Lineas de Investigación

01. Investigación traslacional sobre el efecto de polifenoles del aceite de oliva sobre inflamación vascular y las complicaciones micro y macroagiopáticas en pacientes con diabetes tipo 2.

02. Evaluación de biomarcadores y factores de riesgo relacionados con la evolución de la retinopatía diabética.

03. Evaluación del nivel de respuesta al tratamiento antiagregante con ácido acetilsalicílico en pacientes con diabetes tipo 2 en atención primaria.

04. Caracterización de las fracciones funcionales de la aceituna, formulación de nuevos productos y análisis de sus efectos

05. Intensificación de las actividades en farmacovigilancia mediante un cambio organizativo e intervención formativa en una UGC de Atención Primaria.



Proyectos de Investigación

PI-0120-2020 Efectividad de la asociación aceite de oliva virgen extra- ácido acetilsalicílico vs. ácido acetilsalicílico cada 12 h sobre la resistencia al tratamiento antiagregante en pacientes con diabetes mellitus tipo 2.

Consejería de Salud y Familias
. 2020

PS17173 NUTRADAF,ITC-20161265 Caracterización de las fracciones funcionales de la aceituna, formulación de nuevos productos y análisis de sus defectos

CENTRO PARA EL DESARROLLO TECNOLÓGICO INDUSTRIAL
PROGRAMA FEDER INNTERCONECTA PLURI-REGIONAL 2016

PS17174 NUTRADAF,ITC-20161265 Caracterización de las fracciones funcionales de la aceituna, formulación de nuevos productos y análisis de sus defectos

CENTRO PARA EL DESARROLLO TECNOLÓGICO INDUSTRIAL
PROGRAMA FEDER INNTERCONECTA PLURI-REGIONAL 2016

PI-0129-2017 Efecto Sinérgico de Compuestos Fenólicos del Aceite de Oliva Sobre la Inflamación Vascular en Diabetes

CONSEJERÍA DE SALUD
PROYECTOS DE INVESTIGACIÓN EN SALUD 2017

Publicaciones científicas

  • Todo
  • D1
  • Q1
  • Q2
  • Otro
Association between the Mediterranean Diet and Metabolic Syndrome with Serum Levels of miRNA in Morbid Obesity

Fontalba-Romero MI, Lopez-Enriquez S, Lago-Sampedro A, García-Escobar E, Pastori RL, et al. Nutrients 2021 Jan 29;13(2):

Extra Virgin Oil Polyphenols Improve the Protective Effects of Hydroxytyrosol in an In Vitro Model of Hypoxia-Reoxygenation of Rat Brain

De La Cruz Cortés JP, Pérez de Algaba I, Martín-Aurioles E, Arrebola MM, Ortega-Hombrados L, et al. Brain sciences 2021 Aug 26;11(9):

Her2-Positive and Microsatellite Instability Status in Gastric Cancer-Clinicopathological Implications

Bermúdez A, Arranz-Salas I, Mercado S, López-Villodres JA, González V, et al. Diagnostics (Basel, Switzerland) 2021 May 25;11(6):

Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect

Rodríguez-Pérez MD, López-Villodres JA, Arrebola MM, Martín-Aurioles E, Fernández-Prior Á, et al. Antioxidants (Basel, Switzerland) 2021 Nov 8;10(11):

Occupation and Sickness Absence in the Different Autonomous Communities of Spain

Alba-Jurado ML, Aguado-Benedí MJ, Moreno-Morales N, Labajos-Manzanares MT, Martín-Valero R International journal of environmental research and public health 2021 Oct 30;18(21):

Service Quality in Early Intervention Centres: An Analysis of Its Influence on Satisfaction and Family Quality of Life

Jemes-Campaña IC, Romero-Galisteo RP, Gálvez-Ruiz P, Labajos-Manzanares MT, Moreno-Morales N Children (Basel, Switzerland) 2021 Aug 21;8(8):

Synergistic Effect of 3 ‘,4 ‘-Dihidroxifenilglicol and Hydroxytyrosol on Oxidative and Nitrosative Stress and Some Cardiovascular Biomarkers in an Experimental Model of Type 1 Diabetes Mellitus

De La Cruz Cortés JP, Vallejo-Carmona L, Arrebola MM, Martín-Aurioles E, Rodriguez-Pérez MD, et al. Antioxidants (Basel, Switzerland) 2021 Dec 13;10(12):

