HIV-infected patients

Rivero-Juarez A, Tellez F, Castaño-Carracedo M, Merino D, Espinosa N, et al. HIV medicine 2019 Jul;20(6):359-367

Response to Hepatitis A Virus Vaccine in HIV-Infected Patients Within a Retrospective, Multicentric Cohort: Facing Hepatitis A Outbreaks in the Clinical Practice

Neukam K, Delgado Fernández M, Hernández Quero J, Rivero-Juárez A, Llaves-Flores S, et al. Journal of acquired immune deficiency syndromes (1999) 2019 May 1;81(1):e1-e5

A pragmatic approach for mortality prediction after surgery in infective endocarditis: optimizing and refining EuroSCORE

Fernández-Hidalgo N, Ferreria-González I, Marsal JR, Ribera A, Aznar ML, et al. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2018 Oct;24(10):1102.e7-1102.e15

Antibiotic selection in the treatment of acute invasive infections by Pseudomonas aeruginosa: Guidelines by the Spanish Society of Chemotherapy

Mensa J, Barberán J, Soriano A, Llinares P, Marco F, et al. Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 2018 Feb;31(1):78-100

Appropriateness of antimicrobial prescriptions in the emergency department of a tertiary hospital

Yunquera-Romero L, Márquez-Gómez I, Henares-López A, Morales-Lara MJ, Gallego Fernández C, et al. Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 2018 Jun;31(3):209-216

Baseline resistance-guided therapy does not enhance the response to interferon-free treatment of HCV infection in real life

Real LM, Macías J, Pérez AB, Merino D, Granados R, et al. Scientific reports 2018 Oct 8;8(1):14905

Dalbavancin in the treatment of different gram-positive infections: a real-life experience

Bouza E, Valerio M, Soriano A, Morata L, Carus EG, et al. International journal of antimicrobial agents 2018 Apr;51(4):571-577

Emergence as an outbreak of the HIV-1 CRF19_cpx variant in treatment-naive patients in southern Spain

González-Domenech CM, Viciana I, Delaye L, Mayorga ML, Palacios R, et al. PloS one 2018;13(1):e0190544

Factors associated with bronchiectasis in patients with uncontrolled asthma; the NOPES score: a study in 398 patients

Padilla-Galo A, Olveira C, Fernández de Rota-Garcia L, Marco-Galve I, Plata AJ, et al. Respiratory research 2018 Mar 16;19(1):43

Hepatocellular carcinoma after sustained virological response with interferon-free regimens in HIV/hepatitis C virus-coinfected patients

Merchante N, Rodríguez-Arrondo F, Revollo B, Merino E, Ibarra S, et al. AIDS (London, England) 2018 Jul 17;32(11):1423-1430

HIV in Spain 2017: policies for a new management of chronicity beyond virological control

Del Amo J, Campbell C, Navarro G, Segura F, Suárez I, et al. Revista espanola de salud publica 2018 Sep 6;92():

How to: identify non-tuberculous Mycobacterium species using MALDI-TOF mass spectrometry

Alcaide F, Amlerová J, Bou G, Ceyssens PJ, Coll P, et al. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2018 Jun;24(6):599-603

Infective Endocarditis in Patients With Bicuspid Aortic Valve or Mitral Valve Prolapse

Zegri-Reiriz I, de Alarcón A, Muñoz P, Martínez Sellés M, González-Ramallo V, et al. Journal of the American College of Cardiology 2018 Jun 19;71(24):2731-2740

Lipid changes and tolerability in a cohort of adult HIV-infected patients who switched to rilpivirine/emtricitabine/tenofovir due to intolerance to previous combination ART: the PRO-STR study

Ocampo A, Domingo P, Fernández P, Diz J, Barberá JR, et al. The Journal of antimicrobial chemotherapy 2018 Aug 1;73(8):2171-2176

Evaluation of an immunochromatographic test for the detection of OXA-48 carbapenemase

