Lineas de Investigación

01. Preparación de estructuras dendrimericas para emular macromoléculas bioactivas multivalentes y visualizar sus interacciones.

02. Síntesis de nuevos sistemas dendrímeros y dendrones convenientemente funcionalizados.

03. Preparación de soportes sólidos (nanopartículas) para su funcioanlizació`n con sistemas dendriméricos.

04. PSíntesis de marcadores fluorescentes para sistemas dendriméricos.

05. Diseño y síntesis de sensores para el procesamiento de información biomédica.



Proyectos de Investigación

Perez-Inestrosa Villatoro, Ezequiel

IP Acciones Complementarias

Área 6.IBIMA Tech: Área Tecnología en Salud e Innovación

Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
. 2020

MOV19-001 Síntesis de nuevos cromóforos bifotónicos para aplicaciones en bioimagen.

Instituto de Investigación Biomédica de Málaga (IBIMA)
. 2019

PI-0250-2016 Desarrollo de Nuevos Nanobiosensores para el ..Desarrollo de Nuevos Nanobiosensores para el Diagnostico de Reacciones Adversas A Medicamentos

CONSEJERÍA DE SALUD
PROYECTOS DE INVESTIGACIÓN EN SALUD 2016


Publicaciones científicas

  • Todo
  • D1
  • Q1
  • Q2
  • Otro
ARADyAL: The Spanish Multidisciplinary Research Network for Allergic Diseases

Torres MJ, Agundez J, Barber D, Bartra J, Davila I, et al. Journal of investigational allergology & clinical immunology 2021 Apr 20;31(2):108-119

Dynamic Covalent Properties of a Novel Indolo[3,2-b]carbazole Diradical

Badía-Domínguez I, Peña-Álvarez M, Wang D, Pérez Guardiola A, Vida Y, et al. Chemistry (Weinheim an der Bergstrasse, Germany) 2021 Mar 22;27(17):5509-5520

E/Z Molecular Photoswitches Activated by Two-Photon Absorption: Comparison between Different Families

Marazzi M, García-Iriepa C, Benitez-Martin C, Najera F, Monari A, et al. Molecules (Basel, Switzerland) 2021 Dec 5;26(23):

Emerging glyco-based strategies to steer immune responses

Anderluh M, Berti F, Bzducha-Wróbel A, Chiodo F, Colombo C, et al. The FEBS journal 2021 Aug;288(16):4746-4772

Multiepitope Dendrimeric Antigen-Silica Particle Composites as Nano-Based Platforms for Specific Recognition of IgEs

Gil-Ocaña V, Jimenez IM, Mayorga C, Doña I, Céspedes JA, et al. Frontiers in immunology 2021;12():750109

Rapid amplitude-modulation of a diarylethene photoswitch: en route to contrast-enhanced fluorescence imaging

Naren G, Larsson W, Benitez-Martin C, Li S, Pérez-Inestrosa E, et al. Chemical science 2021 Apr 15;12(20):7073-7078

Role of nanostructures in allergy: Diagnostics, treatments and safety

Mayorga C, Perez-Inestrosa E, Rojo J, Ferrer M, Montañez MI Allergy 2021 Nov;76(11):3292-3306

Semiautomatic method for the ultra-trace arsenic speciation in environmental and biological samples via magnetic solid phase extraction prior to HPLC-ICP-MS determination

Montoro-Leal P, García-Mesa JC, Morales-Benítez I, García de Torres A, Vereda Alonso E Talanta 2021 Dec 1;235():122769

Slightly congested amino terminal dendrimers. The synthesis of amide-based stable structures on a large scale

Morgado, A; Najera, F; Lagunas, A; Samitier, J; Vida, Y; Perez-Inestrosa, E POLYMER CHEMISTRY 2021

Spontaneous macrocyclization through multiple dynamic cyclic aminal formation

Carbajo D, Ruiz-Sánchez AJ, Nájera F, Pérez-Inestrosa E, Alfonso I Chemical communications (Cambridge, England) 2021 Feb 4;57(10):1190-1193

Recent patents in Allergy/Immunology: New pyrazinones for the diagnosis of allergies to aminocephalosporins

Martin-Serrano A, Perez-Inestrosa E, Mayorga C, Torres MJ, Montañez MI Allergy 2021 Apr;76(4):1288-1291

