Lineas de Investigación

01. Investigación traslacional sobre el efecto de polifenoles del aceite de oliva sobre inflamación vascular y las complicaciones micro y macroagiopáticas en pacientes con diabetes tipo 2.

02. Evaluación de biomarcadores y factores de riesgo relacionados con la evolución de la retinopatía diabética.

03. Evaluación del nivel de respuesta al tratamiento antiagregante con ácido acetilsalicílico en pacientes con diabetes tipo 2 en atención primaria.

04. Caracterización de las fracciones funcionales de la aceituna, formulación de nuevos productos y análisis de sus efectos

05. Intensificación de las actividades en farmacovigilancia mediante un cambio organizativo e intervención formativa en una UGC de Atención Primaria.



Proyectos de Investigación

PI-0120-2020 Efectividad de la asociación aceite de oliva virgen extra- ácido acetilsalicílico vs. ácido acetilsalicílico cada 12 h sobre la resistencia al tratamiento antiagregante en pacientes con diabetes mellitus tipo 2.

Consejería de Salud y Familias
. 2020

PS17173 NUTRADAF,ITC-20161265 Caracterización de las fracciones funcionales de la aceituna, formulación de nuevos productos y análisis de sus defectos

CENTRO PARA EL DESARROLLO TECNOLÓGICO INDUSTRIAL
PROGRAMA FEDER INNTERCONECTA PLURI-REGIONAL 2016

PS17174 NUTRADAF,ITC-20161265 Caracterización de las fracciones funcionales de la aceituna, formulación de nuevos productos y análisis de sus defectos

CENTRO PARA EL DESARROLLO TECNOLÓGICO INDUSTRIAL
PROGRAMA FEDER INNTERCONECTA PLURI-REGIONAL 2016

PI-0129-2017 Efecto Sinérgico de Compuestos Fenólicos del Aceite de Oliva Sobre la Inflamación Vascular en Diabetes

CONSEJERÍA DE SALUD
PROYECTOS DE INVESTIGACIÓN EN SALUD 2017

Publicaciones científicas

  • Todo
  • D1
  • Q1
  • Q2
  • Otro


An overview of international regulatory frameworks for mesenchymal stromal cell-based medicinal products: From laboratory to patient

López-Beas J, Guadix JA, Clares B, Soriano-Ruiz JL, Zugaza JL, Gálvez-Martín P
Med Res Rev 2020 Jul;40(4):1315-1334


Embryonic circulating endothelial progenitor cells

Díaz Del Moral S, Barrena S, Muñoz-Chápuli R, Carmona R
Angiogenesis 2020 Nov;23(4):531-541


Epicardial cell lineages and the origin of the coronary endothelium

Carmona R, Barrena S, López Gambero AJ, Rojas A, Muñoz-Chápuli R
FASEB J 2020 Apr;34(4):5223-5239


Indolenine-Based Derivatives as Customizable Two-Photon Fluorescent Probes for pH Bioimaging in Living Cells

Benitez-Martin C, Guadix JA, Pearson JR, Najera F, Perez-Pomares JM, Perez-Inestrosa E
ACS Sens 2020 Apr 24;5(4):1068-1074


Single-Cell RNA Sequencing Analysis Reveals a Crucial Role for CTHRC1 (Collagen Triple Helix Repeat Containing 1) Cardiac Fibroblasts After Myocardial Infarction

Ruiz-Villalba A, Romero JP, Hernández SC, Vilas-Zornoza A, Fortelny N, Castro-Labrador L, San Martin-Uriz P, Lorenzo-Vivas E, García-Olloqui P, Palacio M, Gavira JJ, Bastarrika G, Janssens S, Wu M, Iglesias E, Abizanda G, de Morentin XM, Lasaga M, Planell N, Bock C, Alignani D, Medal G, Prudovsky I, Jin YR, Ryzhov S, Yin H, Pelacho B, Gomez-Cabrero D, Lindner V, Lara-Astiaso D, Prósper F
Circulation 2020 Nov 10;142(19):1831-1847


