Lineas de Investigación

01. Neuroinflamación y respuesta glial en la enfermedad de Alzheimer.

02. Descifrar nuevos mecanismos (enfoques) patogénicos implicados en la enfermedad de Alzheimer que permitan un mayor éxito traslacional a la clínica humana. Identificación de biomarcadores y dianas terapéuticas.

03. Desarrollo de nuevos modelos animales de la enfermedad de Alzheimer que recapitulen mejor la patología de los pacientes. Estudios preclínicos de nuevas estrategias terapéuticas.

04. Desarrollo de modelos in vitro de la enfermedad de Alzheimer mediante el empleo de células iPSCs derivadas de pacientes. Estudios de mecanismos patogénicos y evaluación de nuevos fármacos.

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Proyectos de Investigación

Contrato predoctoral FPI asociado al proyecto PID2019-108911RA-100. Título: Propagación de la patología amiloidea en un modelo esporádico de la enfermedad de Alzheimer: descifrando nuevos meanismos patogénicos y dianas terapéuticas

Ministerio de Ciencia e Innovación
. 2020

Ref. PI18-RT-2233. Astrogliopatía como mecanismo patogénico en la enfermedad de Alzheimer: nuevas opciones terapéuticas

Junta de Andalucía
. 2020

MOV20-003 Impacto de la disfunción glial en la enfermedad de Alzheimer: potencial patológico y terapéutico. Candidato: Marina Mejías Ortega. Jefe de Grupo: Antonia Gutiérrez Pérez

Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
. 2020

Contrato Predoctoral FPI asociado al proyecto PID2019-107090RA-100. Título: Diabetes y Alzheimer. Mecanismos moleculares de coagregación proteica

Ministerio de Ciencia e Innovación
. 2020

Ref. R21AG067311 (Subaward number SA0001215). Protective role of interleuikin33 in abnormal neuronal aging and degeneration

National Institutes of Health (NIH), Estados Unidos
. 2020

Diabetes y Alzheimer. Mecanismos moleculares de coagregación proteica

Ministerio de Ciencia e Innovación
. 2020

Propagación de la patología amiloidea en un modelo esporádico de la enfermedad de Alzheimer: descifrando nuevos meanismos patogénicos y dianas terapéuticas

Ministerio de Ciencia e Innovación
. 2020

001-2019-IBD II PREMIO IBIMA-DIVULGA 2019 A LAS MEJORES PUBLICACIONES DE 2018

FIMABIS
. 2019

Disfunción glial en la enfermedad de Alzheimer: implicaciones patogénicas y potencial clínico Proyecto Colaborativo CIBERNED

Universidad de Málaga
. 2018

PI18/01557. Descifrando la diversidad funcional de la respuesta microglial y astroglial en la enfermedad de Alzheimer: potencial patológico y terapéutico

INSTITUTO DE SALUD CARLOS III
. 2019

Desregulación del Sistema immune innato cerebral y la enfermedad de Alzheimer: nuevas dianas para futuras terapias.

Junta de Andalucía
. 2018

PI-0276-2018 Inmunidad Innata Cerebral y Periférica en la Enfermedad de Alzheimer: Disección Molecular de Nuevas Vías Patogénicas y Potencial Terapéutico

CONSEJERÍA DE SALUD
PROYECTOS DE INVESTIGACIÓN EN SALUD 2018

Publicaciones científicas

  • Todo
  • D1
  • Q1
  • Q2
  • Otro
Amyloid pathology arrangements in Alzheimer’s disease brains modulate in vivo seeding capability

Duran-Aniotz C, Moreno-Gonzalez I, Gamez N, Perez-Urrutia N, Vegas-Gomez L, et al. Acta neuropathologica communications 2021 Mar 30;9(1):56

Amyloid-beta impairs the phagocytosis of dystrophic synapses by astrocytes in Alzheimer’s disease

