
Haematology and Haematotherapy
Lineas de Investigación
1. Study of prognostic factors on the genomics level that influence the treatment and progress of patients with malignant haemopathies. Individualised treatment. Quality of life..
2. Transplantation of haematopoietic stem cells.
- At-home transplantation of haematopoietic stem cells and quality of life.
- Influence of KIR genotyping in the allogenic haematopoietic stem cell transplantation.
- Infusion of mesenchymal stem cells in the treatment of graft-versus-host disease.
- Study of haematopoietic chimerism through new technologies (real-time PCR and digital PCR).
3. Congenital and acquired coagulation disorders.
- Gene therapy in haemophilia and study of non-replacement therapy.
- Molecular definition of Von Willebrand disease.
- Molecular definition of immune thrombocytopaenia.
4. Acute childhood lymphoblastic leukaemia.
- Genomic characterisation of T-cell acute lymphoblastic leukaemia via massive sequencing.
- Studies of minimal residual disease in acute childhood lymphoblastic leukaemia.
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Miembros del grupo
- Todos
- IR
- Co-IR
- Investigador
- Otro

Estudios Clínicos
Estudio de fase 2b, aleatorizado, doble ciego y controlado con placebo para evaluar los efectos de EDP-938 en adultos receptores de un trasplante de células hematopoyéticas con infección aguda de las vías respiratorias altas por el virus respiratorio sinc.
Estudio de fase 3 aleatorizado y abierto para evaluar la eficacia y la seguridad de navitoclax combinado con ruxolitinib en comparación con el mejor tratamiento disponible en pacientes con mielofibrosis en recaída/refractario (TRANSFORM-2).
Estudio de fase 1/2 de dos partes para determinar la seguridad, tolerabilidad, farmacocinética y actividad de K0706, un nuevo inhibidor de la tirosina cinasa (ITC), en pacientes sanos y pacientes con leucemia mieloide crónica (LMC) o leucemia linfoblástic.
Estudio de fase I/II, aleatorizado, abierto y de plataforma abierta en el que se evalúa la seguridad y eficacia de nuevas combinaciones de ruxolitinib en pacientes con mielofibrosis. (ADORE).
Estudio de fase Ib, abierto, aleatorizado, para evaluar la seguridad y la eficacia preliminar de Tafasitamab en combinación con R-CHOP o Tafasitamab más Lenalidomida en combinación con R-CHOP en pacientes con linfoma difuso de células B grandes (LDCBG) de.
Estudio de fase III, aleatorizado, abierto y multicéntrico, para comparar zanubrutinib (BGB-3111) más rituximab frente a bendamustina más rituximab en pacientes con linfoma de células del manto no tratados previamente que no son aptos para recibir un tras.
“IntReALL HR 2010 Estudio internacional para el tratamiento de la LLA infantil de alto riesgo 2010”.
“Estudio de fase III, abierto, aleatorizado y multicéntrico de ravulizumab en pacientes adultos y adolescentes que presentan microangiopatía trombótica (MAT) después de un trasplante de células madre hematopoyéticas (TCMH)”.
CA180406.
261302.
NN7088-3860.
20120215.
BAY 80-6946 / 17833.
15-007.
AG-221-AML-005.
CAMN107AIC05.
AP24534-14-203.
NN7088-3859.
BAY 2599023 (DTX201)/19429.
201501.
NN7088-4410.
CINC424C2301.
NN7415-4255.
MO39129.
AC220-A-U302.
abr-30.
AZA-MDS-003.
CINC424B2401.
BET116183.
CINC424A2353.
200622.
MEDI4736-MDS-001.
CC-486-MDS-006.
205203.
M15-656.
LAMAN-01AN.
PonaZaero_study.
GELTAMO-O-CRT-2011.
ALODEPLETE.
BOS-IIG-01.
GS-US-406-1840.
CETB115EES03.
CAMN107A2303.
Estudio fase III, multicéntrico, abierto, aleatorizado de imatinib frente a nilotinib, en pacientes adultos con leucemia mieloide crónica cromosoma Filadelfia positivo (Ph+) en fase crónica (LMC-FC) de nuevo diagnóstico.