Two genomic regions encoding exopolysaccharide production systems have complementary functions in B

Caro-Astorga J, Álvarez-Mena A, Hierrezuelo J, Guadix JA, Heredia-Ponce Z, Arboleda-Estudillo Y, González-Munoz E, de Vicente A, Romero D
cereus multicellularity and host interaction Sci Rep


Analysis of Fall Risk Factors in an Aging Population Living in Long-Term Care Institutions in SPAIN: A Retrospective Cohort Study

Díaz LB, Casuso-Holgado MJ, Labajos-Manzanares MT, Barón-López FJ, Pinero-Pinto E, Romero-Galisteo RP, Moreno-Morales N
Int J Environ Res Public Health 2020 Oct 3;17(19):7234


The Inventory of Quality in Early Intervention Centres for Service Providers: Preliminary Validating Study in a Spanish Sample

Jemes-Campaña IC, Romero-Galisteo RP, Labajos-Manzanares MT, Gálvez-Ruiz P, Moreno-Morales N
Int J Environ Res Public Health 2020 Apr 9;17(7):2581


Descriptive study of sickness absence in Spanish regions in 2018: database study

Alba-Jurado ML, Aguado-Benedí MJ, Moreno-Morales N, Labajos-Manzanares MT, Martín-Valero R
BMJ Open 2020 Oct 30;10(10):e038239