Sanchez-Mico MV, Jimenez S, Gomez-Arboledas A, Muñoz-Castro C, Romero-Molina C, et al. Glia 2021 Apr;69(4):997-1011

Generation of a humanized A beta expressing mouse demonstrating aspects of Alzheimer’s disease-like pathology

Baglietto-Vargas D, Forner S, Cai L, Martini AC, Trujillo-Estrada L, et al. Nature communications 2021 Apr 23;12(1):2421

Inflammatory Cascade in Alzheimer’s Disease Pathogenesis: A Review of Experimental Findings

de Oliveira J, Kucharska E, Garcez ML, Rodrigues MS, Quevedo J, et al. Cells 2021 Sep 28;10(10):

Longitudinal Assessment of Tau-Associated Pathology by F-18-THK5351 PET Imaging: A Histological, Biochemical, and Behavioral Study

Moreno-Gonzalez I, Edwards GA 3rd, Hasan O, Gamez N, Schulz JE, et al. Diagnostics (Basel, Switzerland) 2021 Oct 12;11(10):

Non-productive angiogenesis disassembles A ss plaque-associated blood vessels

Alvarez-Vergara MI, Rosales-Nieves AE, March-Diaz R, Rodriguez-Perinan G, Lara-Ureña N, et al. Nature communications 2021 May 25;12(1):3098

Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis

Sanchez-Varo R, Sanchez-Mejias E, Fernandez-Valenzuela JJ, De Castro V, Mejias-Ortega M, et al. Frontiers in neuroscience 2021;15():752594

Reactive astrocyte nomenclature, definitions, and future directions

Escartin C, Galea E, Lakatos A, O’Callaghan JP, Petzold GC, et al. Nature neuroscience 2021 Mar;24(3):312-325

Requirement of brain interleukin33 for aquaporin4 expression in astrocytes and glymphatic drainage of abnormal tau

Wu J, Carlock C, Shim J, Moreno-Gonzalez I, Glass W 2nd, et al. Molecular psychiatry 2021 Oct;26(10):5912-5924

Should We Open Fire on Microglia? Depletion Models as Tools to Elucidate Microglial Role in Health and Alzheimer’s Disease

Romero-Molina C, Navarro V, Jimenez S, Muñoz-Castro C, Sanchez-Mico MV, et al. International journal of molecular sciences 2021 Sep 8;22(18):

SPG302 Reverses Synaptic and Cognitive Deficits Without Altering Amyloid or Tau Pathology in a Transgenic Model of Alzheimer’s Disease

Trujillo-Estrada L, Vanderklish PW, Nguyen MMT, Kuang RR, Nguyen C, et al. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2021 Oct;18(4):2468-2483

Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer’s disease

Forner S, Kawauchi S, Balderrama-Gutierrez G, Kramár EA, Matheos DP, et al. Scientific data 2021 Oct 15;8(1):270

Transmission of cerebral amyloid pathology by peripheral administration of misfolded A beta aggregates

Morales R, Bravo-Alegria J, Moreno-Gonzalez I, Duran-Aniotz C, Gamez N, et al. Molecular psychiatry 2021 Oct;26(10):5690-5701

Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer’s mice and patients

Sanchez-Mejias E, Nuñez-Diaz C, Sanchez-Varo R, Gomez-Arboledas A, Garcia-Leon JA, et al. Brain pathology (Zurich, Switzerland) 2020 Mar;30(2):345-363

Editorial: Risk Factors for Alzheimer’s Disease

Moreno-Gonzalez I, Morales R, Baglietto-Vargas D, Sanchez-Varo R Frontiers in aging neuroscience 2020;12():124

Enhancing microtubule stabilization rescues cognitive deficits and ameliorates pathological phenotype in an amyloidogenic Alzheimer’s disease model

Fernandez-Valenzuela JJ, Sanchez-Varo R, Muñoz-Castro C, De Castro V, Sanchez-Mejias E, et al. Scientific reports 2020 Sep 8;10(1):14776