CETB115J2411.
PAC203.
CABL001A2301.
SGN33A-005.
CC-5013-MDS-005.
Pevonedistat-2001.
LR-ESHAP.
ALL-SCT-ped-FORUM.
NKCell_LMA_2015.
MSC-EICH-2014.
Publicaciones científicas
- Todo
- D1
- Q1
- Q2
- Otro
Reduced-intensity conditioning haematopoietic stem cell transplantation in genetic diseases: Experience of the Spanish Working Group for Bone Marrow Transplantation in Children
López-Granados L., Torrent M., Sastre A., Gonzalez-Vicent M., Díaz de Heredia C., Argilés B., Pascual A., Pérez-Hurtado J.M., Sisinni L., Diaz M., Elorza I., Dasí M.A., Badell I.
Anales De Pediatria
PD-1 genotype of the donor is associated with acute graft-versus-host disease after HLA-identical sibling donor stem cell transplantation
Santos, N; Rodriguez-Romanos, R; de la Camara, R; Brunet, S; Nieto, JB; Buno, I; Martinez, C; Jimenez-Velasco, A; Vallejo, C; Gonzalez, M; Solano, C; Ferra, C; Sampol, A; Perez-Simon, JA; Lopez-Jimenez, J; Diez, JL; Gallardo, D
Annals Of Hematology 2018
A novel predictive approach for GVHD after allogeneic SCT based on clinical variables and cytokine gene polymorphisms
Martinez-Laperche, C; Buces, E; Aguilera-Morillo, MC; Picornell, A; Gonzalez-Rivera, M; Lillo, R; Santos, N; Martin-Antonio, B; Guillem, V; Nieto, JB; Gonzalez, M; de la Camara, R; Brunet, S; Jimenez-Velasco, A; Espigado, I; Vallejo, C; Sampol, A; Bellon, JM; Serrano, D; Kwon, M; Gayoso, J; Balsalobre, P; Urbano-Izpizua, A; Solano, C; Gallardo, D; Diez-Martin, JL; Romo, J; Buno, I
Blood Advances 2018
Treatment characteristics, efficacy and safety of thrombopoietin analogues in routine management of primary immune thrombocytopenia
Mingot-Castellano, ME; Caparros, IS; Fernandez, F; Perera-Alvarez, MD; Jimenez-Barcenas, R; Garcia, AC; Gonzalez-Silva, M; Yera-Cobo, M; Nieto-Hernandez, MM; Rodriguez-Fernandez, MJ; Diaz-Canales, D
Blood Coagulation & Fibrinolysis 2018
Busulfan-based myeloablative conditioning regimens for haploidentical transplantation in high-risk acute leukemias and myelodysplastic syndromes
Gayoso J., Balsalobre P., Kwon M., Herrera P., Bermúdez A., Sampol A., Jiménez S., López-Corral L., Serrano D., Piñana J.L., Pascual M.J., Heras I., Bento L., Varela R., Humala K., Zabalza A., Laiglesia A., Bastos-Oreiro M., Pérez-Corral A., Martínez-Laperche C., Buño I., Díez-Martín J.L.
European Journal Of Haematology
Unraveling the effect of silent, intronic and missense mutations on VWF splicing: contribution of next generation sequencing in the study of mRNA.
