Lineas de Investigación

Estudio de las bases biológicas del comportamiento y la fisiopatología de enfermedades degenerativas de gran prevalencia. Estas incluyen los trastornos adictivos (abuso de drogas), los trastornos de la alimentación (obesidad, diabetes, dislipemia), la enfermedad de Alzheimer, así como los síndromes de ansiedad y depresión, a lo largo del desarrollo y en modelos de enfermedad (comorbilidad psiquiátrica)..

01. Esteatohepatitis alcohólica y no alcohólica.

02. Programación metabólica durante el desarrollo y crecimiento (obesidad, diabetes)

03. Desarrollo de nuevas entidades químicas terapéuticas o nuevas indicaciones de fármacos existentes.

04 Evaluación farmacológica de alimentos de uso médico especial (ADUME).



Proyectos de Investigación

Suárez Pérez, Juan

IP Acciones Complementarias

Área 3.Neurociencias, Cronicidad, Envejecimiento y Salud en poblaciones vulnerables.PLAN PROPIO_AREA 3

Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
. 2020

MOV20-002 Análisis de perfiles inflamatorios en pacientes usuarios con trastornos psiquiátricos comorbidos: Depresión, Deterioro cognitivo y uso de alcohol. Candidato: María Flores López. Jefe de Grupo: Antonia María Serrano Criado

Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
. 2020

MOV20-001 Análisis del mecanismo de autofagia en modelos animales de Alzheimer de última generación. Candidato: Dina Medina Vera, Jefe de Grupo: Fernando Rodríguez de Fonseca

Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
. 2020

CD20/00192 Contratos Sara Borrell 2020 Sara Peñasco Iglesias. Jefe de Grupo: Fernando Rodriguez de Fonseca

Instituto de Salud Carlos III
. 2020

PI20/01399 Papel de la señalización lipídica mediada por monoacilgliceroles y ácido lisofosfatídico en la Asociación entre trastornos por uso de alcohol y Depresión: Identificación de Biomarcadores

Instituto de Salud Carlos III
. 2020

P18-TP-5194 VALIDACIÓN PRECLINICA DE LOS INOSITOLES DE LA ALGARROBA SOBRE TRASTORNOS ASOCIADOS A LA RESISTENCIA INSULINICA

Consejería de Transformación Económica, Industria, Conocimiento y Universidades
. 2020

RTC2019-007329-1 Obtención de principios activos antioxidantes a partir de la vaina del algarrobo y validación de su potencial terapéutico. Fernando Rodriguez de Fonseca.

Agencia Estatal de Investigación
. 2020

IFI18/00042 Contrato i-PFIS 2018 Antonio Jesús López Gambero.

Instituto de Salud Carlos III (ISCIII)
Acción Estratégica en Salud 2019 AES 2018 2018

RTC2019-007329-1: Obtención de principios activos antioxidantes a partir de la vaina del algarrobo y validación de su potencial terapéutico | El objetivo tecnológico principal de esta línea de I+D se basa en la extracción y obtención de principios activos naturales de una fracción del fruto del algarrobo para el tratamiento de enfermedades metabólicas crónicas como el NASH, del neurodesarrollo (síndrome de Down, síndrome de X-Frágil) y psiquiátricas infantiles (trastorno por déficit de atención e hiperactividad, TDH), sin tratamiento específico que cursan con deterioro metabólico y/o cognitivo abordando para ello el diseño e ingeniería de una tecnología complementaria que permita desarrollar y completar el reto que supone el presente proyecto.

Agencia Estatal de Investigación. Ministerio de Ciencia e Innovación
Proyectos de I+D+I «Retos Colaboración. 2019

Papel de la señalización lipídica mediada por monoacilgliceroles y ácido lisofosfatídico en la asociación entre trastornos por uso de alcohol y depresión: iIdentificación de biomarcadores.

ISCIII
. 2021

MV19/00060 Papel de las aciletanolamidas y los acilgliceroles en el consumo abusivo de alcohol durante la adolescencia y la vulnerabilidad a desarrollar trastornos por uso de alcohol.

ISCIII
. 2019

PEIBA-2019-040 BIOMARCADORES CIRCULANTES DE COMORBILIODAD NEUROLÓGICA EN EL TRASTORNO POR CONSUMO TEMPRANO DE ALCOHOL Y/O DROGAS ILEGALES: HERRAMIENTA PREDICTIVA DE DETERIORO COGNITIVO Y DEMENCIAS EN POBLACIONES VULNERABLES.

Ministerio de Sanidad, Consumo y Bienestar Social
. 2019

PI19/00343 Estudio de nuevos factores del sistema GH/IGF: análisis de mecanismos moleculares que regulan crecimiento y metabolismo mediane PAPP-A2 y desarrollo de nuevas terapias.

ISCIII
. 2019

Rodríguez de Fonseca, Fernando

IP Acciones Complementarias

EIN2019-103364 – INNOVATIVE DUAL LIGANDS FOR THE TREATMENT OF ALCOHOL USE DISORDERS AND ITS COMPLICATIONS

Agencia Estatal de Investigación
. 2019

DTS19/00125 Evaluación preclínica de ligandos duales para el tratamiento de los trastornos por uso de alcohol

ISCIII
. 2019

PI19/01577 Alcohol, depresión y deterioro cognitivo: Papel de las aciletanolamidas no cannabinoides. IP Fernando Rodriguez de Fonseca

ISCIII
. 2019

PI19/01577 Alcohol, depresión y deterioro cognitivo: Papel de las aciletanolamidas no cannabinoides. IP Fernando Rodriguez de Fonseca

ISCIII
. 2019

FATZHEIMER: High Fat Diet, Microbiota and Neuroinflammation in the Progression of Alzheimer Disease

European Comission (H2020)
EU-LAC Health 2018

Consumo de alcohol durante la adolescencia: Papel del sistema endocannabinoide en el desarrollo de adicción al alcohol y trastornos afectivos y de ansiedad comórbidos.

Ministerio de Sanidad, Servicios Sociales e Igualdad
Plan Nacional sobre Drogas 2018

Papel del ácido lisofosfatídico en el alcoholismo y la cormobilidad psiquiátrica: implicaciones terapéuticas y evaluación de biomarcadores

CONSEJERÍA DE SALUD
: Proyectos de Investigación biomédica y en ciencias de la salud. Consejería de Salud 2016

Early life stress and excessive alcohol consumption in adolescents: Role of the endocannabinoid system in the vulnerability to alcoholism

INSTITUTO DE SALUD CARLOS III
Proyecto de Investigación Miguel Servet Tipo I. Instituto de Salud Carlos III. 2015

Red de Trastornos Adictivos (Red RTA)

INSTITUTO DE SALUD CARLOS III
RETICS. Instituto de Salud Carlos III. Ministerio de Ciencia e Innovación 2013

Implicación del Sistema endocannabinoide en la vulnerabilidad al alcoholismo en adultos tras el consumo abusivo durante la adolescencia

CONSEJERÍA DE SALUD
Consejería de Salud 2013

CD17/00125 Sara Borrell 2017 Victor Echeverry Alzaty.Jefe de Grupo Fernando Rodriguez de Fonseca

INSTITUTO DE SALUD CARLOS III
ACCIÓN ESTRATÉGICA EN SALUD - CONTRATOS SARA BORRELL 2017

FI17/00027 Contrato PFIS 2017 Laura Sanchez Marin.Jefe de Grupo: Fernando Rodriguez de Fonseca