The Role of Benzylpenicilloyl Epimers in Specific IgE Recognition

Mayorga C, Montañez MI, Najera F, Bogas G, Fernandez TD, et al. Frontiers in pharmacology 2021;12():585890

Biotin-Labelled Clavulanic Acid to Identify Proteins Target for Haptenation in Serum: Implications in Allergy Studies

Martín-Serrano Á, Gonzalez-Morena JM, Barbero N, Ariza A, Sánchez Gómez FJ, et al. Frontiers in pharmacology 2020;11():594755

Coherent silicon photonic interferometric biosensor with an inexpensive laser source for sensitive label-free immunoassays

Leuermann J, Stamenkovic V, Ramirez-Priego P, Sánchez-Postigo A, Fernández-Gavela A, et al. Optics letters 2020 Dec 15;45(24):6595-6598

Cyanine-Like Boronic Acid-Derived Salicylidenehydrazone Complexes (Cy-BASHY) for Bioimaging Applications

Santos FMF, Domínguez Z, Fernandes JPL, Parente Carvalho C, Collado D, et al. Chemistry (Weinheim an der Bergstrasse, Germany) 2020 Nov 6;26(62):14064-14069

Dendritic Scaffold onto Titanium Implants. A Versatile Strategy Increasing Biocompatibility

Molina N, González A, Monopoli D, Mentado B, Becerra J, et al. Polymers 2020 Apr 1;12(4):

Design of an antigenic determinant of cefaclor: Chemical structure-IgE recognition relationship

Martín-Serrano A, Mayorga C, Barrionuevo E, Pérez N, Romano A, et al. The Journal of allergy and clinical immunology 2020 Apr;145(4):1301-1304.e4

Indolenine-Based Derivatives as Customizable Two-Photon Fluorescent Probes for pH Bioimaging in Living Cells

Benitez-Martin C, Guadix JA, Pearson JR, Najera F, Perez-Pomares JM, et al. ACS sensors 2020 Apr 24;5(4):1068-1074

MitoBlue as a tool to analyze the mitochondria-lysosome communication

Sánchez MI, Vida Y, Pérez-Inestrosa E, Mascareñas JL, Vázquez ME, et al. Scientific reports 2020 Feb 26;10(1):3528

Naphthalimide Dyes with Orthogonal Functional Groups for Click Chemistry: Attachment to Solid Supports and Applications in Drug Allergy Diagnosis

Ruiz-Sanchez AJ, Collado D, Mayorga C, Torres MJ, Perez-Inestrosa E ChemPlusChem 2020 Apr;85(4):689-693

RGD-Dendrimer-Poly(L-lactic) Acid Nanopatterned Substrates for the Early Chondrogenesis of Human Mesenchymal Stromal Cells Derived from Osteoarthritic and Healthy Donors

Rodríguez-Pereira C, Lagunas A, Casanellas I, Vida Y, Pérez-Inestrosa E, et al. Materials (Basel, Switzerland) 2020 May 13;13(10):

The Janus Role of Adhesion in Chondrogenesis

Casanellas I, Lagunas A, Vida Y, Pérez-Inestrosa E, Andrades JA, et al. International journal of molecular sciences 2020 Jul 24;21(15):

Toward Two-Photon Absorbing Dyes with Unusually Potentiated Nonlinear Fluorescence Response

Benitez-Martin C, Li S, Dominguez-Alfaro A, Najera F, Pérez-Inestrosa E, et al. Journal of the American Chemical Society 2020 Sep 2;142(35):14854-14858

A turn-on two-photon fluorescent probe for detecting lysosomal hydroxyl radicals in living cells

Benitez-Martin, C; Guadix, JA; Pearson, JR; Najera, F; Perez-Pomares, JM; Perez-Inestrosa, E SENSORS AND ACTUATORS B-CHEMICAL 2019

Detection of glycidic receptors in microalgae using glycodendrons as probes: a new tool for studies on cell surface interactions

Goncalves, CD; Figueiredo, RC; Giani, A; Collado, D; Perez-Inestrosa, E; Rojo, J; Figueredo, CC JOURNAL OF APPLIED PHYCOLOGY 2019