Borras, Nina; Orriols, Gerard; Batlle, Javier; Perez-Rodriguez, Almudena; Fidalgo, Teresa; Martinho, Patricia; Lopez-Fernandez, Maria Fernanda; Rodriguez-Trillo, Angela; Loures, Esther; Parra, Rafael; Altisent, Carme; Cid, Ana Rosa; Bonanad, Santiago; Cabrera, Noelia; Moret, Andres; Mingot-Castellano, Maria Eva; Navarro, Nira; Perez-Montes, Rocio; Marcellini, Sally; Moreto, Ana; Herrero, Sonia; Soto, Inmaculada; Fernandez-Mosteirin, Nuria; Jimenez-Yuste, Victor; Alonso, Nieves; de Andres-Jacob, Aurora; Fontanes, Emilia; Campos, Rosa; Paloma, Maria Jose; Bermejo, Nuria; Berrueco, Ruben; Mateo, Jose; Arribalzaga, Karmele; Marco, Pascual; Palomo, Angeles; Castro Quismondo, Nerea; Inigo, Belen; Nieto, Maria Del Mar; Vidal, Rosa; Martinez, Maria Paz; Aguinaco, Reyes; Tenorio, Jesus Maria; Ferreiro, Maria; Garcia-Frade, Javier; Rodriguez-Huerta, Ana Maria; Cuesta, Jorge; Rodriguez-Gonzalez, Ramon; Garcia-Candel, Faustino; Dobon, Manuela; Aguilar, Carlos; Vidal, Francisco; Corrales, Irene
Haematologica 2018
Improvement in clinical outcomes and replacement factor VIII use in patients with haemophilia A after factor VIII pharmacokinetic-guided prophylaxis based on Bayesian models with myPKFiT (R)
Mingot-Castellano, ME; Parra, R; Nunez, R; Martorell, M
Haemophilia 2018
Eltrombopag for advanced myelodysplastic syndromes or acute myeloid leukaemia and severe thrombocytopenia (ASPIRE): a randomised, placebo-controlled, phase 2 trial
Mittelman, M; Platzbecker, U; Afanasyev, B; Grosicki, S; Wong, RSM; Anagnostopoulos, A; Brenner, B; Denzlinger, C; Rossi, G; Nagler, A; Garcia-Delgado, R; Portella, MSO; Zhu, ZW; Selleslag, D
Lancet Haematology 2018
Frequency and prognostic significance of additional cytogenetic abnormalities to the Philadelphia chromosome in young and older adults with acute lymphoblastic leukemia
Motllo, C; Ribera, JM; Morgades, M; Granada, I; Montesinos, P; Mercadal, S; Gonzaalez-Campos, J; Moreno, MJ; Barba, P; Cervera, M; Barrios, M; Novo, A; Bernal, T; Hernaandez-Rivas, JM; Abella, E; Amigo, ML; Tormo, M; Martino, R; Lavilla, E; Bergua, J; Serrano, A; Garciia-Belmonte, D; Guaardia, R; Grau, J; Feliu, E
Leukemia & Lymphoma 2018
Multirefractory primary immune thrombocytopenia; targeting the decreased sialic acid content.
Revilla, Nuria; Corral, Javier; Minano, Antonia; Mingot-Castellano, Maria Eva; Campos, Rosa Maria; Velasco, Francisco; Gonzalez, Nicolas; Galvez, Eva; Berrueco, Ruben; Fuentes, Inmaculada; Gonzalez-Lopez, Tomas Jose; de la Morena-Barrio, Maria Eugenia; Gonzalez-Porras, Jose Ramon; Vicente, Vicente; Lozano, Maria Luisa
Platelets 2018
Role of multimeric analysis of von Willebrand factor (VWF) in von Willebrand disease (VWD) diagnosis: Lessons from the PCM-EVW-ES Spanish project