INSTITUTO DE SALUD CARLOS III
ACCIÓN ESTRATÉGICA EN SALUD - CONTRATOS PFIS: CONTRATOS PREDOCTORALES DE FORMACIÓN EN INVESTIGACIÓN EN SALUD 2017

PI-0139-2018 ESTUDIO DE LA ACTIVACIÓN DEL RECEPTOR PARA GLP1 COMO BASE DEL DESARROLLO DE TERAPIAS COMBINADAS PARA EL TRATAMIENTO DE LA ESTEATOHEPATITIS NO ALCOHÓLICA

CONSEJERÍA DE SALUD
PROYECTOS DE INVESTIGACIÓN EN SALUD 2018

CPII17/00024 Miiguel Servet Tipo II 2017 Juan Suarez Pérez

INSTITUTO DE SALUD CARLOS III
ACCIÓN ESTRATÉGICA EN SALUD - CONTRATOS MIGUEL SERVET TIPO II 2017

PI16/01374 Obesidad infantil grave de comienzo precoz al diagnóstico y tras pérdida ponderal: Fundamentos metabólicos, hormonales, genéticos, genómicos, metabolómicos y de microbiota

INSTITUTO DE SALUD CARLOS III
ACCIÓN ESTRATÉGICA EN SALUD - PROYECTOS DE INVESTIGACIÓN EN SALUD 2016

RC-0003-2018 Acción C Nicolás Monarde F.Rodríguez de Fonseca

SERVICIO ANDALUZ DE SALUD
RENOVACIÓN ACCIÓN C (PROGRAMA NICOLÁS MONARDES) DE LA CONVOCATORIA 2018

PRX18/00608 Estancias de movilidad de profesores e investigadores seniores en centros extranjeros de enseñanza superior e investigación, incluido el Programa Salvador de Madariaga 2018. Investigador: Fernando Antonio Rodríguez de Fonseca

MINISTERIO DE EDUCACIÓN Y FORMACIÓN PROFESIONAL
ESTANCIAS PROGRAMA SALVADOR DE MADARIAGA 2018

RD16/0017/0001 Red de Trastornos Adictivos

INSTITUTO DE SALUD CARLOS III
ACCIÓN ESTRATÉGICA EN SALUD - CONVOCATORIA DE REDES TEMÁTICAS DE INVESTIGACIÓN COOPERATIVA EN SALUD (RETICS) 2016

PND2018/044 BIOMARCADORES CIRCULANTES DE COMORBILIDAD PSIQUIÁTRICA EN EL TRASTORNO POR USO DE DROGAS: COMPARACIÓN CON BIOMARCADORES DE TRASTORNO DEPRESIVO Y TRASTORNO PSICÓTICO

MINISTERIO DE SANIDAD, CONSUMO Y BIENESTAR SOCIAL
PROYECTOS DE INVESTIGACIÓN SOBRE ADICCIONES 2018

RTC-2016-4983-1 Diseño, ingeniería y ensamblaje de línea piloto de nuevos extractos naturales solvent free y validacion in vivo de compuestos bioactivos

MINISTERIO DE ECONOMIA Y EMPRESA
AYUDAS PARA I+D+i RETOS COLABORACIÓN 2016

PI16/01698 Lípidos transmisores derivados del ácido oleico: Estudio traslacional de su papel en los trastornos por uso de alcohol

INSTITUTO DE SALUD CARLOS III
ACCIÓN ESTRATÉGICA EN SALUD - PROYECTOS DE INVESTIGACIÓN EN SALUD 2016

DTS16/00115 Desarrollo de nuevos conjugados de ácidos grasos para el tratamiento de las esteatohepatitis

INSTITUTO DE SALUD CARLOS III
ACCIÓN ESTRATÉGICA EN SALUD - PROYECTOS DE DESARROLLO TECNOLÓGICO EN SALUD 2016

PSI2015-73156-JIN Incremento de la neurogénesis hipocampal adulta como estrategia terapéutica para las alteraciones conductuales inducidas por cocaína (COCANEUROGNSIS)

MINISTERIO DE ECONOMIA Y EMPRESA
PROYECTOS I+D+i PARA JÓVENES INVESTIGADORES 2015

MS14/00173 Contrato Miguel Servet Tipo I Antonia Mª Serrano Criado

INSTITUTO DE SALUD CARLOS III
CONTRATOS MIGUEL SERVET TIPO I 2014

2017i043 Consumo de alcohol durante la adolescencia: papel del sistema endocannabinoide en el desarrollo de adicción al alcohol y trastornos afectivos y de ansiedad comórbidos

MINISTERIO DE SANIDAD, CONSUMO Y BIENESTAR SOCIAL
PROYECTOS DE INVESTIGACIÓN SOBRE ADICCIONES 2017

PI17/02026 Estudio Traslacional del Papel del Sistema Endocannabinoide en la Amígdala Ampliada en la Ansiedad Asociada a la Dependencia Alcohólica

INSTITUTO DE SALUD CARLOS III
ACCIÓN ESTRATÉGICA EN SALUD - PROYECTOS DE INVESTIGACIÓN EN SALUD (FIS) 2017


Publicaciones científicas

  • Todo
  • D1
  • Q1
  • Q2
  • Otro
Discovery of V-0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor toward Oral Treatment for “Diabesity”.

Decara, Juan M; Vazquez-Villa, Henar; Brea, Jose; Alonso, Monica; Srivastava, Raj Kamal; Orio, Laura; Alen, Francisco; Suarez, Juan; Baixeras, Elena; Garcia-Carceles, Javier; Escobar-Pena, Andrea; Lutz, Beat; Rodriguez, Ramon; Codesido, Eva; Garcia-Ladona, F Javier; Bennett, Teresa A; Ballesteros, Juan A; Cruces, Jacobo; Loza, Maria I; Benhamu, Bellinda; Rodriguez de Fonseca, Fernando; Lopez-Rodriguez, Maria L…Less Journal of medicinal chemistry 2022

A combination of circulating chemokines as biomarkers of obesity-induced insulin resistance at puberty

Rivera, P; Martos-Moreno, GA; Barrios, V; Suarez, J; Pavon, FJ; Chowen, JA; de Fonseca, FR; Argente, J PEDIATRIC OBESITY 2021

A Negative Energy Balance Is Associated with Metabolic Dysfunctions in the Hypothalamus of a Humanized Preclinical Model of Alzheimer’s Disease, the 5XFAD Mouse

López-Gambero AJ, Rosell-Valle C, Medina-Vera D, Navarro JA, Vargas A, et al. International journal of molecular sciences 2021 May 20;22(10):

Abrupt cessation of reboxetine along alcohol deprivation results in alcohol intake escalation after reinstatement of drinking

Ballesta, A; Alen, F; Orio, L; Arco, R; Vadas, E; Decara, J; Vargas, A; de Heras, RG; Ramirez-Lopez, M; Serrano, A; Pavon, FJ; Suarez, J; de Fonseca, FR ADDICTION BIOLOGY 2021

Activation of Macrophages by Lysophosphatidic Acid through the Lysophosphatidic Acid Receptor 1 as a Novel Mechanism in Multiple Sclerosis Pathogenesis

Fransson, J; Gomez-Conde, AI; Romero-Imbroda, J; Fernandez, O; Leyva, L; de Fonseca, FR; Chun, J; Louapre, C; Van-Evercooren, AB; Zujovic, V; Estivill-Torrus, G; Garcia-Diaz, B MOLECULAR NEUROBIOLOGY 2021

Activation of PI3K/Akt Signaling Pathway in Rat Hypothalamus Induced by an Acute Oral Administration of D-Pinitol