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  4. Ma, X, Wu, J, Jiang, L, Wang, M, Deng, G, Qu, S et al.. On-chip integration of a metal-organic framework nanomaterial on a SiO2 waveguide for sensitive VOC sensing. Lab Chip. 2021;21 (17):3298-3306. doi: 10.1039/d1lc00503k. PubMed PMID:34378614 .
  5. Yang, M, Chen, Y, Yan, P, Dong, J, Duan, W, Xu, L et al.. A photoelectrochemical aptasensor of ciprofloxacin based on Bi24O31Cl10/BiOCl heterojunction. Mikrochim Acta. 2021;188 (9):289. doi: 10.1007/s00604-021-04952-5. PubMed PMID:34355248 .
  6. Willson-Kerns, C, Brazile, WJ. Noise Exposure and Evaluation at Tire- Changing Facilities. Ann Work Expo Health. 2021; :. doi: 10.1093/annweh/wxab031. PubMed PMID:34228059 .
  7. Zou, Z, Shi, ZZ, Wu, JG, Wu, C, Zeng, QX, Zhang, YY et al.. Atomically Dispersed Co to an End-Adsorbing Molecule for Excellent Biomimetically and Prime Sensitively Detecting O2•- Released from Living Cells. Anal Chem. 2021;93 (31):10789-10797. doi: 10.1021/acs.analchem.1c00483. PubMed PMID:34212722 .
  8. Khalil, S, Elnaggar, AY. Selective Membrane Sensor for Aluminum Determination in Food Products, Real Samples and Standard Alloys. Membranes (Basel). 2021;11 (7):. doi: 10.3390/membranes11070504. PubMed PMID:34209425 PubMed Central PMC8308029.
  9. Areo, OM, Njobeh, PB. Risk assessment of heavy metals in rooibos (Aspalathus linearis) tea consumed in South Africa. Environ Sci Pollut Res Int. 2021; :. doi: 10.1007/s11356-021-14968-2. PubMed PMID:34145539 .
  10. Kapten, K, Orczyk, K, Smolewska, E. The effect of vitamin D3 and thyroid hormones on the capillaroscopy-confirmed microangiopathy in pediatric patients with a suspicion of systemic connective tissue disease-a single-center experience with Raynaud phenomenon. Rheumatol Int. 2021;41 (8):1485-1493. doi: 10.1007/s00296-021-04919-y. PubMed PMID:34132891 PubMed Central PMC8207495.
  11. Lim, JS, Ha, JW. Growth temperature influences the resistance of Escherichia coli O157:H7 and Salmonella enterica serovar Typhimurium on lettuce to X-ray irradiation. Food Microbiol. 2021;99 :103825. doi: 10.1016/j.fm.2021.103825. PubMed PMID:34119110 .
  12. Lim, J, Kim, E, Shin, Y, Ryu, JH, Kim, H. Antimicrobial activity of ClO2 gas against Salmonella Enteritidis on almonds. Food Microbiol. 2021;99 :103819. doi: 10.1016/j.fm.2021.103819. PubMed PMID:34119104 .
  13. Mehmood, K, Bao, Y, Abbas, R, Saifullah,, Petropoulos, GP, Ahmad, HR et al.. Pollution characteristics and human health risk assessments of toxic metals and particle pollutants via soil and air using geoinformation in urbanized city of Pakistan. Environ Sci Pollut Res Int. 2021; :. doi: 10.1007/s11356-021-14436-x. PubMed PMID:34110590 .
  14. Lee, HJ, Chun, KY, Oh, JH, Han, CS. Wearable Triboelectric Strain-Insensitive Pressure Sensors Based on Hierarchical Superposition Patterns. ACS Sens. 2021;6 (6):2411-2418. doi: 10.1021/acssensors.1c00640. PubMed PMID:34100591 .
  15. Liu, B, Yan, Y, Liang, H, Tang, K, Ding, CF. One-step preparation of carbonaceous spheres rich in phosphate groups via hydrothermal carbonization for effective phosphopeptides enrichment. J Chromatogr A. 2021;1651 :462285. doi: 10.1016/j.chroma.2021.462285. PubMed PMID:34090058 .
  16. Chen, ZE, Zang, XF, Zhang, H. An ethyl thioglycolate-based chemosensor: Spectrophotometric detection of Fe3+ and fluorometric detection of Hg2+ with high selectivity. Spectrochim Acta A Mol Biomol Spectrosc. 2021;260 :119955. doi: 10.1016/j.saa.2021.119955. PubMed PMID:34082353 .
  17. Akter, S, Lamminmäki, U. A 15-min non-competitive homogeneous assay for microcystin and nodularin based on time-resolved Förster resonance energy transfer (TR-FRET). Anal Bioanal Chem. 2021;413 (24):6159-6170. doi: 10.1007/s00216-021-03375-8. PubMed PMID:34080035 .