Mediavilla-Gradolph C, Sáinz-Rodriguez R, Valverde-Troya M, de Toro-Peinado I, Bermudez-Ruíz MP, et al. Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 2017 Feb;30(1):45-49

Factors associated with severe sepsis or septic shock in complicated pyelonephritis

Ruiz-Mesa JD, Marquez-Gomez I, Sena G, Buonaiuto VA, Mora-Ordoñez J, et al. Medicine 2017 Oct;96(43):e8371

Hepatitis C virus core antigen in the management of patients treated with new direct-acting antivirals

Arboledas JCA, Guerrero IP, Rodríguez MJB, Martos ET, Pérez AB, et al. Diagnostic microbiology and infectious disease 2017 Sep;89(1):29-34

Lessons learned with molecular methods targeting the BCSP-31 membrane protein for diagnosis of human brucellosis

Sanjuan-Jimenez R, Colmenero JD, Morata P Clinica chimica acta; international journal of clinical chemistry 2017 Jun;469():1-9

Prognostic factors of infective endocarditis in patients on hemodialysis: A case series from a National Multicenter Registry

Ramos-Martínez A, Roque F, Fariñas MC, Muñoz P, Verde E, et al. International journal of cardiology 2017 Aug 15;241():295-301

Real-life experience with sorafenib for the treatment of hepatocellular carcinoma in HIV-infected patients

Merchante N, Ibarra S, Revollo B, Rodríguez-Arrondo F, Merino E, et al. AIDS (London, England) 2017 Jan 2;31(1):89-95

Very low level viraemia and risk of virological failure in treated HIV-1-infected patients

Teira R, Vidal F, Muñoz-Sánchez P, Geijo P, Viciana P, et al. HIV medicine 2017 Mar;18(3):196-203

Week 4 response predicts sustained virological response to all-oral direct-acting antiviral-based therapy in cirrhotic patients with hepatitis C virus genotype 3 infection

Pineda JA, Morano-Amado LE, Granados R, Macías J, Téllez F, et al. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2017 Jun;23(6):409.e5-409.e8

Boceprevir plus pegylated interferon/ribavirin to re-treat hepatitis C virus genotype 1 in HIV-HCV co-infected patients: final results of the Spanish BOC HIV-HCV Study

Laguno M, Von Wichmann MA, Van den Eynde E, Navarro J, Cifuentes C, et al. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2016 Dec;53():46-51

No evidence of firstly acquired acute hepatitis C virus infection outbreak among HIV-infected patients from Southern Spain: a multicentric retrospective study from 2000-2014

Neukam K, Viciana P, Ojeda-Burgos G, Delgado-Fernández M, Ríos MJ, et al. BMC infectious diseases 2016 Sep 15;16():489

Boceprevir or Telaprevir Based Triple Therapy against Chronic Hepatitis C in HIV Coinfection: Real-Life Safety and Efficacy

Neukam K, Munteanu DI, Rivero-Juárez A, Lutz T, Fehr J, et al. PloS one 2015;10(4):e0125080

Comparative Study of a Real-Time PCR Assay Targeting senX3-regX3 versus Other Molecular Strategies Commonly Used in the Diagnosis of Tuberculosis

Sanjuan-Jimenez R, Toro-Peinado I, Bermudez P, Colmenero JD, Morata P PloS one 2015;10(11):e0143025

Left-sided infective endocarditis in patients with liver cirrhosis.

Ruiz-Morales J, Ivanova-Georgieva R, Fernández-Hidalgo N, García-Cabrera E, Miró JM, et al. The Journal of infection 2015 Dec;71(6):627-41

Low Efficacy of Pegylated Interferon plus Ribavirin plus Nitazoxanide for HCV Genotype 4 and HIV Coinfection

Macías J, López-Cortés LF, Téllez F, Recio E, Ojeda-Burgos G, et al. PloS one 2015;10(12):e0143492


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