Medina-Vera D, Navarro JA, Tovar R, Rosell-Valle C, Gutiérrez-Adan A, et al. Nutrients 2021 Jun 30;13(7):

Adolescent binge-ethanol accelerates cognitive impairment and beta-amyloid production and dysregulates endocannabinoid signaling in the hippocampus of APP/PSE mice

Ledesma, JC; Rodriguez-Arias, M; Gavito, AL; Sanchez-Perez, AM; Vina, J; Vera, DM; de Fonseca, FR; Minarro, J ADDICTION BIOLOGY 2021

Analysis of Both Lipid Metabolism and Endocannabinoid Signaling Reveals a New Role for Hypothalamic Astrocytes in Maternal Caloric Restriction-Induced Perinatal Programming

Tovar R, Vargas A, Aranda J, Sánchez-Salido L, González-González L, et al. International journal of molecular sciences 2021 Jun 11;22(12):

ATP13A2 levels in serum and cerebrospinal fluid in patients with idiopathic Parkinson’s disease

Fernandez-Espejo, E; de Fonseca, FR; Suarez, J; Gonzalez-Aparicio, R; Santurtun, A PARKINSONISM & RELATED DISORDERS 2021

Cerebellar and cortical TLR4 activation and behavioral impairments in Wernicke-Korsakoff Syndrome: Pharmacological effects of oleoylethanolamide

Moya, M; San Felipe, D; Ballesta, A; Alen, F; de Fonseca, FR; Garcia-Bueno, B; Marco, EM; Orio, L PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 2021

Chronic central modulation of LPA/LPA receptors-signaling pathway in the mouse brain regulates cognition, emotion, and hippocampal neurogenesis

Rosell-Valle, C; Pedraza, C; Manuel, I; Moreno-Rodriguez, M; Rodriguez-Puertas, R; Castilla-Ortega, E; Carames, JM; Conde, AIG; Zambrana-Infantes, E; Ortega-Pinazo, J; Serrano-Castro, PJ; Chun, J; De Fonseca, FR; Santin, LJ; Estivill-Torrus, G PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 2021

Cocaine and depressive disorders: When standard clinical diagnosis is insufficient

Alias-Ferri, M; Garcia-Marchena, N; Mestre-Pinto, JI; Araos, P; Vergara-Moragues, E; Fonseca, F; Gonzalez-Saiz, F; de Fonseca, FR; Torrens, M; Mateus, J; Papaseit, E; Perez-Mana, C; Rodriguez-Minguela, R; Rossi, P; Tamarit, C; Vallecillo, G ADICCIONES 2021

Energy sensors in drug addiction: A potential therapeutic target

Lopez-Gambero, AJ; de Fonseca, FR; Suarez, J ADDICTION BIOLOGY 2021

Environmental Enrichment Rescues Endocannabinoid-Dependent Synaptic Plasticity Lost in Young Adult Male Mice after Ethanol Exposure during Adolescence

Rico-Barrio I, Peñasco S, Lekunberri L, Serrano M, Egaña-Huguet J, et al. Biomedicines 2021 Jul 16;9(7):

Evaluation of neurotrophic factors and education level as predictors of cognitive decline in alcohol use disorder

Requena-Ocaña N, Araos P, Flores M, García-Marchena N, Silva-Peña D, et al. Scientific reports 2021 Aug 2;11(1):15583

GABAergic deficits in absence of LPA(1) receptor, associated anxiety-like and coping behaviors, and amelioration by interneuron precursor transplants into the dorsal hippocampus

Rosell-Valle, C; Martinez-Losa, M; Matas-Rico, E; Castilla-Ortega, E; Zambrana-Infantes, E; Gomez-Conde, AI; Sanchez-Salido, L; de Guevara-Miranda, DL; Pedraza, C; Serrano-Castro, PJ; Chun, J; de Fonseca, FR; Alvarez-Dolado, M; Santin, LJ; Estivill-Torrus, G BRAIN STRUCTURE & FUNCTION 2021

Gender Perspective in Dual Diagnosis

Torrens-Melich M, Orengo T, Rodríguez de Fonseca F, Almodóvar I, Baquero A, et al. Brain sciences 2021 Aug 21;11(8):

Immunomodulatory, Antioxidant Activity and Cytotoxic Effect of Sulfated Polysaccharides from Porphyridium cruentum. (S.F.Gray) Nageli

Casas-Arrojo V, Decara J, de Los Ángeles Arrojo-Agudo M, Pérez-Manríquez C, Abdala-Díaz RT Biomolecules 2021 Mar 24;11(4):

Influence of gender and education on cocaine users in an outpatient cohort in Spain

Requena-Ocaña N, Flores-Lopez M, Martín AS, García-Marchena N, Pedraz M, et al. Scientific reports 2021 Oct 22;11(1):20928

Met and Unmet Needs in an Inpatient Psychiatry Setting in Spain

Gomez-Sanchez-Lafuente C, Guzman-Parra J, Lopez-Zambrano MA, Moreno-Kustner B, Mayoral-Cleries F Neuropsychiatric disease and treatment 2021;17():1859-1868

Microglia activated by microbial neuraminidase contributes to ependymal cell death

Fernández-Arjona MDM, León-Rodríguez A, López-Ávalos MD, Grondona JM Fluids and barriers of the CNS 2021 Mar 23;18(1):15

Native alpha-Synuclein, 3-Nitrotyrosine Proteins, and Patterns of Nitro-alpha-Synuclein-Immunoreactive Inclusions in Saliva and Submandibulary Gland in Parkinson’s Disease

Fernández-Espejo E, Rodríguez de Fonseca F, Suárez J, Tolosa E, Vilas D, et al. Antioxidants (Basel, Switzerland) 2021 May 1;10(5):

Obesity as a Condition Determined by Food Addiction: Should Brain Endocannabinoid System Alterations Be the Cause and Its Modulation the Solution?

de Ceglia M, Decara J, Gaetani S, Rodríguez de Fonseca F Pharmaceuticals (Basel, Switzerland) 2021 Sep 29;14(10):

Palmitoleoylethanolamide Is an Efficient Anti-Obesity Endogenous Compound: Comparison with Oleylethanolamide in Diet-Induced Obesity

Tovar R, Gavito AL, Vargas A, Soverchia L, Hernandez-Folgado L, et al. Nutrients 2021 Jul 28;13(8):

Persistent changes in exploration and hyperactivity coexist with cognitive impairment in mice withdrawn from chronic cocaine

Mañas-Padilla MC, Ávila-Gámiz F, Gil-Rodríguez S, Ladrón de Guevara-Miranda D, Rodríguez de Fonseca F, et al. Physiology & behavior 2021 Oct 15;240():113542

Pigment epithelium-derived factor (PEDF) and PEDF-receptor in the adult mouse brain: Differential spatial/temporal localization pattern

de Diego-Otero, Y; Giraldez-Perez, RM; Lima-Cabello, E; Heredia-Farfan, R; Medina, RC; Sanchez-Salido, L; Costillas, LP JOURNAL OF COMPARATIVE NEUROLOGY 2021

Plasma concentrations of granulocyte colony-stimulating factor (G-CSF) in patients with substance use disorders and comorbid major depressive disorder

Galván ST, Flores-López M, Romero-Sanchiz P, Requena-Ocaña N, Porras-Perales O, et al. Scientific reports 2021 Jul 1;11(1):13629

Plasma Concentrations of Lysophosphatidic Acid and Autotaxin in Abstinent Patients with Alcohol Use Disorder and Comorbid Liver Disease