Extended Alkenyl and Alkynyl Benzotriazoles with Enhanced Two-Photon Absorption Properties as a Promising Alternative to Benzothiadiazoles

Torres-Moya I, Benitez-Martin C, Donoso B, Tardío C, Martín R, et al. Chemistry (Weinheim an der Bergstrasse, Germany) 2019 Dec 5;25(68):15572-15579

Identification of an antigenic determinant of clavulanic acid responsible for IgE-mediated reactions

Barbero N, Fernández-Santamaría R, Mayorga C, Martin-Serrano Á, Salas M, et al. Allergy 2019 Aug;74(8):1490-1501

pi-Extended Four-Coordinate Organoboron N,C-Chelates as Two-Photon Absorbing Chromophores

Domínguez Z, Pais VF, Collado D, Vázquez-Domínguez P, Albendín FN, et al. The Journal of organic chemistry 2019 Nov 1;84(21):13384-13393

Platinum-Doped Dendritic Structure as a Phosphorescent Label for Bacteria in Two-Photon Excitation Microscopy

Molina N, Cnudde M, Guadix JA, Perez-Pomares JM, Strassert CA, et al. ACS omega 2019 Aug 20;4(8):13027-13033

Synergistic effect between CaCl2 and gamma-Al2O3 for furfural production by dehydration of hemicellulosic carbohydrates

Funez-Nunez, I; Garcia-Sancho, C; Cecilia, JA; Moreno-Tost, R; Perez-Inestrosa, E; Serrano-Cantador, L; Maireles-Torres, P APPLIED CATALYSIS A-GENERAL 2019

Synthesis of Amino Terminal Clicked Dendrimers. Approaches to the Application as a Biomarker

Molina N, Nájera F, Guadix JA, Perez-Pomares JM, Vida Y, et al. The Journal of organic chemistry 2019 Aug 16;84(16):10197-10208

Bis(dioxaborine) Dyes with Variable pi-Bridges: Towards Two-Photon Absorbing Fluorophores with Very High Brightness

Marín ÁM, Telo JP, Collado D, Nájera F, Pérez-Inestrosa E, et al. Chemistry (Weinheim an der Bergstrasse, Germany) 2018 Feb 26;24(12):2929-2935

Dendrimer-based Uneven Nanopatterns to Locally Control Surface Adhesiveness: A Method to Direct Chondrogenic Differentiation

Casanellas I, Lagunas A, Tsintzou I, Vida Y, Collado D, et al. Journal of visualized experiments : JoVE 2018 Jan 20;(131):

Dendrimeric Antigens for Drug Allergy Diagnosis: A New Approach for Basophil Activation Tests

Molina N, Martin-Serrano A, Fernandez TD, Tesfaye A, Najera F, et al. Molecules (Basel, Switzerland) 2018 Apr 24;23(5):

Amoxicillin haptenates intracellular proteins that can be transported in exosomes to target cells

Sánchez-Gómez FJ, González-Morena JM, Vida Y, Pérez-Inestrosa E, Blanca M, et al. Allergy 2017 Mar;72(3):385-396

Beneficial effects of calcium chloride on glucose dehydration to 5-hydroxymethylfurfural in the presence of alumina as catalyst

Garcia-Sancho, C; Funez-Nunez, I; Moreno-Tost, R; Santamaria-Gonzalez, J; Perez-Inestrosa, E; Fierro, JLG; Maireles-Torres, P APPLIED CATALYSIS B-ENVIRONMENTAL 2017

Carborane-stilbene dyads: the influence of substituents and cluster isomers on photoluminescence properties

Ferrer-Ugalde A, Cabrera-González J, Juárez-Pérez EJ, Teixidor F, Pérez-Inestrosa E, et al. Dalton transactions (Cambridge, England : 2003) 2017 Feb 14;46(7):2091-2104

Electronic and Functional Scope of Boronic Acid Derived Salicylidenehydrazone (BASHY) Complexes as Fluorescent Dyes

Alcaide MM, Santos FMF, Pais VF, Carvalho JI, Collado D, et al. The Journal of organic chemistry 2017 Jul 21;82(14):7151-7158

Patients Taking Amoxicillin-Clavulanic Can Become Simultaneously Sensitized to Both Drugs