Generation of oligodendrocytes and establishment of an all-human myelinating platform from human pluripotent stem cells

García-León JA, García-Díaz B, Eggermont K, Cáceres-Palomo L, Neyrinck K, et al. Nature protocols 2020 Nov;15(11):3716-3744

Human Pluripotent Stem Cell-Derived Neural Cells as a Relevant Platform for Drug Screening in Alzheimer’s Disease

Garcia-Leon JA, Caceres-Palomo L, Sanchez-Mejias E, Mejias-Ortega M, Nuñez-Diaz C, et al. International journal of molecular sciences 2020 Sep 18;21(18):

Neocortical tissue recovery in severe congenital obstructive hydrocephalus after intraventricular administration of bone marrow-derived mesenchymal stem cells

García-Bonilla M, Ojeda-Pérez B, García-Martín ML, Muñoz-Hernández MC, Vitorica J, et al. Stem cell research & therapy 2020 Mar 17;11(1):121

Nuclear Translocation of Glutaminase GLS2 in Human Cancer Cells Associates with Proliferation Arrest and Differentiation

López de la Oliva AR, Campos-Sandoval JA, Gómez-García MC, Cardona C, Martín-Rufián M, et al. Scientific reports 2020 Feb 10;10(1):2259

Sex-dependent calcium hyperactivity due to lysosomal-related dysfunction in astrocytes from APOE4 versus APOE3 gene targeted replacement mice

Larramona-Arcas R, González-Arias C, Perea G, Gutiérrez A, Vitorica J, et al. Molecular neurodegeneration 2020 Jun 9;15(1):35

The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease

Oñate M, Catenaccio A, Salvadores N, Saquel C, Martinez A, et al. Cell death and differentiation 2020 Apr;27(4):1169-1185

Amyloid-beta impairs TOM1-mediated IL-1R1 signaling

Martini AC, Gomez-Arboledas A, Forner S, Rodriguez-Ortiz CJ, McQuade A, et al. Proceedings of the National Academy of Sciences of the United States of America 2019 Oct 15;116(42):21198-21206

Astrocytes: From the Physiology to the Disease

Trujillo-Estrada L, Gomez-Arboledas A, Forner S, Martini AC, Gutierrez A, et al. Current Alzheimer research 2019;16(8):675-698

Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer’s disease

Boza-Serrano A, Ruiz R, Sanchez-Varo R, García-Revilla J, Yang Y, et al. Acta neuropathologica 2019 Aug;138(2):251-273

Modifiable Risk Factors for Alzheimer’s Disease

Edwards Iii GA, Gamez N, Escobedo G Jr, Calderon O, Moreno-Gonzalez I Frontiers in aging neuroscience 2019;11():146

Monitoring the Formation of Amyloid Oligomers Using Photoluminescence Anisotropy

Jiang B, Aliyan A, Cook NP, Augustine A, Bhak G, et al. Journal of the American Chemical Society 2019 Oct 2;141(39):15605-15610

Natural Products as Modulators of the Proteostasis Machinery: Implications in Neurodegenerative Diseases

Cuanalo-Contreras K, Moreno-Gonzalez I International journal of molecular sciences 2019 Sep 20;20(19):

Peripheral Delivery of Neural Precursor Cells Ameliorates Parkinson’s Disease-Associated Pathology

Edwards Iii G, Gamez N, Armijo E, Kramm C, Morales R, et al. Cells 2019 Oct 30;8(11):

Use of human pluripotent stem cell-derived cells for neurodegenerative disease modeling and drug screening platform

Garcia-Leon JA, Vitorica J, Gutierrez A Future medicinal chemistry 2019 Jun;11(11):1305-1322

A Distinct Metabolite Profile Correlates with Neurodegenerative Conditions and the Severity of Congenital Hydrocephalus.