Flores-López M, García-Marchena N, Pavon FJ, Lara E, Porras-Perales O, et al. Biomedicines 2021 Sep 13;9(9):

Pregnancy-Associated Plasma Protein (PAPP)-A2 in Physiology and Disease

Barrios V, Chowen JA, Martín-Rivada Á, Guerra-Cantera S, Pozo J, et al. Cells 2021 Dec 18;10(12):

Recombinant IGF-1 Induces Sex-Specific Changes in Bone Composition and Remodeling in Adult Mice with Pappa2 Deficiency

Rubio L, Vargas A, Rivera P, López-Gambero AJ, Tovar R, et al. International journal of molecular sciences 2021 Apr 14;22(8):

Remote memory of drug experiences coexists with cognitive decline and abnormal adult neurogenesis in an animal model of cocaine-altered cognition

Manas-Padilla, MC; Gil-Rodriguez, S; Sampedro-Piquero, P; Avila-Gamiz, F; de Fonseca, FR; Santin, LJ; Castilla-Ortega, E ADDICTION BIOLOGY 2021

Sex-specific Associations of Alcohol Withdrawal in Patients Admitted for the Treatment of Alcohol Use Disorder

Sanvisens, A; Zuluaga, P; Short, A; Rubio, G; Gual, A; Torrens, M; Fuster, D; Bolao, F; de Fonseca, FR; Muga, R JOURNAL OF ADDICTION MEDICINE 2021

Sex-specific behavioral and neurogenic responses to cocaine in mice lacking and blocking dopamineD1or dopamineD2receptors

Rivera, P; Aranda, J; Alen, F; Vargas, A; Serrano, A; Pavon, FJ; Orio, L; Rubio, L; Moratalla, R; de Fonseca, FR; Suarez, J JOURNAL OF COMPARATIVE NEUROLOGY 2021

Sudden cessation of fluoxetine before alcohol drinking reinstatement alters microglial morphology and TLR4/inflammatory neuroadaptation in the rat brain

Aranda J, Fernández-Arjona MDM, Alén F, Rivera P, Rubio L, et al. Brain structure & function 2021 Sep;226(7):2243-2264

The Immune System through the Lens of Alcohol Intake and Gut Microbiota

Calleja-Conde J, Echeverry-Alzate V, Bühler KM, Durán-González P, Morales-García JÁ, et al. International journal of molecular sciences 2021 Jul 13;22(14):

A Novel Agonist of the Type 1 Lysophosphatidic Acid Receptor (LPA(1)), UCM-05194, Shows Efficacy in Neuropathic Pain Amelioration

González-Gil I, Zian D, Vázquez-Villa H, Hernández-Torres G, Martínez RF, et al. Journal of medicinal chemistry 2020 Mar 12;63(5):2372-2390

Abstinent patients with alcohol use disorders show an altered plasma cytokine profile: Identification of both interleukin 6 and interleukin 17A as potential biomarkers of consumption and comorbid liver and pancreatic diseases

García-Marchena N, Maza-Quiroga R, Serrano A, Barrios V, Requena-Ocaña N, et al. Journal of psychopharmacology (Oxford, England) 2020 Nov;34(11):1250-1260

Adult hippocampal neurogenesis as a target for cocaine addiction: a review of recent developments

Castilla-Ortega E, Santín LJ Current opinion in pharmacology 2020 Feb;50():109-116

Better data, better policy and better lives: a call for improved drug monitoring and concerted responses

Comiskey C, Bretteville-Jensen AL, Bergeron H, Bühringer G, Dargan P, et al. Addiction (Abingdon, England) 2020 Feb;115(2):199-200

Cocaine-induced changes in CX(3)CL1 and inflammatory signaling pathways in the hippocampus: Association with IL1 beta

Montesinos J, Castilla-Ortega E, Sánchez-Marín L, Montagud-Romero S, Araos P, et al. Neuropharmacology 2020 Jan 1;162():107840

COX-2 Inhibition Antagonizes Intra-Accumbens 2-Arachidonoylglycerol-Mediated Reduction in Ethanol Self-Administration in Rats

Pavon FJ, Polis I, Stouffer DG, Roberto M, Martin-Fardon R, et al. Alcoholism, clinical and experimental research 2020 Nov;44(11):2158-2165

D-Chiro-Inositol Treatment Affects Oocyte and Embryo Quality and Improves Glucose Intolerance in Both Aged Mice and Mouse Models of Polycystic Ovarian Syndrome

Pericuesta E, Laguna-Barraza R, Ramos-Ibeas P, Gutierrez-Arroyo JL, Navarro JA, et al. International journal of molecular sciences 2020 Aug 22;21(17):

Differential hepatoprotective role of the cannabinoid CB1 and CB2 receptors in paracetamol-induced liver injury

Rivera P, Vargas A, Pastor A, Boronat A, López-Gambero AJ, et al. British journal of pharmacology 2020 Jul;177(14):3309-3326

DSM-5 in patients seeking their first treatment for alcohol use disorder. Sex differences in the multicenter CohRTA study

Sanvisens A, Zuluaga P, Rubio G, Short A, Gual A, et al. Adicciones 2020 Apr 1;32(2):136-144

Epicardial cell lineages and the origin of the coronary endothelium

Carmona R, Barrena S, López Gambero AJ, Rojas A, Muñoz-Chápuli R FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):5223-5239

‘I have anxiety, but I have values and preferences’ Experiences of users with generalized anxiety disorder: A qualitative study

Hurtado MM, Villena A, Vega A, Amor G, Gómez C, et al. International journal of mental health nursing 2020 Jun;29(3):521-530

Imbalance of Endocannabinoid/Lysophosphatidylinositol Receptors Marks the Severity of Alzheimer’s Disease in a Preclinical Model: A Therapeutic Opportunity

Medina-Vera D, Rosell-Valle C, López-Gambero AJ, Navarro JA, Zambrana-Infantes EN, et al. Biology 2020 Nov 5;9(11):

Impact of intermittent voluntary ethanol consumption during adolescence on the expression of endocannabinoid system and neuroinflammatory mediators />

Sanchez-Marin L, Gavito AL, Decara J, Pastor A, Castilla-Ortega E, et al. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2020 Apr;33():126-138

Impact of SARS-CoV-2 infection on neurodegenerative and neuropsychiatric diseases: a delayed pandemic?