Perez-Rodriguez, A; Batlle, J; Corrales, I; Borras, N; Rodriguez-Trillo, A; Loures, E; Cid, AR; Bonanad, S; Cabrera, N; Moret, A; Parra, R; Mingot-Castellano, ME; Navarro, N; Altisent, C; Perez-Montes, R; Marcellini, S; Moreto, A; Herrero, S; Soto, I; Mosteirin, NF; Jimenez-Yuste, V; Alonso, N; Jacob, AD; Fontanes, E; Campos, R; Paloma, MJ; Bermejo, N; Berrueco, R; Mateo, J; Arribalzaga, K; Marco, P; Palomo, A; Quismondo, NC; Inigo, B; Nieto, MD; Vidal, R; Martinez, MP; Aguinaco, R; Tenorio, M; Ferreiro, M; Garcia-Frade, J; Rodriguez-Huerta, AM; Cuesta, J; Rodriguez-Gonzalez, R; Garcia-Candel, F; Dobon, M; Aguilar, C; Batlle, F; Vidal, F; Lopez-Fernandez, MF
Plos One 2018
Donor Selection Based on Killer Cell Immunoglobulin-Like Receptor (KIR) Genotype May Improve Outcome After T-Cell-Replete Haploidentical Transplantation
Torio, A; Pascual, MJ; Vidales, I; Ortiz, M; Caballero, A; Heiniger, AI
Transplantation Proceedings 2018
A BCR-ABL1 cutoff of 1.5% at 3 months, determined by the GeneXpert system, predicts an optimal response in patients with chronic myeloid leukemia
Garcia-Gutierrez, V; Gomez-Casares, MT; Puerta, JM; Alonso-Dominguez, JM; Osorio, S; Hernandez-Boiuda, JC; Collado, R; Ramirez, MJ; Ibanez, F; Martin, ML; Rodriguez-Gambarte, JD; Martinez-Laperche, C; Gomez, M; Fiallo, DV; Redondo, S; Rodriguez, A; Ruiz-Nuno, C; Steegmann, JL; Jimenez-Velasco, APlos One. 2017
Donor CTLA-4 Genotype Modulates the Immune Response to Minor Histocompatibility Antigen Mismatches
Gallardo, D; Bosch-Vizcaya, A; Rodriguez-Romanos, R; Santos, N; Buno, I; de la Camara, R; Brunet, S; Jimenez-Velasco, A; Gonzalez, M; Nieto, JB; Martinez-Laperche, C; Vallejo, C; Ferra, C; Sampol, A; Lopez-Jimenez, J; Perez-Simon, JA; Martinez, C; Diez, JLBiology Of Blood And Marrow Transplantation. 2017
Molecular and clinical profile of von Willebrand disease in Spain (PCM-EVW-ES): comprehensive genetic analysis by next-generation sequencing of 480 patients
Borras, N; Batlle, J; Perez-Rodriguez, A; Lopez-Fernandez, MF; Rodriguez-Trillo, A; Loures, E; Cid, AR; Bonanad, S; Cabrera, N; Moret, A; Parra, R; Mingot-Castellano, ME; Balda, I; Altisent, C; Perez-Montes, R; Fisac, RM; Iruin, G; Herrero, S; Soto, I; de Rueda, B; Jimenez-Yuste, V; Alonso, N; Vilarino, D; Arija, O; Campos, R; Paloma, MJ; Bermejo, N; Berrueco, R; Mateo, J; Arribalzaga, K; Marco, P; Palomo, A; Sarmiento, L; Inigo, B; Nieto, MD; Vidal, R; Martinez, MP; Aguinaco, R; Cesar, JM; Ferreiro, M; Garcia-Frade, J; Rodriguez-Huerta, AM; Cuesta, J; Rodriguez-Gonzalez, R; Garcia-Candel, F; Cornudella, R; Aguilar, C; Vidal, F; Corrales, IHaematologica. 2017
Adipose tissue-derived mesenchymal stromal cells as part of therapy for chronic graft-versus-host disease: A phase I/II study
Jurado, M (Jurado, Manuel)[ 1,2 ] ; De La Mata, C (De La Mata, Claudia)[ 1 ] ; Ruiz-Garcia, A (Ruiz-Garcia, Antonio)[ 3 ] ; Lopez-Fernandez, E (Lopez-Fernandez, Elisa)[ 1 ] ; Espinosa, O (Espinosa, Olga)[ 3 ] ; Remigia, MJ (Jose Remigia, Maria)[ 4 ] ; Moratalla, L (Moratalla, Lucia)[ 1 ] ; Goterris, R (Goterris, Rosa)[ 4 ] ; Garcia-Martin, P (Garcia-Martin, Paloma)[ 1 ] ; Ruiz-Cabello, F (Ruiz-Cabello, Francisco)[ 5 ] ; Garzon, S (Garzon, Sebastian)[ 6 ] ; Pascual, MJ (Jesus Pascual, Maria)[ 7 ] ; Espigado, I (Espigado, Ildefonso)[ 8 ] ; Solano, C (Solano, Carlos)Cytotherapy. 2017