Systematic Review of Therapeutic Physical Exercise in Patients with Amyotrophic Lateral Sclerosis over Time

Ortega-Hombrados L, Molina-Torres G, Galán-Mercant A, Sánchez-Guerrero E, González-Sánchez M, et al. International journal of environmental research and public health 2021 Jan 26;18(3):

Analysis of Fall Risk Factors in an Aging Population Living in Long-Term Care Institutions in SPAIN: A Retrospective Cohort Study

Díaz LB, Casuso-Holgado MJ, Labajos-Manzanares MT, Barón-López FJ, Pinero-Pinto E, et al. International journal of environmental research and public health 2020 Oct 3;17(19):

Descriptive study of sickness absence in Spanish regions in 2018: database study

Alba-Jurado ML, Aguado-Benedí MJ, Moreno-Morales N, Labajos-Manzanares MT, Martín-Valero R BMJ open 2020 Oct 30;10(10):e038239

Post-traumatic stress disorder after subsequent birth to a gestational loss: An observational study

Ordonez, EF; Diaz, CR; Gil, IMM; Manzanares, MTL SALUD MENTAL 2020

The Inventory of Quality in Early Intervention Centres for Service Providers: Preliminary Validating Study in a Spanish Sample

Jemes-Campaña IC, Romero-Galisteo RP, Labajos-Manzanares MT, Gálvez-Ruiz P, Moreno-Morales N International journal of environmental research and public health 2020 Apr 9;17(7):

Association between seasonal serum folate levels and ultraviolet radiation

Valencia-Vera E, Aguilera J, Cobos A, Bernabó JL, Pérez-Valero V, et al. Journal of photochemistry and photobiology. B, Biology 2019 Jan;190():66-71

Evaluation of Inappropriate Prescribing in Patients Older than 65 Years in Primary Health Care

Nuñez-Montenegro A, Montiel-Luque A, Martin-Aurioles E, Garcia-Dillana F, Krag-Jiménez M, et al. Journal of clinical medicine 2019 Mar 4;8(3):

Evaluation of quality of service in Early Intervention: A systematic review

Jemes Campaña IC, Romero-Galisteo RP, Labajos Manzanares MT, Moreno Morales N Anales de pediatria 2019 May;90(5):301-309

Well-Being, Self-Efficacy and Independence in older adults: A Randomized Trial of Occupational Therapy

Toledano-González A, Labajos-Manzanares T, Romero-Ayuso D Archives of gerontology and geriatrics 2019 Jul – Aug;83():277-284

Iron deficiency is associated with Hypothyroxinemia and Hypotriiodothyroninemia in the Spanish general adult population: Di@bet.es study

Maldonado-Araque C, Valdés S, Lago-Sampedro A, Lillo-Muñoz JA, Garcia-Fuentes E, et al. Scientific reports 2018 Apr 26;8(1):6571

Neuroprotective Effect of Hydroxytyrosol in Experimental Diabetic Retinopathy: Relationship with Cardiovascular Biomarkers

González-Correa JA, Rodríguez-Pérez MD, Márquez-Estrada L, López-Villodres JA, Reyes JJ, et al. Journal of agricultural and food chemistry 2018 Jan 24;66(3):637-644

Prevalence and Related Factors of Ineffective Self-Health Management in Polymedicated Patients Over the Age of 65 Years

Montiel-Luque A, Núñez-Montenegro AJ, Martín-Aurioles E, García-Dillana F, Toro-Toro MC, et al. International journal of nursing knowledge 2018 Apr;29(2):133-142

TIMI-AF score and cardiovascular events in vitamin K antagonists-naive outpatients with atrial fibrillation

Pérez Cabeza AI, Bravo Marques R, Chinchurreta Capote PA, Ruiz Mateas F, Fanola CL, et al. Clinical cardiology 2018 Sep;41(9):1252-1258

Does the acromiohumeral distance matter in chronic rotator cuff related shoulder pain?

Navarro-Ledesma S, Struyf F, Labajos-Manzanares MT, Fernandez-Sanchez M, Morales-Asencio JM, et al. Musculoskeletal science & practice 2017 Jun;29():38-42

Is coracohumeral distance associated with pain-function, and shoulder range of movement, in chronic anterior shoulder pain?