Serrano-Castro PJ, Estivill-Torrús G, Cabezudo-García P, Reyes-Bueno JA, Ciano Petersen N, et al. Neurologia (Barcelona, Spain) 2020 May;35(4):245-251

Inhibition of Receptor Protein Tyrosine Phosphatase beta/zeta Reduces Alcohol Intake in Rats

Calleja-Conde J, Fernández-Calle R, Zapico JM, Ramos A, de Pascual-Teresa B, et al. Alcoholism, clinical and experimental research 2020 May;44(5):1037-1045

Intermittent ethanol exposure during adolescence impairs cannabinoid type 1 receptor-dependent long-term depression and recognition memory in adult mice

Peñasco S, Rico-Barrio I, Puente N, Fontaine CJ, Ramos A, et al. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2020 Jan;45(2):309-318

LPA(1) receptor and chronic stress: Effects on behaviour and the genes involved in the hippocampal excitatory/inhibitory balance

Moreno-Fernández RD, Rosell-Valle C, Bacq A, Zanoletti O, Cifuentes M, et al. Neuropharmacology 2020 Mar 1;164():107896

Lysophosphatidic Acid Receptor 1 Specifically Labels Seizure-Induced Hippocampal Reactive Neural Stem Cells and Regulates Their Division

Valcárcel-Martín R, Martín-Suárez S, Muro-García T, Pastor-Alonso O, Rodríguez de Fonseca F, et al. Frontiers in neuroscience 2020;14():811

Peroxisome Proliferator-Activated Receptors: Experimental Targeting for the Treatment of Inflammatory Bowel Diseases

Decara J, Rivera P, López-Gambero AJ, Serrano A, Pavón FJ, et al. Frontiers in pharmacology 2020;11():730

Plasma tryptophan and kynurenine pathway metabolites in abstinent patients with alcohol use disorder and high prevalence of psychiatric comorbidity

Vidal R, García-Marchena N, O’Shea E, Requena-Ocaña N, Flores-López M, et al. Progress in neuro-psychopharmacology & biological psychiatry 2020 Aug 30;102():109958

Potential association of plasma lysophosphatidic acid (LPA) species with cognitive impairment in abstinent alcohol use disorders outpatients

García-Marchena N, Pizarro N, Pavón FJ, Martínez-Huélamo M, Flores-López M, et al. Scientific reports 2020 Oct 13;10(1):17163

Social defeat-induced increase in the conditioned rewarding effects of cocaine: Role of CX3CL1

Montagud-Romero S, Montesinos J, Pavón FJ, Blanco-Gandia MC, Ballestín R, et al. Progress in neuro-psychopharmacology & biological psychiatry 2020 Jan 10;96():109753

Spectrophotometric Color Measurement to Assess Temperature of Exposure in Cortical and Medullar Heated Human Bones: A Preliminary Study

Rubio L, Díaz-Vico R, Smith-Fernández I, Smith-Fernández A, Suárez J, et al. Diagnostics (Basel, Switzerland) 2020 Nov 20;10(11):

The Biomedical Uses of Inositols: A Nutraceutical Approach to Metabolic Dysfunction in Aging and Neurodegenerative Diseases

López-Gambero AJ, Sanjuan C, Serrano-Castro PJ, Suárez J, Rodríguez de Fonseca F Biomedicines 2020 Aug 20;8(9):

The influence of dopaminergic polymorphisms on selective stopping

Rincón-Pérez I, Echeverry-Alzate V, Sánchez-Carmona AJ, Bühler KM, Hinojosa JA, et al. Behavioural brain research 2020 Mar 2;381():112441

Variation in chemokines plasma concentrations in primary care depressed patients associated with Internet-based cognitive-behavioral therapy

Romero-Sanchiz P, Nogueira-Arjona R, Araos P, Serrano A, Barrios V, et al. Scientific reports 2020 Jan 23;10(1):1078

A novel approach to childhood obesity: circulating chemokines and growth factors as biomarkers of insulin resistance

Rivera P, Martos-Moreno GÁ, Barrios V, Suárez J, Pavón FJ, et al. Pediatric obesity 2019 Mar;14(3):e12473

Adipocyte cannabinoid CB1 receptor deficiency alleviates high fat diet-induced memory deficit, depressive-like behavior, neuroinflammation and impairment in adult neurogenesis

Suárez J, Rivera P, Aparisi Rey A, Pérez-Martín M, Arrabal S, et al. Psychoneuroendocrinology 2019 Dec;110():104418

Adult-onset hypothyroidism increases ethanol consumption

Echeverry-Alzate V, Bühler KM, Calleja-Conde J, Huertas E, Maldonado R, et al. Psychopharmacology 2019 Apr;236(4):1187-1197

Alcohol-induced cognitive deficits are associated with decreased circulating levels of the neurotrophin BDNF in humans and rats

Silva-Peña D, García-Marchena N, Alén F, Araos P, Rivera P, et al. Addiction biology 2019 Sep;24(5):1019-1033

Brain Glucose-Sensing Mechanism and Energy Homeostasis

López-Gambero AJ, Martínez F, Salazar K, Cifuentes M, Nualart F Molecular neurobiology 2019 Feb;56(2):769-796

Bupropion, a possible antidepressant without negative effects on alcohol relapse

Ballesta A, Orio L, Arco R, Vargas A, Romero-Sanchiz P, et al. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2019 Jun;29(6):756-765

CB1 and LPA(1) Receptors Relationship in the Mouse Central Nervous System

González de San Román E, Manuel I, Ledent C, Chun J, Rodríguez de Fonseca F, et al. Frontiers in molecular neuroscience 2019;12():223

Cell Phone Use Habits Among the Spanish Population: Contribution of Applications to Problematic Use

De-Sola J, Rubio G, Talledo H, Pistoni L, Van Riesen H, et al. Frontiers in psychiatry 2019;10():883

Central administration of galanin N-terminal fragment 1-15 decreases the voluntary alcohol intake in rats

Millón C, Flores-Burgess A, Castilla-Ortega E, Gago B, García-Fernandez M, et al. Addiction biology 2019 Jan;24(1):76-87

Cognitive and neurobehavioral benefits of an enriched environment on young adult mice after chronic ethanol consumption during adolescence

Rico-Barrio I, Peñasco S, Puente N, Ramos A, Fontaine CJ, et al. Addiction biology 2019 Sep;24(5):969-980

Defensive pessimism, optimism and adaptation to chronic pain

Flores-Lopez, M; Serrano-Ibanez, ER; Ramirez-Maestre, C; Lopez-Martinez, AE; Ruiz-Parraga, GT; Esteve, R BEHAVIORAL PSYCHOLOGY-PSICOLOGIA CONDUCTUAL 2019

Effects of the LPA(1) Receptor Deficiency and Stress on the Hippocampal LPA Species in Mice

Tabbai S, Moreno-Fernández RD, Zambrana-Infantes E, Nieto-Quero A, Chun J, et al. Frontiers in molecular neuroscience 2019;12():146

Ethanol-induced alterations in endocannabinoids and relevant neurotransmitters in the nucleus accumbens of fatty acid amide hydrolase knockout mice

Pavón FJ, Serrano A, Stouffer DG, Polis I, Roberto M, et al. Addiction biology 2019 Nov;24(6):1204-1215

Highlighting the Role of Cognitive and Brain Reserve in the Substance use Disorder Field

Cutuli D, Ladrón de Guevara-Miranda D, Castilla-Ortega E, Santín LJ, Sampedro-Piquero P Current neuropharmacology 2019;17(11):1056-1070

Lysophosphatidic acid-induced increase in adult hippocampal neurogenesis facilitates the forgetting of cocaine-contextual memory

Ladrón de Guevara-Miranda D, Moreno-Fernández RD, Gil-Rodríguez S, Rosell-Valle C, Estivill-Torrús G, et al. Addiction biology 2019 May;24(3):458-470

Neuroplastic and cognitive impairment in substance use disorders: a therapeutic potential of cognitive stimulation

Sampedro-Piquero P, Ladrón de Guevara-Miranda D, Pavón FJ, Serrano A, Suárez J, et al. Neuroscience and biobehavioral reviews 2019 Nov;106():23-48

Oleoylethanolamide Modulates BDNF-ERK Signaling and Neurogenesis in the Hippocampi of Rats Exposed to Delta(9)-THC and Ethanol Binge Drinking During Adolescence

Silva-Peña D, Rivera P, Alén F, Vargas A, Rubio L, et al. Frontiers in molecular neuroscience 2019;12():96

Oleoylethanolamide restores alcohol-induced inhibition of neuronal proliferation and microglial activity in striatum