  18. Lee, S, Kang, D, Kim, Y, Kim, YJ, Kim, SY. Activity-Based Exposure Levels and Cancer Risk Assessment Due to Naturally Occurring Asbestos for the Residents Near Abandoned Asbestos Mines in South Korea. Int J Environ Res Public Health. 2021;18 (10):. doi: 10.3390/ijerph18105225. PubMed PMID:34069013 PubMed Central PMC8156354.
  19. Shah, A, Tauseef, I, Ali, MB, Yameen, MA, Mezni, A, Hedfi, A et al.. In-Vitro and In-Vivo Tolerance and Therapeutic Investigations of Phyto-Fabricated Iron Oxide Nanoparticles against Selected Pathogens. Toxics. 2021;9 (5):. doi: 10.3390/toxics9050105. PubMed PMID:34066825 PubMed Central PMC8150543.
  20. Bullard, TJ, Susner, MA, Taddei, KM, Brant, JA, Haugan, TJ. Magnetic and structural properties of the solid solution CuAl2(1-x)Ga2xO4. Sci Rep. 2021;11 (1):11355. doi: 10.1038/s41598-021-89197-1. PubMed PMID:34059700 PubMed Central PMC8167108.
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  1. Maldonado-Araque, C, Valdés, S, Lago-Sampedro, A, Lillo-Muñoz, JA, Garcia-Fuentes, E, Perez-Valero, V et al.. Iron deficiency is associated with Hypothyroxinemia and Hypotriiodothyroninemia in the Spanish general adult population: Di@bet.es study. Sci Rep. 2018;8 (1):6571. doi: 10.1038/s41598-018-24352-9. PubMed PMID:29700318 PubMed Central PMC5919900.
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  1. González-Correa, JA, Rodríguez-Pérez, MD, Márquez-Estrada, L, López-Villodres, JA, Reyes, JJ, Rodriguez-Gutierrez, G et al.. Neuroprotective Effect of Hydroxytyrosol in Experimental Diabetic Retinopathy: Relationship with Cardiovascular Biomarkers. J Agric Food Chem. 2018;66 (3):637-644. doi: 10.1021/acs.jafc.7b05063. PubMed PMID:29278909 .
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  1. Sankoh, A, Jin, W, Zhong, Z, He, J, Hong, Y, Giddings, R et al.. DFT-Spread Spectrally Overlapped Hybrid OFDM-Digital Filter Multiple Access IMDD PONs. Sensors (Basel). 2021;21 (17):. doi: 10.3390/s21175903. PubMed PMID:34502798 PubMed Central PMC8433889.
  2. Park, YJ, Woo, HY, Kim, MB, Ahn, J, Heo, J. Primary hepatic sarcoidosis presenting with cholestatic liver disease and mimicking primary biliary cholangitis. Yeungnam Univ J Med. 2021; :. doi: 10.12701/yujm.2021.01151. PubMed PMID:34411476 .
  3. Orellana Mendoza, E, Cuadrado, W, Yallico, L, Zárate, R, Quispe-Melgar, HR, Limaymanta, CH et al.. Heavy metals in soils and edible tissues of Lepidium meyenii (maca) and health risk assessment in areas influenced by mining activity in the Central region of Peru. Toxicol Rep. 2021;8 :1461-1470. doi: 10.1016/j.toxrep.2021.07.016. PubMed PMID:34401355 PubMed Central PMC8353470.
  4. Ma, X, Wu, J, Jiang, L, Wang, M, Deng, G, Qu, S et al.. On-chip integration of a metal-organic framework nanomaterial on a SiO2 waveguide for sensitive VOC sensing. Lab Chip. 2021;21 (17):3298-3306. doi: 10.1039/d1lc00503k. PubMed PMID:34378614 .
  5. Yang, M, Chen, Y, Yan, P, Dong, J, Duan, W, Xu, L et al.. A photoelectrochemical aptasensor of ciprofloxacin based on Bi24O31Cl10/BiOCl heterojunction. Mikrochim Acta. 2021;188 (9):289. doi: 10.1007/s00604-021-04952-5. PubMed PMID:34355248 .
  6. Willson-Kerns, C, Brazile, WJ. Noise Exposure and Evaluation at Tire- Changing Facilities. Ann Work Expo Health. 2021; :. doi: 10.1093/annweh/wxab031. PubMed PMID:34228059 .
  7. Zou, Z, Shi, ZZ, Wu, JG, Wu, C, Zeng, QX, Zhang, YY et al.. Atomically Dispersed Co to an End-Adsorbing Molecule for Excellent Biomimetically and Prime Sensitively Detecting O2•- Released from Living Cells. Anal Chem. 2021;93 (31):10789-10797. doi: 10.1021/acs.analchem.1c00483. PubMed PMID:34212722 .