Clinical characteristics of patients with central nervous system relapse in BCR-ABL1-positive acute lymphoblastic leukemia: the importance of characterizing ABL1 mutations in cerebrospinal fluid
Sanchez, R; Ayala, R; Alonso, RA; Martinez, MP; Ribera, J; Garcia, O; Sanchez-Pina, J; Mercadal, S; Montesinos, P; Martino, R; Barba, P; Gonzalez-Campos, J; Barrios, M; Lavilla, E; Gil, C; Bernal, T; Escoda, L; Abella, E; Amigo, ML; Moreno, MJ; Bravo, P; Guardia, R; Hernandez-Rivas, JM; Garcia-Guinon, A; Piernas, S; Ribera, JM; Martinez-Lopez, JAnnals Of Hematology. 2017
Imatinib dose reduction in patients with chronic myeloid leukemia in sustained deep molecular response
Cervantes, F; Correa, JG; Perez, I; Garcia-Gutierrez, V; Redondo, S; Colomer, D; Jimenez-Velasco, A; Steegmann, JL; Sanchez-Guijo, F; Ferrer-Marin, F; Pereira, A; Osorio, SAnnals Of Hematology. 2017
Natural history and clinical characteristics of inhibitors in previously treated haemophilia A patients: a case series
Iorio, A; Barbara, AM; Makris, M; Fischer, K; Castaman, G; Catarino, C; Gilman, E; Kavakli, K; Lambert, T; Lassila, R; Lissitchkov, T; Mauser-Bunschoten, E; Mingot-Castellano, ME; Ozdemir, N; Pabinger, I; Parra, R; Pasi, J; Peerlinck, K; Rauch, A; Roussel-Robert, V; Serban, M; Tagliaferri, A; Windyga, J; Zanon, EHaemophilia. 2017
Predictive factors for anemia response to erythropoiesis-stimulating agents in myelofibrosis
Hernandez-Boluda, JC; Correa, JG; Garcia-Delgado, R; Martinez-Lopez, J; Alvarez-Larran, A; Fox, ML; Garcia-Gutierrez, V; Perez-Encinas, M; Ferrer-Marin, F; Mata-Vazquez, MI; Raya, JM; Estrada, N; Garcia, S; Kerguelen, A; Duran, MA; Albors, M; Cervantes, FEuropean Journal Of Haematology. 2017
Single-agent GvHD prophylaxis with tacrolimus after post-transplant high-dose cyclophosphamide is a valid option for haploidentical transplantation in adults with hematological malignancies
Esquirol A, Pascual MJ, Ortiz M, Piñana JL, Ferra C, Garcia Cadenas I, Vilades
I, Brunet S, Martino R, Sierra JBone Marrow Transplantation. 2017
Acquired haemophilia: Epidemiology, clinical presentation, diagnosis and treatment
Mingot-Castellano, ME; Nunez, R; Rodriguez-Martorell, FJMedicina Clinica. 2017
Characteristics and management of primary and other immune thrombocytopenias: Spanish registry study
Palau, J; Sancho, E; Herrera, M; Sanchez, S; Mingot, ME; Upegui, RI; Salazar, MJR; de la Cruz, F; Fernandez, MC; Lopez, TJG; Hernandez, JJ; Rios, E; Lopez-Fernandez, MF; Garcia, M; Hernandez, JA; Sanz, MAHematology. 2017
Sustained Remission in Patients with Primary Immune Thrombocytopenia after Romiplostim Tapering and Discontinuation: A Case Series in Real Life Management in Spain
Mingot-Castelano, ME; Grande-Garcia, C; Valcarcel-Ferreiras, D; Conill-Cortes, C; De Olivar-Oliver, LCase Reports In Hematology. 2017
Enlaces
Calle Doctor Miguel Díaz Recio , 28 Málaga 29010
(+34) 951 440 260
Fax: (+34) 951 440 263