Rivera P, Silva-Peña D, Blanco E, Vargas A, Arrabal S, et al. Neuropharmacology 2019 Mar 1;146():184-197

Oleoylethanolamide, Neuroinflammation, and Alcohol Abuse

Orio L, Alen F, Pavón FJ, Serrano A, García-Bueno B Frontiers in molecular neuroscience 2018;11():490

Perinatal free-choice of a high-calorie low-protein diet affects leptin signaling through IRS1 and AMPK dephosphorylation in the hypothalami of female rat offspring in adulthood

Rivera P, Ramírez-López MT, Vargas A, Decara J, Vázquez M, et al. Acta physiologica (Oxford, England) 2019 Jun;226(2):e13244

Serotonin is the main tryptophan metabolite associated with psychiatric comorbidity in abstinent cocaine-addicted patients

Araos P, Vidal R, O’Shea E, Pedraz M, García-Marchena N, et al. Scientific reports 2019 Nov 14;9(1):16842

Sex-Dimorphic Behavioral Alterations and Altered Neurogenesis in U12 Intron Splicing-Defective Zrsr1 Mutant Mice

Alén F, Gómez-Redondo I, Rivera P, Suárez J, Ramos-Ibeas P, et al. International journal of molecular sciences 2019 Jul 19;20(14):

The presence of a social stimulus reduces cocaine-seeking in a place preference conditioning paradigm

Sampedro-Piquero P, Ávila-Gámiz F, Moreno Fernández RD, Castilla-Ortega E, Santín LJ Journal of psychopharmacology (Oxford, England) 2019 Dec;33(12):1501-1511

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Sampedro-Piquero P, Mañas-Padilla MC, Ávila-Gámiz F, Gil-Rodríguez S, Santín LJ, et al. Animal cognition 2019 May;22(3):433-443

Deficient endocannabinoid signaling in the central amygdala contributes to alcohol dependence-related anxiety-like behavior and excessive alcohol intake

Serrano A, Pavon FJ, Buczynski MW, Schlosburg J, Natividad LA, et al. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2018 Aug;43(9):1840-1850

Effects of genetic deletion versus pharmacological blockade of the LPA(1) receptor on depression-like behaviour and related brain functional activity

Moreno-Fernández RD, Nieto-Quero A, Gómez-Salas FJ, Chun J, Estivill-Torrús G, et al. Disease models & mechanisms 2018 Sep 10;11(9):

Fatty acid amide hydrolase (FAAH) inactivation confers enhanced sensitivity to nicotine-induced dopamine release in the mouse nucleus accumbens

Pavon FJ, Serrano A, Sidhpura N, Polis I, Stouffer D, et al. Addiction biology 2018 Mar;23(2):723-734

Higher Impulsivity As a Distinctive Trait of Severe Cocaine Addiction among Individuals Treated for Cocaine or Alcohol Use Disorders

García-Marchena N, Ladrón de Guevara-Miranda D, Pedraz M, Araos PF, Rubio G, et al. Frontiers in psychiatry 2018;9():26

Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice

Horiuchi K, Perez-Cerezales S, Papasaikas P, Ramos-Ibeas P, López-Cardona AP, et al. Cell reports 2018 Apr 3;23(1):143-155

Inclusion of Alcoholic Associations Into a Public Treatment Programme for Alcoholism Improves Outcomes During the Treatment and Continuing Care Period: A 6-Year Experience

Rubio G, Marín M, Arias F, López-Trabada JR, Iribarren M, et al. Alcohol and alcoholism (Oxford, Oxfordshire) 2018 Jan 1;53(1):78-88

Increased plasma oleoylethanolamide and palmitoleoylethanolamide levels correlate with inflammatory changes in alcohol binge drinkers: the case of HMGB1 in women

Antón M, Rodríguez-González A, Rodríguez-Rojo IC, Pastor A, Correas Á, et al. Addiction biology 2018 Nov;23(6):1242-1250

Inflammatory gene expression in adipose tissue according to diagnosis of anxiety and mood disorders in obese and non-obese subjects

Coín-Aragüez L, Pavón FJ, Contreras A, Gentile AM, Lhamyani S, et al. Scientific reports 2018 Nov 30;8(1):17518

Octadecylpropyl Sulfamide Reduces Neurodegeneration and Restores the Memory Deficits Induced by Hypoxia-Ischemia in Mice

Kossatz E, Silva-Peña D, Suárez J, de Fonseca FR, Maldonado R, et al. Frontiers in pharmacology 2018;9():376

Palmitoylethanolamide attenuates cocaine-induced behavioral sensitization and conditioned place preference in mice

Zambrana-Infantes E, Rosell Del Valle C, Ladrón de Guevara-Miranda D, Galeano P, Castilla-Ortega E, et al. Pharmacology, biochemistry, and behavior 2018 Mar;166():1-12

Palmitoylethanolamide prevents neuroinflammation, reduces astrogliosis and preserves recognition and spatial memory following induction of neonatal anoxia-ischemia

Holubiec MI, Romero JI, Suárez J, Portavella M, Fernández-Espejo E, et al. Psychopharmacology 2018 Oct;235(10):2929-2945

Pharmacological blockade of fatty acid amide hydrolase (FAAH) by URB597 improves memory and changes the phenotype of hippocampal microglia despite ethanol exposure

Rivera P, Fernández-Arjona MDM, Silva-Peña D, Blanco E, Vargas A, et al. Biochemical pharmacology 2018 Nov;157():244-257

PPAR alpha/CB1 receptor dual ligands as a novel therapy for alcohol use disorder: Evaluation of a novel oleic acid conjugate in preclinical rat models

Alen F, Decara J, Brunori G, You ZB, Bühler KM, et al. Biochemical pharmacology 2018 Nov;157():235-243

Red Bull (R) energy drink increases consumption of higher concentrations of alcohol

Roldán M, Echeverry-Alzate V, Bühler KM, Sánchez-Diez IJ, Calleja-Conde J, et al. Addiction biology 2018 Sep;23(5):1094-1105

Stress, Depression, Resilience and Ageing: A Role for the LPA-LPA(1) Pathway

Moreno-Fernandez RD, Tabbai S, Castilla-Ortega E, Perez-Martin M, Estivill-Torrus G, et al. Current neuropharmacology 2018 Mar 5;16(3):271-283

Systemic blockade of LPA(1/3) lysophosphatidic acid receptors by ki16425 modulates the effects of ethanol on the brain and behavior

Sánchez-Marín L, Ladrón de Guevara-Miranda D, Mañas-Padilla MC, Alén F, Moreno-Fernández RD, et al. Neuropharmacology 2018 May 1;133():189-201

The adiponectin promoter activator NP-1 induces high levels of circulating TNF alpha and weight loss in obese (fa/fa) Zucker rats

Decara J, Serrano A, Pavón FJ, Rivera P, Arco R, et al. Scientific reports 2018 Jun 29;8(1):9858

Training memory without aversion: Appetitive hole-board spatial learning increases adult hippocampal neurogenesis

Sampedro-Piquero P, Moreno-Fernández RD, Mañas-Padilla MC, Gil-Rodríguez S, Gavito AL, et al. Neurobiology of learning and memory 2018 May;151():35-42

A Positive Allosteric Modulator of the Serotonin 5-HT2c Receptor for Obesity

García-Cárceles J, Decara JM, Vázquez-Villa H, Rodríguez R, Codesido E, et al. Journal of medicinal chemistry 2017 Dec 14;60(23):9575-9584