  8. Khalil, S, Elnaggar, AY. Selective Membrane Sensor for Aluminum Determination in Food Products, Real Samples and Standard Alloys. Membranes (Basel). 2021;11 (7):. doi: 10.3390/membranes11070504. PubMed PMID:34209425 PubMed Central PMC8308029.
  9. Areo, OM, Njobeh, PB. Risk assessment of heavy metals in rooibos (Aspalathus linearis) tea consumed in South Africa. Environ Sci Pollut Res Int. 2021; :. doi: 10.1007/s11356-021-14968-2. PubMed PMID:34145539 .
  10. Kapten, K, Orczyk, K, Smolewska, E. The effect of vitamin D3 and thyroid hormones on the capillaroscopy-confirmed microangiopathy in pediatric patients with a suspicion of systemic connective tissue disease-a single-center experience with Raynaud phenomenon. Rheumatol Int. 2021;41 (8):1485-1493. doi: 10.1007/s00296-021-04919-y. PubMed PMID:34132891 PubMed Central PMC8207495.
  11. Lim, JS, Ha, JW. Growth temperature influences the resistance of Escherichia coli O157:H7 and Salmonella enterica serovar Typhimurium on lettuce to X-ray irradiation. Food Microbiol. 2021;99 :103825. doi: 10.1016/j.fm.2021.103825. PubMed PMID:34119110 .
  12. Lim, J, Kim, E, Shin, Y, Ryu, JH, Kim, H. Antimicrobial activity of ClO2 gas against Salmonella Enteritidis on almonds. Food Microbiol. 2021;99 :103819. doi: 10.1016/j.fm.2021.103819. PubMed PMID:34119104 .
  13. Mehmood, K, Bao, Y, Abbas, R, Saifullah,, Petropoulos, GP, Ahmad, HR et al.. Pollution characteristics and human health risk assessments of toxic metals and particle pollutants via soil and air using geoinformation in urbanized city of Pakistan. Environ Sci Pollut Res Int. 2021; :. doi: 10.1007/s11356-021-14436-x. PubMed PMID:34110590 .
  14. Lee, HJ, Chun, KY, Oh, JH, Han, CS. Wearable Triboelectric Strain-Insensitive Pressure Sensors Based on Hierarchical Superposition Patterns. ACS Sens. 2021;6 (6):2411-2418. doi: 10.1021/acssensors.1c00640. PubMed PMID:34100591 .
  15. Liu, B, Yan, Y, Liang, H, Tang, K, Ding, CF. One-step preparation of carbonaceous spheres rich in phosphate groups via hydrothermal carbonization for effective phosphopeptides enrichment. J Chromatogr A. 2021;1651 :462285. doi: 10.1016/j.chroma.2021.462285. PubMed PMID:34090058 .
  16. Chen, ZE, Zang, XF, Zhang, H. An ethyl thioglycolate-based chemosensor: Spectrophotometric detection of Fe3+ and fluorometric detection of Hg2+ with high selectivity. Spectrochim Acta A Mol Biomol Spectrosc. 2021;260 :119955. doi: 10.1016/j.saa.2021.119955. PubMed PMID:34082353 .
  17. Akter, S, Lamminmäki, U. A 15-min non-competitive homogeneous assay for microcystin and nodularin based on time-resolved Förster resonance energy transfer (TR-FRET). Anal Bioanal Chem. 2021;413 (24):6159-6170. doi: 10.1007/s00216-021-03375-8. PubMed PMID:34080035 .
  18. Lee, S, Kang, D, Kim, Y, Kim, YJ, Kim, SY. Activity-Based Exposure Levels and Cancer Risk Assessment Due to Naturally Occurring Asbestos for the Residents Near Abandoned Asbestos Mines in South Korea. Int J Environ Res Public Health. 2021;18 (10):. doi: 10.3390/ijerph18105225. PubMed PMID:34069013 PubMed Central PMC8156354.
  19. Shah, A, Tauseef, I, Ali, MB, Yameen, MA, Mezni, A, Hedfi, A et al.. In-Vitro and In-Vivo Tolerance and Therapeutic Investigations of Phyto-Fabricated Iron Oxide Nanoparticles against Selected Pathogens. Toxics. 2021;9 (5):. doi: 10.3390/toxics9050105. PubMed PMID:34066825 PubMed Central PMC8150543.
  20. Bullard, TJ, Susner, MA, Taddei, KM, Brant, JA, Haugan, TJ. Magnetic and structural properties of the solid solution CuAl2(1-x)Ga2xO4. Sci Rep. 2021;11 (1):11355. doi: 10.1038/s41598-021-89197-1. PubMed PMID:34059700 PubMed Central PMC8167108.
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