Navarro-Ledesma S, Struyf F, Labajos-Manzanares MT, Fernandez-Sanchez M, Luque-Suarez A BMC musculoskeletal disorders 2017 Apr 4;18(1):136

Medication-related factors associated with health-related quality of life in patients older than 65 years with polypharmacy

Montiel-Luque A, Núñez-Montenegro AJ, Martín-Aurioles E, Canca-Sánchez JC, Toro-Toro MC, et al. PloS one 2017;12(2):e0171320

Neuroprotective Effect of Hydroxytyrosol in Experimental Diabetes Mellitus

Reyes JJ, Villanueva B, López-Villodres JA, De La Cruz JP, Romero L, et al. Journal of agricultural and food chemistry 2017 Jun 7;65(22):4378-4383

Population-Based National Prevalence of Thyroid Dysfunction in Spain and Associated Factors: Di@bet.es Study

Valdés S, Maldonado-Araque C, Lago-Sampedro A, Lillo JA, Garcia-Fuentes E, et al. Thyroid : official journal of the American Thyroid Association 2017 Feb;27(2):156-166

Reference Values for TSH may be Inadequate to Define Hypothyroidism in Persons with Morbid Obesity: Di@bet.es Study

Valdés S, Maldonado-Araque C, Lago-Sampedro A, Lillo-Muñoz JA, Garcia-Fuentes E, et al. Obesity (Silver Spring, Md.) 2017 Apr;25(4):788-793

Contribution Levels of Intrinsic Risk Factors to the Management of Patients with Plantar Heel Pain A Pilot Study

Ortega-Avila AB, Cuesta-Vargas AI, Jiménez-Cebrián AM, Labajos-Manzanares MT, Barón-López FJ, et al. Journal of the American Podiatric Medical Association 2016 Mar;106(2):88-92

Effects of hydroxytyrosol on cardiovascular biomarkers in experimental diabetes mellitus

López-Villodres JA, Abdel-Karim M, De La Cruz JP, Rodríguez-Pérez MD, Reyes JJ, et al. The Journal of nutritional biochemistry 2016 Nov;37():94-100

Evaluation of the Bioavailability and Metabolism of Nitroderivatives of Hydroxytyrosol Using Caco-2 and HepG2 Human Cell Models

Gallardo E, Sarria B, Espartero JL, Gonzalez Correa JA, Bravo-Clemente L, et al. Journal of agricultural and food chemistry 2016 Mar 23;64(11):2289-97

Synthesis and Antioxidant Activity of Alkyl Nitroderivatives of Hydroxytyrosol

Gallardo E, Palma-Valdés R, Sarriá B, Gallardo I, de la Cruz JP, et al. Molecules (Basel, Switzerland) 2016 May 18;21(5):

The dynamic experience of pain in burn patients: A phenomenological study

Pérez Boluda MT, Morales Asencio JM, Carrera Vela A, García Mayor S, León Campos A, et al. Burns : journal of the International Society for Burn Injuries 2016 Aug;42(5):1097-1104

Changes in thyroid function with age: results from the Pizarra population-based longitudinal study

Lago-Sampedro AM, Gutiérrez-Repiso C, Valdés S, Maldonado C, Colomo N, et al. International journal of clinical practice 2015 May;69(5):577-87

C-peptide modifies leptin and visfatin secretion in human adipose tissue

Garcia-Serrano S, Gutiérrez-Repiso C, Gonzalo M, Garcia-Arnes J, Valdes S, et al. Obesity (Silver Spring, Md.) 2015 Aug;23(8):1607-15

Cross-reactivity of insulin analogues with three insulin assays

Dayaldasani A, Rodríguez Espinosa M, Ocón Sánchez P, Pérez Valero V Annals of clinical biochemistry 2015 May;52(Pt 3):312-8

Differences in the Neuroprotective Effect of Orally Administered Virgin Olive Oil (Olea europaea) Polyphenols Tyrosol and Hydroxytyrosol in Rats

De La Cruz JP, Ruiz-Moreno MI, Guerrero A, Reyes JJ, Benitez-Guerrero A, et al. Journal of agricultural and food chemistry 2015 Jul 1;63(25):5957-63

Role of the catechol group in the antioxidant and neuroprotective effects of virgin olive oil components in rat brain

De La Cruz JP, Ruiz-Moreno MI, Guerrero A, López-Villodres JA, Reyes JJ, et al. The Journal of nutritional biochemistry 2015 May;26(5):549-55

Study of paracetamol levels in serum samples as predictive indicator of gastric emptying].

Rodríguez Acosta MV, González Correa JA, Moreno Fontiveros MÁ, Benítez JA Nutricion hospitalaria 2015 Jun 1;31(6):2648-50


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