Acetaminophen-Induced Liver Injury Alters the Acyl Ethanolamine-Based Anti-Inflammatory Signaling System in Liver

Rivera P, Pastor A, Arrabal S, Decara J, Vargas A, et al. Frontiers in pharmacology 2017;8():705

Acylethanolamides and endocannabinoid signaling system in dorsal striatum of rats exposed to perinatal asphyxia

Holubiec MI, Romero JI, Blanco E, Tornatore TL, Suarez J, et al. Neuroscience letters 2017 Jul 13;653():269-275

Decreased plasma concentrations of BDNF and IGF-1 in abstinent patients with alcohol use disorders

García-Marchena N, Silva-Peña D, Martín-Velasco AI, Villanúa MÁ, Araos P, et al. PloS one 2017;12(11):e0187634

Development of a Mobile Phone addiction craving scale and its Validation in a spanish adult Population

De-Sola J, Talledo H, Rubio G, de Fonseca FR Frontiers in psychiatry 2017;8():90

Differences in the Rates of Drug Polyconsumption and Psychiatric Comorbidity among Patients with Cocaine Use Disorders According to the Mental Health Service

Araos P, Vergara-Moragues E, González-Saiz F, Pedraz M, García-Marchena N, et al. Journal of psychoactive drugs 2017 Sep-Oct;49(4):306-315

Dopamine D-4 receptor stimulation prevents nigrostriatal dopamine pathway activation by morphine: relevance for drug addiction

Rivera A, Gago B, Suárez-Boomgaard D, Yoshitake T, Roales-Buján R, et al. Addiction biology 2017 Sep;22(5):1232-1245

Effects of Intermittent Alcohol Exposure on Emotion and Cognition: A Potential Role for the Endogenous Cannabinoid System and Neuroinflammation

Sanchez-Marin L, Pavon FJ, Decara J, Suarez J, Gavito A, et al. Frontiers in behavioral neuroscience 2017;11():15

Glutamate and Brain Glutaminases in Drug Addiction

Márquez J, Campos-Sandoval JA, Peñalver A, Matés JM, Segura JA, et al. Neurochemical research 2017 Mar;42(3):846-857

Glutaminase and MMP-9 Downregulation in Cortex and Hippocampus of LPA(1) Receptor Null Mice Correlate with Altered Dendritic Spine Plasticity

Peñalver A, Campos-Sandoval JA, Blanco E, Cardona C, Castilla L, et al. Frontiers in molecular neuroscience 2017;10():278

Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis

Ladrón de Guevara-Miranda D, Millón C, Rosell-Valle C, Pérez-Fernández M, Missiroli M, et al. Disease models & mechanisms 2017 Mar 1;10(3):323-336

Long-Term Effects of Intermittent Adolescent Alcohol Exposure in Male and Female Rats

Marco EM, Peñasco S, Hernández MD, Gil A, Borcel E, et al. Frontiers in behavioral neuroscience 2017;11():233

maLPA1-null mice as an endophenotype of anxious depression

Moreno-Fernández RD, Pérez-Martín M, Castilla-Ortega E, Rosell Del Valle C, García-Fernández MI, et al. Translational psychiatry 2017 Apr 4;7(4):e1077

Neuronal Damage Induced by Perinatal Asphyxia Is Attenuated by Postinjury Glutaredoxin-2 Administration

Romero JI, Holubiec MI, Tornatore TL, Rivière S, Hanschmann EM, et al. Oxidative medicine and cellular longevity 2017;2017():4162465

Plasma Chemokines in Patients with Alcohol Use Disorders: Association of CCL11 (Eotaxin-1) with Psychiatric Comorbidity

García-Marchena N, Araos PF, Barrios V, Sánchez-Marín L, Chowen JA, et al. Frontiers in psychiatry 2016;7():214

Plasma concentrations of oleoylethanolamide and other acylethanolamides are altered in alcohol-dependent patients: effect of length of abstinence

Garcia-Marchena N, Pavon FJ, Pastor A, Araos P, Pedraz M, et al. Addiction biology 2017 Sep;22(5):1366-1377

Psychiatric comorbidity and plasma levels of 2-acyl-glycerols in outpatient treatment alcohol users. Analysis of gender differences

García Marchena N, Araos P, Pavón FJ, Ponce G, Pedraz M, et al. Adicciones 2016 Sep 29;29(2):83-96

Psychological Factors and Alcohol Use in Problematic Mobile Phone Use in the Spanish Population

De-Sola J, Talledo H, Rubio G, de Fonseca FR Frontiers in psychiatry 2017;8():11

Text mining and expert curation to develop a database on psychiatric diseases and their genes

Gutiérrez-Sacristán A, Bravo À, Portero-Tresserra M, Valverde O, Armario A, et al. Database : the journal of biological databases and curation 2017 Jan 1;2017():

The CB1 receptor is required for the establishment of the hyperlocomotor phenotype in developmentally-induced hypothyroidism in mice

Giné E, Echeverry-Alzate V, Lopez-Moreno JA, Rodriguez de Fonseca F, Perez-Castillo A, et al. Neuropharmacology 2017 Apr;116():132-141

The impact of cocaine on adult hippocampal neurogenesis: Potential neurobiological mechanisms and contributions to maladaptive cognition in cocaine addiction disorder

Castilla-Ortega E, Ladrón de Guevara-Miranda D, Serrano A, Pavón FJ, Suárez J, et al. Biochemical pharmacology 2017 Oct 1;141():100-117

The neuropeptides Galanin and Galanin(1-15) in depression-like behaviours

Millón C, Flores-Burgess A, Narváez M, Borroto-Escuela DO, Gago B, et al. Neuropeptides 2017 Aug;64():39-45

A place for the hippocampus in the cocaine addiction circuit: Potential roles for adult hippocampal neurogenesis

Castilla-Ortega E, Serrano A, Blanco E, Araos P, Suárez J, et al. Neuroscience and biobehavioral reviews 2016 Jul;66():15-32

An Internet-Based Intervention for Depression in Primary Care in Spain: A Randomized Controlled Trial

Montero-Marín J, Araya R, Pérez-Yus MC, Mayoral F, Gili M, et al. Journal of medical Internet research 2016 Aug 26;18(8):e231

Antiobesity efficacy of GLP-1 receptor agonist liraglutide is associated with peripheral tissue-specific modulation of lipid metabolic regulators

Decara J, Arrabal S, Beiroa D, Rivera P, Vargas A, et al. BioFactors (Oxford, England) 2016 Nov 12;42(6):600-611

Both genetic deletion and pharmacological blockade of lysophosphatidic acid LPA(1) receptor results in increased alcohol consumption

Castilla-Ortega E, Pavón FJ, Sánchez-Marín L, Estivill-Torrús G, Pedraza C, et al. Neuropharmacology 2016 Apr;103():92-103

Can symptoms help in differential diagnosis between substance-induced vs independent psychosis in adults with a lifetime diagnosis of cocaine use disorder?