García-Bonilla M, García-Martín ML, Muñoz-Hernández MC, Domínguez-Pinos D, Martínez-León MI, et al. Journal of neuropathology and experimental neurology 2018 Dec 1;77(12):1122-1136

Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology

Romero-Molina C, Navarro V, Sanchez-Varo R, Jimenez S, Fernandez-Valenzuela JJ, et al. Frontiers in cellular neuroscience 2018;12():421

Generation of a human induced pluripotent stem cell-based model for tauopathies combining three microtubule-associated protein TAU mutations which displays several phenotypes linked to neurodegeneration

García-León JA, Cabrera-Socorro A, Eggermont K, Swijsen A, Terryn J, et al. Alzheimer’s & dementia : the journal of the Alzheimer’s Association 2018 Oct;14(10):1261-1280

Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer’s disease

Baglietto-Vargas D, Prieto GA, Limon A, Forner S, Rodriguez-Ortiz CJ, et al. Aging cell 2018 Aug;17(4):e12791

Microglia in Alzheimer’s Disease: Activated, Dysfunctional or Degenerative

Navarro V, Sanchez-Mejias E, Jimenez S, Muñoz-Castro C, Sanchez-Varo R, et al. Frontiers in aging neuroscience 2018;10():140

Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer’s disease

Gomez-Arboledas A, Davila JC, Sanchez-Mejias E, Navarro V, Nuñez-Diaz C, et al. Glia 2018 Mar;66(3):637-653

SOX10 Single Transcription Factor-Based Fast and Efficient Generation of Oligodendrocytes from Human Pluripotent Stem Cells

García-León JA, Kumar M, Boon R, Chau D, One J, et al. Stem cell reports 2018 Feb 13;10(2):655-672

Toward a New Concept of Alzheimer’s Disease Models: A Perspective from Neuroinflammation

Gutierrez A, Vitorica J Journal of Alzheimer’s disease : JAD 2018;64(s1):S329-S338

Dual roles of A beta in proliferative processes in an amyloidogenic model of Alzheimer’s disease

Baglietto-Vargas D, Sánchez-Mejias E, Navarro V, Jimenez S, Trujillo-Estrada L, et al. Scientific reports 2017 Aug 30;7(1):10085

Glutaminase and MMP-9 Downregulation in Cortex and Hippocampus of LPA(1) Receptor Null Mice Correlate with Altered Dendritic Spine Plasticity

Peñalver A, Campos-Sandoval JA, Blanco E, Cardona C, Castilla L, et al. Frontiers in molecular neuroscience 2017;10():278

N370S-GBA1 Mutation Causes Lysosomal Cholesterol Accumulation in Parkinson’s Disease

García-Sanz P, Orgaz L, Bueno-Gil G, Espadas I, Rodríguez-Traver E, et al. Movement disorders : official journal of the Movement Disorder Society 2017 Oct;32(10):1409-1422

Asp32 and Asp228 determine the selective inhibition of BACE1 as shown by docking and molecular dynamics simulations

Hernández-Rodríguez M, Correa-Basurto J, Gutiérrez A, Vitorica J, Rosales-Hernández MC European journal of medicinal chemistry 2016 Nov 29;124():1142-1154

Soluble phospho-tau from Alzheimer’s disease hippocampus drives microglial degeneration

Sanchez-Mejias E, Navarro V, Jimenez S, Sanchez-Mico M, Sanchez-Varo R, et al. Acta neuropathologica 2016 Dec;132(6):897-916

Amyloid-beta reduces the expression of neuronal FAIM-L, thereby shifting the inflammatory response mediated by TNF alpha from neuronal protection to death

Carriba P, Jimenez S, Navarro V, Moreno-Gonzalez I, Barneda-Zahonero B, et al. Cell death & disease 2015 Feb 12;6():e1639

Expression of Gls and Gls2 Glutaminase Isoforms in Astrocytes

Cardona C, Sánchez-Mejías E, Dávila JC, Martín-Rufián M, Campos-Sandoval JA, et al. Glia 2015 Mar;63(3):365-82


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