Dietary Intervention in Food Allergy: Microbiome, Epigenetic and Metabolomic interactions
Financed by : Instituto de Salud Carlos III – ISCIII
Program : ERA-HDHL JFA2 “Nutrition & the Epigenome” (Epigenome)
Grant Agreement ID: AC18/00031
Role in the project: Coordinator
Duration: January 2019 to December 2021
Cumulative evidence suggests that food allergy (FA) is associated with a multitude of environmental factors including hygiene habits, antibiotic use, lifestyle changes and in particular, diet. Changes in nutrition can result in dysbiosis of the skin, gut and lung microbiota and generate changes in microbial metabolites produced, which may in turn produce epigenetic modifications. Current evidence supports the view that epigenetic mechanisms are involved in immune regulation and may represent a key-missing piece of the etiological puzzle for FA, at the interface between the environment and the genome. Dietary fiber can change the gut microbiota composition and therefore cause epigenome changes promoting health.
DIFAMEM aims to investigate the effects of FA treatment through intervention with a prebiotic dietary component, pectin, and using peach allergy as a model.
This project will advance our understanding on how the interaction between dietary components and gut microbiota composition leads to epigenetic changes that provoke the immune modulation, and establish new strategies for dietary intervention in FA, with potential applications for other immune-related diseases.