Vergara-Moragues E, Mestre-Pintó JI, Gómez PA, Rodríguez-Fonseca F, Torrens M, et al. Psychiatry research 2016 Aug 30;242():94-100

Cannabinoid CB1 Receptors Are Localized in Striated Muscle Mitochondria and Regulate Mitochondrial Respiration

Mendizabal-Zubiaga J, Melser S, Bénard G, Ramos A, Reguero L, et al. Frontiers in physiology 2016;7():476

Cocaine-conditioned place preference is predicted by previous anxiety-like behavior and is related to an increased number of neurons in the basolateral amygdala

Ladrón de Guevara-Miranda D, Pavón FJ, Serrano A, Rivera P, Estivill-Torrús G, et al. Behavioural brain research 2016 Feb 1;298(Pt B):35-43

Cocaine-induced behavioral sensitization decreases the expression of endocannabinoid signaling-related proteins in the mouse hippocampus

Blanco E, Galeano P, Palomino A, Pavón FJ, Rivera P, et al. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2016 Mar;26(3):477-92

ENVIRONMENTAL ENRICHMENT AS A THERAPEUTIC AVENUE FOR ANXIETY IN AGED WISTAR RATS: EFFECT ON CAT ODOR EXPOSITION AND GABAergic INTERNEURONS

Sampedro-Piquero P, Castilla-Ortega E, Zancada-Menendez C, Santín LJ, Begega A Neuroscience 2016 Aug 25;330():17-25

Environmental Enrichment, Age, and PPAR alpha Interact to Regulate Proliferation in Neurogenic Niches

Pérez-Martín M, Rivera P, Blanco E, Lorefice C, Decara J, et al. Frontiers in neuroscience 2016;10():89

Nalmefene is effective at reducing alcohol seeking, treating alcohol-cocaine interactions and reducing alcohol-induced histone deacetylases gene expression in blood

Calleja-Conde J, Echeverry-Alzate V, Giné E, Bühler KM, Nadal R, et al. British journal of pharmacology 2016 Aug;173(16):2490-505

Pharmacological reduction of adult hippocampal neurogenesis modifies functional brain circuits in mice exposed to a cocaine conditioned place preference paradigm

Castilla-Ortega E, Blanco E, Serrano A, Ladrón de Guevara-Miranda D, Pedraz M, et al. Addiction biology 2016 May;21(3):575-88

Role of the satiety factor oleoylethanolamide in alcoholism

Bilbao A, Serrano A, Cippitelli A, Pavón FJ, Giuffrida A, et al. Addiction biology 2016 Jul;21(4):859-72

Single administration of recombinant IL-6 restores the gene expression of lipogenic enzymes in liver of fasting IL-6-deficient mice

Gavito AL, Cabello R, Suarez J, Serrano A, Pavón FJ, et al. British journal of pharmacology 2016 Mar;173(6):1070-84

Spinal cord compression injury in lysophosphatidic acid 1 receptor-null mice promotes maladaptive pronociceptive descending control.

Suardíaz M, Galan-Arriero I, Avila-Martin G, Estivill-Torrús G, de Fonseca FR, et al. European journal of pain (London, England) 2016 Feb;20(2):176-85

Activation of Lysophosphatidic Acid Receptor Type 1 Contributes to Pathophysiology of Spinal Cord Injury

Santos-Nogueira E, López-Serrano C, Hernández J, Lago N, Astudillo AM, et al. The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Jul 15;35(28):10224-35

Anatomical location of LPA(1) activation and LPA phospholipid precursors in rodent and human brain

González de San Román E, Manuel I, Giralt MT, Chun J, Estivill-Torrús G, et al. Journal of neurochemistry 2015 Aug;134(3):471-85

Chronic administration of recombinant IL-6 upregulates lipogenic enzyme expression and aggravates high-fat-diet-induced steatosis in IL-6-deficient mice

Vida M, Gavito AL, Pavón FJ, Bautista D, Serrano A, et al. Disease models & mechanisms 2015 Jul 1;8(7):721-31

Cocaine-Induced Behavioral Sensitization Is Associated With Changes in the Expression of Endocannabinoid and Glutamatergic Signaling Systems in the Mouse Prefrontal Cortex

Blanco E, Pavón FJ, Palomino A, Luque-Rojas MJ, Serrano A, et al. The international journal of neuropsychopharmacology 2014 Oct 31;18(1):

Common single nucleotide variants underlying drug addiction: more than a decade of research

Bühler KM, Giné E, Echeverry-Alzate V, Calleja-Conde J, de Fonseca FR, et al. Addiction biology 2015 Sep;20(5):845-71

Effects of Synchronous and Asynchronous Embryo Transfer on Postnatal Development, Adult Health, and Behavior in Mice

López-Cardona AP, Fernández-González R, Pérez-Crespo M, Alén F, de Fonseca FR, et al. Biology of reproduction 2015 Oct;93(4):85

Expectations Among Patients and Health Professionals Regarding Web-Based Interventions for Depression in Primary Care: A Qualitative Study

Montero-Marín J, Prado-Abril J, Botella C, Mayoral-Cleries F, Baños R, et al. Journal of medical Internet research 2015 Mar 10;17(3):e67

Histone Deacetylase Gene Expression Following Binge Alcohol Consumption in Rats and Humans

López-Moreno JA, Marcos M, Calleja-Conde J, Echeverry-Alzate V, Bühler KM, et al. Alcoholism, clinical and experimental research 2015 Oct;39(10):1939-50

Life-long environmental enrichment counteracts spatial learning, reference and working memory deficits in middle-aged rats subjected to perinatal asphyxia

Galeano P, Blanco E, Logica Tornatore TM, Romero JI, Holubiec MI, et al. Frontiers in behavioral neuroscience 2014;8():406

Loss of lysophosphatidic acid receptor LPA(1) alters oligodendrocyte differentiation and myelination in the mouse cerebral cortex

García-Díaz B, Riquelme R, Varela-Nieto I, Jiménez AJ, de Diego I, et al. Brain structure & function 2015 Nov;220(6):3701-20

Narrow Specificity of Responsibility and Intolerance of Uncertainty in Obsessive-Compulsive Behavior and Generalized Anxiety Symptoms

Romero-Sanchiz, P; Nogueira-Arjona, R; Godoy-Avila, A; Gavino-Lazaro, A; Freeston, MH INTERNATIONAL JOURNAL OF COGNITIVE THERAPY 2015

Novel Oxazolidinone-Based Peroxisome Proliferator Activated Receptor Agonists: Molecular Modeling, Synthesis, and Biological Evaluation

Fresno N, Macías-González M, Torres-Zaguirre A, Romero-Cuevas M, Sanz-Camacho P, et al. Journal of medicinal chemistry 2015 Aug 27;58(16):6639-52

Pharmacological Blockade of Cannabinoid CB1 Receptors in Diet-Induced Obesity Regulates Mitochondrial Dihydrolipoamide Dehydrogenase in Muscle

Arrabal S, Lucena MA, Canduela MJ, Ramos-Uriarte A, Rivera P, et al. PloS one 2015;10(12):e0145244

Plasma Concentrations of BDNF and IGF-1 in Abstinent Cocaine Users with High Prevalence of Substance Use Disorders: Relationship to Psychiatric Comorbidity

Pedraz M, Martín-Velasco AI, García-Marchena N, Araos P, Serrano A, et al. PloS one 2015;10(3):e0118610

Spectrophotometric analysis of color changes in teeth incinerated at increasing temperatures

Rubio L, Sioli JM, Suarez J, Gaitan MJ, Martin-de-las-Heras S Forensic science international 2015 Jul;252():193.e1-6

Systemic Administration of Oleoylethanolamide Protects from Neuroinflammation and Anhedonia Induced by LPS in Rats

Sayd A, Antón M, Alén F, Caso JR, Pavón J, et al. The international journal of neuropsychopharmacology 2014 Dec 28;18(6):

THE ROLE OF MATERNAL DIET IN METABOLIC AND BEHAVIOURAL PROGRAMMING: REVIEW OF BIOLOGIC MECHANISMS INVOLVED

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