A European Network for Connective Tissue Calcifying Diseases.

Financed by : European Commission


Reference: CA16115

Duration: April 2017 to October 2021



Calcification and crystal deposition into the connective tissues is an independent risk factor for cardiovascular disease, also associated to aging, several chronic metabolic diseases & tumor malignancy and in rare inherited diseases. Initially considered as a passive, unregulated and degenerative dystrophic process, there is now evidence that this process is regulated. Advances have been made in the understanding of these finely tuned biological mechanisms. However, discoveries remain to be made to provide efficient treatments to patients. Indeed, the study of these diseases is crucial for the understanding of the mechanisms of connective tissue calcification (CTC) but is hampered by the rarity of the cases and cohorts with limited access for researchers.

Advances in the diagnosis, management and treatment of inherited CTC remain also a major drawback mainly because of the lack of training among both clinicians and patients.

In view of the different actors and their common objectives, creating a network would be the opportunity to build a community bringing together for the first time not only researchers and clinicians groups but also patients and patients’ associations, public institutions and industries through meetings, training schools, short term scientific missions and the use of social media in order to provide visibility, funding and advances in health management.

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