Salas M, Laguna JJ, Doña I, Barrionuevo E, Fernandez-Santamaría R, et al. The journal of allergy and clinical immunology. In practice 2017 May – Jun;5(3):694-702.e3

Review of analytical methodologies for the determination of 5-HT3 receptor antagonists

Bosch, ME; Sanchez, AJR; Rojas, FS; Ojeda, CB MICROCHEMICAL JOURNAL 2017

Tailoring RGD local surface density at the nanoscale toward adult stem cell chondrogenic commitment

Lagunas, A; Tsintzou, I; Vida, Y; Collado, D; Perez-Inestrosa, E; Pereira, CR; Magalhaes, J; Andrades, JA; Samitier, J NANO RESEARCH 2017

The Value of In Vitro Tests to DiminishDrug Challenges

Mayorga C, Doña I, Perez-Inestrosa E, Fernández TD, Torres MJ International journal of molecular sciences 2017 Jun 7;18(6):

Dendrimer surface orientation of the RGD peptide affects mesenchymal stem cell adhesion

Vida, Y; Collado, D; Najera, F; Claros, S; Becerra, J; Andrades, JA; Perez-Inestrosa, E RSC ADVANCES 2016

Development of nanostructures in the diagnosis of drug hypersensitivity reactions

Mayorga C, Perez-Inestrosa E, Molina N, Montañez MI Current opinion in allergy and clinical immunology 2016 Aug;16(4):300-7

Fluorescent BAPAD Dendrimeric Antigens Are Efficiently Internalized by Human Dendritic Cells

Mesa-Antunez, P; Collado, D; Vida, Y; Najera, F; Fernandez, T; Torres, MJ; Perez-Inestrosa, E POLYMERS 2016

New Advances in the Study of IgE Drug Recognition

Martin-Serrano A, Barbero N, Agundez JA, Vida Y, Perez-Inestrosa E, et al. Current pharmaceutical design 2016;22(45):6759-6772

Red-Emitting Tetracoordinate Organoboron Chelates: Synthesis, Photophysical Properties, and Fluorescence Microscopy

Pais VF, Ramírez-López P, Romero-Arenas A, Collado D, Nájera F, et al. The Journal of organic chemistry 2016 Oct 21;81(20):9605-9611

The influence of the carrier molecule on amoxicillin recognition by specific IgE in patients with immediate hypersensitivity reactions to betalactams

Ariza A, Mayorga C, Salas M, Doña I, Martín-Serrano Á, et al. Scientific reports 2016 Oct 12;6():35113

The role of IgE recognition in allergic reactions to amoxicillin and clavulanic acid

Torres MJ, Montañez MI, Ariza A, Salas M, Fernandez TD, et al. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2016 Feb;46(2):264-74

Effect of chemical heterogeneity on photoluminescence of graphite oxide treated with S-/N-containing modifiers

Ebrahim, AM; Rodriguez-Castellon, E; Montenegro, JM; Bandosz, TJ APPLIED SURFACE SCIENCE 2015

Highly sensitive dendrimer-based nanoplasmonic biosensor for drug allergy diagnosis

Soler M, Mesa-Antunez P, Estevez MC, Ruiz-Sanchez AJ, Otte MA, et al. Biosensors & bioelectronics 2015 Apr 15;66():115-23

Recognition of multiepitope dendrimeric antigens by human immunoglobulin E

Montañez MI, Najera F, Mayorga C, Ruiz-Sanchez AJ, Vida Y, et al. Nanomedicine : nanotechnology, biology, and medicine 2015 Apr;11(3):579-88

Strongly Emissive and Photostable Four-Coordinate Organoboron N,C Chelates and Their Use in Fluorescence Microscopy

Pais VF, Alcaide MM, López-Rodríguez R, Collado D, Nájera F, et al. Chemistry (Weinheim an der Bergstrasse, Germany) 2015 Oct 19;21(43):15369-76

Synthesis of all-aliphatic polyamide dendrimers based on a 3,3 ‘-diaminopivalic acid scaffold

Ruiz-Sanchez, AJ; Mesa-Antunez, P; Barbero, N; Collado, D; Vida, Y; Najera, F; Perez-Inestrosa, E POLYMER CHEMISTRY 2015


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